-
821
Global gene expression analysis of canine osteosarcoma stem cells reveals a novel role for COX-2 in tumour initiation.
Published 2014-01-01“…Utilizing the Affymetrix canine microarray, we are able to definitively show that there are significant differences in global gene expression profiles of isolated osteosarcoma stem cells and the daughter adherent cells. …”
Get full text
Article -
822
Immunohistochemistry guided segmentation of benign epithelial cells, in situ lesions, and invasive epithelial cells in breast cancer slides.
Published 2025-01-01“…The sections were derived from four breast cancer cohorts. Tissue microarray cores from a fifth cohort of 21 patients was used as a second test set. …”
Get full text
Article -
823
Gene expression profiling of lymphoblasts from autistic and nonaffected sib pairs: altered pathways in neuronal development and steroid biosynthesis.
Published 2009-06-01“…The present "case-control" study takes a global approach to understanding the molecular basis of autism spectrum disorders based upon large-scale gene expression profiling. DNA microarray analyses were conducted on lymphoblastoid cell lines from over 20 sib pairs in which one sibling had a diagnosis of autism and the other was not affected in order to identify biochemical and signaling pathways which are differentially regulated in cells from autistic and nonautistic siblings. …”
Get full text
Article -
824
Prognostic and therapeutic potential of CXCR6 expression on CD8 + T cells in gastric cancer: a retrospective cohort study
Published 2025-03-01“…The prognostic significance of CXCR6 was evaluated via immunohistochemical staining of a GC tissue microarray. Results High CD8 + T cell infiltration correlated with improved survival in patients with GC. …”
Get full text
Article -
825
CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.
Published 2011-01-01“…CHD5 protein was predominantly nuclear in primary rat neurons and brain sections. Microarray analysis revealed genes that were upregulated and downregulated when CHD5 was depleted from primary neurons. …”
Get full text
Article -
826
An erythrocyte vesicle protein exported by the malaria parasite promotes tubovesicular lipid import from the host cell surface.
Published 2008-08-01“…Here, we combined bioinformatics and genome-wide expression analyses with a new series of transgenic and cellular assays to show for the first time in malaria parasites that microarray read out from a chemical perturbation can have predictive value. …”
Get full text
Article -
827
Identification of natural killer cell-characteristic genes in atherosclerosis based on bioinformatics analysis
Published 2025-05-01“…We conducted differential expression analysis and functional enrichment analysis via microarray datasets from AS patients, identified NK cell-characteristic genes and performed subgroup analysis of AS on the basis of the expression levels of these genes. …”
Get full text
Article -
828
Emerging generalization advantage of quantum-inspired machine learning in the diagnosis of hepatocellular carcinoma
Published 2025-03-01“…In particular, quantum machine learning shows promising generalization capabilities, which we have exploited in the classification of hepatocellular carcinoma tissue based on microarray gene expressions. By using previously characterized genetic communities, we minimize the computational complexity associated with the number of qubits, enabling the execution of quantum-inspired algorithms on classical machines. …”
Get full text
Article -
829
Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant.
Published 2011-01-01“…We assessed the effects of GLA on murine and human dendritic cells (DC) by combining microarray, mRNA and protein multiplex assays and flow cytometry analyses. …”
Get full text
Article -
830
Integrative analysis of co-expression networks and codon usage bias in maize under biotic stress.
Published 2025-01-01“…We identified 1449 differentially expressed genes (DEGs) by meta-analysis of the public microarray gene expression profile. Weighted Gene Co-expression Network Analysis on the DEGs resulted in positive module-trait correlation (0.71, 0.69, 0.58, and 0.46) in the brown, grey, blue, and green modules, respectively, and negative correlation in the turquoise module. …”
Get full text
Article -
831
High prevalence of multidrug-tolerant bacteria and associated antimicrobial resistance genes isolated from ornamental fish and their carriage water.
Published 2009-12-01“…Representative isolates were also examined for the presence of 54 resistance genes by a combination of miniaturized microarray and conventional PCR. Forty-seven of 94 Aeromonas spp. isolates recovered from tropical ornamental fish and their carriage water were tolerant to > or =15 antibiotics, representing seven or more different classes of antimicrobial. …”
Get full text
Article -
832
A Case Report on 13q12.3 Microdeletion Syndrome Caused by HMGB1 Haploinsufficiency
Published 2024-01-01“…Here, we report a pediatric patient who had typical phenotypic features of 13q12.3 microdeletion syndrome, including motor and moderate speech developmental delays, microcephaly, and severe atopy, along with anxiety and aggressive behaviors. Trio-based microarray analysis identified a 62-kb apparently de novo heterozygous deletion at 13q12.3 in the proband, fully encompassing all coding exons of the HMGB1 gene yet not affecting any other neighboring genes. …”
Get full text
Article -
833
c-Triadem: A constrained, explainable deep learning model to identify novel biomarkers in Alzheimer's disease.
Published 2025-01-01“…We trained the model with blood genotyping data, microarray, and clinical features from the Alzheimer's Neuroimaging Disease Initiative (ADNI). …”
Get full text
Article -
834
Identification of the Exercise and Time Effects on Human Skeletal Muscle through Bioinformatics Methods
Published 2022-01-01“…To determine the effects of exercise and time on human skeletal muscle, we downloaded the microarray expression profile of GSE1832 and analyzed it to select differentially expressed genes (DEGs). …”
Get full text
Article -
835
Apoptosis-associated genetic mechanisms in the transition from rheumatoid arthritis to osteoporosis: A bioinformatics and functional analysis approach
Published 2024-12-01“…This study explores the mechanisms of glucocorticoid-induced osteoporosis (OP) and Rheumatoid arthritis (RA), focusing on apoptosis and its role in the progression from RA to OP. Using microarray data from the GEO database, differential gene expression analysis was conducted with the limma package, identifying significant genes in RA and OP. …”
Get full text
Article -
836
A plant diterpene counteracts juvenile hormone-mediated gene regulation during Drosophila melanogaster larval development.
Published 2018-01-01“…Gene ontology analysis also suggested that some of the genes activated-by-JHA/repressed-by-JHD play roles in spermatogenesis. Affymetrix microarray-based analysis indicated that the expression of genes activated-by-JHA/repressed-by-JHD was testis-specific. …”
Get full text
Article -
837
Transcriptomic characterization of temperature stress responses in larval zebrafish.
Published 2012-01-01“…In this study, we characterized the transcriptional responses in larval zebrafish exposed to cold or heat stress using microarray analysis. In comparison with genes expressed in the control at 28 °C, a total of 2680 genes were found to be affected in 96 hpf larvae exposed to cold (16 °C) or heat (34 °C) for 2 and 48h and most of these genes were expressed in a temperature-specific and temporally regulated manner. …”
Get full text
Article -
838
Whole-genome analysis of histone H3 lysine 27 trimethylation in Arabidopsis.
Published 2007-05-01“…We identified regions containing H3K27me3 in the genome of the flowering plant Arabidopsis thaliana using a high-density whole-genome tiling microarray. The results suggest that H3K27me3 is a major silencing mechanism in plants that regulates an unexpectedly large number of genes in Arabidopsis (~4,400), and that the maintenance of H3K27me3 is largely independent of other epigenetic pathways, such as DNA methylation or RNA interference. …”
Get full text
Article -
839
Cuproptosis genes in predicting the occurrence of allergic rhinitis and pharmacological treatment.
Published 2025-01-01“…Researching the interaction between cuproptosis and allergic rhinitis will likely pave the way for future treatment of this disease.<h4>Methods</h4>A microarray dataset of AR patients and normal controls (GSE43523) were obtained from the Gene Expression Omnibus (GEO) database for differential gene analysis. …”
Get full text
Article -
840
Genome-Wide Identification, Characterization, and Expression Analysis of the Grapevine Superoxide Dismutase (SOD) Family
Published 2019-01-01“…Gene expression analysis based on microarray data showed that the 10 VvSOD genes were expressed in all the tested tissues. …”
Get full text
Article