Application of Metabolomics in Thyroid Cancer Research by Anna Wojakowska, Mykola Chekan, Piotr Widlak, Monika Pietrowska

“…Beside genomics, transcriptomics, and proteomics, metabolomic approach emerges as the most downstream attitude reflecting phenotypic changes and alterations in pathophysiological states of biological systems. Metabolomics using mass spectrometry and magnetic resonance spectroscopy techniques allows qualitative and quantitative profiling of small molecules present in biological systems. …”
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Vascular Remodeling in Experimental Hypertension by Norma R. Risler, Montserrat C. Cruzado, Roberto M. Miatello

“…This review will provide an overview of the evidence, explaining some of the pathophysiologic mechanisms participating in the development of the vascular remodeling, in experimental models of hypertension, with special reference to the findings in spontaneously hypertensive rats as a model of essential hypertension, and in fructose-fed rats as a model of secondary hypertension, in the context of the metabolic syndrome. …”
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Connecting electronic health records to a biomedical knowledge graph to link clinical phenotypes and molecular endotypes in atopic dermatitis by Francesca Frau, Paul Loustalot, Margaux Törnqvist, Nina Temam, Jean Cupe, Martin Montmerle, Franck Augé

“…We applied our innovative methodology to deepen our understanding of atopic dermatitis, a condition with a complex underlying pathophysiological mechanism. Through our analysis, we identified seven subgroups of patients each characterized by clinical and genomic characteristics.…”
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Sympathovagal Imbalance in Prehypertensive Offspring of Two Parents versus One Parent Hypertensive by G. K. Pal, Pravati Pal, Nivedita Nanda, V. Lalitha, T. K. Dutta, C. Adithan

“…Though prehypertension has strong familial predisposition, difference in pathophysiological mechanisms in its genesis in offspring of both parents and single parent hypertensive have not been elucidated. …”
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Prominent Naturally Derived Oxidative-Stress-Targeting Drugs and Their Applications in Cancer Treatment by Eunsun Lee, Dongki Yang, Jeong Hee Hong

“…Reactive oxygen species (ROS) are involved in various pathophysiological processes and play crucial roles in DNA damage and angiogenesis. …”
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Acute Pericarditis Occurring Three Days after Intravesical Instillation of Mitomycin C after Transurethral Bladder Tumor Resection in a 64-Year-Old Woman by Vineet Meghrajani, Arsalan Hashmi, Shuo Cheng Lin, Zvi Plawes, Shelly Brejt

“…It is likely that the patient’s presentation was the result of a perimyocardial inflammatory process secondary to intravesically administered mitomycin C, rather than an acute coronary syndrome. While the pathophysiological basis of cardiotoxicity of systemically administered mitomycin C is well documented, more studies are needed to determine whether intravesical MMC may cause cardiotoxicity.…”
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Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review by Feixuan Wang, Jingqiong Wan, Yangzhen Liao, Shangyu Liu, Yuan Wei, Zhen Ouyang

“…The impairment of energy homeostasis is recognized as a key pathophysiological basis for brain metabolic disorders and related neurodegenerative diseases. …”
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Unveiling the molecular and cellular links between obstructive sleep apnea-hypopnea syndrome and vascular aging by Wei Liu, Le Zhang, Wenhui Liao, Huiguo Liu, Wukaiyang Liang, Jinhua Yan, Yi Huang, Tao Jiang, Qian Wang, Cuntai Zhang, Peifang Wei

“…The accumulation and combination of these features may underlie the pathophysiological link between OSAHS and VA, but the exact mechanisms by which OSAHS affects VA may require further investigation. …”
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Role of calpain system in meat tenderness: A review by Z.F. Bhat, James D. Morton, Susan L. Mason, Alaa El-Din A. Bekhit

“…These ubiquitous proteases are also present in mitochondria and play important roles in a variety of pathophysiological conditions including apoptotic and necrotic cell death phenomena. …”
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Surgical Tips in Frozen Abdomen Management: Application of Coliseum Technique by Ioannis D. Kyriazanos, Dimitrios K. Manatakis, Nikolaos Stamos, Christos Stoidis

“…Relatively recently the concept of “intentional open abdomen” was described and both clinical entities share common pathophysiological and clinical pathways (“postoperative open abdominal wall”). …”
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Tea and depression by Klaus W. Lange, Yukiko Nakamura, Katharina M. Lange, Hui Zhao

“…Potent pharmacological effects on circumscribed neurobiological systems may be produced not by individual tea components but rather by the synergistic action of various compounds on multiple pathophysiological mechanisms involved in depression. While epidemiological studies have generally demonstrated beneficial effects of tea consumption on mood and depressive symptoms, cross-sectional studies are unable to prove a cause-effect relationship. …”
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The role of the interplay between macrophage glycolytic reprogramming and NLRP3 inflammasome activation in acute lung injury/acute respiratory distress syndrome by Lan Luo, Xiaoli Zhuang, Lin Fu, Ziyuan Dong, Shuyuan Yi, Kan Wang, Yu Jiang, Ju Zhao, Xiaofang Yang, Feilong Hei

“…Understanding their complex pathophysiological mechanisms is crucial for developing new preventive and therapeutic strategies. …”
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Parathyroid carcinoma and pheochromocytoma in a patient with neurofibromatosis type 1: a rare association by Jardelina Brena Rocha Leite, Nicole Ramalho De Freitas, Rafaella Nelice de Holanda Cardoso, Erik Trovão Diniz, Gabriel Rodrigues de Assis Ferreira, Fernão Henrique Costa e Alvim, Camila Ribeiro Coutinho Madruga, Ana Carolina Thé Garrido, Luciano Albuquerque, Patricia Sampaio Gadelha, Ruy Lyra, Lucio Vilar

“…Further investigation into the underlying mechanisms linking these conditions is warranted to elucidate their pathophysiological interplay and inform optimal therapeutic strategies for affected individuals. …”
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Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering by Dominika Skołuba, Dariusz Sobolewski, Adam Prahl, Edyta Proniewicz

“…Bradykinin (BK), an endogenous peptide hormone, which is involved in a number of physiological and pathophysiological processes, and the potent B2 bradykinin receptor antagonists, [D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, Aaa[D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, [D-Arg0,Hyp3,Thi5,D-Phe7,L-Pip8]BK, and Aaa[D-Arg0,Hyp3,Thi5,D-Phe7,L-Pip8]BK, were deposited onto colloidal Au particles of 20 nm size. …”
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Urologic Characteristics and Sexual Behaviors Associated with Prostate Cancer in an African-Caribbean Population in Barbados, West Indies by Anselm J. M. Hennis, Suh-Yuh Wu, Barbara Nemesure, M. Cristina Leske

“…The contribution of sexual behaviors to the development and the outcomes of PC is likely due to multiple mechanisms, and further study will be necessary to elucidate the underlying pathophysiologic mechanisms in this and similar populations.…”
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The generation and evaluation of TKO/hCD55/hTM/hEPCR gene-modified pigs for clinical organ xenotransplantation by Guoli Huai, Yong Wang, Jiaxiang Du, Zhenhui Cheng, Yuxuan Xie, Jia Zhou, Hongmei Tang, Yanyan Jiang, Xiangyang Xing, Shaoping Deng, Dengke Pan, Dengke Pan, Dengke Pan

“…Blood from gene-edited pigs was used for pathophysiological analysis.ResultsComplete knockout of GGTA1, CMAH, and B4GALNT2 was confirmed in 6GE pigs. …”
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Mechanisms of Action of Mesenchymal Stem Cells in Metabolic-Associated Fatty Liver Disease by Sitong Yi, Qingwei Cong, Ying Zhu, Qiumin Xu

“…Metabolic-associated fatty liver disease (MAFLD) is currently the most common chronic liver disease worldwide. However, its pathophysiological mechanism is complicated, and currently, it has no FDA-approved pharmacological therapies. …”
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Preoperative evaluation of red blood cell distribution width as a promising biomarker for discriminating between benign and malignant breast tumors and assessing breast cancer acti... by Ajay Singh Thakur, Chandrashekhar Indoria, Ruby Sahu, Pratima Kujur, Renuka Gahine

“…Background: The red cell distribution width (RDW) has been recognized as a new prognostic factor in various pathophysiological states including breast cancers. The aim of this study was to compare the RDW values between patients diagnosed with benign and malignant breast tumors and to evaluate the potential of elevated RDW as a biomarker for breast cancer activity. …”
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Glutathione: A Key Regulator of Extracellular Matrix and Cell Death in Intervertebral Disc Degeneration by Fudong Li, Shaofei Li, Yangyang Shi, Feng Lin, Lining Rui, Jiangang Shi, Kaiqiang Sun

“…It has been reported that GSH can protect cells against the damage of oxidative stress and various pathophysiological stimulus that can lead to different types of cell death. …”
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Thymus and activation-regulated chemokine (CCL17) as a clinical biomarker in atopic dermatitis: significance and limitations in the new treatment era by Yoko Kataoka

“…In this new era, TARC remains a useful biomarker for more accurate drug selection and the determination of therapeutic efficacy; Currently, in clinical trials of AD, all outcome measurements depend on the clinical score; however the use of a biomarker, such as TARC, as a secondary outcome measure will clarify the characteristics of each drug and the pathophysiological conditions for which it is expected to be effective.…”
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