METTL1-mediated m7G tRNA modification drives papillary thyroid cancer progression and metastasis by regulating the codon-specific translation of TNF-α by Weiwei Li, Ruiwang Xie, Huaying Chen, Junyu Lin, Minjie Zhong, Junsi Zhang, Shengkai Zheng, Cen Jiang, Xiangjin Chen, Sunwang Xu

“…Positive correlations between METTL1, WDR4, and TNF-α expression, which affect the proliferation and metastasis of PTC, were confirmed via analysis of microarrays containing PTC tissues. These results demonstrate the oncogenic role of METTL1-mediated m7G tRNA modification in regulating codon-specific translation efficiency in PTC and suggest that targeting METTL1 may be a promising therapeutic approach for overcoming PTC progression by inhibiting PTC cell proliferation and metastasis.…”
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DJ-1 as a potential biomarker for the early diagnosis in lung cancer patients by Binbin Han, Jiwen Wang, Jia Gao, Shana Feng, Yu Zhu, Xuexiang Li, Ting Xiao, Jun Qi, Wei Cui

“…Preoperative serum DJ-1 levels were measured in 300 lung cancer patients and compared with benign pulmonary disease (n = 44) and healthy volunteers (n = 64). Using tissue microarrays and immunohistochemical analyses, we compared the DJ-1 expression between the primary squamous cell carcinoma tumours and matched metastatic tissues from a lymph node. …”
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ADAR1-regulated miR-142-3p/RIG-I axis suppresses antitumor immunity in nasopharyngeal carcinoma by Haoyuan Xu, Wanpeng Li, Kai Xue, Huankang Zhang, Han Li, Haoran Yu, Li Hu, Yurong Gu, Houyong Li, Xicai Sun, Quan Liu, Dehui Wang

“…Through comprehensive miRNA sequencing, tumor tissue microarrays and tissue samples analysis, we identified miR-142-3p as a significantly upregulated miRNA that is strongly associated with poor prognosis in recurrent NPC patients. …”
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Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker by Venkata Ramana Mallela, Marie Rajtmajerová, Esraa Ali, Lenka Červenková, Andriy Trailin, Petr Hošek, Richard Pálek, Ondřej Daum, Václav Liška, Kari Hemminki, Filip Ambrozkiewicz

“…Methods: We conducted microRNA profiling by microarrays in 45 paired (tumor and non-tumor adjacent tissue) samples from non-viral HCC patients. …”
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Constitutional Chromosome 21 Abnormality in B-ALL with iAMP21 in a Patient Developing Treatment-Related Myelodysplastic Syndrome by Inhwa Kim, Su Hyun Yoon, Sunghan Kang, Kyung-Nam Koh, Mi Young Kim, Young-Uk Cho, Sang-Hyun Hwang, Seongsoo Jang, Eul-Ju Seo, Beom Hee Lee, Sunghee Min, Hyunwoo Bae, Ho Joon Im, Hyery Kim

“…However, abnormal karyotype was sustained in bone marrow. Microarrays with her buccal swab raised the possibility that the abnormal karyotype was not from the leukemic blasts but rather from the germline. …”
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B4GALT5 inhibits CD8+ T-cell response by downregulating MHC-I level through ERAD pathway in PDAC by Hui Li, Hao Zhang, Xiao-Mei Yang, Xue-Li Zhang, Zhigang Zhang, Yan Yang, Xin Xing, Shi-Qi Yin, Xia-Qing Li, Hong-Tai Ma, Aziguli Tulamaiti, Shu-Yu Xiao, Yu-Tong Liu, Yan-Miao Huo

“…This study aims to investigate the role of beta-1,4-galactosyltransferase-5 (B4GALT5) in immune evasion by pancreatic cancer cells and evaluate its potential as an immunotherapeutic target.Methods We conducted a comprehensive analysis using RNA sequencing data and tissue microarrays from patients with PDAC to investigate the association between B4GALT5 expression and patient prognosis. …”
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The role of the aging process and related factor EMP1 in promoting progression of resectable pancreatic cancer by Junfeng Zhang, Jianyou Gu, Tao Zhang, Renpei Xia, Jianbo Li, Mingda Tan, Yongjun Yang, Jifeng Xiang, Bin Xie, Rong Tang, Wangge Li, Xianxing Wang, Shixiang Guo, Huaizhi Wang

“…We employed lentiviral vectors for both knockdown and overexpression of EMP1 in Panc02 cells, followed by the establishment of subcutaneous, pulmonary metastasis, and orthotopic pancreatic liver metastasis models in mice. Using tissue microarrays, we evaluated the expression of EMP1 and its downstream entities, and then conducted clinical correlation analysis. …”
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Predicting estrogen receptor status from HE-stained breast cancer slides using artificial intelligence by Maren Høibø, Maren Høibø, Ute Spiske, André Pedersen, Borgny Ytterhus, Lars A. Akslen, Lars A. Akslen, Elisabeth Wik, Elisabeth Wik, Cecilie Askeland, Cecilie Askeland, Ingerid Reinertsen, Ingerid Reinertsen, Erik Smistad, Erik Smistad, Marit Valla, Marit Valla

“…The aim of this study was to develop a model for prediction of ER status from HE-stained tissue microarrays (TMAs). Our methodology can be used as proof-of-concept for the prediction of more complex and costly molecular analyses in cancer.MethodsIn this study, TMAs from more than 2,000 Norwegian breast cancer patients were used to train and predict ER status using the clustering-constrained attention multiple-instance learning (CLAM) framework. …”
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Whole stromal fibroblast signature is linked to specific chemokine and immune infiltration patterns and to improved survival in NSCLC by Stefan Koeck, Arno Amann, Johan Kern, Marit Zwierzina, Edith Lorenz, Sieghart Sopper, Heinz Zwierzina, Finn Mildner, Martina Sykora, Susanne Sprung, Hubert Hackl, Florian Augustin, Hubert T. Maier, Andreas Pircher, Georg Pall, Dominik Wolf, Gabriele Gamerith

“…Immune cell infiltration was assessed via flow cytometry, chemokines were analyzed by immunoassays and RNA microarrays. Results were confirmed in specimens from NSCLC patients by flow cytometry or immunohistochemistry as well as in the TCGA data set. …”
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Expression patterns of MCM8 in lung adenocarcinoma and its correlation with key biological processes by Xu-Sheng Liu, Jin Xie, Rui-Min Wu, Gao-Chun Xiao, Yu Zhang, Zhi-Jun Pei

“…MCM8 expression was assessed by immunohistochemistry (IHC) using tissue microarrays. The diagnostic value of MCM8 was assessed by Receiver Operating Characteristic curve analysis, and its prognostic significance was determined by Kaplan–Meier analysis. …”
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Genetic heterogeneity in familial forms of genetic generalized epilepsy: from mono- to oligogenism by Maha Dahawi, Jean-Madeleine de Sainte Agathe, Mohamed S. Elmagzoub, Elhami A. Ahmed, Julien Buratti, Thomas Courtin, Eric Noé, Julie Bogoin, Bruno Copin, Fatima A. Elmugadam, Wasma A. Abdelgadir, Ahmed K. M. A. Ahmed, Mohamed A. Daldoum, Rayan Mamoon Ibrahim Altayeb, Mohamed Bashir, Leena Mohamed Khalid, Sahar Gamil, Sara Baldassari, Liena Elsayed, Boris Keren, Gregory Nuel, Ammar E. Ahmed, Eric Leguern

“…Moreover, a polygenic mode of inheritance is suspected in most cases. We performed SNP microarrays and whole exome sequencing in 20 families from Sudan, focusing on those with at least four affected members. …”
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A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. by Bernadette Sosa-García, Volkan Gunduz, Viviana Vázquez-Rivera, W Douglas Cress, Gabriela Wright, Haikuo Bian, Philip W Hinds, Pedro G Santiago-Cardona

“…We generated knockout mice in which the RB gene was excised specifically in osteoblasts using the cre-lox P system and found that osteoblasts from pRb knockout mice did not assemble adherens junction at their membranes. pRb depletion in wild type osteoblasts using RNAi also disrupted adherens junctions. Microarrays comparing pRb-expressing and pRb-deficient osteoblasts showed that pRb controls the expression of a number of cell adhesion genes, including cadherins. …”
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Evaluation of the diagnostic concordance of FDA-approved PD-L1 assays in clear cell renal cell carcinoma by Yoko Koh, Taigo Kato, Gaku Yamamichi, Eisuke Tomiyama, Makoto Matsushita, Koji Hatano, Atsunari Kawashima, Norio Nonomura, Motohide Uemura

“…In this study, we constructed tissue microarrays from 286 clear cell renal cell carcinoma (ccRCC) tissue samples and evaluated PD-L1 expression using the 22C3, 28 − 8, SP142, and SP263 PD-L1 assays. …”
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Identification of Anoikis-Related Genes in Driving Immune-Inflammatory Responses in Ulcerative Colitis Based on Bioinformatics Analysis and Machine Learning by Diao W, Huang X, Huang W, Jiang J, Li W, Liu H, Yan B, Shen L

“…This study aims to explore the biological and clinical implications of anoikis-related genes (ARGs) in UC.Methods: Gene expression microarrays from normal and UC mucosal tissues focused on ARGs. …”
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Membranous Overexpression of Fibronectin Predicts Microvascular Invasion and Poor Survival Outcomes in Patients with Hepatocellular Carcinoma by Yoon Jung Hwang, Hyejung Lee, Suk Kyun Hong, Su Jong Yu, Haeryoung Kim

“…Methods: Immunohistochemical analysis of FN was conducted using tissue microarrays from 258 surgically resected HCCs and matched nontumorous liver tissues. …”
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HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity by Karen Giménez-Orenga, Eva Martín-Martínez, Lubov Nathanson, Elisa Oltra

“…By using HERV-V3 high-density microarrays (including over 350k HERV elements and more than 1500 immune-related genes) to interrogate the transcriptomes of peripheral blood mononuclear cells from female patients diagnosed with ME/CFS, FM, or both, and matched healthy controls (n = 43), this study fills this gap of knowledge. …”
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Identification of CCNB1 as a biomarker for cellular senescence in hepatocellular carcinoma: a bioinformatics and experimental validation study by Zhilan Zhang, Jie Zhou, Ruiru Huang, Xingxing Zhuang, Shoudong Ni

“…Methods We integrated data from GEO microarrays (GSE14520, GSE45267 and GSE64041) to analyse differentially expressed genes (DEGs) using the R package limma. …”
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TMEM101 expression and its impact on immune cell infiltration and prognosis in hepatocellular carcinoma by Lingyun Kuang, Yilin Pang, Quangang Fang

“…Additionally, differences in TMEM101 expression in HCC cell lines and HCC tissue microarrays were examined using RT-qPCR, western blotting, and in situ hybridization staining. …”
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Effects of proteasome inhibitor MG-132 on the parasite Schistosoma mansoni. by Enyara R Morais, Katia C Oliveira, Renato G de Paula, Alice M M Ornelas, Érika B C Moreira, Fernanda Rafacho Badoco, Lizandra G Magalhães, Sergio Verjovski-Almeida, Vanderlei Rodrigues

“…Here, we used expression microarrays to measure the genome-wide changes in gene expression of S. mansoni adult worms exposed in vitro to MG-132, followed by in silico functional analyses of the affected genes using Ingenuity Pathway Analysis (IPA). …”
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Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. by Romina Briffa, Inhwa Um, Dana Faratian, Ying Zhou, Arran K Turnbull, Simon P Langdon, David J Harrison

“…PDCD6 was differentially expressed in all three treatment responses. Tissue microarrays were constructed for a cohort of 118 CRC patients and TRIB1 and MYC amplifications were measured using fluorescence in situ hybridisation. …”
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