Stochastic population models to identify optimal and cost‐effective harvest strategies for feral pig eradication by Peter W. Hamnett, Frédérik Saltré, Brad Page, Myall Tarran, Matt Korcz, Kate Fielder, Lindell Andrews, Corey J. A. Bradshaw

“…We used effort and cost data from a feral pig‐control program on Kangaroo Island, South Australia, over 17 months to derive functional‐response relationships between control effort (in hours per pig) and pig abundance for four control methods: (1) ground‐based shooting, (2) trapping with remote triggers, (3) poison baiting, and (4) thermal‐assisted aerial culling. …”
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Beta-Blockers After PCI for Stable Coronary Artery Disease and Preserved Left Ventricular Ejection Fraction by Safi U. Khan, MD, MS, Usman Ali Akbar, MD, Muhammad Shahzeb Khan, MD, Kershaw V. Patel, MD, Amna Nadeem, MBBS, Samarth Thakkar, MD, Hassaan B. Arshad, MD, Salim S. Virani, MD, PhD, Khurram Nasir, MD, MPH, Sachin S. Goel, MD, Alpesh R. Shah, MD, William Zoghbi, MD, Neal S. Kleiman, MD

“…Results: Out of 11,681 matched patients per group, beta-blocker therapy was associated with increased all-cause mortality (HR: 1.11 [95% CI: 1.09-1.18]). …”
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A Retrospective, Single-Center Assessment of Changes in Pain, Agitation, and Delirium Management Before and During the COVID-19 Pandemic by Rachel L. Winner, PharmD, BCCCP, Lydia R. Ware, PharmD, BCPS, BCCCP, Kevin M. Dube, PharmD, BCPS, BCCCP, Mary P. Kovacevic, PharmD, BCPS, BCCCP, Kenneth E. Lupi, PharmD, BCPS, BCCCP, Paul M. Szumita, PharmD, FCCM, FASHP, BCCCP, BCPS, Jeremy R. DeGrado, PharmD, BCCCP

“…The median number of Richmond Agitation-Sedation Scale assessments per 24-hour period was greater in the pre-group (13 vs. 12 assessments; p = 0.02) within the first 48 hours of MV. …”
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Diagnosis and management of type 2 diabetes mellitus in patients with ischaemic heart disease and acute coronary syndromes - a review of evidence and recommendations by Muhammad Usman Shah, Muhammad Usman Shah, Alun Roebuck, Bala Srinivasan, Joanna Kate Ward, Paul Edward Squires, Claire Elizabeth Hills, Kelvin Lee, Kelvin Lee

“…In the United Kingdom UK alone, around 120 amputations, 770 CVA, 590 heart attacks, and more than 2300 presentations with heart failure per week are attributed to diabetes DM. with One 1 in six 6 hospital beds and around 10% of the healthcare budget may be being spent on managing diabetes DM or its complications. …”
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Growth, fat metabolism and hepatic health in largemouth bass fed varying fat-level diets by Digen Qin, Jiale Chen, Junxiong Li, Zhiyou Liu, Weibin Huang, Yuanzhi Yang, Jing Zhang, Beiping Tan, Xiaohui Dong

“…The results revealed that fish fed HFD exhibited significantly better protein efficiency ratio (PER) and lower feed conversion ratio (FCR) than LFD group (P<0.05), but survival rate (SR) and weight gain rate (WGR) were unaffected (P>0.05). …”
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Characteristics, clinical manifestations and management of leprosy in KwaZulu-Natal, South Africa: A 20-year retrospective study by J S Sons, Z N Mkhize, N C Dlova, C Aldous, P R Bhat, A V Chateau

“…Although leprosy, a neglected tropical disease, has been eliminated (<1 case per 10 000 population) in South Africa (SA) since 1926, according to the World Health Organization, new cases continue to be reported. …”
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Costs of community-wide mass drug administration and school-based deworming for soil-transmitted helminths: evidence from a randomised controlled trial in Benin, India and Malawi by Judd Walson, ROBIN BAILEY, Katya Galactionova, Maitreyi Sahu, Samuel Paul Gideon, Saravanakumar Puthupalayam Kaliappan, Chloe Morozoff, Sitara Swarna Rao Ajjampur, Khumbo Kalua, Euripide Avokpaho, Moudachirou Ibikounle, Arianna Rubin Means, James Simwanza, Wongani Lungu, Parfait Houngbegnon, Adrian J F Luty, Rachel Pullan

“…We compared the costs of cMDA to SBD to inform decision-making about future updates to STH policy.Design We conducted activity-based microcosting of cMDA and SBD for 2 years in Benin, India and Malawi within an ongoing cMDA trial.Setting Field sites and collaborating research institutions.Primary and secondary outcomes We calculated total financial and opportunity costs and costs per treatment administered (unit costs in 2019 USD ($)) from the service provider perspective, including costs related to community drug distributors and other volunteers.Results On average, cMDA unit costs were more expensive than SBD in India ($1.17 vs $0.72) and Malawi ($2.26 vs $1.69), and comparable in Benin ($2.45 vs $2.47). cMDA was more expensive than SBD in part because most costs (~60%) were ‘supportive costs’ needed to deliver treatment with high coverage, such as additional supervision and electronic data capture. …”
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A Regional Gravimetric and Hybrid Geoid Model in Northern Greece from Dedicated Gravity Campaigns by Georgios S. Vergos, Dimitrios A. Natsiopoulos, Elisavet G. Mamagiannou, Eleni A. Tzanou, Anastasia I. Triantafyllou, Ilias N. Tziavos, Dimitrios Ramnalis, Vassilios Polychronos

“…After the deterministic fit, a std to the GNSS/leveling data of 10.1 cm has been achieved, with 54.8% and 83.1% of the absolute height differences being below the 1 cm and 2 cm per square root km of baseline length. The final hybrid geoid model, i.e., after the stochastic treatment of the adjusted residuals, gave a std of the difference to the GNSS/leveling data of 1.1 cm, with 99.8% and 99.9% of the height difference being smaller than the 1 cm and 2 cm standard errors, thus achieving a 1 cm accuracy regional geoid.…”
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Clinical and genetic drivers of oligo-metastatic disease in colon cancer by Alessandro Ottaiano, Mariachiara Santorsola, Roberto Sirica, Annabella Di Mauro, Antonella Di Carlo, Monica Ianniello, Francesco Sabbatino, Rosa Castiello, Francesca Del Peschio, Marco Cascella, Francesco Perri, Maurizio Capuozzo, Nicola Martucci, Edoardo Mercadante, Valentina Borzillo, Rossella Di Franco, Francesco Izzo, Vincenza Granata, Carmine Picone, Antonella Petrillo, Massimiliano Berretta, Salvatore Stilo, Luca Tarotto, Anna Chiara Carratù, Gerardo Ferrara, Madhura Tathode, Alessia Maria Cossu, Marco Bocchetti, Michele Caraglia, Guglielmo Nasti, Giovanni Savarese

“…OMD was defined as ≤3 lesions per organ, each with a total diameter <70 mm and none exceeding 25 mm. …”
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Cardiovascular Disease Multimorbidity and Decreased Health‐Related Quality of Life in Haiti: A Cross‐Sectional Study by Shalom Sabwa, Vanessa Rouzier, Rodney Sufra, Reichling St. Sauveur, Nour Mourra, Rehana Rasul, Joseph Inddy, Lily D. Yan, Madeline Sterling, Laura Pinheiro, Marie Deschamps, Jean William Pape, Margaret L. McNairy

“…Among 2,996 participants, the median age was 40 years (interquartile range [IQR], 27–55), 58.0% were women, and 70.3% earned <1 US dollar per day. CVD multimorbidity prevalence was 24.1%; compared with those without CVD multimorbidity, those with CVD multimorbidity were older (median age, 56.0 years [IQR, 47.0–53.0]) and women (70.5%). …”
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Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: seconda... by Helen Macpherson, Robin M Daly, Patricia M Livingston, Declan G Murphy, Patrick J Owen, Timo Rantalainen, Niamh L Mundell, Jeremy L Millar, Steve F Fraser, Jack Dalla Via, Stephen J Foulkes

“…Data were analysed with linear mixed models and an intention-to-treat and prespecified per-protocol approach (exercise-training: ≥66%, nutritional supplement: ≥80%).Results Sixty (86%) men completed the trial (Ex + Suppl, n=31; control, n=29). …”
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Snacking Behaviour and Its Determinants among College-Going Students in Coastal South India by Prasanna Mithra, Bhaskaran Unnikrishnan, Rekha Thapar, Nithin Kumar, Sharana Hegde, Anjali Mangaldas Kamat, Vaman Kulkarni, Ramesh Holla, B. B. Darshan, Kanchan Tanuj, Vasudev Guddattu, Avinash Kumar

“…A significantly larger proportion of males had a higher frequency of snacking per day (69.3% versus 57.2%, p<0.0001) and consumed aerated drinks more frequently (22.6% versus 15.8%, p=0.011), skipped meals more often (58.6% versus 50.6%, p=0.022), and preferred adding fruits in snacks (78.1% versus 69.4%, p=0.005). …”
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Determinants and impact of calcium oxalate crystal deposition on renal outcomes in acute kidney injury patients by Weiwei Yang, Tao Zhao, Xuejing Chen, Suxia Wang, Yu Wang, Tao Su

“…This study investigates its determinants and effects.Methods We studied 814 AKI patients with native kidney biopsies from 2011 to 2020, identifying CaOx crystal deposition severity (mild: <5, moderate: 5–10, severe: >10 crystals per section). We assessed factors like urinary oxalate, citrate, urate, electrolytes, pH, tubular calcification index, and SLC26A6 expression, comparing them with creatinine-matched AKI controls without oxalosis. …”
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Effects of Salt Stress During the Growth Period on the Yield and Grain Quality of Hybrid Rice by Ruopeng Li, Dan Zhang, Yinlin Pan, Huimin Liu, Chanjuan Tang, Xiaolin Liu, Lin Mo, Yaxi Du, Guoqiang Zhou, Yuanyi Hu

“…The lower salt tolerance index of the hybrid varieties might be owing to the lower relative loss number of effective panicles, total number of grains per panicle, seed setting rate, and thousand-grain weight. …”
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Pharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway by Yuyu An, Shanshan Cao, Leilei Shi, Yuhan Zhang, Xin Wang, Shiyu Yuan, Yongheng Shi, Bin Wang, Jiping Liu, Chao-jun Han

“…The rats were divided into Control, Model, Sig-1R agonist PRE-084 (0.3, 0.6, 1 mg/kg), and metformin (Met, 20 mg/kg) groups, with seven rats per group, and their body weight, fasting blood glucose, mechanical withdrawal threshold and thermal withdrawal latency were tested weekly for two weeks. …”
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Transauricular vagus nerve stimulation in preventing post-traumatic stress disorder in emergency trauma surgery patients in China: a study protocol for a multicenter, double-blind,... by Jun Zhang, Xin Yu, Gang Chen, Yu Li, Qi-Hong Shen, Xinru Lin, Tieshuai Liu, Yunyun Yu, Jingwen Liang

“…For the four postoperative days, the intervention will be administered two times per day in 2-h sessions each morning and evening. …”
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Robotic-assisted surgery and kinematic alignment in total knee arthroplasty (RASKAL study): a protocol of a national registry-nested, multicentre, 2×2 factorial randomised trial as... by Ian A Harris, Samuel J MacDessi, Aziz Bhimani, Darren B Chen, Ian Harris, Michelle Lorimer, David Parker, Tamara Hooper, Richard Boyle, Jonathan Mulford, Daniel Franks, Gregory C Wernecke, Durga Bastiras, Emma Heath, Anthony Leong, Brett Fristch, David Penn, George Kirsh, John Limbers, Julian Yu, Maurice Guzman, Peter McEwen

“…Primary intention-to-treat and secondary per-protocol analyses will be performed. Statistical analysis will include a generalised linear mixed model for repeated measures for continuous KOOS-12 scores. …”
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Prohexadione-Calcium Reduced Stem and Tiller Damage and Maintained Yield by Improving the Photosynthetic and Antioxidant Capacity of Rice (<i>Oryza sativa</i> L.) Under NaCl Stress by Wanqi Mei, Shaoxia Yang, Jian Xiong, Aaqil Khan, Liming Zhao, Xiaole Du, Jingxin Huo, Hang Zhou, Zhiyuan Sun, Xiaohui Yang, Nana Yue, Naijie Feng, Dianfeng Zheng

“…The results showed that Pro-Ca significantly improved Changmaogu’s (CMG’s) productive tillering rate and the total yield per plant by 17.1% and 59.4%, respectively. At tillering stage, the results showed that Pro-Ca significantly improved the morph-physiological traits, i.e., leaf area, and photosynthetic traits of the rice variety with salt tolerance, under NaCl stress. …”
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Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment by Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk, Luana Colloca

“…Throughout this study time period, methadone dosages will be adjusted by an addiction clinician blind to patient assignment, per standard clinical methods. The primary outcome is methadone dose at 3 months. …”
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Outcome evaluation and cost-effectiveness analysis for an integrated multidisciplinary diabetic limb salvage program: a combined observational and simulation study by Yan Sun, Xiaoli Zhu, Jaime Lin, John Abisheganaden, Zhiwen Joseph Lo, Lixia Ge, Joseph Molina, Elaine Tan, Huiling Liew, Jeremy Hoe, Gary Ang, Kai Qiang Low, Theophilus Yap, Nur Aberleen Syafirah Binte Azmi, Enming Yong, Tiffany Chew, Hui Yan Koo, Chelsea Law, Dexter Yak Seng Chan, Claris Shi, Julia Choo, Wai Han Hoi, Sadhana Chandraskear, Jo Ann Lim, Jemes Siow, Sabariah Binte Kaspon, Subramaniam Tavintharan, Daniel Chew

“…The ICER was US$22 707 (SE: 430) per quality-adjusted life year gained, indicating long-term cost-effectiveness. …”
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