Non-motor Disorders and their Neuro-anatomical Substrate in Parkinson's Disease by Julio López Argüelles, Leydi María Sosa Águila

“…New studies are necessary to clarify the pathophysiological bases of Parkinson's disease that allow establishing future therapeutic strategies for the follow-up of patients with these disorders.…”
Get full text

Oxidative Stress and Its Biomarkers in Cardiovascular Diseases by Julija Valaitienė, Agnė Laučytė-Cibulskienė

“…CVDs share heterogeneous pathophysiologic mechanisms, one of which includes increased oxidative stress. …”
Get full text

Leukotrienes as Modifiers of Preclinical Atherosclerosis? by Graziano Riccioni, Magnus Bäck

“…Preclinical atherosclerosis represents a crucial period associated with several pathophysiological reactions in the vascular wall. Failure to diagnose preclinical atherosclerosis at this stage misses a major opportunity to prevent the long-term consequences of this disease. …”
Get full text

The Enigma of the Tinnitus-Free Dream State in a Bayesian World by Dirk De Ridder, Kathleen Joos, Sven Vanneste

“…There are pathophysiological, clinical, and treatment analogies between phantom limb pain and phantom sound (i.e., tinnitus). …”
Get full text

Physiopathological Mechanisms of Association between Metabolic Syndrome and Arterial Hypertension: an Update by Luis Enrique Jiménez Franco, Dianelys María Gutiérrez Pérez, Milagros Lisset León Regal, Claudia González Martínez, Lucía Baños Leyva, Arionnis Matos Olivero

“…The objective was to argue the pathophysiological mechanisms of association between the metabolic syndrome and arterial hypertension. …”
Get full text

PATHOGENETIC ROLE OF THROMBOCYTES IN THE DEVELOPMENT OF AUTOIMMUNE PATHOLOGY OF THE THYROID GLAND by I. Yu. Bahmut, O. O. Halmyz, S. М. Hramatiuk, A. V. Titkova

“…According to the results of our study, we hypothesized that PMPs can interact with circulating autoantibodies and C1q involved in the formation of immune complexes, which can be a pathophysiological cause of the immune response.…”
Get full text

Short Bowel Syndrome: Intestinal Adaptation and Medical Therapy by WD Buie, OG Thurston, Richard N Fedorak

“…Medical treatment of short bowel syndrome remains supportive and centres around the control of three pathophysiological defects: decreased intestinal transit time, gastric hypersecretion, and reduced functional mucosal surface area.…”
Get full text

Multivessel Coronary Artery Vasospasm-Induced Takotsubo Cardiomyopathy by Vishal I. Patel, Serap Sobnosky

“…Epicardial coronary vasospasm is a rarely reported etiology for takotsubo cardiomyopathy, and its pathophysiologic mechanisms still remain incompletely understood. …”
Get full text

Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases: Potential Role in Macrophage-Mediated Inflammatory Diseases by Yuki Murakami, Masato Hoshi, Yukio Imamura, Yuko Arioka, Yasuko Yamamoto, Kuniaki Saito

“…Originally known for its regulatory function during pregnancy and chronic inflammation in tumorigenesis, the activity of IDO1 seems to modify the inflammatory state of infectious diseases. The pathophysiologic activity of L-tryptophan metabolites, kynurenines, is well recognized. …”
Get full text

Complement Diagnostics: Concepts, Indications, and Practical Guidelines by Bo Nilsson, Kristina Nilsson Ekdahl

“…Aberrations in the complement system have been shown to be direct or indirect pathophysiological mechanisms in a number of diseases and pathological conditions such as autoimmune disease, infections, cancer, allogeneic and xenogeneic transplantation, and inflammation. …”
Get full text

Current Concepts on Antiplatelet Therapy: Focus on the Novel Thienopyridine and Non-Thienopyridine Agents by L. Testa, G. G. L. Biondi Zoccai, M. Valgimigli, R. A. Latini, S. Pizzocri, S. Lanotte, M. L. Laudisa, N. Brambilla, M. R. Ward, G. A. Figtree, F. Bedogni, R. Bhindi

“…They significantly reduce platelet activity and are therefore clinically beneficial in settings where platelet activation is a key pathophysiological feature, particularly myocardial infarction. …”
Get full text

Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease by Dongping Huang, Jing Xu, Jinghui Wang, Jiabin Tong, Xiaochen Bai, Heng Li, Zishan Wang, Yulu Huang, Yufei Wu, Mei Yu, Fang Huang

“…Here, we provide an overview of the dynamic changes in the nigrostriatal pathway in the MPTP mouse model of PD. Pathophysiological events, such as reductions in the striatal dopamine (DA) concentrations and levels of the tyrosine hydroxylase (TH) protein, depletion of TH-positive nerve fibers, a decrease in the number of TH-positive neurons in the substantia nigra pars compacta (SNpc), and glial activation, are addressed. …”
Get full text

Methods of risk prediction and monitoring of treatment response rate of bleedings from esophageal varices in patients with liver cirrhosis by D. V. Garbuzenko

“…Optimization of known methods of assessment of portal hypertension, and development of new, pathophysiologically based methods, allows to increase efficacy of VEV bleedings prophylaxis in patients with liver cirrhosis.…”
Get full text

Pediatric Migraine by Ubaid Hameed Shah, Veena Kalra

“…Migraine is the most common cause of acute recurrent headaches in children. The pathophysiological concepts have evolved from a purely vascular etiology to a neuroinflammatory process. …”
Get full text

Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19 by Adriana Martinez-Cuazitl, Monica M. Mata-Miranda, Miguel Sanchez-Brito, Daniel Valencia-Trujillo, Amanda M. Avila-Trejo, Raul J. Delgado-Macuil, Consuelo Atriano-Colorado, Francisco Garibay-Gonzalez, Virginia Sanchez-Monroy, Gustavo J. Vazquez-Zapien

“…Therefore, to describe the pathophysiological response to SARS-CoV-2 infection in hospitalized patients with severe COVID-19, we compared according to survival or death, the sociodemographic and clinical characteristics, the biochemical and immunological attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra from saliva samples and their correlation with chemometric findings. …”
Get full text

The Impact of Incretin-Based Medications on Lipid Metabolism by Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…Pathophysiological pathways that are induced by chronic hyperglycemia negatively impact lipid metabolism. …”
Get full text

Hyponatremia and Congestive Heart Failure: A Marker of Increased Mortality and a Target for Therapy by Adam Romanovsky, Sean Bagshaw, Mitchell H. Rosner

“…The recent introduction of specific vasopressin-receptor antagonists offers a targeted pharmacological approach to these pathophysiological derangements. Thus far, clinical trials with vasopressin-receptor antagonists have demonstrated an increase in free-water excretion, improvement in serum sodium, modest improvements in dyspnea but no improvement in mortality. …”
Get full text

Cardiovascular and Renal Links along the Cardiorenal Continuum by José A. García-Donaire, Luis M. Ruilope

“…Moreover, cardiovascular events rarely occur in patients without underlying disease; rather, they typically take place as the final stage of a pathophysiological process that results in progressive vascular damage, including vital organ damage, specifically the kidney and the heart if these factors are uncontrolled. …”
Get full text

Molecular Pathogenesis of Cholangiocarcinoma by G. Fava, I. Lorenzini

“…Epidemiological data from the last years show an increasing trend of incidence and mortality of cholangiocarcinoma (CC) worldwide. Many pathophysiologic aspects of this neoplasia are still unknown and need to be fully discovered. …”
Get full text

The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options by Jiayong Yao, Xiaohong Dai, Xueping Yv, Lei Zheng, Jia Zheng, Binglin Kuang, Wei Teng, Weiwei Yu, Mingyue Li, Hongtao Cao, Wei Zou, Wei Zou

“…According to a large number of experimental research, oxidative stress is an important pathophysiological processes of cerebral hemorrhage. In this paper, we aim to determine how changes in oxidative stress biomarkers indicate the damage degree of cerebral hemorrhage, and to explore and summarize potential treatments or interventions. …”
Get full text