Evaluation and testing of polymethylmetacrylic (PMMA) bone cements with admixed Amphotericin B by Florian A. Frank, Barbara Krampitz, Julia Steiner, Rainer Strathausen, Mario Morgenstern, Martin Clauss, Klaus-Dieter Kühn

“…PMMA mixed with such pharmaceutical Amphotericin B formulations colored the cement orange. …”
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Induced pathomorphism and manifestations of residual focal lesions in parenchymatous organs of patients after noninvasive procedures by Z. A. Lemeshko, A. V. Borsukov, A. V. Mamoshin, T. G. Morozova

“…Total of 1281 noninvasive medical manipulation at ultrasound guidance and X-ray navigation — installation of drainages/catheters and local treatment by antibiotics, intraportal injection of pharmaceuticals, sclerotherapy of 96% ethyl alcohol of liver and kidney cysts, metastases to the liver, interstitial laser photocoagulation of focal goiter, radio-frequency ablation of metastases in the liver, electrochemical destruction of liver metastases and fibrous adenomas of breast gland etc. was carried out. …”
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Flavonoid Compounds from Ethanol Extract of Sungkai Leaves (Peronema canescens. Jack) and Antibacterial Activity Test Against Staphylococcus epidermidis and Escherchia coli by Nindita Clourisa Amaris Susanto, Jammes Ardhica, Nelson, Madyawati Latief

“…Further studies focusing on compound purification and in vivo antibacterial testing are recommended to explore its pharmaceutical applications. …”
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Assessment of the essential oil extracted from Citrus aurantifolia leaves using solvent-free microwave extraction technique by G.M. Masud Rana, Md. Jasim Uddin, Jaytirmoy Barmon, Bijoy Chandra Ghos, Tahmina Akter Chowdhury, Amit Kumar Dey, Bijoy Maitra, Ismat Moin Tamanna, AHM Mahbubur Rahman, Barun Kanti Saha, Mst. Sarmina Yeasmin

“…These findings suggest possible applications of EO in both the pharmaceutical and food sectors, as an antioxidant and an antimicrobial.…”
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The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model by Jan Dusek, Ivana Mejdrová, Klára Dohnalová, Tomas Smutny, Karel Chalupsky, Maria Krutakova, Josef Skoda, Azam Rashidian, Ivona Pavkova, Kryštof Škach, Jana Hricová, Michaela Chocholouskova, Lucie Smutna, Rajamanikkam Kamaraj, Miloš Hroch, Martin Leníček, Stanislav Mičuda, Dirk Pijnenburg, Rinie van Beuningen, Michal Holčapek, Libor Vítek, Magnus Ingelman-Sundberg, Oliver Burk, Thales Kronenberger, Radim Nencka, Petr Pavek

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OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma by Kinjal Desai, Siyi Wanggou, Erika Luis, Heather Whetstone, Chunying Yu, Robert J. Vanner, Hayden J. Selvadurai, Lilian Lee, Jinchu Vijay, Julia E. Jaramillo, Jerry Fan, Paul Guilhamon, Michelle Kushida, Xuejun Li, Gregory Stein, Santosh Kesari, Benjamin D. Simons, Xi Huang, Peter B. Dirks

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An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice by Xiaojuan Wang, Guohui Zhang, Zhiwei Bian, Vimanda Chow, Marina Grimaldi, Coralie Carivenc, Savannah Sirounian, Hao Li, Lucia Sladekova, Stefano Mott, Yulia Luperi, Yufeng Gong, Cait Costello, Linhao Li, Matthew Jachimowicz, Miao Guo, Shian Hu, Derek Wilson, Patrick Balaguer, William Bourguet, Sridhar Mani, Laura Bonati, Hui Peng, John March, Hongbing Wang, Shengpeng Wang, Henry M. Krause, Jiabao Liu

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Real-world outcomes with tisagenlecleucel in aggressive B-cell lymphoma: subgroup analyses from the CIBMTR registry by Frederick L Locke, Grant Schofield, Marcelo Pasquini, Matthew J Frigault, Cameron J Turtle, Stephen Lim, Brian Hill, Samantha Jaglowski, Caron A Jacobson, Gunjan Shah, Daniel J Landsburg, Michael Heim, Stephen Ronan Foley, Ron Ram, Peter A Riedell, Leslie L Popplewell, Ranjan Tiwari, Marta Majdan, Aisha Masood

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Bioactivity of plants used traditionally in the treatment and management of men’s sexual health by Tsumbedzo Nemandalali, Monde A. Nyila, Thilivhali E. Tshikalange

“…Contribution: The investigated plants have potential therapeutic effects and can be used as leads in the development of new pharmaceuticals to manage men’s sexual disorders.…”
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Valbenazine for the Treatment of Adults with Tardive Dyskinesia by Harshit Gupta, Alycee R. Moity, Allison Jumonville, Sarah Kaufman, Amber N. Edinoff, Alan D. Kaye

“…Compared to other pharmaceutical agents, it is more selective and has limited toxicities making it an effective treatment regimen. …”
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Phytochemical composition and antioxidant properties of Canarium odontophyllum (Sarawak Olive): A seasonal fruit from Borneo, East Malaysia by Gilbert Ringgit, Bo Eng Cheong, Muhammad Dawood Shah, Shafiquzzaman Siddiquee

“…Conclusion: The results indicate that C. odontophyllum shows a promising potential an alternative drug in pharmaceutical developments.…”
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Suvorexant, a Novel Dual Orexin Receptor Antagonist, for the Management of Insomnia by Andrew H. Han, Caroline R. Burroughs, Evan P. Falgoust, Jamal Hasoon, Grace Hunt, Juyeon Kakazu, Tim Lee, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…It covers the background, pathophysiology, and significance of addressing insomnia, the pharmaceutical details of Suvorexant, and its safety, efficacy, and implications in treating insomnia. …”
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Determination of Ketotifen Fumarate in Syrup Dosage Form by High Performance Liquid Chromatography by Mohammed Ali Salih, Dlivan Fattah Aziz, Salar Ibrahim Ali

“…The goal of the current study was to establish and authenticate an isocratic reverse-stage High-Performance Liquid Chromatography (HPLC) method for quantifying ketotifen fumarate (KF) in pharmaceutical liquid dosage compositions. Easy, quick, accurate, exact, and accurate reverse-stage high-performance liquid chromatography was advanced for the simultaneous assessment of ketotifen fumarate in the liquid syrup dosage type. …”
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Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction by Etukudo Okon Jimmy, Grace Edet Bassey, Abijah Ekwere, Udoh Idorenyin Umoh, Adeyemi Fatai Odetayo, Udoh Nsikan Malachy

“…Traditional herbal remedies, rooted in cultural practices, have been explored as alternative therapies for ED, and this study focuses on Uvara chemea and Cylicodiscus gabunensis, two plants with reported medicinal properties, as potential alternatives to sildenafil, a standard pharmaceutical for ED. Experimental procedure: Forty male Wistar rats were randomly divided into five groups: control (treated with distilled water), low, medium, and high doses (treated with 61.23, 122.47, and 183.71 mg/kg each of Uvara chemea and Cylicodiscus gabunensis respectively), and a positive control group (treated with sildenafil citrate). …”
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Functional Disorders of the Biliary Tract and Cholelithiasis: Analysis of a Possible Relationship by Yu. O. Shulpekova, I. R. Popova, V. M. Nechaev

“…The domestic drug hymecromone “Odecromone” entered the pharmaceutical market.   Conclusion. There is no doubt that the relevance of further study of the patterns of development of biliary dysfunctions and GI is obvious. …”
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Efficient biosynthesis of β-caryophyllene by engineered Yarrowia lipolytica by Young-Kyoung Park, Lucie Studena, Piotr Hapeta, Ramdane Haddouche, David J. Bell, Pablo Torres-Montero, Jose Luis Martinez, Jean-Marc Nicaud, Adriana Botes, Rodrigo Ledesma-Amaro

“…Abstract Background β-Caryophyllene, a sesquiterpenoid, holds considerable potential in pharmaceutical, nutraceutical, cosmetic, and chemical industries. …”
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Advancing the accuracy of tyrosinase inhibitory peptides prediction via a multiview feature fusion strategy by Watshara Shoombuatong, Nalini Schaduangrat, Nutta Homdee, Saeed Ahmed, Pramote Chumnanpuen

“…Tyrosinase inhibitory peptides (TIPs), mainly designed to regulate the activity of the enzyme tyrosinase, are of interest in various domains, including cosmetics, dermatology, and pharmaceuticals, due to their potential applications in controlling skin pigmentation. …”
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Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents by Muhammad Abdullah Bhatti, Atif Ali Khan Khalil, Sayed Muhammad Ata Ullah Shah Bukhari, Faisal Hanif, Mi-Jeong Ahn, Sumra Wajid Abbasi, Nazir Ahmed Lone, Wen-Jun Li, Wasim Sajjad

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Hyssopus cuspidatus volatile oil: a potential treatment for steroid-resistant asthma via inhibition of neutrophil extracellular traps by Xu Wang, Hui-Ming Peng, Meng-Ru Zhang, Jing-Jing Li, Chuan-Peng Zhao, Ya-Li Zhang, Si-Yu Wang, Si-Ying Zhu, Jian-Kang Lu, Hai-Long Yin, Qiang Yin, Jin-Bo Fang

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Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn [ver... by ShamaPrasada K, Reshma Kumarchandra, Vasavi Kumblekar, K Sreedhara Ranganath Pai, Suman Manandhar, Sharada Rai, Rajeshwari Shastry

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