LncRNA-mRNA co-expression network in the mechanism of butylphthalide treatment for ischemic stroke by Yangfang An, Lingyun Huang, Jun Li, Zhuo Chen, Jizhang Cai, Biao Wang, Qiong Zhou

“…Methods Peripheral blood samples were collected from ischemic stroke patients treated with butylphthalide and from control subjects. mRNA and lncRNA expression profiles were obtained using microarray scanning, and differentially expressed lncRNAs (DElncRNAs) were validated by qRT-PCR. …”
Get full text

Genetic test results and one-year developmental outcomes of fetuses with congenital heart disease by Hui Hu, Bo Zhou, Qunda Shan, Shuangshuang Shen, Xiangdong Zhang, Penglong Chen, Jiao Liu, Xiaofang Lan

“…ObjectiveThis study evaluated the utility of single nucleotide polymorphism (SNP) microarray analysis in prenatal genetic assessment of fetuses diagnosed with congenital heart disease (CHD), retrospectively analyzing pregnancy outcomes and their association with physical and intellectual development within the first year of life.Patients and methodsIt included 105 fetuses diagnosed with CHD via prenatal echocardiography from January 2016 to June 2020, categorized into two groups: isolated cardiac structural abnormalities (76 cases) and additional extracardiac structural abnormalities (29 cases). …”
Get full text

Molecular endotypes in sepsis: integration of multicohort transcriptomics based on RNA sequencing by Kengo Mekata, Michihito Kyo, Modong Tan, Nobuaki Shime, Nobuyuki Hirohashi

“…Although growing evidence has identified sepsis endotypes based on the microarray data, studies using RNA-seq data—which offers higher sensitivity and a broader dynamic range—remain limited. …”
Get full text

From Gene to Intervention: NLRC4 and WIPI1 Regulate Septic Acute Lung Injury Through Autophagy by Yang X, Sun Z, Liu Z, Chen H, Fang Y, Tao W, Zhao N, Ouyang X, Liu F, Qian K

“…Although autophagy is crucially involved in the inflammatory response, its precise molecular mechanisms in SALI remain unclear, forming the basis of this study.Methods: Herein, two microarray datasets (GSE33118 and GSE131761) and three single-cell sequencing datasets (SCP43, SCP548, and SCP2156) derived from human samples were used to ascertain the interrelationship between Differentially Expressed Autophagy-Related Genes (DEARGs) and SALI. …”
Get full text

Deciphering the methylation landscape of long noncoding RNAs in hepatocellular carcinoma: a focus on LINC00942 by Zhaoqi Shi, Xiaolong Liu, Duguang Li, Jing Yang, Haonan Chen, Hui Lin, Xiaoxiao Fan

“…Methods We conducted a methylation microarray analysis on 11 HCC samples alongside adjacent non-tumor tissue specimens. …”
Get full text

Exploration of potential biomarkers and immune cell infiltration characteristics for peripheral atherosclerosis in sjögren’s syndrome based on comprehensive bioinformatics analysis... by Chunjiang Liu, Yuan Wang, Lina Zhou, Feifei Cai, Xiaoqi Tang, Liying Wang, Xiang Zhang

“…Despite a notable rise in atherosclerosis risk among SS patients in prior investigations, the precise mechanisms remain elusive.MethodsA comprehensive analysis was conducted on seven microarray datasets (GSE7451, GSE23117, GSE143153, GSE28829, GSE100927, GSE159677, and GSE40611). …”
Get full text

The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses by Chenfei He, Shan Wang, Marion Moreews, Shengduo Pei, Guangchun Chen, Quan-Zhen Li, Alberto Del Monte Monge, Almudena R. Ramiro, Curtis Cai, Mauro Gaya, Patricia Barral, Marcus Buggert, Facundo D. Batista, Mikael C.I. Karlsson

Get full text

Combination of RNA-sequencing data analysis, network pharmacology, molecular docking techniques to investigate the mechanism of Prunella vulgaris L. in the treatment of non-small c... by Yanggang Dan, Yangli Jin, Jing Wang, Lu Wang, Dawei Zheng

“…Materials and methods The differentially expressed genes (DEGs) associated with NSCLC were obtained by analyzing microarray dataset GSE136043 in Gene Expression Omnibus. …”
Get full text

Spatial transcriptomic characteristics of gastric cancer in young and the expression and role of TMEM176B in gastric cancer cells by Zhenhua Jiang, Yongfeng Wang, Chi Zhang, Shuangyin Han

“…Methods The surgical specimens of six patients with GCY were included to construct a tissue microarray containing the tumor core region (TCR), cancer-adjacent tissue (CAT), and normal gastric tissue (NGT). …”
Get full text

Spatial transcriptomics reveal high T cell and monocyte status as predictive and prognostic markers in pancreatic cancer by Yeon Bi Han, Sejoon Lee, Jin-Ok Lee, Se In Jeong, Ki Rim Lee, Soomin Ahn, Kwangrok Jung, Jong-Chan Lee, Yoo-Seok Yoon, Jin-Hyeok Hwang, Ho-Seong Han, Hee Young Na, Jaihwan Kim

“…Methods Forty-eight PDAC cases that were surgically resected with or without NAT were included. A tissue microarray was constructed for DSP and IHC. Pathological tumor regression to NAT was graded based on the College of American Pathologists (CAP) system. …”
Get full text

Integration analysis of cis- and trans-regulatory long non-coding RNAs associated with immune-related pathways in non-small cell lung cancer by Yinqiang Liu, Hongjv Yang, Guoli Lv, Jin Duan, Wei Zhao, Yunfei Shi, Youming Lei

“…Methods and results: We utilized microarray technology to analyze lncRNAs and mRNAs in twenty paired NSCLC tumor tissues and adjacent normal tissues. …”
Get full text

Identification of Key Biomarkers and Candidate Molecules in Non-Small-Cell Lung Cancer by Integrated Bioinformatics Analysis by Liyan Yu, Xuemei Liang, Jianwei Wang, Guangxiang Ding, Jinhai Tang, Juan Xue, Xin He, Jingxuan Ge, Xianzhang Jin, Zhiyi Yang, Xianwei Li, Hehuan Yao, Hongtao Yin, Wu Liu, Shengchen Yin, Bing Sun, Junxiu Sheng

“…From the Gene Expression Omnibus database, GSE118370 and GSE10072 microarray datasets were obtained. Identifying the differentially expressed genes (DEGs) between lung adenocarcinoma and normal samples was done. …”
Get full text

RETRACTED ARTICLE: LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146 by Liping Shan, Wei Liu, Yunhong Zhan

“…Methods LncRNA and miRNA microarray was conducted to explore different expressed RNA in primary bladder cancer specimens. …”
Get full text

Diverse regulated cell death patterns and immune traits in kidney allograft with fibrosis: a prediction of renal allograft failure based on machine learning, single-nucleus RNA seq... by Yuqing Li, Jiandong Zhang, Xuemeng Qiu, Yifei Zhang, Jiyue Wu, Qing Bi, Zejia Sun, Wei Wang

“…However, the role of different regulated cell death (RCD) pathways in post-transplant allograft fibrosis remains unclear.Methods and Results: Microarray transcriptome profiling and single-nuclei sequencing data of post-transplant fibrotic and normal grafts were obtained and used to identify RCD-related differentially expressed genes. …”
Get full text

Interleukin-17A Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacte... by Petra Borilova Linhartova, Jakub Kastovsky, Svetlana Lucanova, Jirina Bartova, Hana Poskerova, Jan Vokurka, Antonin Fassmann, Katerina Kankova, Lydie Izakovicova Holla

“…Bacterial colonization was investigated by a DNA-microarray kit. Production of IL-17 after in vitro stimulation of mononuclear cells by mitogens and bacteria was examined by the Luminex system. …”
Get full text

Gene expression profiling of sequential metastatic biopsies for biomarker discovery in breast cancer by Theodoros Foukakis, John Lövrot, Patricia Sandqvist, Hanjing Xie, Linda S. Lindström, Carla Giorgetti, Hans Jacobsson, Elham Hedayati, Jonas Bergh

“…Aspirated tumor material was used for microarray analysis, and treatment‐induced changes (T2 versus T1) in gene expression and standardized uptake values (SUV) were investigated and correlated to clinical outcome measures. …”
Get full text

The Functions and Mechanism of a New Oligopeptide BP9 from Avian Bursa on Antibody Responses, Immature B Cell, and Autophagy by Xiu Li Feng, Man Man Zong, Guang Fang Zhou, Yang Zheng, Yuan Nan Yu, Rui Bing Cao, Pu Yan Chen, Mei Yang

“…The results of immunization experiments showed that mice injected with 0.01 and 0.05 mg/mL BP9 plus JEV vaccine generated the significant increased antibody levels, compared to those injected with JEV vaccine only. The microarray analysis on the molecular basis of BP9-treated immature B cell showed that vast genes were involved in various immune-related biological processes in BP9-treated WEHI-231 cells, among which the regulation of cytokine production and T cell activation were both major immune-related processes in WEHI-231 cells with BP9 treatment following network analysis. …”
Get full text

Genome-wide association studies of the PR interval in African Americans. by J Gustav Smith, Jared W Magnani, Cameron Palmer, Yan A Meng, Elsayed Z Soliman, Solomon K Musani, Kathleen F Kerr, Renate B Schnabel, Steven A Lubitz, Nona Sotoodehnia, Susan Redline, Arne Pfeufer, Martina Müller, Daniel S Evans, Michael A Nalls, Yongmei Liu, Anne B Newman, Alan B Zonderman, Michele K Evans, Rajat Deo, Patrick T Ellinor, Dina N Paltoo, Christopher Newton-Cheh, Emelia J Benjamin, Reena Mehra, Alvaro Alonso, Susan R Heckbert, Ervin R Fox, Candidate-gene Association Resource (CARe) Consortium

“…Genotyping was performed using the Affymetrix 6.0 microarray. Imputation was performed for 2.8 million single nucleotide polymorphisms (SNPs) using combined YRI and CEU HapMap phase II panels. …”
Get full text

Bioinformatics analysis identifies dysregulation of MiR-548F-3p and its hub gene in triple-negative breast cancer by Samira Behroozi, Mahdieh Salimi, Najaf Allahyari Fard

“…To unravel its unique regulatory role, this study focused on miRNA microarray analysis, particularly miR-548F-3p, in TNBC samples.Materials and Methods: Using the GSE76275 dataset, gene expression profiles were analyzed using the Affymetrix Human Genome U133 Plus 2.0 Array. …”
Get full text

Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation by Shaopeng Yang, Yuqi Li, Rongwei Ruan, Jiangping Yu, Bo Zhu, Haibin Lou, Xiaolan Zhang, Shi Wang

“…Results TSG-6 treatment significantly attenuated DSS-induced colitis symptoms and inflammatory cell infiltration. Microarray analysis revealed that TSG-6 decreased pro-inflammatory cytokine levels in colon tissue. …”
Get full text