Renin-Angiotensin System Inhibitors in COVID-19: Current Concepts by Kunal Mahajan, Prakash Chand Negi, Neeraj Ganju, Sachin Sondhi, Naresh Gaur, Rao Somendra

“…We review the current data and pathophysiological mechanisms behind this intriguing interplay between the RAS inhibitors and the COVID-19.…”
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Research progress on protective effect of polysaccharide from traditional Chinese medicine on myocardial ischemia-reperfusion injury by Qian Sun, Hongtian Fei, Siqi Zhao, Lijiao Zhang, Rui Fei

“…Myocardial ischemia-reperfusion injury (MIRI) is a prevalent pathophysiological process associated with ischemic heart disease and significantly exacerbates myocardial damage, particularly in the elderly population.This condition not only poses serious risks to individual health but also brings creates substantial societal and economic burdens.Polysaccharides, natural macromolecule found in animals, plants and microorganisms, serve as active substance that confer various health benefits.Among these, polysaccharides extracted from traditional Chinese medicine(TCM) through modern scientific techniques have gained prominence in the medical field due to their safety and high efficiency, playing a vital role in the management of various cardiovascular diseases.This paper, provides a comprehensive review of the role and mechanisms of TCM-derived polysaccharide in MIRI, aiming to furnish valuable insights for the future treatment of cardiovascular diseases in the elderly.…”
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Comprehensive Approach to Cancer Pain in Pediatric Patients by Alexis Ramón Pineda González, Grettel Águila Calero, Anaelys Acosta Hernández, Marilyn Ramírez Méndez

“…This work aims to expose the main characteristics of pain from cancer in pediatrics, its evaluation and management, based on the pathophysiological knowledge, taking into account the aspects referenced in the most current specialized literature. …”
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Motion – Laparoscopic Nissen Fundoplication Is More Cost Effective Than Oral PPI Administration: Arguments for the Motion by Lee L Swanström

“…While medications can only provide symptom relief, surgery can correct the pathophysiological abnormality of the lower esophageal sphincter. …”
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Confusion and Hallucination: A Case Report of an Unusual Presentation of COVID-19 by Rawabi Aljumaiah, Wael Alturaiki, Bandar Alosaimi

“…Further studies are needed to establish the underlying pathophysiological mechanisms involved.…”
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Could Hallucinogens Induce Permanent Pupillary Changes in (Ab)users? A Case Report from New Zealand by Ahmed Al-Imam

“…All these tests failed to detect any pathophysiological or anatomical abnormalities. The patient is a known case of chronic endogenous depression in association with attention deficit hyperactivity disorder, for which she is taking citalopram and Ritalin, respectively. …”
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Bone-spicule pattern in retinitis pigmentosa by Krzysztof Eder, Rafał Leszczyński, Ewa Mrukwa-Kominek, Paulina Langosz, Sebastian Sirek

“…Rather, it is a multifactorial pathophysiological process involving the failure of various cellular regulatory mechanisms and the presence of histopathological changes. …”
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Gastroesophageal reflux disease and the functional diseases of gastro-intestinal tract: are there any interrelations? by A. A. Sheptulin, M. A. Vize-Khripunova

“…It can be caused by common pathophysiological mechanisms of these diseases. Within the framework of non-erosive form of GERD it is possible to define 2 subgroups of patients, at which: 1)correlation of clinical symptoms to episodes of physiological gastroesophageal reflux (GER) is present – patients with hypersensitive esophagus or 2) clinical symptoms are not related to GER at all – patients with functional heartburn, which can be considered within the framework of functional pathology. …”
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Intestinal Motility after Ileal Pouch-Anal Anastomosis by Jacques Heppell

“…Colectomy, mucosal proctectomy and ileal pouch-anal anastomosis, has become the procedure of choice for carefully selected patients with ulcerative colitis requiring surgery. Pathophysiological studies after the operation have led to a better understanding of the mechanisms of continence and to the development of new technology to study anorectal function. …”
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Multiple cranial neuropathies in Churg-Strauss syndrome: case report by G. Rutkauskaitė, R. Masaitienė, J. Dadonienė, D. Jatužis

“…There are no clear pathophysiologic mechanisms that explain the development of CSS but association between CSS and HLA-DRB4 has been reported. …”
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Leading causes of fever in patients with liver function disorders by V. T. Ivashkin, M. A. Morozova, M. V. Mayevskaya

“…Article presents pathophysiological mechanisms of development of fever. The algorithm of assessment of patient with disorder of liver function and fever is submitted.Original positions. …”
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IgG4-Related Disease Presenting as Isolated Scleritis by Eran Berkowitz, Ella Arnon, Alona Yaakobi, Yuval Cohen, Beatrice Tiosano

“…This case highlights the significance of IgG4-RD in the differential diagnosis of scleritis and raises the question as to whether various organs affected by IgG4-RD may have different underlying pathophysiological mechanisms in which pathogenic T cells play a role.…”
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Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor Chronic Toxigenic Mold Exposures by Ebere C. Anyanwu, Andrew W. Campbell, John E. Ehiri

“…Fundamental bases of pathophysiological, neurodevelopmental, and cellular mechanisms of mycotoxic effects are evaluated. …”
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Masked Hypotension due to Elevated Venous Pressure in a Patient with Complex Adult Congenital Heart Disease by Wytch Rigger, Sean P. Javaheri, Gyanendra K. Sharma, Norris Stanley Nahman, Mark Sheynshteyn, Neal L. Weintraub

“…We have coined the term “masked hypotension” to describe this unique pathophysiological phenomenon.…”
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Firework-Related Chorioretinitis Sclopetaria: A Case Report and Literature Review by Greta Kazlauskaitė, Aušrinė Misevičė

“…We also discuss the prevalence of chorioretinitis sclopetaria, risk factors, the pathophysiological mechanism, the main clinical findings, treatment options, and outcomes. …”
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Extreme Insulin Resistance in a Patient with Diabetes Ketoacidosis and Acute Myocardial Infarction by Yin H. Oo, Jocelyne G. Karam, Christine A. Resta

“…In hospitalized patients, multiple factors contribute to hyperglycemia, such as underlying medical conditions, pathophysiological stress, and medications. The development of transient insulin resistance is a known cause of hyperglycemia in both diabetic and nondiabetic patients. …”
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Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage by Bolin Cai, Edwin A. Deitch, Luis Ulloa

“…Here, we review the inflammatory responses and the anti-inflammatory strategies in experimental models of sepsis and hemorrhage, as they may have a consistent inflammatory pathway in spite of their different pathophysiological processes.…”
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P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction by Segundo J. Guzman, Zoltan Gerevich

“…ATP released from neurons and astrocytes during neuronal activity or under pathophysiological circumstances is able to influence information flow in neuronal circuits by activation of ionotropic P2X and metabotropic P2Y receptors and subsequent modulation of cellular excitability, synaptic strength, and plasticity. …”
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Synaptic Structure and Function in the Mouse Somatosensory Cortex during Chronic Pain: In Vivo Two-Photon Imaging by Sun Kwang Kim, Kei Eto, Junichi Nabekura

“…These updated in vivo approaches are just beginning to be used for the study of pathophysiological mechanisms of chronic diseases. In this paper, we introduce recent in vivo two-photon imaging studies demonstrating how plastic changes in synaptic structure and function of the mouse somatosensory cortex, following peripheral injury, contribute to chronic pain conditions, like neuropathic and inflammatory pain.…”
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Spindle Bursts in Neonatal Rat Cerebral Cortex by Jenq-Wei Yang, Vicente Reyes-Puerta, Werner Kilb, Heiko J. Luhmann

“…In this review we discuss (i) the functional properties of spindle bursts, (ii) the mechanisms underlying their generation, (iii) the synchronous patterns and cortical networks associated with spindle bursts, and (iv) the physiological and pathophysiological role of spindle bursts during early cortical development.…”
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