Esophageal submucosal gland duct adenoma: a case report and literature review by Bing Zhou, Jian Zheng, Ling Huang, Hua Hao

“…Local tumor resection was performed, the longest follow-up period was 132 months of the 20 patients, the prognosis was favorable, and no recurrence or metastasis.DiscussionESGDA is more common in the lower esophagus in elderly patients, and its clinical symptoms are atypical. …”
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A Rare Form of Melanoma Masquerading as a Diabetic Foot Ulcer: A Case Report by Susan Thomas, Yuan-Xiang Meng, Vijaykumar G. Patel, Gregory Strayhorn

“…Subsequent definitive wide excision and sentinel node biopsy confirmed ALM with metastasis to inguinal lymph nodes (stage IIIb). The treatment included wide margin excision of the lesion with en bloc amputations of 4th and 5th toes, followed by adjuvant chemotherapy. …”
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Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells by Minkoo Seo, Seung Min Kim, Eun Young Woo, Ki-Cheol Han, Eun Joo Park, Seongyeol Ko, Eun wook Choi, Mihue Jang

“…Cancer stem cells (CSCs) with self-renewal abilities endorse cellular heterogeneity, resulting in metastasis and recurrence. However, there are no promising therapeutics directed against CSCs. …”
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Bisphosphonate-Related Osteonecrosis of the Jaw: A Review of the Literature by Eder Alberto Sigua-Rodriguez, Renato da Costa Ribeiro, Ana Caroline Ramos de Brito, Natalia Alvarez-Pinzon, José Ricardo de Albergaria-Barbosa

“…Bisphosphonates (BPs) are a class of drugs used to treat osteoporosis and malignant bone metastasis. BPs show high binding capacity to the bone matrix, especially in sites of active bone metabolism. …”
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POTENCY OF SOURSOP LEAF EXTRACT AND CURCUMIN WITH MAGNETIC AND MUCUS-PENETRATING NANOPARTICLE AS COLORECTAL CANCER ALTERNATIVE THERAPY by Faiza Rahma Ebnudesita, Ayik Rochyatul Jannah, Savira Butsainah Dienanta, Reny I'tishom

“…Curcumin works molecularly on cyclooxygenase-2 (COX-2) to prevent inflammation, thereby inhibit the growth of cancer cells and reducing the risk of metastasis. Curcumin also plays a role in the inhibition of nuclear factor κ-light-chain-enhancer of activated B (NF-κB) cells, thus inhibits carcinogenesis. …”
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Sinonasal Melanoma: A Case Report and Literature Review by I. S. S. Alves, L. G. S. Berriel, R. T. Alves, M. B. Pinto, C. F. P. Oliveira, A. C. Cazzotto, W. V. Moura

“…The patient remains healthy, with no metastasis or recurrence. He is currently being monitored by the clinical oncology team.…”
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Arthroscopic Management of Juxta‐Articular Proximal Tibial Chondroblastoma: A Case Report and Literature Review by Cong Xiao, Shaoyun Zhang, Zhixiang Gao, Lifu Wang, Yixin Dai, Jian Li

“…ABSTRACT Background Chondroblastoma is a rare bone tumor that originates from the epiphysis, constitutes around 1% of all primary bone tumors and is recognized for its tendency to exhibit local invasiveness, as well as the possibility of metastasis and recurrence in nearby areas. Currently, the main surgical treatment for chondroblastoma is open surgery, involving excision of the lesion. …”
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Tumor Markers in Pleural Fluid: A Comprehensive Study on Diagnostic Accuracy by Vladimir Aleksiev, Daniel Markov, Kristian Bechev

“…These effusions are a leading cause of debilitating dyspnea and a diminished quality of life among cancer patients, with distant metastasis to the pleural layers occurring in about 20% of cases during treatment. …”
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MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers by Yixin Yang, Christopher Alderman, Ayoub Sehlaoui, Yuan Xiao, Wei Wang

“…Gastroenterological cancers are characterized by late diagnosis, metastasis, high recurrence, and being refractory to current therapies. …”
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Evaluation of Preoperative CA15-3 Level and its Relationship with Clinico-Pathological Characteristics in Primary Breast Cancer Patients by Braihan Hamdi Hameed, Izzat Abdulsatar Al-Rayahi, Salwa S. Muhsin

“…Furthermore, the present study showed that higher preoperative CA15-3 level was significantly associated with a larger tumor size and lymph node metastasis. This means that elevated CA15-3 is correlated with an increased tumor burden, suggesting its predictive value. …”
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Recurrent Giant Malignant Phyllodes Tumor of the Breast by Erik Kudela, Karol Kajo, Erik Kozubik, Tomas Rokos, Terezia Pribulova, Jan Danko, Eva Kudelova, Igor Homola, Pavol Slavik, Barbora Macurova, Kamil Biringer

“…In addition, they are associated with an increased risk of local recurrence and distant metastasis. The authors hereby present a case report of a 34-year-old woman with recurrent malignant PT with an increasing aggressiveness. …”
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Investigation of CD47 Expression in Renal Cell Tumors and Evaluation of Its Relationship with Prognostic Parameters by Ömer Faruk Dizibüyük, Zehra Bozdağ, Metin Karakök

“…<b>Results:</b> The statistical analysis yielded a significant correlation between CD47 expression and survival, metastasis, and capsule invasion for the unclassified RCC cases. …”
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Impact of interferon-free regimens in patients with chronic HCV and successfully ablated HCC by Amr Maged Mahmoud Rasheed, Maissa E. L. Raziky, Mohammad El Sayed, Mai Mehrez, Gamal Esmat

“…Results Four patients with distant metastasis, three dying from liver-related incidents, received surgical resection, TACE, and RFA treatment, while one patient survived with compensated chronic liver disease. …”
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Hypoxia Promotes Glioma Stem Cell Proliferation by Enhancing the 14-3-3β Expression via the PI3K Pathway by Weidong Cao, Qiang Zhou, Hongwei Wang, Wei Rao, Gang Cheng, Peng Wang, Shengli Guo, Bin Ren, Jianning Zhang

“…Hypoxia induced by using CoCl2 application and 14-3-3β protein knockdown by specific small interfering RNA transfection were performed in GSCs both in vitro and in vivo to observe their role in glioma progression and metastasis occurrence by using western blot analysis and MTT assay. …”
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Small Cell Neuroendocrine Carcinoma of the Urinary Tract Successfully Managed with Neoadjuvant Chemotherapy by Mustapha Ahsaini, Omar Riyach, Mohammed Fadl Tazi, Mohammed Jamal El Fassi, My Hassan Farih, Hind Elfatmi, Afaf Amarti

“…After 24 months of followup, no local or distant metastasis was detected. Conclusion. The purpose of this review is to present a rare case of pure small cell neuroendocrine carcinoma of the urinary tract and review the literature about the place of neoadjuvant chemotherapy in this rare tumors.…”
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Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging by Fukuko Shimizu, Kenji Okami, Koji Ebisumoto, Daisuke Maki, Akihiro Sakai, Go Ogura, Naoya Nakamura, Masahiro Iida

“…Early diagnosis without the inspection under general anesthesia is beneficial for the patients with lymph node metastasis from unknown primary lesion.…”
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Liposarcoma of the Nasopharynx: Diagnosis and Management of a Rare Diagnostic Entity by George X. Papacharalampous, Dimitrios Kikidis, Alexios Vasileiou, Aggeliki Bousiotou, Aristeidis Chrysovergis

“…However, there is no adequate evidence that the combination of surgery and radiotherapy lowers the possibility of distant metastasis of the head and neck liposarcomas. The role of adjuvant or neoadjuvant chemotherapy still remains controversial.…”
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A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment by Zixuan Xiong, Yichun Huang, Shulong Cao, Xuqun Huang, Haiyuan Zhang

“…In the non-immune TME, mechanisms such as apoptosis inhibition, DNA damage response (DDR), and epithelial-mesenchymal transition (EMT) can promote tumor growth, metastasis, and drug resistance. Despite the challenges posed by the TME in the treatment of AOC, the unique biological advantages of nanoparticles (NPs) make it possible to regulate the TME. …”
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Unraveling the PVTGlu-mPFCGlu circuit: A new frontier in chronic pain management for bone cancer pain by Liqun Duan, Qianliang Wang, Jianpeng Chen, Zelin Fan, Wenzhi Zhang, Jun Yan

“…Bone cancer pain (BCP) is a type of ongoing or breakthrough pain caused by a primary bone tumor or bone metastasis. BCP impairs patients’ quality of life. Depending upon clinical observations, the administration of centrally acting analgesic has been associated with the alleviation of pain symptoms BCP patients. …”
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Do Not Miss the Tumor: A Novel Presentation of Osteosarcoma by Michael DePalma, Sachin Gupta, Jie Nguyen, Divya Talwar, Alexandre Arkader, Lawrence Wells

“…Because primary-care physicians and pediatricians may be the first medical providers to encounter patients with osteosarcoma, it is imperative that such clinicians are familiar with the signs and symptoms associated with osteosarcomas in order to reduce the risk of metastasis and disease progression and prevent treatment delays. …”
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