Duodenal Gangliocytic Paraganglioma Requiring a Pancreaticoduodenectomy: A Case Report and Review of the Literature by Laurie Adams, Theodore M. Friedman, Timothy R. Shaver, George Younan

“…Duodenal GPs were initially viewed as benign tumors of the duodenum; however, there have been increasing incidence reports of hematogenous and lymphatic metastasis. Appropriate treatment of duodenal GPs is still controversial and ranges from local endoscopic submucosal resection to major radical surgery. …”
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Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases by Nathan C. Rowland, Jennifer Andrews, Daxa Patel, David V. LaBorde, Adam Nowlan, Bradley George, Claire Mazewski, Andrew Reisner, Howard M. Katzenstein

“…Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. …”
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Hyperthermic intraperitoneal chemotherapy: Ideal and reality by Fan-He Dong, Yu-Qiang Shan, Wen-Cheng Kong, Hao-Ran Wei, Lin-Po Zhou, Ye-Bin Yang, Jing Shi, Cheng-Hao Ji, Yi-Jia Zhang

“…The HIPEC technique can effectively kill residual lesions in the abdominal cavity through the synergistic sensitization effect of thermal chemotherapy and the circulating perfusion and washing effect of large volume perfusion fluid, thereby reducing the occurrence of malignant ascites and reducing the risk of postoperative recurrence and metastasis. However, there are still many problems in the practical operation of HIPEC, such as non-uniform distribution of perfusate temperature, inadequate perfusion due to the presence of ‘dead space’, incomplete cytoreductive surgery (CRS), instances of catheter obstruction during perfusate circulation, the lack of a uniform standard for selecting appropriate HIPEC techniques, occupational exposure of medical personnel during the HIPEC procedure, and the selection of HIPEC chemotherapy regimens for patients with various types of tumors. …”
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miR-224 activates cancer-associated fibroblasts to enhance lung cancer cell migration and invasion by targeting Akirin1 by Seonyeong Oh, Sieun Lee, Inyoung Cheon, Young-Ho Ahn

“…In a mouse orthotopic injection model, miR-224 overexpression in LFs increased lung cancer metastasis. Using target prediction tools and subsequent 3′-UTR luciferase assay, Akirin1 was validated as a direct target gene of miR-224. …”
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Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage by Tomas Rohan, Barbora Cechova, Peter Matkulcik, Matej Straka, Jan Zavadil, Michal Eid, Michal Uher, Marek Dostal, Tomas Andrasina

“…A multivariate analysis showed that mass forming tumor with mass larger than 5 cm and presence of metastasis at the time of PTBD served as a negative prognostic factor (p = 0.002), better survival was associated with lower preprocedural bilirubin and lower CRP (p = 0.003). …”
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Outcome of 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy in Progressive Metastatic Neuroendocrine Tumors from a Tertiary Care Center by David Mathew, Saumya S. Sunny, Justin Benjamin, Junita R. John, Felix K. Jebasingh, Josh T. Georgy, Ashish Singh, Regi Oommen

“…Despite symptomatic improvement, there was no significant survival benefit for those with pancreatic, liver, or nodal metastasis. Conclusion: A majority of patients who were treated with PRRT demonstrated clinical, radiological as well as biochemical positive responses warranting an earlier consideration for this well-tolerated treatment modality.…”
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Multiomic machine learning on lactylation for molecular typing and prognosis of lung adenocarcinoma by Mengmeng Hua, Tao Li

“…In the subsequent prognosis validation, the high-risk group included more patients with stage T3 + 4, N1 + 2 + 3, M1, and III + IV cancer; higher recurrence/metastasis rates; and lower 1, 3, and 5 year overall survival rates. …”
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Identification of Crotonylation Metabolism Signature Predicting Overall Survival for Clear Cell Renal Cell Carcinoma by Jie Zheng, Yingqing Liu, Kai Wei, Jiewu Shi, Lin Li, Xuefeng Jiang, Lingsong Tao

“…Reducing KAT2A expression hindered ccRCC cell growth and metastasis. Conclusion. Our study highlights the critical role of crotonylation metabolism in cancer development and progression, particularly its link to poor prognosis. …”
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To study the expression of estrogen, progesterone receptor and p53 immunohistochemistry markers in subtyping endometrial carcinoma by Anuja Yadav, Anuradha Sistla, Meenakshi Swain, Swarnalata Gowrishankar, Michelle de Padua, Tejal Modi, Rallabandi Himabindu, Neha Agarwal, Aditya Kulkarni, Trilok Bhandari, Hemanth Vudayaraju, Chinnababu, Vijay A. Reddy

“…There was a statistical association between ER and PR status and lymph node metastasis. p53 did not show a statistical significance. …”
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Regulatory Role of the RUNX2 Transcription Factor in Lung Cancer Apoptosis by Camila Bernal, Andrea Otalora, Alejandra Cañas, Alfonso Barreto, Karol Prieto, Martin Montecino, Adriana Rojas

“…Current studies have confirmed that RUNX2 is closely related to the proliferation, invasion, and bone metastasis of multiple cancer types, such as osteosarcoma, breast cancer (BC), prostate cancer, gastric cancer, colorectal cancer, and lung cancer. …”
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Unraveling the Molecular Nexus between GPCRs, ERS, and EMT by Niti Kumari, Somrudee Reabroi, Brian J. North

“…The epithelial-mesenchymal transition (EMT) is a fundamental process in promoting cancer cell invasion and tumor dissemination leading to metastasis, an often intractable state of the disease. …”
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CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis by Jianqiang Wu, Lixia Chen, Peijun Wen

“…Abstract Metastasis is the leading cause of death in patients with cutaneous melanoma. …”
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Result of Surgery to Patients with Brain Tumor in Cienfuegos by Jorge Luis Acevedo Cardoso, Samuel Sánchez Sánchez, Yoniel Suárez Guerrero, Tamara García Alfonso de Armas, Wendy Gómez Menéndez

“…<br /><strong>Conclusion:</strong> a greater survival was associated with meningothelial meningioma, emphasizing lethality in grade IV astrocytomas and lung metastasis. The most frequent and associated mortality complication was postoperative neurological deterioration.…”
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Tratamiento endoscópico de las lesiones premalignas y el cáncer in situ de colon y recto by Yesael Descalzo García, Raúl Brizuela Quintanilla, Dayron Páez Suarez, Vivianne Anido Escobar, Maricela Morera Pérez

“… Introducción: El tratamiento endoscópico se considera actualmente de elección para el cáncer digestivo precoz sin metástasis en los ganglios linfáticos. Objetivo: Describir la utilidad de la resección mucosa endoscópica y la disección submucosa endoscópica en pacientes con lesiones pre-malignas y cáncer in situ de colon y recto. …”
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To describe the subsets of malignant epithelial cells in gastric cancer, their developmental trajectories and drug resistance characteristics by Tingting Xu, Tianying Zhang, Yan Sun, Sijia Wu

“…Cell–cell communication analysis uncovered a dynamic network of interactions within the tumor microenvironment, potentially influencing tumor growth and metastasis. Differential gene expression analysis identified key genes (LDHA, GPC3, MIF, CD44, and TFF3) that were used to construct a prognostic risk score model. …”
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Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis by Hong Lin, Jinpeng Yuan, Guoxi Liang, Yanxuan Wu, Liming Chen

“…Upregulated expression of oncogenic circRNA was correlated with poor clinicopathological features, including lymph node metastasis, tumor size, and T classification, while downregulation of tumor-suppressor circRNA was contributed to worse TNM stage. …”
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The Influence of Radiological “Disappearing Lesions” on the Efficacy and Prognosis of Patients with Colorectal Liver Metastases Undergoing Conversion Therapy by Zhi-yang Song, Dong Yang, Yang Liu, Yong Cheng

“…The purpose of the current study was to analyze the influence of radiological “disappearing liver metastasis” (DLM) on the efficacy and prognosis of patients with colorectal liver metastases (CRLM) undergoing conversion therapy. …”
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Clear Cell Carcinoma Arising in Vulvar Endometriosis by Pranom Buppasiri, Pilaiwan Kleebkaow, Chantip Tharanon, Apiwat Aue-aungkul, Chumnan Kietpeerakool

“…Computed tomography of the abdominopelvic region showed an ulcerative mass at the right labia majora and nodal metastasis at the external iliac and inguinal regions. …”
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A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER database by Mengxiang Tian, Kangtao Wang, Ming Li

“…Abstract The liver stands out as one of the most frequent sites for distant metastasis in breast cancer cases. However, effective risk stratification tools for patients with breast cancer liver metastases (BCLM) are still lacking. …”
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Durable Effect of Radioactive Iodine in a Patient with Metastatic Follicular Thyroid Carcinoma by Aubrey A. Carhill, Rena Vassilopoulou-Sellin

“…Traditionally, differentiated thyroid cancer (DTC) carries a good prognosis when diagnosed early, but increasingly patients are presenting with late-stage disease and bone metastasis which carries a poor prognosis. Treatment of DTC involves surgical resection followed by radioactive iodine (RAI), which conventionally is thought to reach maximal effectiveness between 6 and 12 months following treatment. …”
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