Disease Burden and Harm of Osteoarthritis by WU Haotian, LIN Jianhao

“…In 2019, approximately 530 million people suffered from osteoarthritis, with the age-standardized incidence rate of 492.2 per 100 000, the age-standardized prevalence rate of 6348.3 per 100 000 and the age-standardized rate of disability-adjusted life years (DALYs) of 228.0 per 100 000. …”
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Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness by Xuran Zhang, Xuran Zhang, Jian Wang, Qun Feng, Li Lei, Zhiyong Zhu

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Differential Diagnosis of MutYH-Associated Polyposis from Sporadic Colon Polyps by A. S. Tsukanov, V. P. Shubin, A. M. Kuzminov, M. Kh. Toboeva, T. A. Savelyeva, V. N. Kashnikov, Yu. A. Shelygin

“…A search for mutations in the MutYH gene was carried out using the PCR, electrophoresis and direct sequencing methods among the following groups of people: 18 patients under 45 years old with more than 100 polyps diagnosed in the large intestine; 86 patients over 45 years old with 4–100 polyps; 150 people of the control group.Results. …”
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PERSPECTIVES ON THE CHALLENGES TO THE WATCHDOG FUNCTION OF THE MEDIA IN NIGERIA by EMMANUEL OMULA, ROSELINE OGBOLE

“… The study sought to find out the challenges to the watchdog function of the media, and the impact of these challenges on democracy and the people. The study is anchored on Agenda Setting Theory of the Press. …”
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Radioactivity concentration of 14C in the air of 14C urea breath test rooms and the resulting internal dose to medical staff by Bei Yu, Fei Chen, Jing Cao, Dingxin Long

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Characteristics of Low Back Pain Patients at The West Aceh Health Center for The Period January 2022 - June 2023 by Adico Notareza Aulia, Safrizal Rahman, Laila Apriani Hasanah Harahap

“…Namely, 112 samples (48.7%), female gender 140 people (60.9%) and male 90 people (39.1%), and the type of work patients who experience the most LBP are housewives, as many as 61 people from the total sample.…”
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Association of loneliness with the risk of pain in older Chinese adults by Aijun Song, Siying Yu, Yao Shen, Zongyan Guo, Jian Shi

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Generosity and Solidarity -A Biblical Contribution and Perspective in Response to Poverty in Africa. by Rugyendo, Medard

“…The Word of God confirms that people who don’t lack what they need as a consequence of the Fall that brought sin into the world (Gen.3). …”
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Cooperative Association as a Tool for Rural Development and Poverty Reduction in Rwanda: A Study of Abahuzamugambi ba Kawa in Maraba Sector by Adebayo, Sanni T., Onuoha Helen Chinedum, Christopher S.P. Dabo, Pascal Harelimana

“…The research questions focused on the principles of cooperative identity, participation and decision making, internal and external communications, organisational and leadership development, the relationship between the cooperative’s leadership, the initiatives of people to lift themselves out of poverty, the knowledge would support poor people own development. …”
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Clinical Characteristics of 31 Patients with Chest Pain Variant Asthma by Mao W, Gao Y, Sun W, Li J, Wang J, Wang Z, Zhang L, Huang K

“…Wenping Mao,1 Yanli Gao,2 Wanlu Sun,1 Jie Li,1 Jing Wang,1 Zhaomei Wang,1 Liming Zhang,1 Kewu Huang1 1Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Kewu Huang, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China, Tel +86-010-85231167, Email kewuhuang@126.comPurpose: Asthma is a major public health challenge in China. …”
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Establishment and Clinical Application of Rh Blood Group Bank in the East China Region by Jin Y, Fu X, Xie S, Liu Z, Xu Z, Wang M, Wang Y, Lu R, Wang L

“…Yiming Jin,1,* Xiaoyan Fu,2,* Shuhong Xie,3 Zhen Liu,1 Zihao Xu,1 Mingyuan Wang,1 Yihan Wang,1 Rong Lu,1 Lingling Wang1 1Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China; 2Department of Blood Screening Test, Tai Cang Blood Branch Station, Tai Cang, People’s Republic of China; 3Division of Transfusion Medicine, Suzhou Blood Center, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingling Wang; Rong Lu, Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China, Email linglingwang0716@163.com; cv-25a@163.comPurpose: To investigate the expression and distribution of Rh phenotypes (C, c, D, E, e) among voluntary blood donors in a specific region of East China, to establish a regional Rh phenotype database, and to enhance the precision and efficacy of clinical blood transfusions.Patients and Methods: A total of 28979 blood samples were collected from voluntary donors at a central blood station in East China between May 2023 and December 2023. …”
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Impact of obesity, overweight and underweight on life expectancy and lifetime medical expenditures: the Ohsaki Cohort Study by Shinichi Kuriyama, Miyuki Kawado, Shuji Hashimoto, Ichiro Tsuji, Atsushi Hozawa, Toshimasa Sone, Masato Nagai, Masako Kakizaki, Kaori Ohmori-Matsuda

“…Objectives People who are obese have higher demands for medical care than those of the normal weight people. …”
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Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain by Chen Y, Tang G, Lu J, Tang S, Xiong X, Chen C, Pei L, Shi J

“…Yunfu Chen,1,* Guangling Tang,1,* Jun Lu,1,* Sijie Tang,1 Xinglong Xiong,1 Chao Chen,1 Lijian Pei,2 Jing Shi1 1Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guizhou, People’s Republic of China; 2Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Shi, Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China, Tel +86-18685034016, Email shijing81@gmc.edu.cn Lijian Pei, Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, People’s Republic of China, Email hazelbeijing@vip.163.comBackground: The neuropathic pain side induced by Vincristine severely limit its clinical application. …”
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Serum Ferritin Levels in Pregnancy and Their Association with Gestational Diabetes Mellitus: A Prospective Longitudinal Study by Qin Z, Du Y, Wang Z, Qin X, Wu H, Yu X, Zhao C, Mo L, Huang B

“…Zhenhua Qin,1 Yao Du,1 Zidi Wang,1 Xianfeng Qin,1 Hongchi Wu,1 Xiangyuan Yu,1 Chaochao Zhao,1 Lei Mo,2 Bo Huang1 1Guangxi Key Laboratory of Diabetic Systems Medicine, Guangxi Key Laboratory of Environmental Exposomics and Life-Course Health, Guangxi Health Commission Key Laboratory of Health and Care for Life-Course, School of Public Health, Guilin Medical University, Guilin, Guangxi, People’s Republic of China; 2Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, People’s Republic of ChinaCorrespondence: Bo Huang, Guangxi Key Laboratory of Diabetic Systems Medicine, Guangxi Key Laboratory of Environmental Exposomics and Life-Course Health, Guangxi Health Commission Key Laboratory of Health and Care for Life-Course, School of Public Health, Guilin Medical University, Guilin, Guangxi, 541199, People’s Republic of China, Tel +86-773-5591452, Email Bo.Huang@glmc.edu.cn Lei Mo, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, People’s Republic of China, Email 50442117@qq.comObjective: Elevated serum ferritin (SF) levels are associated with oxidative stress (OS) and systemic inflammation in various disorders. …”
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Analysis of the predictive value of the prostate-specific antigen-to-neutrophil ratio for the diagnosis of prostate cancer by Yuxuan Chen, Haisheng Yan, Yaoqin Xu, Kexin Chen, Runqin Yang, Jiali Yang, Ruian Zhu, Rui Lin, Jiang Wang, Jie Liu, Pingsheng Gao, Lei Pang, Lexin Wang

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Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance by Senhui Wei, Ying Li, Jing Zhou, Yongming Xia

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Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy by Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding

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Clinical Features and Prognosis of Double-Positive Anti-MDA5 and Anti-CCP Antibodies in Dermatomyositis: A Retrospective Study by Xu X, Zhu L, Li S, Wang G, Ge Y

“…Xiayu Xu,1 Longyang Zhu,2 Sizhao Li,3 Guochun Wang,3 Yongpeng Ge3 1Department of Rheumatology and Immunology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, People’s Republic of China; 2Peking University, China-Japan Friendship School of Clinical Medicine, Beijing, People’s Republic of China; 3Department of Rheumatology, The Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yongpeng Ge, Department of Rheumatology, The Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China, Email gyp2016@163.comObjective: To investigate the clinical features and prognosis of anti-melanoma differentiation-related gene 5 (MDA5) antibody and anti-cyclic citrullinated peptide (CCP) antibody double-positive dermatomyositis (DM) (MDA5+/CCP+ DM).Methods: A retrospective analysis of 264 consecutive cases of MDA5+ DM hospitalized from March 2018 to March 2022, and patients with anti-CCP antibodies were screened out. …”
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Understanding and reducing delayed dental care for early childhood caries: a structural equation model approach by Mengmeng Wang, Yu Zhang, Xiaofei Li, Xin Liu

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ATF3 Knockdown Exacerbates Astrocyte Activation by Inhibiting Phosphorylation of Drp1 in Ischemic Stroke by Huang R, Huang X, Yang H, Wu H, Liu F, Saw PE, Cao M

“…Rong Huang,1 Xiaoyan Huang,1 Hongmei Yang,1 Haixuan Wu,1 Fan Liu,1 Phei Er Saw,2,3 Minghui Cao1,4 1Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 4Department of Anesthesiology, Shenshan Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Shanwei, 516600, People’s Republic of ChinaCorrespondence: Phei Er Saw; Minghui Cao, Email caipeie@mail.sysu.edu.cn; caomh@mail.sysu.edu.cnIntroduction: ATF3, a stress-induced transcription factor, has been implicated in the injury processes of various cell types, including neurons. …”
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