Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

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A dual-band microwave sensor for glucose measurements utilizing an enclosed split ring metamaterial-based array by Abhishek Kandwal, Ziheng Ju, Louis W.Y. Liu, Rohit Jasrotia, Choon Kit Chan, Zedong Nie, Ali M. Almuhlafi, Hamsakutty Vettikalladi

“…At 9.2 GHz, there was no significant resonant frequency shift with varying glucose concentrations, but the magnitude of the reflection coefficient changed with the glucose concentration nonlinearly in an amount-dependent manner, with a sensitivity of 16.6 dB per unit glucose concentration within the clinical diabetic range. …”
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Healthcare performance of leprosy management in peripheral health facilities of Dhanusa and Mahottari, Nepal by Ram Kumar Mahato, Uttam Ghimire, Bijay Bajracharya, Binod K. C., Deepak Bam, Deepak Ghimire, Uttam Raj Pyakurel, David T. S. Hayman, Basu Dev Pandey, Chuman Lal Das, Krishna Prasad Paudel

“…An average of 6 patients (paucibacillary, PB, or multibacillary, MB) per health facility registered within the 2018/2019 fiscal year were also enrolled in the study. …”
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Water homeostasis gene expression in the kidney of broilers divergently selected for water conversion ratio by Kentu Lassiter, Loujain Aloui, Elizabeth S. Greene, Marciela Maqaeda, Travis Tabler, Sami Dridi, Robert F. Wideman, Jr., Sara Orlowski, Walter G. Bottje

“…In Exp. 2, HWE and modern random bred (MRB) broilers were placed in 12 controlled-environmental chambers (2 floor pens/chamber, 6 chambers/line, 11 birds per pen, 132 birds/line) on day of hatch. The broilers were brooded at thermoneutral temperatures from 0 to 4 wks. …”
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Dynamics of inland saline ground water and associated growth potential of common carp Cyprinus carpio for a sustainable aquaculture by P. S. Nagaraja, V. Susitharan, Siddhant Shivaji Upaskar, Jay Prakash Yadav, Pankaj Kumar, Sreedharan Krishnan, A. M. Babitha Rani, Ashok Kumar, Satyendra Singh, Dhalongsaih Reang, Sunil Kumar Nayak, Mohammad Aklakur, Angom Lenin Singh, Aparna Chaudhari, Mujahidkhan A. Pathan

“…The Feed Conversion Ratio (FCR), Feed Conversion Efficiency (FCE), and Protein Efficiency Ratio (PER) obtained for Pond 1 and Pond 2 were 2.19, 45.8, 1.53; 2.25, 44.44, and 1.48, respectively. …”
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Integrated transcriptomic hypothalamic-pituitary-ovarian axis network analysis reveals the role of energy availability on egg production in layers by Jianling Peng, Yong Cui, Haiping Liang, Shenyijun Xu, Linjian Weng, Meng Ru, Ramlat Ali, Qing Wei, Jiming Ruan, Jianzhen Huang

“…Each treatment consisted of 10 replicates with 3 birds per replicate. The study found that energy deprivation significantly decreased reproductive performance such as egg laying rate, ovarian index, number of small yellow follicles (SYF), and normal hierarchical follicles (NHIE) (P < 0.05), which recovered after refeeding, indicating the importance of energy availability for sustained ovulation in layers. …”
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Challenges and Opportunities for Data Sharing Related to Artificial Intelligence Tools in Health Care in Low- and Middle-Income Countries: Systematic Review and Case Study From Tha... by Aprajita Kaushik, Capucine Barcellona, Nikita Kanumoory Mandyam, Si Ying Tan, Jasper Tromp

“…All identified barriers and enablers were classified according to 7 categories as per the predefined framework—technical, motivational, economic, political, legal and policy, ethical, social, organisational, and managerial. …”
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Life cycle assessment of paper products based on recycled and virgin fiber by J. Simamora, E.I. Wiloso, M. Yani

“…All impact magnitudes were measured in functional units per 1 ton of paper product.CONCLUSION: The study has revealed the environmental impact of paper products produced in Indonesia. …”
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Impact of Cordyceps sinensis on coronary computed tomography angiography image quality and renal function in a beagle model of renal impairment by Peiji Song, Peiji Song, Kun Li, Xiaodie Xu, Guifeng Zhang, Zengkun Wang, Linbing Sun, Zekai Zhao, Ting Li, Ximing Wang, Zhangyong Xia, Zhangyong Xia, Zhangyong Xia, Zhangyong Xia

“…ObjectiveThis study aims to investigate the protective effects of Cordyceps sinensis against renal injury induced by low-dose contrast medium (CM) in coronary computed tomography angiography (CCTA) imaging, and to evaluate its efficacy using functional magnetic resonance imaging (fMRI).MethodsTwenty Beagle dogs with induced renal insufficiency were enrolled in the study and randomly assigned to one of four groups (n = 5 per group). Group A received Cordyceps sinensis for 1 week prior to undergoing heart rate-dependent personalized CM CCTA scanning; Group B received Cordyceps sinensis for 1 week followed by conventional dose CM CCTA scanning; Group C did not receive Cordyceps sinensis but underwent HR-dependent CM CCTA scanning; and Group D did not receive Cordyceps sinensis but underwent conventional dose CM CCTA scanning. …”
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Cardiovascular risk factors and markers of myocardial injury and inflammation in people living with HIV in Nairobi, Kenya: a pilot cross-sectional study by Pablo Perel, Kuan Ken Lee, Anoop SV Shah, Mohammed K Ali, Shirjel R Alam, Jasmit Shah, Hassan Adan Ahmed, Jeilan Mohamed, Isaiah G Akuku, Sherry Eskander, Michael H Chung

“…Older age (adjusted OR (aOR) per year increase 1.05, 95% CI 1.01 to 1.08) and systolic blood pressure (140–159 mm Hg (aOR 2.96; 95% CI 1.09 to 7.90) and &gt;160 mm Hg (aOR 4.68, 95% CI 1.55 to 14) compared with &lt;140 mm Hg) were associated with hscTnI levels. …”
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Strategies and resources used by public health units to encourage COVID-19 vaccination among priority groups: a behavioural science-informed review of three urban centres in Canada by Tori Langmuir, Mackenzie Wilson, Nicola McCleary, Andrea M. Patey, Karim Mekki, Hanan Ghazal, Elizabeth Estey Noad, Judy Buchan, Vinita Dubey, Jana Galley, Emily Gibson, Guillaume Fontaine, Maureen Smith, Amjad Alghamyan, Kimberly Thompson, Jacob Crawshaw, Jeremy M. Grimshaw, Trevor Arnason, Jamie Brehaut, Susan Michie, Melissa Brouwers, Justin Presseau

“…Results PHUs operationalised 21 out of 93 BCTs, ranging from 15 to 20 BCTs per PHU. The most frequently operationalised BCTs were found in strategies/resources that provided information about COVID-19 infection and vaccines, increased access to COVID-19 vaccination, and integrated social supports such as community ambassadors and engagement sessions with healthcare professionals. …”
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Atrial fibrillation outcomes in patients from Asia and non-Asia countries: insights from GARFIELD-AF by Karen Pieper, Xian-hong Fang, Kai Sun, Ajay K Kakkar, Saverio Virdone, Shinya Goto, Gloria Kayani, Zhi-Cheng Jing, John Camm, Chun-Yan Cheng, Tian-Yu Lian, Xi-Jie Zhu, Xian-Mei Li

“…The association of geographical region with clinical outcomes (event rates per 100 person-years) were estimated using multivariable Cox models.Results 13 841/52 057 (26.6%) GARFIELD-AF participants were enrolled in Asia. …”
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Efficacy and safety of everolimus for patients with focal cortical dysplasia type 2 by Se Hee Kim, Hoon‐Chul Kang, Yun Ho Roh, Jongsung Hahn, Kyung Lok Min, Seok‐Jin Lee, Donghwa Yang, Han Som Choi, Soyoung Park, Jeong Ho Lee, Sang‐Guk Lee, Se Hoon Kim, Min Jung Chang, Heung Dong Kim

“…Methods A prospective, crossover, placebo‐controlled clinical trial (ClinicalTrials.gov: NCT03198949) enrolled patients aged 4–40 years with pathologically confirmed FCD 2 and a history of ≥3 seizures per month for two out of the 3 months prior to screening. …”
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Beyond identification of familial hypercholesterolemia: Improving downstream visits and treatments in a large health care system by Harin Lee, Tarun Kadaru, Ruth Schneider, Taylor Triana, Carol Tujardon, Colby Ayers, Mujeeb Basit, Zahid Ahmad, Amit Khera

“…A total of 180 patient contact attempts were made (mean 1.7 per patient) with most being by MyChart (48 %) and telephone (41 %). …”
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Human versus Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings (HumAn-1): protocol for a randomised controlled trial by Éimhín Ansbro, Jing Luo, Chung-Chou H Chang, Kaushik Ramaiya, Bruce L Rollman, Sylvia Kehlenbrink, Sae-Rom Chae, Abigail Foulds, Claire Josey, Christina Lalama, Margaret L Prust, Bedowra Zabeen, Graham Ogle

“…The co-primary outcomes are the per cent time in serious hypoglycaemia (&lt;54 mg/dL) and TIR (70–180 mg/dL) at 6 months of follow-up. …”
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Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Subjects and participants: Fourteen healthy individuals (28 eyes, age range: 22-54 years) underwent TRT measurements using both Old and New OCT models, with each eye receiving three consecutive scans per visit. Methods and testing: TRT measurements were performed using the Posterior Pole Algorithm (PPA) and Early Treatment Diabetic Retinopathy Study (ETDRS) grid protocols. …”
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Pilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease by Tanner Kim, MD, Anand Brahmandam, MBBS, Dana Alameddine, MD, Rachel Forman, MD, Amin Hardik, MD, Lisa Fucito, PhD, Carlos Mena-Hurtado, MD, Raul Guzman, MD, Cassius Iyad Ochoa Chaar, MD, MS, MPH

“…The mean number of cigarettes consumed before enrollment was 17 ± 9 per day over a mean period of 40 ± 11 years. All patients had previously attempted to quit smoking and 97% had received advice from their surgeons or interventionalists to quit smoking in the prior year. …”
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Association of blood group types and clinico-pathological features of gynecological cancers (GCs) by Syed Sameer Aga, Muhammad Anwar Khan, Mubarak Al Mansour, Rana Mohammed Hasosah, Lulu Abdullah Alsubaie, Dala Ahmad Alfaify, Malak Badr Alansari, Shahad Obaidallah Almutairi, Saniya Nissar

“…The sample included all the patients having age > 18 with a record of blood group and confirmed histological or cytological diagnosis as per International Federation of Gynecology and Obstetrics (FIGO) guidelines. …”
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Phase I study of efineptakin alfa (NT-I7) for the treatment of Kaposi sarcoma by Leonard D’Amico, Martin Cheever, Steven P Fling, Anna Wright, Kathryn Lurain, Ramya Ramaswami, Irene Ekwede, Thomas S Uldrick, Robert Yarchoan, Judith C Kaiser, Angela Shaulov Kask, Manoj P Menon, Paul Couey, Eli Burnham, Allysson Angeldekao, Byung Ha Lee, Li-Lian Kwok, Chia-Ching Jackie Wang

“…Secondary endpoints included evaluation of antitumor activity per the modified AIDS Clinical Trials Group Criteria and assessment of the effect of NT-I7 on the kinetics of CD4+ and CD8+ T-cells.Results Eight cisgender male participants (five with HIV infection) were enrolled. …”
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Effects of group communication norms on daily steps in a team-based financial incentive mobile phone intervention in Shanghai, China by Yingnan Jia, Yingcheng Xiao, Hao Chen, Klaus Gebel, Chengshu Li, Shuangyuan Sun, Qinping Yang, Siyuan Wang, Li Zhang, Jing Wang, Minna Cheng, Dantong Gu, Yan Shi, Ding Ding

“…For the intervention group (n = 2,049), participants set a goal of 10,000 steps per day. The teams and individual members would receive points for meeting the daily goal, contributing to team-based rankings and financial rewards for the teams and their members. …”
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