Comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patient by Shenghua Yu, Tianxiao Zou, Sisi Wei, Yani Yu, Guili Ding

“…Subsequent genetic testing identified a mutation in the VHL gene. After further medical management, the left adrenal tumor was also successfully removed. …”
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An enhanced dung beetle optimizer with multiple strategies for robot path planning by Wei Hu, Qi Zhang, Shan Ye

“…Thirdly, T-distribution mutation and differential evolutionary variation strategies are introduced to provide perturbation to enhance the diversity of the population and avoid falling into local optimization. …”
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The genetic architecture of local adaptation in a cline by Laroche, Fabien, Lenormand, Thomas

“…In particular, it required that migration rate was neither too low nor too large and that the full optimization of trait values could not be eventually achieved by a mutation at a single locus. Here, we investigate this question in a spatially-explicit model, considering two contiguous habitats with distinct trait optima on a circular stepping-stone. …”
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One-step diagnosis of infection and lung cancer using metagenomic sequencing by Shaoqiang Li, Yangqing Zhan, Yan Wang, Weilong Li, Xidong Wang, Haoru Wang, Wenjun Sun, Xuefang Cao, Zhengtu Li, Feng Ye

“…Notably, more abundant CNV mutation types and higher mutation rates were observed in adenocarcinoma (ADC) compared to squamous cell carcinoma (SCC). …”
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An approximate likelihood method reveals ancient gene flow between human, chimpanzee and gorilla by Galtier, Nicolas

“…Accounting for the among-loci variance in mutation rate and gene flow time, Aphid returns estimates of the speciation times and ancestral effective population size, and a posterior assessment of the contribution of gene flow and incomplete lineage sorting to the conflict. …”
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Identification and validation of TSPAN13 as a novel temozolomide resistance-related gene prognostic biomarker in glioblastoma. by Haofei Wang, Zhen Liu, Zesheng Peng, Peng Lv, Peng Fu, Xiaobing Jiang

“…Functional enrichment and mutation analyses were conducted to explore the underlying mechanisms of the risk score and its relationship with immune cell infiltration levels in GBM. …”
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The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis. by Qiuling Li, Kayla Y Lim, Raad Altawell, Faith Verderose, Xiling Li, Wanying Dong, Joshua Martinez, Dion Dickman, Nicholas Stavropoulos

“…Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances and altered synaptic function. …”
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Computationally expensive constrained problems via surrogate-assisted dynamic population evolutionary optimization by Zan Yang, Chen Jiang, Jiansheng Liu

“…The evolution strategies adapted to dynamic populations are designed to arrange targeted search resources for individuals with different potentials. Specifically, for mutation, targeted base solution selection for the top 2 and other center points is designed for emphasizing the exploitation in promising regions; for selection, the search sources arranged on the best and other population individuals are adaptively adjusted with the iteration progresses; for constraint handling, the diversity of infeasible solutions is integrated into the original constraint-domination principle to avoid the locality of only using constraint violation to rank infeasible solutions. …”
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RECQ4-MUS81 interaction contributes to telomere maintenance with implications to Rothmund-Thomson syndrome by Raghib Ashraf, Hana Polasek-Sedlackova, Victoria Marini, Jana Prochazkova, Zdenka Hasanova, Magdalena Zacpalova, Michala Boudova, Lumir Krejci

“…We also observe that a mutation associated with Rothmund-Thomson syndrome, which produces a truncated RECQ4 unable to interact with MUS81, recapitulates these chromosome instability phenotypes. …”
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Liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction: pilot study by M. Yu. Nadinskaya, Ye. O. Liusina, Ch. S. Pavlov

“…Following causes for PVT were established: systemic factors - myeloproliferative diseases, G20210A prothrombin gene mutation, and local factors: complications after pancreatobiliary surgery, omphalitis and neonatal umbilical sepsis. …”
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Targeting ceramide transfer protein sensitizes AML to FLT3 inhibitors via a GRP78-ATF6-CHOP axis by Xiaofan Sun, Yue Li, Juan Du, Fangshu Liu, Caiping Wu, Weihao Xiao, Guopan Yu, Xiaowei Chen, Robert Peter Gale, Hui Zeng

“…Here, we show that knocking down CERT inhibits the growth and promotes the apoptosis of AML cells carrying FLT3-ITD mutation. Combining CERT inhibitor with FLT3 inhibitor exhibits synergistic effects on FLT3-ITD mutated acute myeloid leukemia (AML) cells. …”
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Genomic assessment of targets implicated in Rhipicephalus microplus acaricide resistance. by Christina Meiring, Michel Labuschagne

“…Novel mutations emerged from the 11 targets, but distinctions between susceptible and resistant isolates were not evident, except for the prevalent kdr mutation in synthetic pyrethroid-resistant isolates. …”
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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…Today‘s methods of NAFLD modelling can be divided into two extensive groups: induction of liver disease by genetic mutation, and phenotypic development of NAFLD due to alimentary factor. …”
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A 19-year-old Patient with Recurrent Pruritus and Jaundice by K. S. Nezhdanov, E. N. Shirokova, Yu. O. Shulpekova, A. S. Ostrovskaya, M. S. Zharkova, V. T. Ivashkin

“…Workup was negative for viral hepatitis, autoimmune liver diseases, obstructive choledochal lesions, storage diseases, although mutation in gene ABCB11 was found. Benign recurrent intrahepatic cholestasis type 2 was diagnosed. …”
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Proline isomerization modulates the bacterial IsdB/hemoglobin interaction: an atomic force spectroscopy study by Francesca Pancrazi, Omar De Bei, Francesco Lavecchia di Tocco, Marialaura Marchetti, Barbara Campanini, Salvatore Cannistraro, Stefano Bettati, Anna Rita Bizzarri

“…Here, we show that the single point mutation of Pro173 in the IsdB domain responsible for Hb binding, which weakens the IsdB:Hb interaction without hampering heme extraction, totally abolishes the previously observed behavior. …”
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Perancangan Knowledge Management System Berbasis Web pada Tenaga Kependidikan Fakultas Teknik Universitas PGRI Madiun by Sri Anardani, Slamet Riyanto, Dimas Setiawan

“…The PGRI Madiun University routinely carries out mutation, rotation and retirement activities for educational staff. …”
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Association of functional variants in miRNA genes with the risk of coronary heart disease by Taqweem Ul Haq, Muhammad Riaz Khan, Sajjad Ali, Tariq Aziz, Thamer H. Albekairi, Aftab Ali Shah

“…Tetra-Primer Amplification Refractory Mutation System-Polymerase Chain Reaction (T-ARMS-PCR) was used for genotyping, and Sanger sequencing was applied for validation in selected cases. …”
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Complete chloroplast genomes of 13 species of the Impatiens genus for genomic features and phylogenetic relationships studies by Qinqin Yong, Meijun Li, Zhi Li, Chao Luo, Jinling Zhang, Xinxiang Bai

“…The frequency of codon usage was essentially the same, with a total of 31 high-frequency codons detected, the vast majority ending in A/U. Five mutation hotspots were detected: rps16-trnQ-UUG, ndhF, ccsA-ndhD, ycf1, and trnN-GUU, among which ycf1 had the highest Pi value and the greatest potential as a DNA barcode marker. …”
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Host 3' flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation. by Hu Zhang, Quanxin Long, Yuanjie Liu, Alexander L Marchetti, Cheng-Der Liu, Ning Sun, Haitao Guo

“…To address these questions, a mutant HBV cell line HepDES-C1822G was established with a C1822G mutation in the pgRNA coding sequence, altering the sequence of 3' TR of (-) strand DNA while the 5' TR remained wild type (wt). …”
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Impact of Interleukin-10 Promoter Region Polymorphisms on Recurrent Miscarriage: A Case–Control Approach by Neha Sudhir, Mandeep Kaur, Sukhjashanpreet Singh, Archana Beri, Tajinder Kaur, Anupam Kaur

“…Genotype analysis of IL-10 polymorphisms rs1800872 and rs1800896 was performed using the polymerase chain reaction (PCR) restriction fragment length polymorphism and amplification mutation refractory system PCR, respectively. Statistical Analysis Used: Student's t-test was used to compare the demographic features and reproductive history amongst both groups. …”
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