GABA Metabolism and Transport: Effects on Synaptic Efficacy by Fabian C. Roth, Andreas Draguhn

Get full text

Chiari Malformation and Attention Deficit Hyperactivity Disorder by Anaïs DuBow, Aurélie Mourot, Smadar Valérie Tourjman

“…Our case highlights the need for further studies pertaining to the role of the cerebellum in the pathophysiology of ADHD and the importance of considering the presence of CM when evaluating a patient with ADHD.…”
Get full text

Early Myocardial Strain Reduction and miR-122-5p Elevation Associated with Interstitial Fibrosis in Anthracycline-Induced Cardiotoxicity by María de Regla Caballero-Valderrama, Elisa Bevilacqua, Miriam Echevarría, Francisco Javier Salvador-Bofill, Antonio Ordóñez, José Eduardo López-Haldón, Tarik Smani, Eva M. Calderón-Sánchez

Get full text

Integrated Bioinformatic Analysis Identifies Networks and Promising Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma by Yun Ji, Yue Yin, Weizhen Zhang

Get full text

Identification of Biomarkers of Arrhythmogenic Cardiomyopathy (ACM) by Plasma Proteomics by Sinda Zarrouk, Houda Ben-Miled, Nadia Rahali, Josef Finsterer, Fatma Ouarda

“…<i>Background and Objectives:</i> The pathophysiology of arrhythmogenic cardiomyopathy (ACM), previously known as arrhythmogenic right ventricular cardiomyopathy (ARVC), and its specific biological features remain poorly understood. …”
Get full text

Myocardial Ischemia and Diabetes Mellitus: Role of Oxidative Stress in the Connection between Cardiac Metabolism and Coronary Blood Flow by Paolo Severino, Andrea D’Amato, Lucrezia Netti, Mariateresa Pucci, Fabio Infusino, Viviana Maestrini, Massimo Mancone, Francesco Fedele

“…For this reason, considering the role of oxidative and ion channels in the pathophysiology of myocardial ischemia, it is allowed to consider new therapeutic perspectives in the treatment of IHD.…”
Get full text

Effect of In Vitro Exposure of Corticosteroid Drugs, Conventionally Used in AMD Treatment, on Mesenchymal Stem Cells by Raffaele Nuzzi, Monica Gunetti, Deborah Rustichelli, Barbara Roagna, Francesca Fronticelli Bardelli, Franca Fagioli, Ivana Ferrero

Get full text

Advances in functional MRI research in bipolar disorder: from the perspective of mood states by Yun-Ai Su, Tianmei Si, Yankun Wu, Linlin Zhu, Jitao Li

“…Current breakthroughs in functional MRI techniques have uncovered the functional neuroanatomy of bipolar disorder. However, the pathophysiology underlying mood instability, mood switching and the development of extreme mood states is less well understood. …”
Get full text

SESN2 ablation weakens exercise benefits on resilience of gut microbiota following high-fat diet consumption in mice by Chunxia Yu, Peng Zhang, Sujuan Liu, Yanmei Niu, Li Fu

Get full text

GATA4 binding to the Sox9 enhancer mXYSRa/Enh13 is critical for testis differentiation in mouse by Yuya Ogawa, Iku Tsuchiya, Shogo Yanai, Takashi Baba, Ken-Ichirou Morohashi, Takehiko Sasaki, Junko Sasaki, Miho Terao, Atsumi Tsuji-Hosokawa, Shuji Takada

Get full text

Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Thus, kaempferol holds great promise for treating neurodegenerative diseases where both mitochondrial and ER dysfunction are causally linked to the pathophysiology. Graphical abstract…”
Get full text

Obsessive–Compulsive Symptoms in Neurologic Disease: A Review by M. S. George, J. A. Melvin, C. H. Kellner

“…Although the exact pathophysiology of OCD in its pure form remains unknown, there are numerous reports of obsessive–compulsive symptoms arising in the setting of known neurological disease. …”
Get full text

The Rise of Inflow Cisternostomy in Resource-Limited Settings: Rationale, Limitations, and Future Challenges by Ulrick Sidney Kanmounye

“…In this narrative review, the author discusses the history, pathophysiology, practice, evidence, and implications of cisternostomy. …”
Get full text

The venom of South American rattlesnakes inhibits macrophage functions and is endowed with anti-inflammatory properties by Maria C. C. de Sousa e Silva, Luis R. C. Gonçalves, Mario Mariano

Get full text

Functional Consequences of the Disturbances in the GABA-Mediated Inhibition Induced by Injuriesin the Cerebral Cortex by Barbara Imbrosci, Thomas Mittmann

Get full text

Alveolar Osteitis: A Comprehensive Review of Concepts and Controversies by Antonia Kolokythas, Eliza Olech, Michael Miloro

“…A great body of literature is devoted to alveolar osteitis addressing the etiology and pathophysiology of this condition. In addition numerous studies are available discussing methods and techniques to prevent this condition. …”
Get full text

Novel distribution of the secretory leucocyte proteinase inhibitor in kidney by Sophie Ohlsson, Irena Ljungkrantz, Kjell Ohlsson, Mårten Segelmark, Jörgen Wieslander

Get full text

SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

Get full text

Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease by Tommaso Mello, Simone Polvani, Andrea Galli

Get full text

Contemporary treatment of right ventricular failure by Bibhuti B. Das, MD, Shashi Raj, MD, FAAP, FACC

“…Factors modulating RV function include afterload, preload, contractility, and interventricular dependency. The pathophysiology of RVF involves complex interactions, such as maladaptive hypertrophy, metabolic reprogramming, inflammation, fibrosis, apoptosis, and endothelial dysfunction. …”
Get full text