Bayesian sequential monitoring strategies for trials of digestive cancer therapeutics by Guillaume Mulier, Ruitao Lin, Thomas Aparicio, Lucie Biard

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Mitoxantrone in combination with clofarabine (MITCL) in children, adolescents and young adults with relapsed/refractory acute leukaemia: final results of a phase I/II trialResearch... by Jessica Hochberg, Javier Oesterheld, Aliza Gardenswartz, Allyson Flower, Liana Klejmont, Jackie Basso, Qiuhu Shi, Lauren Harrison, Michael J. Borowitz, Michael R. Loken, Mitchell S. Cairo

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Methodology for environmental risk assessment associated with the use of veterinary medicinal products by Ioana Valentina Tihulca

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Prospects of clinical trials for novel therapeutic approaches in celiac disease by Anmar AL-Taie, Amina Murodalieva, Maryam Abdullah, Nawaz Khoshnaw

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Immunotherapy for gastric cancer: Advances and challenges by Pei Zhang, Chenyan Zhang, Xiaoying Li, Chen Chang, Cailing Gan, Tinghong Ye, Dan Cao

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Family-based treatment with metacognitive therapy for adolescents with anorexia nervosa: findings from a phase II trial by Beate Østgård, Gunn Julie D. Nordahl, Arve Strandheim, Hans M. Nordahl

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Long-Term Safety and Efficacy of Macitentan in Inoperable Chronic Thromboembolic Pulmonary Hypertension: Results from MERIT and its Open-Label Extension by Nick H. Kim, Andrea M. D’Armini, Luke S. Howard, David P. Jenkins, Zhi-Cheng Jing, Eckhard Mayer, Liliya Chamitava, Gabriela Lack, Hany Rofael, Maria Solonets, Hossein-Ardeschir Ghofrani

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A Multicenter Randomized Double-Blind Vehicle-Controlled Parallel Group Phase 2 Study Evaluating the Efficacy and Safety of GN-037 Cream in Patients with Mild-to-Moderate Plaque Ps... by Burhan Engin, Müge Güler Özden, Özge Sevil Karstarlı Bakay, Selda Pelin Kartal, İlkin Zindancı, Salih Levent Çınar, Recep Dursun, Gizem Pehlivan Ulutaş, Tuğba Özkök Özkök Akbulut, Fatma Aslı Hapa, Emel Bülbül Başkan, Mehmet Melikoğlu, Algün Polat Ekinci, Neslihan Demirel Öğüt, Pelin Hızlı, Zafer Türkoğlu, Özlem Su Küçük, Zeynep Topkarcı, Ümit Türsen, Filiz Canpolat, Hanife Uçgun, Şirin Yaşar, Selami Aykut Temiz, Asena Çiğdem Doğramacı, Sedat Altuğ, Serhat Kozlu, Nadir Ulu, Server Serdaroğlu

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Inhibition of Interleukin-33 to Reduce Glomerular Endothelial Inflammation in Diabetic Kidney Disease by Alexis Hofherr, Elena Liarte Marin, Barbara Musial, Asha Seth, Tim Slidel, James Conway, David Baker, Pernille B.L. Hansen, Benjamin Challis, Stefano Bartesaghi, Maria Bhat, Roberto Pecoits-Filho, Xiao Tu, Viknesh Selvarajah, Kevin Woollard, Hiddo J.L. Heerspink

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drugdevelopR: Planning of phase II/III drug development programs with optimal sample size allocation and Go/No-go decision rules in R by Johannes Cepicka, Lukas D. Sauer, Marietta Kirchner, Meinhard Kieser, Stella Erdmann

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The Sm14+GLA-SE Recombinant Vaccine Against <i>Schistosoma mansoni</i> and <i>S. haematobium</i> in Adults and School Children: Phase II Clinical Trials in West Africa by Amadou Tidjani Ly, Doudou Diop, Modou Diop, Anne-Marie Schacht, Abdoulaye Mbengue, Rokhaya Diagne, Marieme Guisse, Jean-Pierre Dompnier, Carolina Messias, Rhea N. Coler, Celso R. Ramos, Jacques-Noël Tendeng, Seynabou Ndiaye, Miryam Marroquin-Quelopana, Juçara de Carvalho Parra, Tatiane dos Santos, Marília Sirianni dos Santos Almeida, Daniella Arêas Mendes-da-Cruz, Steven Reed, Wilson Savino, Gilles Riveau, Miriam Tendler

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HLX07 alone or combined with serplulimab, cisplatin and 5‐fluorouracil for advanced esophageal squamous cell carcinoma: A phase 2 study by Yun Liu, Yanfeng Wang, Yanrong Zhu, Tao Wu, Zhenyang Liu, Jin Zhou, Yuan Yuan, Mudan Yang, Bo Liu, Zhenbo Tan, Wu Zhuang, Jiayan Chen, Ning Li, Ying Wang, Xuhui Hu, Lin Wang, Haoyu Yu, Qingyu Wang, Jun Zhu, Jing Huang

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Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells by Karakurt Sedar

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Safety and Immunogenicity of OVX836, a Nucleoprotein-Based Universal Influenza Vaccine, Co-Administered with Fluarix^® Tetra, a Seasonal Hemagglutinin-Based Vaccine by Nicola Groth, Jacques Bruhwyler, Jessika Tourneur, Emilie Piat, Philippe Moris, Alexandre Le Vert, Florence Nicolas

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Hepatic artery infusion of FOLFOX chemotherapy plus camrelizumab combined with sorafenib for advanced hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (Double-IA-0... by Lujun Shen, Fei Cao, Ying Liu, Gulijiayina Nuerhashi, Letao Lin, Hontong Tan, Chunyong Wen, Yujia Wang, Shuanggang Chen, Hongliang Zou, Lin Xie, Weijun Fan

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Evaluation of Safety, Immunogenicity and Cross-Reactive Immunity of OVX836, a Nucleoprotein-Based Universal Influenza Vaccine, in Older Adults by Bart Jacobs, Isabel Leroux-Roels, Jacques Bruhwyler, Nicola Groth, Gwenn Waerlop, Yorick Janssens, Jessika Tourneur, Fien De Boever, Azhar Alhatemi, Philippe Moris, Alexandre Le Vert, Geert Leroux-Roels, Florence Nicolas

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Buparlisib in combination with tamoxifen in pretreated patients with hormone receptor‐positive, HER2‐negative advanced breast cancer molecularly stratified for PIK3CA mutations and... by Anja Welt, Marcel Wiesweg, Sarah Theurer, Wolfgang Abenhardt, Matthias Groschek, Lothar Müller, Jan Schröder, Mitra Tewes, Marco Chiabudini, Karin Potthoff, Agnes Bankfalvi, Norbert Marschner, Martin Schuler, Frank Breitenbücher

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Adrenomedullin Therapy for Moderate-to-Severe COVID-19 Pneumonia: Double-Blind Placebo-Controlled Phase 2a Trial by Toshihiro Kita, Norio Ohmagari, Sho Saito, Hiroshi Mukae, Takahiro Takazono, Taka-Aki Nakada, Tadanaga Shimada, Yuji Hirai, Yuichiro Shindo, Kosaku Komiya, Atsushi Saito, Masaya Yamato, Koichiro Homma, Masaki Okamoto, Yoshihiro Yamamoto, Yoshikazu Mutoh, Chihiro Hasegawa, Nobuaki Mori, Fukumi Nakamura-Uchiyama, Mitsuru Honda, Keisuke Tomii, Hiroshi Ishii, Ichiro Takajo, Koji Watanabe, Kazuo Kitamura

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Efficacy and safety of first‐line sintilimab plus anlotinib versus chemotherapy for metastatic non‐small cell lung cancer: a phase II, open‐label, randomized controlled trial by Tianqing Chu, Hua Zhong, Zhuang Yu, Jing Wang, Yanqiu Zhao, Xiaoqian Mu, Xinmin Yu, Xun Shi, Qingming Shi, Maojing Guan, Cuimin Ding, Nan Geng, Jialin Qian, Baohui Han

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Tolerability, safety and feasibility of metformin combined with chemoradiotherapy in patients with locally advanced cervical cancer: A phase II, randomized study by Kjersti Skipar, Tord Hompland, Kjersti V. Lund, Christina S. Fjeldbo, Kristina Lindemann, Taran P. Hellebust, Heidi Lyng, Kjersti Bruheim

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