Pathophysiological Models of Hypersomnolence Associated With Depression by Christophe Moderie, Diane B. Boivin

“…Low-sodium oxybate, which is approved for idiopathic hypersomnia, needs additional study in patients with depression. Neuromodulation that targets prefrontal cortex anomalies should be systematically explored, while tailored light therapy protocols may mitigate light hyposensitivity. …”
Get full text

From Molecule to Patient Rehabilitation: The Impact of Transcranial Direct Current Stimulation and Magnetic Stimulation on Stroke—A Narrative Review by Anca Badoiu, Smaranda Ioana Mitran, Bogdan Catalin, Tudor Adrian Balseanu, Aurel Popa-Wagner, Florin Liviu Gherghina, Carmen Valeria Albu, Raluca Elena Sandu

“…This success is attributed to their capacity to enhance cellular neuromodulation. This modulation includes the reduction of the inflammatory response, autophagy suppression, antiapoptotic effects, angiogenesis enhancement, alterations in the blood-brain barrier permeability, attenuation of oxidative stress, influence on neurotransmitter metabolism, neurogenesis, and enhanced structural neuroplasticity. …”
Get full text

An integrated toolbox for creating neuromorphic edge applications by Lars Niedermeier, Nikil Dutt, Jeffrey L Krichmar

“…SNNs have local learning rules, are able to learn on small data sets, and can adapt through neuromodulation. Although research has shown their advantages, there are still few compelling practical applications, especially at the edge where sensors and actuators need to be processed in a timely fashion. …”
Get full text

Advancing Obsessive–Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies by Xinyuejia Huang, Linglong Xiao, Mengqi Wang, Yang Wu, Hao Deng, Wei Wang

“…Here, we highlight current frontline treatment approaches for OCD, including neuromodulation and surgical interventions, and propose potential future directions. …”
Get full text

Erratum to ‘Role of nanotechnology in neurosurgery: A review of recent advances and their applications’ [World Neurosurgery: X (22C) (2024)100298)] by Javed Iqbal, Evan Courville, Syed Faraz Kazim, Michael Kogan, Meic H. Schmidt, Christian A. Bowers

“…The association with neurosurgery had been less well established compared to other organ systems but has recently offered the promising future potential for a wide range of utilities, including CNS drug delivery, neuro-regeneration, neuro oncology, neuroimaging, and neuromodulation. This review summarizes the current developments in nanotechnology and nanomedicine that may yield future neurosurgery applications. …”
Get full text

Repetitive transcranial magnetic stimulation for fibromyalgia: are we there yet? by Jorge Dornellys da Silva Lapa, Valquíria Aparecida da Silva, Daniel Ciampi de Andrade

Get full text

Mechanisms Underlying Adaptation of Respiratory Network Activity to Modulatory Stimuli in the Mouse Embryo by Marc Chevalier, Rafaël De Sa, Laura Cardoit, Muriel Thoby-Brisson

“…By combining electrophysiology and calcium imaging performed on embryonic brainstem slice preparations, we provide evidence showing that embryonic inspiratory pacemaker neurons are already intrinsically sensitive to neuromodulation and external conditions (i.e., temperature) affecting respiratory network activity, suggesting a potential role of pacemaker neurons in mediating rhythm adaptation to modulatory stimuli in the embryo.…”
Get full text

Bayesian Optimization Of NeuroStimulation (BOONStim) by Lindsay D. Oliver, Jerrold Jeyachandra, Erin W. Dickie, Colin Hawco, Salim Mansour, Stephanie M. Hare, Robert W. Buchanan, Anil K. Malhotra, Daniel M. Blumberger, Zhi-De Deng, Aristotle N. Voineskos

Get full text

Pairing Cholinergic Enhancement with Perceptual Training Promotes Recovery of Age-Related Changes in Rat Primary Auditory Cortex by Patrice Voss, Maryse Thomas, You Chien Chou, José Miguel Cisneros-Franco, Lydia Ouellet, Etienne de Villers-Sidani

“…Overall, these findings demonstrate that combining auditory training with neuromodulation of the cholinergic system can restore many of the auditory cortical functional deficits observed as a result of normal aging and add to the growing body of evidence demonstrating that many age-related perceptual and neuroplastic changes are reversible.…”
Get full text

Spectrum-specific encephalography standardized low-resolution brain electromagnetic tomography network and gray matter correlations in vascular dementia patients by Yan Lv, Huijuan Chen, Zhiyan Sui, Yingliu Huang, Shixiong Huang, Feng Chen, Guoqiang Wen

“…The spectrum-specific standardized low-resolution brain electromagnetic tomography analysis and connectivity network analysis could shed light on the neuromodulator targets in the early phase of dementia.…”
Get full text

Distinctive Delta and Theta Responses in Deductive and Probabilistic Reasoning by Emir Faruk Sevim, Yasin Yildirim, Esra Ünsal, Esra Dalmizrak, Bahar Güntekin

Get full text

Mettl3-m6A-NPY axis governing neuron–microglia interaction regulates sleep amount of mice by Qihang Sun, Jinpiao Zhu, Xingsen Zhao, Xiaoli Huang, Wenzheng Qu, Xia Tang, Daqing Ma, Qiang Shu, Xuekun Li

“…Abstract Sleep behavior is regulated by diverse mechanisms including genetics, neuromodulation and environmental signals. However, it remains completely unknown regarding the roles of epitranscriptomics in regulating sleep behavior. …”
Get full text

Treadmill exercise prevents stress-induced anxiety-like behaviors via enhancing the excitatory input from the primary motor cortex to the thalamocortical circuit by Zhihua Luo, Junlin Chen, Yuchu Liu, Yelin Dai, Hui Gao, Borui Zhang, Haibin Ou, Kwok-Fai So, Ji-an Wei, Li Zhang

“…Our findings provide more insights into the neural circuits connecting motor and mental regions under exercise paradigm and implicate potential targets for neuromodulation in treating anxiety disorders.…”
Get full text

Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis by Yao Zhang, Nan Mu, Shun Qi, Chuanzhu Sun, Yang Rao, Xinyi Yang, Jianying Guo, Yunfeng Mu

“…Individual target-transcranial magnetic stimulation (IT-TMS) using Stanford Neuromodulation Therapy over individualized left dorsolateral prefrontal cortex was performed to treat MDD/SI+ with the ethical approval (KY20212218-C-1). …”
Get full text

Transcranial direct current stimulation combined with physical exercise in rotator cuff tendinopathy: a protocol for a blinded randomised controlled trial by César Augusto Medeiros Silva, Clécio Gabriel de Souza, Vinicius Batista Lima, Hannely Beatriz Menezes Cosme, Romário Nóbrega Santos Fonseca, Fuad Ahmad Hazime, Rodrigo Scattone da Silva, Rodrigo Pegado de Abreu Freitas

“…Physical exercise serves as the main approach for managing this condition, aiming to restore movement patterns, optimise scapular kinematics and improve strength and local muscular endurance. Pain neuromodulation techniques, such as transcranial direct current stimulation (tDCS), may offer complementary non-pharmacological options for pain relief by promoting central modulation and altering cortical excitability.Methods and analysis This protocol outlines a randomised, blinded clinical trial. …”
Get full text

High-definition transcranial infraslow pink noise stimulation for chronic low back pain: protocol for a pilot, safety and feasibility randomised placebo-controlled trial by Ramakrishnan Mani, Dirk De Ridder, Sven Vanneste, Divya Bharatkumar Adhia, John N J Reynolds

“…This pilot study aims to (1) evaluate feasibility, safety and acceptability of a novel neuromodulation technique, high-definition transcranial infraslow pink noise stimulation (HD-tIPNS), in people with CLBP, (2) explore the trend of effect of HD-tIPNS on pain and function, and (3) derive treatment estimates to support sample size calculation for a fully powered trial should trends of effectiveness be present.Methods and analysis A pilot, triple-blinded randomised two-arm placebo-controlled parallel trial. …”
Get full text

The opposite effect of convulsant drugs on neuronal and endothelial nitric oxide synthase – A possible explanation for the dual proconvulsive/anticonvulsive action of nitric oxide... by Vega Rasgado Lourdes A., Ramón-Gallegos Eva, Rodríguez-Páez Lorena, Alcántara-Farfán Verónica

“…Nitric oxide (NO) participates in processes such as endothelium-dependent vasodilation and neurotransmission/neuromodulation. The role of NO in epilepsy is controversial, attributing it to anticonvulsant but also proconvulsant properties. …”
Get full text

Alexithymia in multiple sclerosis: past, present and future by Samar S. Ayache, Samar S. Ayache, Samar S. Ayache, Samar S. Ayache, Moussa A. Chalah, Moussa A. Chalah, Moussa A. Chalah

Get full text

LIFU Alleviates Neuropathic Pain by Improving the KCC2 Expression and Inhibiting the CaMKIV–KCC2 Pathway in the L4–L5 Section of the Spinal Cord by Ye-Hui Liao, Bin Wang, Mo-Xian Chen, Yao Liu, Li-Juan Ao

“…Low-intensity focused ultrasound (LIFU), a noninvasive, cutting-edge neuromodulation technique, can effectively enhance inhibition of the central nervous system (CNS) and reduce neuronal excitability. …”
Get full text

A review of parameter settings for galvanic vestibular stimulation in clinical applications by Yishai Valter, Yishai Valter, Linda Vataksi, Aaron R. Allred, Jeffrey R. Hebert, Tad T. Brunyé, Tad T. Brunyé, Torin K. Clark, Jorge Serrador, Abhishek Datta, Abhishek Datta

“…As GVS continues to grow in popularity and applications, the field lacks clarity on appropriate stimulation parameters, despite their importance for safe and efficacious neuromodulation. This study aims to review the parameters used in various treatment applications while also providing a concise overview of the mechanisms underlying GVS thereby offering essential context and justification for the chosen parameters. …”
Get full text