The Role of Pentacyclic Triterpenoids in Non-Small Cell Lung Cancer: The Mechanisms of Action and Therapeutic Potential by Young-Shin Lee, Ryuk Jun Kwon, Hye Sun Lee, Jae Heun Chung, Yun Seong Kim, Han-Sol Jeong, Su-Jung Park, Seung Yeon Lee, Taehwa Kim, Seong Hoon Yoon

“…Pentacyclic triterpenoids, such as lupeol, betulinic acid, betulin, oleanolic acid, ursolic acid, glycyrrhetinic acid, glycyrrhizin, and asiatic acid, have demonstrated the ability to inhibit cell proliferation and angiogenesis, induce apoptosis, suppress metastasis, and modulate inflammatory and immune pathways in NSCLC cell line models. …”
Get full text

Multiomics characterization of breast angiosarcoma from an Asian cohort reveals enrichment for angiogenesis signaling pathway and tumor-infiltrating macrophages by Tun Kiat Ko, Zexi Guo, Bavani Kannan, Boon Yee Lim, Jing Yi Lee, Zhimei Li, Elizabeth Chun Yong Lee, Bin Tean Teh, Bin Tean Teh, Jason Yongsheng Chan, Jason Yongsheng Chan, Jason Yongsheng Chan

“…By NanoString gene expression profiling, ASB, compared to AS-HN, were enriched for angiogenesis, notch signaling and metastasis-associated matrix remodeling pathways. Additionally, AS-B were enriched for macrophages and CD8+ T cells expression signatures. …”
Get full text

Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma by Mengzhu Sun, Laure Garnier, Romane Chevalier, Martin Roumain, Chen Wang, Julien Angelillo, Julien Montorfani, Robert Pick, Dale Brighouse, Nadine Fournier, David Tarussio, Stéphanie Tissot, Jean-Marc Lobaccaro, Tatiana V. Petrova, Camilla Jandus, Daniel E. Speiser, Manfred Kopf, Caroline Pot, Christoph Scheiermann, Krisztian Homicsko, Giulio G. Muccioli, Abhishek D. Garg, Stéphanie Hugues

“…Abstract In melanoma, lymphangiogenesis correlates with metastasis and poor prognosis and promotes immunosuppression. …”
Get full text

The PROMISE-V2 PRIMARY score and SULmax [18F]PSMA-1007 PET/CT in primary staging of prostate cancer by J. Antonio Serna-Macias, M. Lourdes Garcia-Colmenero, Emilly A. Cortes-Mancera, E. David Muñoz-Carpio, Mixel Z. Baltierra-Hernandez

“…Lymph node (pelvic or extrapelvic) spread and metastasis (bone, lung, and/ or brain) were determined. …”
Get full text

Repurposing of Metformin to Improve Survival Outcomes in Patients With Upper Tract Urothelial Carcinoma by Hsiang Ying Lee, Po‐Hung Lin, See‐Tong Pang, Jen‐Kai Fang, Chung‐You Tsai, Yao‐Chou Tsai, Yung‐Tai Chen, Wei‐Chieh Chen, Hsin‐Chih Yeh, Wei‐Ming Li

“…The protective effect of metformin on OS was particularly significant in patients with advanced T stage, metastasis, and high‐grade tumors. Conclusion The study suggests that metformin use in UTUC patients with diabetes is associated with improved OS and CSS but not BRFS. …”
Get full text

MRTX1133 attenuates KRASG12D mutated-colorectal cancer progression through activating ferroptosis activity via METTL14/LINC02159/FOXC2 axis by Junwei Zou, Xiuhua Shi, Zhaoying Wu, Siyuan Zuo, Xiaolei Tang, Hailang Zhou, Yong Huang

“…Studies have shown that CRC patients with KRAS mutations, especially KRASG12D, have an increased risk of metastasis. Emerging evidence indicates that long non-coding RNAs (lncRNAs) are crucial in the carcinogenesis and progression of various cancers, regulating multiple biological processes but the link between KRASG12D mutations and lncRNAs in CRC remains unclear. …”
Get full text

Posttraumatic Cranial Cystic Fibrous Dysplasia by Arata Tomiyama, Kazuya Aoki, Haruo Nakayama, Hideaki Izukura, Hitoshi Kimura, Jun-ichi Harashina, Keisuke Ito, Morito Hayashi, Norihiko Saito, Takatoshi Sakurai, Toshiaki Oharaseki, Hitoshi Terada, Satoshi Iwabuchi

Get full text

Advances in Cell and Immune Therapies for Melanoma by Tanase Timis, Sanda Buruiana, Delia Dima, Madalina Nistor, Ximena Maria Muresan, Diana Cenariu, Adrian-Bogdan Tigu, Ciprian Tomuleasa

“…Despite better early diagnosis and better therapies, melanoma has remained a significant public health challenge because of its aggressive behavior and high potential for metastasis. In 2020, cutaneous melanoma constituted approximately 1.3% of all cancer deaths that occurred within the European Union, thereby highlighting the necessity for effective prevention, timely diagnosis, and sustainable treatment measures, especially as a growing number of cases occur among younger patients. …”
Get full text

Artificial Intelligence and Radiomics in Cholangiocarcinoma: A Comprehensive Review by Marta Zerunian, Tiziano Polidori, Federica Palmeri, Stefano Nardacci, Antonella Del Gaudio, Benedetta Masci, Giuseppe Tremamunno, Michela Polici, Domenico De Santis, Francesco Pucciarelli, Andrea Laghi, Damiano Caruso

“…The aim of this review is to provide an overview of how radiological features of CCA can be analyzed through radiomics and with the help of AI for many different purposes, such as differential diagnosis, the prediction of lymph node metastasis, the defining of prognostic groups, and the prediction of early recurrence. …”
Get full text

Sustained Endocytosis Inhibition via Locally‐Injected Drug‐Eluting Hydrogel Improves ADCC‐Mediated Antibody Therapy in Colorectal Cancer by Chong Wu, Xiaoting Liu, Rong Liu, Shiyao Song, Zi‐Fan Zheng, Yilin Zeng, Yong Mei, Jing‐Yang Zhang, Qijia Duan, Run Lin, Jin‐Zhi Du, Weiling He

“…Peritumoral injection of Gel@Cmab/PCZ shows strong antitumor efficacy in subcutaneous and orthotopic CRC tumor models and completely abrogated liver metastasis when combined with chemotherapy. In a humanized patient‐derived xenograft model, a single injection of Gel@Cmab/PCZ with one‐third of the conventional cetuximab dose achieved 91% tumor growth inhibition, which promoted NK cell infiltration into tumor tissues and their antibody‐dependent cell‐mediated cytotoxicity effect. …”
Get full text

Genetic variations and clinical significance in young-onset nasopharyngeal cancer: Analysis of EBV interaction with cellular receptor variants and viral glycoproteins by Sulistyo Emantoko Dwi Putra, Farizky Martriano Humardani, Hikmawan Wahyu Sulistomo, Yulanda Antonius, Jonathan Jonathan, Riyan Charlie Milyantono, Artika Uthary, Risma Ikawaty

“…Our comparative study between the two subjects showed that the first had milder symptoms and a lower metastasis than the second. In the first subject, we identified unique genetic variants: NRP1 c.536T > C (p.Val179Ala) and MYH9 c.4876A > G (p.Ile1626Val). …”
Get full text

The Role of Advanced Cardiac Imaging in Monitoring Cardiovascular Complications in Patients with Extracardiac Tumors: A Descriptive Review by Annamaria Tavernese, Valeria Cammalleri, Rocco Mollace, Giorgio Antonelli, Mariagrazia Piscione, Nino Cocco, Myriam Carpenito, Carmelo Dominici, Massimo Federici, Gian Paolo Ussia

“…Cardiac computed tomography (CT) provides precise anatomical detail, especially for cardiac involvement due to metastasis or adjacent mediastinal or lung tumors. Coronary assessment is also important for initial risk stratification and monitoring potential coronary artery disease progression after radiotherapy or chemotherapeutic treatment. …”
Get full text

Transcription Factor E2F-1 Is Upregulated in Human Gastric Cancer Tissues and Its Overexpression Suppresses Gastric Tumor Cell Proliferation by Qiang Xiao, Lei Li, Yubo Xie, Ning Tan, Changqing Wang, Junyi Xu, Keyi Xia, Kevin Gardner, Qingdi Q. Li

“…However, no correlation was observed between the E2F-1 levels and patients’ clinical features, such as sex, age, histological types, lymph node metastasis, and clinical stages (P >0.05). Finally, the influence of E2F-1 overexpression on the growth of human gastric carcinoma MKN-45 cells in vitro was assessed by measuring colony formation, cell survival, and cell cycle progression. …”
Get full text

Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and no... by Zhirui Zhang, Wenhuan Song, Wenyu Chen, Wenze Cui, Wenyi Chen, Qinheng Zhang, Wenwen Ji, Yinglin Wang, Jiayi Wang, Wenhao Yu, Mingkun Yu, Mingkun Yu, Tao Hao, Hong Jiang

“…Background and objectiveMicroRNAs (miRNAs) are implicated in cancer by exerting roles in tumor growth, metastasis, and even drug resistance. The general trends of miRNA research in diverse cancers are not fully understood. …”
Get full text

Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works by Wangcai Ren, Jialing Wen, Gang Guo, Gang Guo, Wenchao Gu, Shenke Zhang, Shenke Zhang, Chang Liu, Chang Liu, Kensuke Osada, Takashi Shimokawa, Qiaojuan Wang, Qiaojuan Wang, Yue Wang, Yue Wang, Xuanzhang Tu, Chen Li, Li Sui, Liqiu Ma, Liqiu Ma, Liqiu Ma

“…In the process of radiotherapy for cancer patients, there is an extremely low probability phenomenon that the distal tumor/metastasis away from the irradiation field undergoes regression after localized radiation therapy, which is called the abscopal effect. …”
Get full text

Telomerase and mitochondria inhibition promote apoptosis and TET2 and ANMT3a expression in triple negative breast cancer cell lines by Zeinab Mazloumi, Ali Rafat, Khadijeh Dizaji Asl, Mohammad Karimipour, Dariush Shanehbandi, Mehdi Talebi, Majid Montazer, Ali Akbar Movassaghpour, Alireza Dehnad, Raheleh Farahzadi, Hojjatollah Nozad Charoudeh

“…Introduction: High metastasis, resistance to common treatments, and high mortality rate, has made triple-negative breast cancer (TNBC) to be the most invasive type of breast cancer. …”
Get full text

MSTD: A Multi-Scale Transformer-Based Method to Diagnose Benign and Malignant Lung Nodules by Xiaoyu Zhao, Jiao Li, Man Qi, Xuxin Chen, Wei Chen, Yongqun Li, Qi Liu, Jiajia Tang, Zhihai Han, Chunyang Zhang

“…The identification of benign and malignant lung nodules is crucial for timely treatment to reduce the risk of the progression and metastasis of diseases. However, the varied sizes, diverse morphologies, non-fixed positions, and dynamic growth of lung nodules in computed tomography (CT) images make their accurate identification challenging. …”
Get full text

PDPN+ cancer‐associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF‐κB activation and the CCL2‐ACKR1 axis by Zhenxiong Zhao, Hui Sun, Yingxue Liu, Yanqiu Zhang, Xin Wang, Xu Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Wenchao Gu, Jinjia Chang, Weiqi Sheng, Mi‐die Xu

“…Abstract Cancer‐associated fibroblasts (CAFs) are intrinsic components of the tumor microenvironment that promote cancer progression and metastasis. Through an unbiased integrated analysis of gastric tumor grade and stage, we identified a subset of proangiogenic CAFs characterized by high podoplanin (PDPN) expression, which are significantly enriched in metastatic lesions and secrete chemokine (CC‐motif) ligand 2 (CCL2). …”
Get full text

The association between Chlamydia pneumoniae infection and prognosis in lung cancer patients: a prospective study by Maolin Liu, Hailing Ye, Tao Lin, Zishan Chen, Xinying Xu, Jinman Zhuang, Yongsheng Yang, Xuezhen Chen, Chunting Chen, Mengxin Lin, Fei He

“…Results Cpn IgA infection status was found to be associated with lymph node metastasis in lung cancer patients. The overall survival of patients with Cpn IgA(++) was shorter compared to negative and positive patients(with IgA(-) group as the control group, P < 0.001, HR = 5.441, 95%CI: 2.341–12.645). …”
Get full text

Enhancing PDAC therapy: Decitabine-olaparib synergy targets KRAS-dependent tumors by Giorgia Anastasio, Michela Felaco, Alessia Lamolinara, Francesco del Pizzo, Elisa Cacciagrano, Carla Mottini, Margherita Mutarelli, Francesca Di Modugno, Manuela Iezzi, Luca Cardone

“…The combination was especially effective in dKRAS-PDAC with a BRCA2 mutation, preventing metastasis growth. Our results support the clinical evaluation of DEC+OLA in PDAC.…”
Get full text