The history of Drosophila studies: steps in the development of genetics by N. N. Yurchenko, A. V. Ivannikov, I. K. Zakharov

Subjects: Get full text

STUDYING GENETIC EFFECTS IN NATURAL ECOSYSTEMS WITH APPLICATION OF A PLANT TEST OBJECT by E. A. Aghajanyan, R. E. Avalyan, A. L. Atoyants, A. E. Simonyan, R. M. Aroutiounian

Subjects: Get full text

Adaptation of the sulfophosphovanillin method of analysis of total lipids for various biological objects as exemplified by <i>Drosophila melanogaster</i> by M. A. Eremina, N. E. Gruntenko

Subjects: Get full text

Nursing of a pediatric patient with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (1例罕见IPEX综合征患儿的护理) by ZHU Huiyun (朱慧云), WANG Suling (王苏玲)

Subjects: Get full text

Two Strategies to Improve the Differential Evolution Algorithm for Optimizing Design of Truss Structures by Ching-Yun Kao, Shih-Lin Hung, Budy Setiawan

“…The performance of differential evolution (DE) mostly depends on mutation operator. Inappropriate configurations of mutation strategies and control parameters can cause stagnation due to over exploration or premature convergence due to over exploitation. …”
Get full text

Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children by Xue Tang, Ju Gao, Xia Guo, Zhi Wan, Jing‐jing Sun

“…In these LCH cases, 49 kinds of MAP2K1 mutations, 31 kinds of BRAF mutations, and 4 kinds of ARAF mutations were found. …”
Get full text

Elucidating the Prognostic Role of BRAFV600E and the Activation Status of the Downstream MAPK Pathway in PTC: A Study from a Tertiary Centre in India by Nadeem Kocheri, Priti Chatterjee, Shipra Agarwal, Mehar C. Sharma, Sanjana Ballal, Chandrasekhar Bal, Sunil Chumber

“…Five of the seven radioiodine-resistant tumours were BRAFV600E-mutated. An Allred cut-off score of 7 had a sensitivity of 100% and a specificity of 84% for detecting the mutation by IHC. …”
Get full text

Detection of BRAF V600E in Fine-Needle Aspiration Samples of Thyroid Nodules by Droplet Digital PCR by Sang-Yu Lu, Ying-Chao Chen, Jia-Lin Feng, Qin-Yi Zhou, Jing Chen, Chen-Fang Zhu, Miao-Miao Guo, Man-Man Zhang, Qian-Yue Zhang, Meng Lu, Liu Yang, Jing Wu, Shuang-Xia Zhao, Huai-Dong Song, Xiao-Ping Ye

“…Sanger sequencing is the gold standard for detecting BRAF V600E mutations but fails to identify low-frequency mutations. …”
Get full text

Network moving target defense technique based on optimal forwarding path migration by Cheng LEI, Duo-he MA, Hong-qi ZHANG, Qi HAN, Ying-jie YANG

“…Moving target defense is a revolutionary technology which changes the situation of attack and defense.How to effectively achieve forwarding path mutation is one of the hotspot in this field.Since existing mechanisms are blindness and lack of constraints in the process of mutation,it is hard to maximize mutation defense benefit under the condition of good network quality of services.A novel of network moving target defense technique based on optimal forwarding path migration was proposed.Satisfiability modulo theory was adopted to formally describe the mutation constraints,so as to prevent transient problem.Optimization combination between routing path and mutation period was chosen by using optimal routing path generation method based on security capacity matrix so as to maximum defense benefit.Theoretical and experimental analysis show the defense cost and benefit in resisting passive sniffing attacks.The capability of achieving maximum defense benefit under the condition of ensuring network quality of service is proved.…”
Get full text

Whole-genome resequencing reveals collagen-related genes in Kele pigs. by Yu Dan Zhang, Wei Yuan, Huan Bi, Xiao Yang, Yi Yu Zhang, Wei Chen

“…There were 132,256 middle-impact mutation sites and 318,150 low-impact mutation sites that could potentially impact protein properties. …”
Get full text

Factor VIII Intron 22 Inversion in Severe Hemophilia A Patients in Palestine by Caesar Mahmoud Abu Arra, Fekri Samarah, Nael Sudqi Abu Hasan

“…The Inv22 mutation is a major cause of the disease worldwide, accounting for up to 40%–50% of severe FVIII mutations. …”
Get full text

Influence of Genetic Algorithm Parameters on Their Performance for Parameter Identification of a Yeast Fed-batch Fermentation Process Model by Maria Angelova, Tania Pencheva

“…Eight single (SGA) and eight multi-population (MGA) genetic algorithms (GA) differing in the sequence of implementation of the main genetic operators’ selection, crossover and mutation, or omitting the mutation operator, have been examined for the purposes of parameter identification of a Saccharomyces cerevisiae fed-batch fermentation process model. …”
Get full text

Molecular, Biochemical, and Clinical Characterization of Thirteen Patients with Glycogen Storage Disease 1a in Malaysia by Siti Aishah Abdul Wahab, Yusnita Yakob, Mohd Khairul Nizam Mohd Khalid, Noraishah Ali, Huey Yin Leong, Lock Hock Ngu

“…Patients were presented with hepatomegaly (92%), hypoglycaemia (38%), poor weight gain (23%), and short stature (15%). Mutation analysis revealed nine heterozygous mutations; eight previously reported mutations (c.155 A > T, c.209 G > A, c.226 A > T, c.248 G > A, c.648 G > T, c.706 T > A, c.1022 T > A, c.262delG) and a novel mutation (c.325 T > C). …”
Get full text

PENGARUH MUTASI TERHADAP SEMANGAT KERJA PEGAWAI NEGERI SIPIL PADA KANTOR PELAYANAN PAJAK PRATAMA KOTA PEMATANG SIANTAR by Arnimisari Juliana Ambarita, Hatta Ridho

“…Employee development efforts i.e. mutation with the process of the transfer of functions, responsibilities and status of employees. …”
Get full text

Predicting breast cancer prognosis using PR and PIK3CA biomarkers: a comparative analysis of diagnostic groups by Yuting Feng, Qingzhen Song, Lei Yan, Ruoqi Li, Mengqin Yang, Peng Bu, Jing Lian

“…Methods A retrospective analysis was conducted on 152 HR+/HER2 − breast cancer patients stratified by PR expression levels and PIK3CA mutation status. The study population was divided into groups on the basis of a median PR threshold of 50% and further subdivided by PIK3CA mutation status. …”
Get full text

A DE-Based Scatter Search for Global Optimization Problems by Kun Li, Huixin Tian

“…To adaptively select the mutation operator that is most appropriate to the current problem, an adaptive mechanism for the candidate mutation operators is developed. …”
Get full text

Impact of Novel Resistance Profiles in HIV-1 Reverse Transcriptase on Phenotypic Resistance to NVP by Liyan Jiao, Hanping Li, Lin Li, Daomin Zhuang, Yongjian Liu, Zuoyi Bao, Siyang Liu, Jingyun Li

“…To clarify the impact of H221Y mutation on drug resistance to NVP. Methods. 646 bp HIV-1 pol gene fragments (from 592 to 1237 nucleotide) with different NNRTIs mutation profiles from AIDS patients receiving antiretroviral therapy containing NVP regimens were introduced into pNL4-3 backbone plasmid. …”
Get full text

Novel Genetic Findings in a Chinese Family with Axenfeld-Rieger Syndrome by Kuanshu Li, Liu Yang, Ying Liu, Ding Lin

“…A homozygous mutation c.1139_1141dupGCG(p.Gly380_Ala381insGly) and a heterozygous mutation c.1359_1361dupCGG(p.Gly456_Gln457insGly) in FOXC1 were identified in all subjects. …”
Get full text

Host security threat analysis approach for network dynamic defense by Lixun LI, Bin ZHANG, Shuqin DONG

“…Calculating the host security threat in network dynamic defense (NDD) situation has to consider the vulnerabilities’ uncertainty because of dynamic mutation.Firstly,the vulnerabilities’ uncertainty caused by the mutation space and the mutation period was calculated by random sampling model,and combined with the CVSS,the attack success probability formula of single vulnerability was derived.Secondly,to avoid self-loop during the path searching process in multiple vulnerabilities situation,an improved recursive depth first algorithm which combined with node visited queue was proposed.Then,the host security threat was calculated based on attack success probability in the situation of multiple vulnerabilities and paths.Finally,approach’s availability and effectiveness were verified by an experiment conducted in a typical NDD situation.…”
Get full text

Genetic Analysis of Undiagnosed Juvenile GM1-Gangliosidosis by Microarray and Exome Sequencing by Ahmed Bouhouche, Houyam Tibar, Yamna Kriouale, Mohammed Jiddane, Imane Smaili, Naima Bouslam, Ali Benomar, Mohamed Yahyaoui, Elmostafa El Fahime

“…GM1 gangliosidosis is an autosomal recessive lysosomal storage disorder due to mutations in the lysosomal acid 3-galactosidase gene, GLB1. …”
Get full text