RNA structure in alternative splicing regulation: from mechanism to therapy by Bao Nengcheng, Wang Zhechao, Fu Jiayan, Dong Haiyang, Jin Yongfeng

Subjects: Get full text

TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis by Jing Li, Yosuke Nagasaka, Hongtao Shen, Xinyu Zhou, Jianjie Ma, Dilza Trevisan-Silva, Nicholas E. Sherman, Jayakrishna Ambati, Bradley D. Gelfand, Lian-Wang Guo

Subjects: “…MT: Oligonucleotides: Therapies and Applications…”
Get full text

Therapeutic landscape for inherited ocular diseases: current and emerging therapies by Hwei Wuen Chan, Jaslyn Oh, Bart Leroy

Subjects: “…antisense oligonucleotides…”
Get full text

Extracellular viral microRNAs as biomarkers of virus infection in human cells by Cheryl Chan, Joanne Xin Yi Loh, Wei-Xiang Sin, Denise Bei Lin Teo, Nicholas Kwan Zen Tan, Chandramouli Nagarajan, Yunxin Chen, Francesca Lorraine Wei Inng Lim, Michael E. Birnbaum, Rohan B.H. Williams, Stacy L. Springs

Subjects: “…MT: Oligonucleotides: Diagnostics and Biosensors…”
Get full text

Targeted allele-specific FGFR2 knockdown via human recombinant ferritin nanoparticles for personalized treatment of Crouzon syndrome by Federica Tiberio, Martina Salvati, Luca Polito, Giada Tisci, Alessia Vita, Ornella Parolini, Luca Massimi, Lorena Di Pietro, Pierpaolo Ceci, Gianpiero Tamburrini, Alessandro Arcovito, Elisabetta Falvo, Wanda Lattanzi

Subjects: “…MT: Oligonucleotides: Therapies and Applications…”
Get full text

DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model by Xin Yang, Chi Ho Chan, Shanshan Yao, Hang Yin Chu, Minchuan Lyu, Ziqi Chen, Huan Xiao, Yuan Ma, Sifan Yu, Fangfei Li, Jin Liu, Luyao Wang, Zongkang Zhang, Bao-Ting Zhang, Lu Zhang, Aiping Lu, Yaofeng Wang, Ge Zhang, Yuanyuan Yu

Subjects: “…MT: Oligonucleotides: Therapies and Applications…”
Get full text

Redefining NSP12 activity in SARS-CoV-2 and its regulation by NSP8 and NSP7 by Deepa Singh, Tushar Kushwaha, Rajkumar Kulandaisamy, Vikas Kumar, Kamal Baswal, Saras H. Tiwari, Arkadyuti Ghorai, Manoj Kumar, Saroj Kumar, Soumya De, Aparoy Polamarasetty, Deepak Sehgal, Madhumohan R. Katika, Suresh Gadde, Marceline Côté, Sarala R. Kayampeta, Mohan Babu Appaiahgari, Krishna K. Inampudi

Subjects: “…MT: Oligonucleotides: Therapies and Applications…”
Get full text

In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection by Yuta Suzuki, Takayuki Miyazaki, Yoko Ida, Tatsuya Suzuki, Yumi Itoh, Shuto Nakao, Keita Kondo, Kenji Kubara, Keisuke Nishioka, Hiroki Muto, Ryuji Watari, Toshifumi Hirayama, Dai Kakiuchi, Shinya Sato, Satoshi Inoue, Yoshifumi Uemoto, Yohei Mukai, Atsushi Hoshino, Toru Okamoto, Junji Matsui

Subjects: “…MT: Oligonucleotides: Therapies and Applications…”
Get full text

Oligodeoxynucleotide Containing Disulphide Bond Stabilizes Triplex DNA Structure by Ajay Kumar

“…The stability of the triplex formed with disulphide containing oligonucleotide was compared with unmodified oligonucleotide and C-5 propyne deoxyuridine containing oligonucleotide. …”
Get full text

Statistical analysis on avoidance of palindromic sequences in genomes of microorganisms by Tomas Rekašius, Albertas Timinskas

“… The statistical analysis of oligonucleotide combinations and mathematical modelling of outgoing processes is very successfully used in the research. …”
Get full text

Clinical Perspectives - Biologics in IBD: What's All the Fuss? by Hillary Steinhart

“…This article examines the evidence behind the use of biologic therapies such as anti-tumour necrosis factor-alpha, interleukin-10, interleukin-11, anti-integrin antibody and antisense intercellular adhesion molecule-1 oligonucleotide.…”
Get full text

DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge by Victoria Gnazzo, Hanaa Saleh, Ítalo A. Castro, Adrianus C. M. Boon, Amelia K. Pinto, James D. Brien, Carolina B. López

“…Here, we tested the viral-derived oligonucleotide DDO268 as an adjuvant in the context of a model influenza A virus (IAV) nucleoprotein (NP) mRNA vaccine in C57BL/6 mice. …”
Get full text

Proteins with RNA Chaperone Activity: A World of Diverse Proteins with a Common Task—Impediment of RNA Misfolding by Katharina Semrad

“…RNA chaperone activity is studied in vitro and in vivo using oligonucleotide- or ribozyme-based assays. Due to their functional as well as structural diversity, a common chaperoning mechanism or universal motif has not yet been identified. …”
Get full text

Genome-Wide and Gene-Specific Epigenomic Platforms for Hepatocellular Carcinoma Biomarker Development Trials by Christina Michailidi, Ethan Soudry, Mariana Brait, Leonel Maldonado, Andrew Jaffe, Carmen Ili-Gangas, Priscilla Brebi-Mieville, Jimena Perez, Myoung Sook Kim, Xiaoli Zhong, Quiang Yang, Blanca Valle, Stephen J. Meltzer, Michael Torbenson, Manel Esteller, David Sidransky, Rafael Guerrero-Preston

“…To assess that potential, we used quantitative Methylation Specific PCR, oligonucleotide tiling arrays, and Methylation BeadChip assays. …”
Get full text

Heterogeneous Chromosomal Aberrations in Intraductal Breast Lesions Adjacent to Invasive Carcinoma by Michaela Aubele, Margaret Cummings, Axel Walch, Horst Zitzelsberger, Jörg Nährig, Heinz Höfler, Martin Werner

“…Isolated DNA was amplified by degenerate oligonucleotide primed PCR (DOP‐PCR) and further processed for CGH analysis.…”
Get full text

High Resolution Comparative Genomic Hybridization Detects 7–8 Megabasepair Deletion in PCR Amplified DNA1 by Jacob Larsen, Anne Marie Ottesen, Maria Kirchhoff, Claes Lundsteen, Jørgen K. Larsen

“…We investigated if any change in spatial resolution of comparative genomic hybridization analysis could be detected when using DNA amplified by degenerate oligonucleotide primed PCR (DOP‐PCR) as opposed to the use of unamplified DNA. …”
Get full text

Midregion PTHrP and Human Breast Cancer Cells by Claudio Luparello

“…In addition, midregion PTHrP appears to be imported in the nucleoplasm of cultured MDA-MB231 cells and in vitro, it can bind chromatin of metaphase spread preparations and also an isolated 20-mer oligonucleotide, thereby appearing endowed with a putative transcription factor–like DNA-binding ability. …”
Get full text

True Lies: The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair by Nicolas Le May, Jean-Marc Egly, Frédéric Coin

“…During NER, more than 30 polypeptides cooperate to recognize, incise, and excise a damaged oligonucleotide from the genomic DNA. Recent papers reveal an additional and unexpected role for the NER factors. …”
Get full text

Intrafamilial Genotyping of Helicobacter pylori from Faecal DNA by M. McMillan, W. G. MacKay, C. L. Williams, A. J. Shepherd, C. Malcolm, L. T. Weaver

“…H. pylori DNA was chemically recovered and isolated using a specific biotinylated oligonucleotide probe with magnetic capture from 28 H. pylori positive faecal samples obtained from children attending hospital for the investigation of suspected H. pylori infection, together with close family members. …”
Get full text

Differential Gene Expression Profile of Human Neutrophils Cultured with Plasmodium falciparum-Parasitized Erythrocytes by Mohamad Alaa Terkawi, Ryo Takano, Kentaro Kato

“…Therefore, we examined the transcriptional gene profile of human PMNs in response to Plasmodium falciparum-parasitized erythrocytes (iRBCs) by using oligonucleotide microarrays. Results revealed that PMNs induced a broad and vigorous set of changes in gene expression in response to malarial parasites, represented by 118 upregulated and 216 downregulated genes. …”
Get full text