TMBIM6 promotes glioma progression according to integrated bioinformatics and experimental evidence by Mst Sahida Khatun, Mohammad Mamun Ur Rashid, Ahsan Ullah, Hyung-Ryong Kim

“…This study investigates TMBIM6’s prognostic value by using data from TCGA (The Cancer Genome Atlas), GEO (Gene Expression Omnibus), and CGGA (Chinese Glioma Genome Atlas) databases, along with histopathological analysis of tissue microarray slide. Survival analysis confirmed the prognostic significance of TMBIM6 in glioma, while co-expression analysis identified positively and negatively correlated genes with TMBIM6, and Enrichment analysis suggested TMBIM6’s association with protein processing in the ER and NOD-like receptor signaling pathways. …”
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Evaluating the green credentials and performance of deep eutectic solvents in the extraction of antibiotics and mycotoxins in foods by Oluwatobi Kolawole, Chongdee Thammakhet-Buranachai, Awanwee Petchkongkaew, Thanasat Sooksimuang, Christopher Elliott, Nitsara Karoonuthaisiri

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c-Myc-dependent LAMP3 regulates the proliferation, metastasis and metabolic reprogramming of tongue squamous cell carcinoma by Jing Feng, Wei He, Jin Fang

“…Differential expression of LAMP3 in TSCC from GEO microarray was analyzed, and pathway enrichment analysis of LAMP3 was performed utilizing GSEA. …”
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Integrated Bioinformatics Analysis to Screen Hub Gene Signatures for Fetal Growth Restriction by Jingjin Yang, Yuxin Liu, Minyue Dong

“…We downloaded FGR-related gene microarray data, used weighted gene co-expression network analysis (WGCNA), differentially expressed genes (DEGs), and protein-protein interaction (PPI) networks to screen hub genes. …”
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Exosomal circRNA-0008302 from Adipose-derived Stem Cells Protects Against Myocardial Injury by Chengyan Hu, Shuai Wang, Yanling Wang, Zhenxing Fan, Xipeng Sun, Zhi Liu

“…Methods: We screened differentially expressed circRNAs between ADSCs and ADSC-Exos with a circRNA microarray. A differential circRNA-0008302 siRNA plasmid was constructed to obtain ADSC-Exo and ADSC Exommu-circ-0008302 siRNA, respectively; subsequently, M6200 cells were divided into a control group, hydrogen peroxide (H 2 O 2 ) induced group, H 2 O 2 + ADSC-Exo group, and H 2 O 2 + ADSC-Exo mmu-circ-0008302 siRNA group, and cell viability was evaluated. …”
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Estimation of relevant variables on high-dimensional biological patterns using iterated weighted kernel functions. by Sergio Rojas-Galeano, Emily Hsieh, Dan Agranoff, Sanjeev Krishna, Delmiro Fernandez-Reyes

“…Our method scaled-up to dimensionalities of much higher orders of magnitude as shown with gene expression microarray datasets in which we obtained classification accuracies close to 90% with fewer than 1% of the total number of variables.…”
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Prognostic value of immune biomarkers in melanoma loco-regional metastases. by Emilia Hugdahl, Sura Aziz, Tor A Klingen, Lars A Akslen

“…In a patient series of loco-regional metastases from nodular melanomas (n = 78; n = 26 skin metastases, n = 52 lymph node metastases), expression of PD-L1 in tumour cells and the number of CD3, CD8, FOXP3 and PD-L1 positive TILs were determined by immunohistochemistry on tissue microarray (TMA) slides. Due to limited tumour tissue in the paraffin blocks, 67 of the 78 cases were included for tissue microarrays. …”
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Parallel clustering algorithm for large-scale biological data sets. by Minchao Wang, Wu Zhang, Wang Ding, Dongbo Dai, Huiran Zhang, Hao Xie, Luonan Chen, Yike Guo, Jiang Xie

“…The parallel affinity propagation also achieves a good performance when clustering large-scale gene data (microarray) and detecting families in large protein superfamilies.…”
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The impact of the nucleosome code on protein-coding sequence evolution in yeast. by Tobias Warnecke, Nizar N Batada, Laurence D Hurst

“…We identify nucleosome positioning as a likely candidate to set up such a DNA-level selective regime and use high-resolution microarray data in yeast to compare the evolution of coding sequence bound to or free from nucleosomes. …”
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Morin inhibited lung cancer cells viability, growth, and migration by suppressing miR-135b and inducing its target CCNG2 by Dongjie Yao, Hujun Cui, Shufen Zhou, Ling Guo

“…We found that morin-treated A549 cells showed statistically decreased cell viability, colony formation, and migration rate when comparing with the dimethyl sulfoxide–treated cells. Microarray results showed that with the treatment of morin, the expression level of miR-135b significantly reduced compared the control group, suggesting that morin may exert its anti-cancer property by suppressing the expression of miR-135b. …”
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Human Cord Blood-Derived CD133+/C-Kit+/Lin− Cells Have Bipotential Ability to Differentiate into Mesenchymal Stem Cells and Outgrowth Endothelial Cells by Carlos Cardenas, Ja-Young Kwon, Yong-Sun Maeng

“…Moreover, we confirmed that OECs or MSCs differentiated from CKL− cells had the ability to form capillary-like structures in Matrigel and differentiate into osteoblasts, chondrocytes, and adipocytes. Finally, using microarray analysis, we identified specific factors of OECs or MSCs that could potentially be involved in the differentiation fate of CKL− cells. …”
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Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease by Senthooran Selvarajah, Ian Todd, Patrick J. Tighe, Michelle John, Charlotte E. Bolton, Timothy Harrison, Lucy C. Fairclough

“…To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum. …”
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Therapeutic implications of GIPC1 silencing in cancer. by Thomas W Chittenden, Jane Pak, Renee Rubio, Hailing Cheng, Kristina Holton, Niall Prendergast, Vladimir Glinskii, Yi Cai, Aedin Culhane, Stefan Bentink, Mathew Schwede, Jessica C Mar, Eleanor A Howe, Martin Aryee, Razvan Sultana, Anthony A Lanahan, Jennifer M Taylor, Chris Holmes, William C Hahn, Jean J Zhao, J Dirk Iglehart, John Quackenbush

“…Additionally, a GIPC1 knock-down gene signature was used to interrogate publically available breast and ovarian cancer microarray datasets. This GIPC1 signature statistically correlates with a number of breast and ovarian cancer phenotypes and clinical outcomes, including patient survival. …”
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Genetic insights and molecular pathways in Alzheimer's disease: Unveiling the complexity of neurodegeneration by Chandana Yesudas, Neethu P, Illakkiam Devaraj

“…We conducted a comprehensive Differential Gene Expression (DGE) analysis using RNA sequencing and microarray datasets from the Gene Expression Omnibus (GEO) database to elucidate the molecular mechanisms underlying AD. …”
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Gene Expression Analysis of Alfalfa Seedlings Response to Acid-Aluminum by Peng Zhou, Liantai Su, Aimin Lv, Shengyin Wang, Bingru Huang, Yuan An

“…To understand the responses of plants to acid soils and Aluminum toxicity, we examined global gene expression using microarray data in alfalfa seedlings with the treatment of acid-Aluminum. 3,926 genes that were identified significantly up- or downregulated in response to Al3+ ions with pH 4.5 treatment, 66.33% of which were found in roots. …”
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Hub genes and associated drugs for multiple myeloma with 1q21+: identified by bioinformatic analysis by Zhiqiang Xu, Jieni Yu, Yamei Chen

“…Identification of related genes may provide additional help for rational intervention. The microarray dataset GSE2658 associated with MM was downloaded from the Gene Expression Omnibus (GEO) database. …”
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The melanocortin receptor genes are linked to and associated with the risk of polycystic ovary syndrome in Italian families by Rongling Wu, Claudia Gragnoli

“…In this study, we used microarray to test 12 single nucleotide polymorphisms (SNPs) in the MC1R gene, 10 SNPs in the MC2R gene, 5 SNPs in the MC3R gene, 6 SNPs in the MC4R gene, and 4 SNPs in the MC5R gene in 212 original Italian families with PCOS. …”
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Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway. by Yuan-Ching Chang, Yi-Chiung Hsu, Chien-Liang Liu, Shih-Yuan Huang, Meng-Chun Hu, Shih-Ping Cheng

“…Lidocaine and bupivacaine caused disruption of mitochondrial membrane potential and release of cytochrome c, accompanied by activation of caspase 3 and 7, PARP cleavage, and induction of a higher ratio of Bax/Bcl-2. Based on microarray and pathway analysis, apoptosis is the prominent transcriptional change common to lidocaine and bupivacaine treatment. …”
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M2-like macrophage-derived exosomes inhibit osteoclastogenesis via releasing miR-1227-5p by Shan Chen, Jian Liu, Lilei Zhu

“…The molecular mechanism was evaluated using microarray analysis, RT-qPCR, dual-luciferase reporter analysis, and RNA pull-down assay. …”
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Simultaneous assessment of mitochondrial DNA copy number and nuclear epigenetic age towards predictive models of development and aging by Phyo W. Win, Julia Nguyen, Amanda L. Morin, Charles E. Newcomb, Shiva M. Singh, Noha Gomaa, Christina A. Castellani

“…This includes qPCR to estimate mtDNA-CN, representing the number of circular mitochondrial genomes in a cell, and DNA methylation microarray data to estimate the epigenetic age of an individual. …”
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