Applying Focal Therapy to Lesions Detected via Magnetic Resonance Imaging: Delivering Cancer Ablation Beyond the Visibility Phenomenon by Clement Orczyk, Teresa Marsden, Francesco Giganti, Joseph M. Norris, Santosh Waigankar, Louise Dickinson, Shonit Punwani, Alex Kirkham, Alex Freeman, Aiman Haider, Caroline M. Moore, Arnauld Villers, Clare Allen, Mark Emberton

“…We propose a 10-step framework that incorporates the contribution of all MRI sequences, the cancer growth pattern within the zonal anatomy to establish a margin around the MRI-visible lesion, safeguards for critical anatomic structures, and guidance for energy selection on the basis of specific properties. …”
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Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings by Maria Meira, Aurore Frey, Neila Chekkat, Magda Rybczynska, Zaki Sellam, Joon Seok Park, Francesca Smylie Gazzaniga, Alexia Parmentier, Marianne Le Gall, Gordon James Freeman, Dennis Lee Kasper, Arlene Helen Sharpe, Eric Rambeaux, Abdijapar Shamshiev

“…The emergence of Repulsive Guidance Molecule b (RGMb), a ligand for PD-L2, as a novel co-inhibitory pathway in T cells, together with its regulation by the gut microbiome, encouraged the discovery and development of fully human anti-RGMb antibodies. …”
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Role of Cardiac Magnetic Resonance Imaging in Detecting Myocardial Viability in Patients with Chronic Ischaemic Heart Disease: A Prospective Observational Study by Subhosree Dey, Parul Dutta, Bornali Dutta, Baloy Jyoti Talukdar, Sushant Agarwal, Dhiraj Baruah

“…The assessment of myocardial viability using Contrast-enhanced Magnetic Resonance Imaging (CE-MRI) has become a quintessential imaging method for the guidance of treatment in patients with Myocardial Infarction (MI). …”
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The lingering menace: How legacy organochlorine pesticides still threaten our rivers and food chains by Wenping Xie, Guangjun Wang, Ermeng Yu, Jun Xie, Wangbao Gong, Zhifei Li, Kai Zhang, Yun Xia, Jingjing Tian, Hongyan Li

“…The current research provides valuable guidance for aquatic food consumption.…”
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Habitat suitability modeling for Posidonia oceanica distribution along a Mediterranean region (NW Italy) by Rachele Bordoni, Chiara Paoli, Monica Montefalcone, Alice Oprandi, Ilaria Rigo, Francesca Ruggeri, Paolo Vassallo

“…The west coast of Liguria was found to have a greater extent of seagrass meadows compared to the east coast.This study provides valuable guidance for the sustainable management of P. oceanica meadows and offers practical tools for scientific research, land managers, stakeholders, and policy makers. …”
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Top 10 palliative care research priorities in France: a 3-step, mixed-methods protocol (AXEPRO study) by Stéphane Sanchez, Guillaume Economos, Fiona Ecarnot, Cecile Barbaret, Raphaëlle Habert-Dantigny, Héloïse Rouze, Doan Huynh, Roseline Huynh, Caroline Tête, Martin Julier-Costes, Valérie Amouroux-Gorsse, Isabelle Lavault, Justine Bret

“…There is clearly a low level of investment in palliative care research. Following the guidance from the James Lind Alliance and the UK public consultation (‘Palliative and End of Life Care Research Priorities Project’), we developed a 3-step protocol aimed at prioritising 10 unanswered questions in palliative care (PC) research in France, from the viewpoint of patients, volunteers, healthcare professionals and family caregivers.Methods and analysis To identify unanswered questions in PC (stage 1), an unstructured questionnaire will be used. …”
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Developing an automatic treatment record review system for quality assurance of patient treatment delivery in radiation therapy by Peng Huang, Yingjie Xu, Fukui Huan, Yanxin Zhang, Min Ma, Kuo Men, Jianrong Dai

“…Eight review categories (parameter consistency, treatment completeness, treatment progression, image guidance, override, treatment couch, documentation, and treatment mode) are created. …”
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Culturally appropriate terminologies in health research: a participatory study with pregnant and breastfeeding mothers in Uganda by Ritah Nakijoba, Adelline Twimukye, Josephine Bayigga, Aida N. Kawuma, Simon Peter Asiimwe, Fredrick Byenume, Jacqueline Kyeyune, Sylvia Nabukenya, Francis Williams Ojara, Francis Williams Ojara, Catriona Waitt, Catriona Waitt

“…By adopting community-preferred terms, researchers can avoid confusion and stigma fostering respectful health communication. The findings offer guidance for future research, advocating for community-driven inclusive language in research involving pregnant and breastfeeding women. …”
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Unveiling prognostic value of JAK/STAT signaling pathway related genes in colorectal cancer: a study of Mendelian randomization analysis by Nan Zhang, Wenli Yue, Bihang Jiao, Duo Cheng, Jingjing Wang, Fang Liang, Yingnan Wang, Xiyue Liang, Kunkun Li, Junwei Liu, Yadong Li

“…Conclusions A new JAK-STAT related CRC prognostic model was constructed and validated, which possessed an underlying predictive potential for CRC patients’ prognosis and could potentially enhance tailored guidance for immunotherapy.…”
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Biochar Application and Mowing Independently and Interactively Influence Soil Enzyme Activity and Carbon Sequestration in Karst and Red Soils in Southern China by Wenjia Luo, Daniel F. Petticord, Shiwen Zhu, Shaowu Zhu, Yuanlong Wu, Xun Yi, Xinyue Wang, Yili Guo, Xuxin Song

“…These findings offer valuable theoretical guidance for developing sustainable land management in sensitive ecosystems.…”
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The Tools for Integrated Management of Childhood Illness (TIMCI) study protocol: a multi-country mixed-method evaluation of pulse oximetry and clinical decision support algorithms by Fenella Beynon, Hélène Langet, Leah F. Bohle, Shally Awasthi, Ousmane Ndiaye, James Machoki M’Imunya, Honorati Masanja, Susan Horton, Maymouna Ba, Silvia Cicconi, Mira Emmanuel-Fabula, Papa Moctar Faye, Tracy R. Glass, Kristina Keitel, Divas Kumar, Gaurav Kumar, Gillian A. Levine, Lena Matata, Grace Mhalu, Andolo Miheso, Deusdedit Mjungu, Francis Njiri, Elisabeth Reus, Michael Ruffo, Fabian Schär, Kovid Sharma, Helen L. Storey, Irene Masanja, Kaspar Wyss, Valérie D’Acremont, TIMCI Collaborator Group

“…Devices are implemented with guidance and training, mentorship, and community engagement. …”
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Development and Validation of Risk Stratification for Heart Failure After Acute Coronary Syndrome Based on Dynamic S100A8/A9 Levels by Jie Ma, Ke Ma, Jing Chen, Xinying Yang, Fei Gao, Hai Gao, Hui Zhang, Xin‐Liang Ma, Jie Du, Ping Li, Yulin Li

“…Conclusions S100A8/A9 levels on day 1 accurately classified patients at varying risks of HF, serving as a robust tool for HF risk prediction and treatment guidance. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT03752515.…”
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Evaluation of a Guided Chatbot Intervention for Young People in Jordan: Feasibility Randomized Controlled Trial by Anne Marijn de Graaff, Rand Habashneh, Sarah Fanatseh, Dharani Keyan, Aemal Akhtar, Adnan Abualhaija, Muhannad Faroun, Ibrahim Said Aqel, Latefa Dardas, Chiara Servili, Mark van Ommeren, Richard Bryant, Kenneth Carswell

“…STARS consisted of 10 lessons in which participants interacted with a chatbot and learned several cognitive behavioral therapy strategies, with optional guidance by a trained e-helper through 5 weekly phone calls. …”
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A bibliometric analysis of exosomes in aging from 2007 to 2023 by Zenghui Niu, Meiyu Cui, Yingkun Fu, Lingfeng Zhou, Jiali Wang, Jiali Wang, Yan Lei, Xinrong Fan, Qiang Wang, Jing Yang

“…The present study provides valuable new perspectives on the history and current status of exosomes in the field of aging and aging-related diseases, and also offering guidance for future research directions.…”
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Scoping review of costs of implementation strategies in community, public health and healthcare settings by Hongmei Wang, Jungyoon Kim, Tzeyu L Michaud, Emiliane Pereira, Gwenndolyn Porter, Caitlin Golden, Jennie Hill, Cindy Schmidt, Paul A Estabrooks

“…Most studies presented limited information on costing methodology, making interpretation difficult.Conclusions The quantity of published D&I strategy cost analyses is increasing, yet guidance on conducting and reporting of D&I strategy cost analysis is necessary to facilitate and promote the application of comparative economic evaluation in the field of D&I research.…”
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The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib by Jing Zhang, Zequn Wang, Xihua Wei, Mengyuan Han, Ribai Yan, Lijie Ma, Yan Pan

“…These genes were predominantly associated with pathways such as axon guidance, microRNAs in cancer, and the JAK-STAT signaling pathway, among others. …”
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Pengembangan Game Edukasi Bilomatika untuk Meningkatkan Hasil Belajar Siswa pada Mata Pelajaran Matematika Kelas 1 SD by Risqi Ervera Nur Arifah, Sukirman Sukirman, Sujalwo Sujalwo

“…One reason is that the learning method applied still uses books as a guidance. For this reason, fun learning media needs to be used, for example using games. …”
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Damage of Green Synthetic Cement Slurry to Clastic Rock Reservoir by Meng Xu, Xin Tan, Libo Yang, Hanlie Cheng, David Cofell

“…The work provides an important application guidance to green synthesis and metal oxide composites.…”
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Weighing temporal fluctuations of drought features in Rwanda through the implementation of the standardized precipitation evapotranspiration index and standardized precipitation in... by Kazora Jonah, Zhu Weijun, Kyaw Oo Than, Temesgen Gebremariam Asfaw, Emmanuel Adu Gyamfi Kedjanyi, Abraham Okrah, Akimana Diane, Mathieu Mbati Mugunga

“…The findings offer essential guidance for policymakers, stakeholders, and communities in developing targeted interventions to mitigate the adverse impacts of droughts and enhance resilience to climate change.…”
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Molecular genetic diagnosis and surgical management in a cohort of children with 46,XY disorders/differences of sex development by Yuenshan Sammi Wong, Yuenshan Sammi Wong, Ho Ming Luk, Ho Chung Yau, Lap Ming Wong, Sarah Wing Yiu Poon, Joanna Yuet Ling Tung, Yuk Him Tam, Yuk Him Tam

“…Of the whole group, seven patients were found to inherit genetic alterations from their parents.ConclusionsMolecular genetic diagnosis enhances the understanding of etiology, improves diagnostic accuracy, and provides precise guidance in the counseling and surgical management of children with 46,XY DSD.…”
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