Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory study by Peng Zeng, Bang Zeng, Xiaohua Wang, Feiyue Yin, Binglan Li, Lisha Nie, Lin Tian, Dan Luo, Yongmei Li

“…Cerebral neurovascular coupling (NVC) dysfunction is an important pathophysiological mechanism of CSVD. However, evidence linking the features of carotid artery hemodynamics to cerebral NVC is still lacking.ObjectiveThis study is aimed to explore the impact of PI and WSS on NVC and cognitive performance in CSVD patients using neuroimaging.MethodsThis study included 52 CSVD patients and 41 healthy controls. …”
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Protective and anti-inflammatory effects of caffeic acid phenethyl ester on arsenic-induced vasculitis in vivo by Yasser Kofiah, Eman A.A. Abdallah, Mohamed F. El-Refaei

“…Vasculitis encompasses a broad spectrum of disorders and has a variety of pathophysiological causes. Purpose: This study aimed to investigate the mechanism by which caffeic acid phenethyl ester (CAPE) protects against arsenic trioxide (AsIII)-induced vasculitis. …”
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Hypokalemic paralysis in an adolescent following dexamethasone and B12 injection: A case report and literature review by Keivan Sahebi, Hassan Foroozand, Mohammad Bahmei, Raziee Taghizadeh, Samane Zare, Soroor Inaloo

“…However, this hypothesis is based on a few cases, and further pathophysiological and clinical studies are needed to clarify whether B12 supplementation exacerbates hypokalemia induced by glucocorticoids or if the observation is coincidental or context-specific. …”
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IUPHAR Review: Alpha6-containing GABAA receptors – Novel targets for the treatment of schizophrenia by Lih-Chu Chiou, Werner Sieghart

“…This also impairs the function of the dopamine system, can explain a variety of schizophrenia symptoms observed, and might be one of the pathophysiological causes of schizophrenia. Enhancing GABAergic transmission at α6GABAARs should thus reduce the symptoms of schizophrenia. …”
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Automated quantification of axonal and myelin changes in contusion, dislocation, and distraction spinal cord injuries: Insights into targeted remyelination and axonal regeneration by Xuan Li, Yuan He, Fangyao Chen, Xin Tong, Yunlong Fan, Yuzhe Langzhou, Jie Liu, Kinon Chen

“…These findings highlight the importance of tailoring treatments to the distinct pathophysiological features of each SCI type to optimize recovery outcomes.…”
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Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects by Zi-Han Xu, Ming-Min Xie, Chun-Lan Xie, Xian-Wen Yang, Jun-Song Wang

“…These diseases involve complex pathophysiological mechanisms, including inflammatory responses, oxidative stress, and ferroptosis. …”
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Individual Differences in Behavioural Despair Predict Brain GSK-3beta Expression in Mice: The Power of a Modified Swim Test by Tatyana Strekalova, Nataliia Markova, Elena Shevtsova, Olga Zubareva, Anastassia Bakhmet, Harry M. Steinbusch, Sergey Bachurin, Klaus-Peter Lesch

“…While deficient brain plasticity is a well-established pathophysiologic feature of depression, little is known about disorder-associated enhanced cognitive processing. …”
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MFG-E8 Knockout Aggravated Nonalcoholic Steatohepatitis by Promoting the Activation of TLR4/NF-κB Signaling in Mice by Jun Hu, Hui Du, Yinglin Yuan, Peipei Guo, Junxia Yang, Xinru Yin, Jin Liu, Shengwang Wu, Jingyuan Wan, Xia Gong

“…Nonalcoholic steatohepatitis (NASH) is the common liver disease characterized by hepatic steatosis, inflammation, and fibrosis; there are no approved drugs to treat this disease because of incomplete understanding of pathophysiological mechanisms of NASH. Milk fat globule-epidermal growth factor-factor 8 (MFG-E8), a multifunctional glycoprotein, has shown anti-inflammation and antifibrosis. …”
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Hypermethylation of Hif3a and Ifltd1 is associated with atrial remodeling in pressure-overload murine model by Keiko Abe, Tetsuo Sasano, Yurie Soejima, Haruhisa Fukayama, Shigeru Maeda, Tetsushi Furukawa

“…Abstract Atrial remodeling is a major pathophysiological mechanism of atrial fibrillation (AF). …”
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Risk Factors for Urgency Incontinence in Women Undergoing Stress Urinary Incontinence Surgery by Leslie M. Rickey, Liyuan Huang, David D. Rahn, Yvonne Hsu, Heather J. Litman, Elizabeth R. Mueller

“…Further research is necessary to elucidate the pathophysiologic mechanisms that explain the associations between these medical conditions and bladder function.…”
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Topical steroids as alternative to systemic hormonal treatment for inflammatory bowel diseases in pediatric practice by E. N. Fedulova, O. V. Shumilova, O. V. Fedorova, O. A. Tutina, G. V. Medyantseva

“…Etiopathogenesis of IBD represents the cascade of self-maintaining pathophysiological reactions: adaptive microcirculational, hypoxicmetabolic, autoimmune inflammatory and dysbiotic disorders emerging on a background of genetic features of the body under the effect of unfavorable environmental factors. …”
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Investigation of the Pulmonary Artery Hypertension Using an Ad Hoc OpenFOAM CFD Solver by Francesco Duronio, Paola Marchetti

“…The analysis of the data confirmed the importance of CFD as a supportive tool in understanding, diagnosing, and monitoring the pathophysiological mechanisms underlying cardiovascular diseases, proving to be a powerful means for personalizing surgical treatments.…”
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Generalized Extension of Referred Trigeminal Pain due to Greater Occipital Nerve Entrapment by Jung-woo Hyung, Byung-chul Son

“…Generalized extension of referred pain due to GON entrapment is thought to involve two possible pathophysiologies. One is the possibility that generalized pain is caused by sensitization of third-order nociceptive neurons in the thalamus. …”
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Télémonitorage des grandes fonctions physiologiques chez les primates vigiles by Guy Germain

“…These systems should help characterizing the trends of certain physiological states (ethophysiological studies, field studies) or pathophysiologic states (pathology, pharmacology) quickly enough to alert the observers so that they can apply feedback corrective actions when necessary. …”
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Clinical Characteristics of Children with Acute Post-Streptococcal Glomerulonephritis and Re-Evaluation of Patients with Artificial Intelligence by Emre LEVENTOGLU, Mustafa SORAN

“…Questions assessing the definition, epidemiologic characteristics, pathophysiologic mechanisms, diagnosis, and treatment of APSGN were answered correctly by ChatGPT 3.5. …”
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Auditory function in humans at high altitude. A scoping review. by Michela Masè, Andrea Viziano, Giacomo Strapazzon, Marco Alessandrini, Alessandro Micarelli

“…Future studies in larger populations, using standardized protocols and multi-technique auditory function evaluation, are needed to further characterize the spatio-temporal pattern of HA effects along the auditory pathways and clarify the pathophysiological implications and reversibility of the observed changes.…”
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The Predictive Significance of Platelet‐to‐Lymphocyte Ratio for Miscarriage: A Systematic Review and Meta‐Analysis by Xiaoyi Wang, Yanfang Zhao, Yangyang Fan, Yun Liu

“…ABSTRACT Background Miscarriage is a common complication of pregnancy, and its underlying pathophysiologic mechanisms remains unclear. The platelet‐to‐lymphocyte ratio (PLR), a prothrombotic and inflammatory marker, has been controversially discussed as a potential predictor of miscarriage. …”
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Protective Effect of Hydroalcoholic Extract of Stachys pilifera on Oxidant-Antioxidant Status in Renal Ischemia/Reperfusion Injuries in Male Rats by Zahra Moslemi, Izadpanah Gheitasi, Amir Hossein Doustimotlagh

“…Reactive oxygen species are considered the major constituents involved in the biochemical and pathophysiological changes that were shown during kidney I/R. …”
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p38 MAPK Endogenous Inhibition Improves Neurological Deficits in Global Cerebral Ischemia/Reperfusion Mice by Kun Hou, Zhi-cheng Xiao, Hai-Long Dai

“…Cerebral ischemia/reperfusion (I/R) injury is a complex pathophysiological process that can lead to neurological function damage and the formation of cerebral infarction. …”
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Gut microbiota and atrial cardiomyopathy by Tingting Sun, Beibei Song, Bo Li

“…We focus on the pathophysiological aspects of atrial cardiomyopathy, the impact of gut microbiota dysbiosis on atrial structure and function, and therapeutic strategies exploring modulation of the microbiota for the treatment of atrial cardiomyopathy. …”
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