Potentials of transanal endoscopic surgery at early rectal cancer by Yu. A. Shelygin, S. V. Chernyshov, L. P. Orlova, E. G. Rybakov

“…In female patient with Т2 adenocarcinoma radical operation was executed, in the removed specimen pararectal lymph node (N1) metastasis was found out. The mean follow-up of patients was 12 (2–20) months, no signs of local tumor relapse were found.Conclusion. …”
Get full text

Thapsigargin Induces Apoptosis by Impairing Cytoskeleton Dynamics in Human Lung Adenocarcinoma Cells by Fei Wang, Da-zhong Liu, Hao Xu, Yi Li, Wei Wang, Bai-lu Liu, Lin-you Zhang

“…The present findings highlight important roles of calcium entry in cytoskeleton organization and apoptosis in human lung adenocarcinoma cells and will help to set a stage to the clinical treatment of cancer cell metastasis.…”
Get full text

Multi-pathway oxidative stress amplification via controllably targeted nanomaterials for photoimmunotherapy of tumors by Song Li, Yunheng Liu, Xiaokang Zhang, Yurong Liu, Longqing Si, Shaojing Jiang, Aoya Wang, Xukai Che, Jing Chen, Jinghui Hu

“…Mature dendritic cells transmit signals to T cells, increasing T cells infiltration and activation, facilitating tumor growth inhibition and the suppression of lung metastasis. Furthermore, the myeloid-derived suppressor cells in the tumor decreases significantly after treatment. …”
Get full text

The differential expression of AFF3 in cervical cancer and its correlation with clinicopathological features and prognosis by Yaxuan Zhang, Lanying Li, Qingling Han, Lanying Wen

“…The Univariate analysis of prognostic risk factors was conducted using the COX proportional hazards model, followed by multivariate COX regression analysis including variables with p < 0.01.Results AFF3 expression was downregulated in CC, and its levels were correlated with lymph node metastasis (LNM) and International Federation of Gynaecology and Obstetrics (FIGO) stage. …”
Get full text

CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment by Yu Wang, Haiyan Xu, Li Cai, Yang Sun, Liwei Wang, Ming Yue, Xiaofei Zhang, Yanling Wang, Shumin Li, Shengbai Xue, Jingyu Ma, Tiebo Mao, Weiyu Ge, Daiyuan Shentu, Wenxin Lu, Yongchao Wang, Jiong Hu, Jiujie Cui

“…Functionally, we confirmed CREB3L1 contributing to PDAC malignant progression including growth and metastasis by multiple in in vitro and in vivo models. …”
Get full text

ERBB4 selectively amplifies TGF-β pro-metastatic responses by Peihong Luo, Huanyu Hong, Baoling Zhang, Jie Li, Shuyi Zhang, Chaomin Yue, Jin Cao, Jia Wang, Yuhan Dai, Qingqing Liao, Pinglong Xu, Bing Yang, Xia Liu, Xia Lin, Yi Yu, Xin-Hua Feng

“…These selective effects facilitate lung cancer metastasis in mouse models. This discovery sheds light on the previously unrecognized role of SMAD4 as a substrate of ERBB4 and highlights the selective involvement of the ERBB4-SMAD4 regulatory axis in tumor metastasis.…”
Get full text

The Application of Traditional Chinese Medicine-Derived Formulations in Cancer Immunotherapy: A Review by Li Y, Li C, Fan J, Liu Y, Xu Y, Pang G

“…They enhance the immune system’s ability to detect and destroy cancer cells, promote apoptosis in tumor cells, inhibit tumor growth and metastasis, and augment the effectiveness of conventional cancer treatments. …”
Get full text

FTO Facilitates Cervical Cancer Malignancy Through Inducing m6A‐Demethylation of PIK3R3 mRNA by Bingxin Chen, Liming Wang, Xiaomin Li, Ci Ren, Chun Gao, Wencheng Ding, Hui Wang

“…After changing the FTO expression level by lentivirus transfection, the proliferation and metastasis ability of cervical cancer cells were detected both in vitro and in vivo. …”
Get full text

Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy by Ming Hao, Xingchen Li, Xinxin Zhang, Boqiang Tao, He Shi, Jianing Wu, Yuyang Li, Xiang Li, Shuangji Li, Han Wu, Jingcheng Xiang, Dongxu Wang, Weiwei Liu, Guoqing Wang

“…Abstract Tongue squamous cell carcinoma (TSCC) is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion. Accurate diagnosis and effective treatment are essential for enhancing the quality of life and the survival rates of TSCC patients. …”
Get full text

Efficacy Analysis of Hypofractionated Radiotherapy for Oligometastatic Tumors: A Retrospective Study by Qian Sun MD, Hanqing Zhao MS, Xianwen Zhang MS, Suli Zhang MS, Zelai He MD, Gengming Wang MD, Hao Jiang MS, Aili Xuan MS, Xianming Li MD

“…Introduction Metastasis remains a major cause of death among patients with malignant tumors. …”
Get full text

Silencing of STEAP3 suppresses cervical cancer cell proliferation and migration via JAK/STAT3 signaling pathway by Zouyu Zhao, Panpan Yu, Yan Wang, Hong Li, Hui Qiao, Chongfeng Sun, Lina Zhu, Ping Yang

“…Abstract Background Six-transmembrane epithelial antigen of prostate 3 (STEAP3), an essential constituent of the STEAP family protein, plays a notable role in promoting cancer proliferation and metastasis. Despite the importance of the STEAP gene family in tumor progression, the function of STEAP3 in cervical cancer (CC) remains unclear. …”
Get full text

A Smart Nanomedicine Unleashes a Dual Assault of Glucose Starvation and Cuproptosis to Supercharge αPD‐L1 Therapy by Yiming Xu, Yuan Wu, Xinjie Zheng, Dongxue Wang, Hangqi Ni, Weiyu Chen, Kai Wang

“…Additionally, a combination of CMGCL can sensitize the therapeutic effects of αPD‐L1, substantially promoting tumor inhibition in both subcutaneous and lung metastasis LLC‐bearing mice models. Overall, these findings highlight the potential connections between glucose metabolism and cell cuproptosis, offering a promising approach for treating lung cancer by integrating starvation, cuproptosis, and immunotherapy.…”
Get full text

Aberrant SNHG expression predicts poor prognosis in esophageal cancer using meta-analysis and bioinformatics analysis by Ke Shi, Li-De Huang, Dan Li, Wei-Min Luo, Hua-Song Liu, Dong-Xiao Ding, Qiang Guo, Yue-Feng Liu

“…Elevated SNHG expression also implied advanced TNM stage (OR 1.578, 95%CI = 1.273–1.956) and lymph node metastasis (OR: 1.533, 95%CI = 1.205–1.950). Conclusion Increased expression of SNHG2, SNHG5, and SNHG12, and decreased expression of other SNHGs tended to have a favorable prognosis in patients with EC. …”
Get full text

The heterogeneity of NOTCH1 to tumor immune infiltration in pan-cancer by XiaoJun Duan, Rihan Wu, Mingyang Zhang, Kexin Li, Lei Yu, Huirong Sun, Xingxia Hao, Changshan Wang

“…We further analyzed the changes of immune infiltration in pan-carcinoma species from the perspectives of NOTCH1 expression, mutation, gene function, tumor metastasis and drugs. NOTCH1 expression was significantly up-regulated in cold tumors but down-regulated in hot tumors. …”
Get full text

Mucin-producing urothelial-type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma: case report and literature review by Ao Yu, Ao Yu, Hongbo Su, Peiling Yu, Siqi Cai, Shuaixian Mu, Jinhui Yu, Qianting Lu, Yuan Miao, Ailin Li

“…Ablation therapy was performed for the lung metastasis, followed by radical prostate chemoradiotherapy. …”
Get full text

Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancer by Sinem İnan, Semra Bilaçeroğlu, Burcu Uludağ Artun

“…In this study, we aimed to investigate the significance of the correlation of NT-proBNP levels in lung cancer with tumor stage, tumor diameter, histopathology, and specific sites of mediastinal metastasis: lymphadenopathy; pericardial, cardiac, major vessel, other mediastinal organ or lymphatic involvement/invasion. …”
Get full text

Integrative analysis of anoikis-related prognostic signature to evaluate the immune landscape and predict therapeutic response in stomach adenocarcinoma by Ziyi Zhou, Lanlan Yang, Yuan Fang, Rongzhong Xu, Xi Wang, Yuli Wang, Zhihong Fang

“…Anoikis, a process of programmed cell death that occurs when cells detach from the extracellular matrix, is closely associated with tumor invasion and metastasis. In this study, we used the TCGA-STAD database to identify the expression patterns and prognostic relevance of anoikis-related genes (ARGs) in STAD. …”
Get full text

The XIAP inhibitor AZD5582 improves the treatment effect of microwave ablation on hepatocellular carcinoma by Wenhui Wang, Fuyuan Wu, Zhe Wu, Mengfan Zhang, Qiang Lu

“…However, the residual tumor, resulting from insufficient ablation, led to recurrence and metastasis of liver cancer. Novel combination strategies are urgently needed to enhance efficiency of MWA.MethodsWe detected the expression of XIAP protein after ablation in primary liver cancer patients using immunohistochemistry. …”
Get full text

Triiodothyronine (T3) increases the expression of the amphiregulin (AREG) oncogene by activating extranuclear pathways in MCF-7 breast cancer cells by Maria Teresa De Sibio, Fernanda Cristina Fontes Moretto, Regiane Marques Castro Olimpio, Miriane de Oliveira, Lucas Solla Mathias, Vinícius Vigliazzi Peghinelli, Helena Paim Tilli, Bianca Mariani Gonçalves, Dariane Beatriz Marino Cardoso, Larissa Silva Dall Aqua, Igor de Carvalho Depra, Mariana Menezes Lourenço, Aline Carbonera Luvizon, Paula de Oliveira Montandon Hokama, Maria Tereza Nunes, Marna Eliana Sakalem, Célia Regina Nogueira

“…ABSTRACT Objective: Considering that the αvβ3 integrin plays an important role in tumor metastasis, this study investigated the involvement of these pathways in mediating the triiodothyronine (T3) effects on amphiregulin (AREG) expression. …”
Get full text

Dual Functions of Androgen Receptor Overexpression in Triple-Negative Breast Cancer: A Complex Prognostic Marker by Umay Kiraz, Emma Rewcastle, Silja K. Fykse, Ingrid Lundal, Einar G. Gudlaugsson, Ivar Skaland, Håvard Søiland, Jan P. A. Baak, Emiel A. M. Janssen

“…High AR-DIA correlated with lower grade (<i>p</i> = 0.014), and lower proliferation (<i>p</i> = 0.004) but also with larger tumors (<i>p</i> = 0.047), distant metastasis (<i>p</i> = 0.052), and lymph node (LN) positivity (<i>p</i> < 0.001), highlighting its dual roles. …”
Get full text