MUC5B modulation of early oral biofilm glucose metabolism by Carolina Robertsson, Carolina Robertsson, Julia Davies, Gunnel Svensäter, Anders Bay Nord, Niclas Norrström, Claes Wickström

“…In early biofilms where they were each present, pyruvate, ethanol, and metabolite 134 were present in significantly higher abundance in the presence of 25% MUC5B with 20 mM glucose (MUC5B + G) compared with a physiologic buffer with 20 mM glucose (PBS + G), while metabolites 84, 97, and sarcosine were present at significantly lower abundance. …”
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Cadmium and lead uptake by wild swamp eel in the populous river by N. Nurhasanah, L. Sulistyowati, E. Riani, M. Cordova

“…However, cadmium and lead pollution must be handled with extreme caution because it interferes with the physiological processes of the biota, hence decreasing the population of eels and posing a health risk if consumed. …”
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Evaluation of Root Canal Diameters and Radicular Wall Thickness of the Human Primary Molars by using Multidetector Computed Tomography: A Cross-sectional Study by Piyali Datta, Shabnam Zahir, Kaushik Dutta, Pratik Kumar Lahiri, Sudipta Kar, Biswaroop Chandra, Trishik Basak, Shreya Tripathi

“…Introduction: Paediatric endodontics is critical for preserving the primary tooth until its physiologic exfoliation and ensuring the child’s quality of life. …”
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Association of extreme heat events with sleep and cardiovascular health: a scoping review by Nathan Ashe, Sarah Wozniak, Malcolm Conner, Rayan Ahmed, Olivia Keenan, Michelle R. Demetres, Nour Makarem, Parisa Tehranifar, Rajalakshmi Nandakumar, Arnab K. Ghosh

“…Conclusions Few studies examine the link between CVD, sleep, and extreme heat as a possible mechanism of elevated CVD risk during EHEs, despite a strong physiological rationale. Our findings highlight an important gap in the literature that should be closely examined as EHEs become more frequent and their harmful impacts of health increase.…”
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Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study by Renhua Lu, Yan Fang, Wangshu Wu, Xiaojun Zeng, Tingting Liu, Yue Qian, Yuanyuan Xie, Yijun Zhou, Leyi Gu

“…Additionally, it retains essential physiological compounds like albumin and branched-chain amino acids, underscoring its commendable safety profile.…”
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In vivo and in silico study of europinidin against streptozotocin-isoproterenol-induced myocardial damage via alteration of hs-CRP/CPK-MB/Caspase-3/Bcl-2 pathways by Khalid Saad Alharbi, Muhammad Afzal, Fahad A. Al-Abbasi, Ehssan Moglad, Salwa D. Al-Qahtani, Naif A. R. Almalki, Faisal Imam, Nadeem Sayyed, Imran Kazmi

“…Abstract Europinidin is a novel anthocyanidin found in the petals of Plumbago europea that exhibits several physiological effects. Research was conducted to assess europinidin’s cardioprotective efficacy in a diabetic and myocardial infarction (MI) experimental model. …”
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Effects of dietary l-carnosine supplementation on the growth, intestinal microbiota, and serum metabolome of fattening lambs by Yaxuan Meng, Yaxuan Meng, Yaxuan Meng, Tingting Xian, Tingting Xian, Guolei Kang, Hongna Wang, Tao Feng, Tao Feng, Tao Feng

“…However, the mechanisms underlying the effects of l-carnosine on the physiological functions of animals have not been fully elucidated. …”
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Ion homeostasis and coordinated salt tolerance mechanisms in a barley (Hordeum vulgare L.)doubled haploid line by Hongwei Xu, Hui Chen, Nigel G. Halford, RugenXu, Ting He, Bangwei Yang, Longhua Zhou, HuiminGuo, ChenghongLiu

“…However, one of the primary obstacles to achieving this goal in crops is the physiological complexity of the salt-tolerance trait. …”
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In Vitro and In Vivo Evaluation of Sorghum (Sorghum bicolor L. Moench) Genotypes for Pre- and Post-attachment Resistance against Witchweed (Striga asiatica L. Kuntze) by V. O. Gwatidzo, J. T. Rugare, S. Mabasa, R. Mandumbu, J. Chipomho, S. Chikuta

“…The second experiment was a seven (7) (sorghum genotypes)∗two (2) (Striga treatments) factorial glasshouse experiment conducted to evaluate the effects of Striga on sorghum growth, physiological and yield components of sorghum, Striga syndrome rating, and number of Striga per plant. …”
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Application of the DEB-TKTD model with multi-omics data: Prediction of life history traits of Chinese mitten crab (Eriocheir sinensis) under different salinities by Hanzun Zhang, Shipeng Dong, Hongwei Shan, Chao Yang, Fang Wang

“…The omics data were used to ascertain the physiological mode of action (pMoA) affected by salinity in the crabs. …”
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Multimodal Pain Recognition in Postoperative Patients: Machine Learning Approach by Ajan Subramanian, Rui Cao, Emad Kasaeyan Naeini, Seyed Amir Hossein Aqajari, Thomas D Hughes, Michael-David Calderon, Kai Zheng, Nikil Dutt, Pasi Liljeberg, Sanna Salanterä, Ariana M Nelson, Amir M Rahmani

“…Multimodal pain assessment, integrating physiological and behavioral data, presents an opportunity to create more objective and accurate pain measurement systems. …”
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Neospora caninum infection specifically suppresses the expression of a host lncRNA XR_001919077.1 to facilitate parasite propagation by modulating host cell mitochondrial function... by Shan-Shan Zhao, De-Liang Tao, Jin-Ming Chen, Ming-Yi Zhang, Xin Yang, Jun-Ke Song, Qun Liu, Guang-Hui Zhao

“…Long non-coding RNAs (lncRNAs) have been reported to be important regulators involved in a great number of physiological and pathological processes. Our previous study found that N. caninum infection induced significantly aberrant expression of lncRNA profiles in caprine endometrial epithelial cells (EECs). …”
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Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis by Victoria Kulesh, Victoria Kulesh, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov

“…Overall, it provides the most up-to-date view of physiological T-cell dynamics and its variance and may be used as a consistent reference for gaining further mechanistic understanding of the human immune status in health and disease.…”
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Characterization and Study of Gene Expression Profiles of Human Periodontal Mesenchymal Stem Cells in Spheroid Cultures by Transcriptome Analysis by Takenori Suga, Michihiko Usui, Satoru Onizuka, Kotaro Sano, Tsuyoshi Sato, Kohji Nakazawa, Wataru Ariyoshi, Tatsuji Nishihara, Keisuke Nakashima

“…A spheroid is known as a three-dimensional culture model, which better simulates the physiological conditions of stem cells. This study is aimed at identifying genes specifically expressed in spheroid-cultured human periodontal ligament mesenchymal stem cells (hPDLMSCs) using RNA-seq analysis to evaluate their functions. …”
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Multi-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury by Ren Zhou, Jibao Chen, Yunhan Tang, Chuijin Wei, Ping Yu, Xinmei Ding, Li’ao Zhu, Jiajia Yao, Zengqiang Ouyang, Jing Qiao, Shumin Xiong, Liaoliao Dong, Tong Yin, Haiqing Li, Ye Feng, Lin Cheng

“…Subsequently, we established a weight-loaded ladder-climbing mouse model to mimic the physiological effects of resistance exercise, and we analyzed the plasma proteome and metabolome, as well as the transcriptomes of PBMC and muscle tissue. …”
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No major impact of new grape varieties on Bordeaux wine typicity: expert assessments in blind and non-blind tastings by Marc Plantevin, Sophie Tempère, Cécile Thibon, Lucile Dijkstra, Julien Lecourt, Agnès Destrac-Irvine, Cornelis van Leeuwen

“…In Bordeaux (France), a considerable research effort addresses the physiological traits of new varieties to thrive in a climate becoming increasingly dry and warm. …”
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Crystalloid resuscitation is associated with decreased treatment delays and improved systolic blood pressures in a blood-constrained setting by Melissa Carvalho, Alain Chichom-Mefire, Catherine Juillard, S Ariane Christie, Rasheedat Oke, Thompson Kinge, Jean-Gustave Tsiagadigui, Mbiarikai A Mbianyor, Mark T Yost, Matt Driban, Fanny Nadia Dissak Delon, Richard Njock, Daniel Nkusu

“…In blood-constrained settings, treatment delays associated with blood product transfusion may offset the physiologic benefits of an early BL strategy. CB prior to definitive hemorrhage control in this resource-limited setting may be a necessary strategy to optimize perfusion pressure.Level of evidence and study type III, retrospective study.…”
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Impact of Lower-Volume Training on Physical Fitness Adaptations in Team Sports Players: A Systematic Review and Meta-analysis by Filipe Manuel Clemente, Rodrigo Ramirez-Campillo, Jason Moran, Piotr Zmijewski, Rui Miguel Silva, Morten Bredsgaard Randers

“…Thus, the objectives of this systematic review with meta-analysis are twofold: (i) to summarize the primary physiological and physical fitness outcomes of lower-volume versus higher-volume training interventions in team sports players; and (ii) to compare the effects of lower-volume training with higher, considering the training modalities used. …”
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Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain by Christian Kirschneck, Erika Calvano Küchler, Michael Wolf, Gerrit Spanier, Peter Proff, Agnes Schröder

“…In this in vitro study, we investigated possible side effects of two clinically relevant etoricoxib concentrations on the expression pattern of mechanically strained hPDL fibroblasts and associated osteoclastogenesis in a model of simulated orthodontic compressive strain occurring during orthodontic tooth movement. hPDL fibroblasts were incubated for 72 h under physiological conditions with etoricoxib at 0 μM, 3.29 μM, and 5.49 μM, corresponding to clinically normal and subtoxic dosages, with and without mechanical strain by compression (2 g/cm2) for the final 48 h, simulating conditions during orthodontic tooth movement in compressive areas of the periodontal ligament. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…The cytotoxicity of 64-8a CFR T cells was significantly inhibited by free human IgG at a physiological dose (P < 0.001), which was not observed in 16s3, 32-8a CFR T cells. …”
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