In Vivo Antiplasmodial Activity and Toxicological Analyses of the Ethanolic Leaf and Twig Extract of Faurea speciosa Welw. (Proteaceae) by Felix Ayisi, Caleb Nketia Mensah, Lawrence Sheringham Borquaye

“…The antiplasmodial effect against early infection, curative effect against established infection, and prophylactic effect against residual infection were studied in vivo in Plasmodium berghei-infected mice while the carrageenan-induced edema model in chicks was used for anti-inflammatory tests. …”
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Monitoring of enzymatic cleavage reaction of GST-fusion protein on biolayer interferometry sensor by Sena Tarumoto, Sei Inoue, Rina Yanagimoto, Takashi Saitoh

“…The soluble domain of the Tic22 protein from Plasmodium falciparum was expressed and purified as a GST-tagged fusion protein, GST-Tic22, in Escherichia coli. …”
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Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides by Beus Maja, Fontinha Diana, Held Jana, Rajić Zrinka, Prudêncio Miguel, Zorc Branka

“…Title compounds showed marked, dose dependent activity in vitro against hepatic stages of Plasmodium berghei. IC50 values of the most active compounds 5, 7 and 9 bearing 3-fluoro, 3-chloro and 3-trifluoromethyl substituents were 3.04–4.16 µmol L−1, respectively. …”
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Significant Decline of Malaria Incidence in Southwest of Iran (2001–2014) by Shokrollah Salmanzadeh, Masoud Foroutan-Rad, Shahram Khademvatan, Sasan Moogahi, Shahla Bigdeli

“…The highest number of infections was seen in 2001 with 161 (29.75%) cases and the lowest was in 2014 with 0 (0%). Also, Plasmodium vivax was identified as dominant species in 478 (88.35%) individuals and P. falciparum comprised 63 (11.65%). …”
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Systematic characterization of all Toxoplasma gondii TBC domain-containing proteins identifies an essential regulator of Rab2 in the secretory pathway. by Justin J Quan, Lachezar A Nikolov, Jihui Sha, James A Wohlschlegel, Isabelle Coppens, Peter J Bradley

“…We show that the conserved dual-finger active site in the TBC domain of the protein is critical for its GTPase-activating protein (GAP) function and that the Plasmodium falciparum orthologue of TgTBC9 can rescue the lethal knockdown. …”
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Antimalarial Activity of Piperine by Artitaya Thiengsusuk, Phunuch Muhamad, Wanna Chaijaroenkul, Kesara Na-Bangchang

“…Malaria remains a public health problem in tropical and subtropical regions. Resistance of Plasmodium falciparum to artemisinins in Southeast Asia is a great concern for disease control and research on discovery and development of new alternative antimalarial drugs is urgently required. …”
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Analysis of Five-Year Trend of Malaria at Bichena Primary Hospital, Amhara Region, Ethiopia by Awoke Minwuyelet, Yibeltal Aschale

“…Malaria is a life-threating infectious diseases caused by protozoan parasite of the genus Plasmodium. The WHO African region bears the largest burden of malaria morbidity and mortality every year. …”
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Endothelial molecule levels (VCAM-1, ICAM-1) in uncomplicated malaria cases in Lagos, Nigeria by Uche T. Igbasi, Wellington A. Oyibo

“…Elevated endothelial activation markers are linked to malaria syndromes due to the sequestration of Plasmodium falciparum-infected red blood cells in deep tissue vessels. …”
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Assessing the Roles of Molecular Markers of Antimalarial Drug Resistance and the Host Pharmacogenetics in Drug-Resistant Malaria by Peter Hodoameda, Nancy Odurowah Duah-Quashie, Neils Ben Quashie

“…Malaria caused by the Plasmodium parasites is a major public health concern in malaria-endemic regions with P. falciparum causing the most severe form of the disease. …”
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Emerging trends and new developments in global research on artemisinin and its derivatives by Yu Lai, Huize Zhang, Xi Chen

“…''Antimalarials,'' ''synthesis,'' ''drug resistance,'' and ''Plasmodium vivax'' are areas of intense research. Potential areas for future investigations may include ''proliferation,'' ''oxidative stress,'' ''pathways,'' and ''mechanisms.'' …”
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Repellency Potential, Chemical Constituents of Ocimum Plant Essential Oils, and Their Headspace Volatiles against Anopheles gambiae s. s., Malaria Vector by Jonathan Osei-Owusu, William K. Heve, Owusu Fordjour Aidoo, Maxwell Jnr Opoku, Joseph Apau, Kodwo Ninsin Dadzie, Bright Yaw Vigbedor, Kwaafo Akoto Awuah-Mensah, Margaret Appiah, Akwasi Acheampong, Michael Birkett, Antony Hooper

“…African malaria mosquitoes (Anopheles gambiae sensu stricto) transmit a malaria parasite (Plasmodium falciparum) to humans. The current control strategies for the vector have mainly focussed on synthetic products, which negatively impact the environment and human health. …”
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Review of Atypical Organometallic Compounds as Antimalarial Drugs by Samuel K. Kwofie, Emmanuel Broni, Bismark Dankwa, Kweku S. Enninful, Joshua Teye, Cedar R. Davidson, Josephine B. Nimely, J. Chioma Orizu, Prakasha Kempaiah, Brijesh Rathi, Whelton A. Miller

“…Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. …”
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Development and experimental validation of a machine learning model for the prediction of new antimalarials by Mukul Kore, Dimple Acharya, Lakshya Sharma, Shruthi Sridhar Vembar, Sandeep Sundriyal

“…Rather than depending on high throughput screening (HTS) data, molecules tested at multiple doses against blood stages of Plasmodium falciparum were used for model development. …”
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Acquisition of Fc-afucosylation of PfEMP1-specific IgG is age-dependent and associated with clinical protection against malaria by Mary Lopez-Perez, Zakaria Seidu, Mads Delbo Larsen, Wenjun Wang, Jan Nouta, Manfred Wuhrer, Gestur Vidarsson, Michael F. Ofori, Lars Hviid

“…Abstract Protective immunity to malaria depends on acquisition of parasite-specific antibodies, with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) being one of the most important target antigens. …”
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A matter of timing: Biting by malaria-infected Anopheles mosquitoes and the use of interventions during the night in rural south-eastern Tanzania. by Isaac Haggai Namango, Sarah J Moore, Carly Marshall, Adam Saddler, David Kaftan, Frank Chelestino Tenywa, Noely Makungwa, Alex J Limwagu, Salum Mapua, Olukayode G Odufuwa, Godfrey Ligema, Hassan Ngonyani, Isaya Matanila, Jameel Bharmal, Jason Moore, Marceline Finda, Fredros Okumu, Manuel W Hetzel, Amanda Ross

“…Mosquitoes were collected hourly from 6PM to 6AM indoors and outdoors by human landing catches in 2019, and tested for Plasmodium falciparum sporozoite infections using ELISA. …”
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Free Radical Scavenging, Anti-Infectious, and Toxicity Activities from Stenochlaena palustris (Burm.f.) Bedd. Extracts by Rudi Hendra, Rohimatul Khodijah, Muhammad Almurdani, Yuli Haryani, Ari Satia Nugraha, Neni Frimayanti, Hilwan Yuda Teruna, Rizky Abdulah

“…The antiplasmodial and toxicity assays were conducted using two Plasmodium falciparum strains (3D7 and W2) and the brine shrimp lethality test. …”
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Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms by Renato M. S. de Lima, Luana K. R. Leão, Luana C. Martins, Adelaide da C. Fonseca Passos, Evander de J. Oliveira Batista, Anderson M. Herculano, Karen R. H. M. Oliveira

“…Cerebral malaria is the most severe and lethal complication caused by Plasmodium falciparum infection, leading to critical neurological impairments and long-term cognitive, behavioral, and neurological sequelae in survivors, particularly affecting children under the age of five. …”
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Molecular Modeling of Antimalarial Agents by 3D-QSAR Study and Molecular Docking of Two Hybrids 4-Aminoquinoline-1,3,5-triazine and 4-Aminoquinoline-oxalamide Derivatives with the... by Hanine Hadni, Mohamed Mazigh, El’mbarki Charif, Asmae Bouayad, Menana Elhallaoui

“…Modeling studies using 3D-QSAR and molecular docking methods were performed on a set of 34 hybrids of 4-aminoquinoline derivatives previously studied as effective antimalarial agents of wild type and quadruple mutant Plasmodium falciparum dihydrofolate reductase (DHFR). …”
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Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana by Patrick Adu, David Larbi Simpong, Godfred Takyi, Richard K. D. Ephraim

“…In Ghana, severe anaemia is mostly due to malaria caused by severe Plasmodium falciparum infection, road traffic accidents, and haemoglobinopathy-induced acute haemolysis. …”
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Factors Associated with Malaria Infection among Head Porters in Agbogbloshie Market in the Greater Accra Region of Ghana by Patience Kwofie, John Tetteh, Reindorf Elijah Akakpo, Bismark Sarfo

“…The study revealed 12% (CI 95%=8.2‐16.9) and 9.6% (CI 95%=6.3‐14.4) infection of malaria using RDT and microscopy, respectively. Plasmodium falciparum (21/218) was the main parasite detected in all positive blood samples. …”
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