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    In-silico screening and analysis of missense SNPs in human CYP3A4/5 affecting drug-enzyme interactions of FDA-approved COVID-19 antiviral drugs by Amro A. Abdelazim, Mohamad Maged, Ahmed I. Abdelmaksoud, Sameh E. Hassanein

    Published 2025-01-01
    “…An ensemble of bioinformatics tools, [SIFT, PolyPhen-2, cadd, revel, metaLr, mutation assessor, Panther, SNP&GO, PhD-SNP, SNAP, Meta-SNP, FATHMM, I-Mutant, MuPro, INPS, CONSURF, GPS 5.0, MusiteDeep and NetPhos], identified a total of 94 variants (47 SNPs in CYP3A4, 47 SNPs in CYP3A5) to potentially impact the structural integrity as well as the activity of the CYP3A4/5 enzymes. …”
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    The Complexity of Social Networks in Healthy Aging: Novel Metrics and Their Associations with Psychological Well-Being by Sueur, Cédric, Fancello, Giovanna, Naud, Alexandre, Kestens, Yan, Chaix, Basile

    Published 2024-02-01
    “…Dimension 1 (homophily) was positively linked with perceived accessibility to services in one’s residential neighborhood but this same dimension was negatively linked with the level of study (i.e., Bachelor, Master, PhD, etc.). Dimension 2 (social integration) and Dimension 3 (social support) were only linked to the number of people living (being in the same residence) with ego (i.e. the interviewed participant). …”
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