A 15-year pheochromocytoma and paraganglioma experience in a single centre: a Singapore perspective by Yingshan Lee, Leon Yuan Rui Tan, Shaikh Abdul Kader Kamaldeen Abdul Shakoor

“…Disease recurrences and metastasis occurred in up to one-fifth of the patients. …”
Get full text

Leiomyosarcoma after Total Laparoscopic Hysterectomy with Power Morcellation by Tsukasa Takahashi, Tomohisa Ugajin, Noriaki Imai, Atsushi Hayasaka, Nobuo Yaegashi, Takeo Otsuki

“…Since there was no metastasis, she was followed-up without additional treatment. …”
Get full text

Case report: Patients with positive HER-2 amplification locally advanced gastroesophageal junction cancer achieved pathologic complete response with the addition of pembrolizumab t... by Huanhuan Li, Chao Ren, Donghai Cui, Tao Wu, Zhiyong Nie

“…Therefore, addition of PD-1 to chemotherapy plus trastuzumab may lead to a better response in patients with G/GEJ cancer.Case presentationA 66-year-old man was diagnosed with stage III GEJ adenocarcinoma with celiac lymph node metastasis. Immunohistochemical results indicated HER-2(3+) and PD-L1 CPS=5. …”
Get full text

Osteosarcoma of the Mandible in an Elderly Patient by Isao Hoshi, Ryosuke Abe, Kei Onodera, Yu Ohashi, Tadashi Kawai, Ikuya Miyamoto, Toshimi Chiba, Yasunori Takeda, Hiroyuki Yamada

“…There was no evidence of tumor recurrence or metastasis 4 years after surgery. This case showed that it was not necessary to exclude surgical treatment merely because the patient was 90 years old. …”
Get full text

Extended Distal Pancreatectomy with En Bloc Resection of the Celiac Axis for Locally Advanced Pancreatic Cancer: A Case Report and Review of the Literature by Patrick H. Alizai, Andreas H. Mahnken, Christian D. Klink, Ulf P. Neumann, Karsten Junge

“…The patient underwent laparoscopy to exclude hepatic and peritoneal metastasis. Subsequently, a selective embolization of the common hepatic artery was performed to enlarge arterial flow to the hepatobiliary system and the stomach via the pancreatoduodenal arcades from the superior mesenteric artery. …”
Get full text

Evaluation of C-X-C chemokine receptor type 4 (CXCR4) and Peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in colorectal carcinoma: Relation to the available cl... by Asmaa E. Bedeer, Nehal Abd El-Ghaffar Heabah

“…High CXCR4 expression showed significant associations with the depth of tumor invasion (P = 0.024), lymph node metastasis (P = 0.009), advanced tumor stage (P = 0.001) and the presence of vascular invasion (P = 0.035). …”
Get full text

Oculodermal melanocytosis in Asian Indian patients: Prevalence, clinical presentation, and association with choroidal melanoma by Prapti Chheda, Srishti Ramamurthy, Vishal Raval, Swathi Kaliki

“…During a mean follow-up period of 21 months, one patient died because of lung metastasis. Conclusion: Although rare, choroidal melanoma does occur in the presence of ODM with an increased risk in Asian Indians compared to the Caucasian population. …”
Get full text

Heterogeneity in polyamine metabolism dictates prognosis and immune checkpoint blockade response in hepatocellular carcinoma by Jianyan Pan, Zhong Lin, Qinchun Pan, Tao Zhu

“…In vitro experiments suggested that FIRRE, the gene with the greatest impact on the PAscore, significantly contributed to HCC proliferation and metastasis. This study underscores the potential of our polyamine-related signature in predicting the prognosis and immunotherapy response in HCC patients, and also reveals the polyamine metabolic heterogeneity among HCC cells that influences their crosstalk with infiltrating myeloid cells.…”
Get full text

The neuroscience in breast cancer: Current insights and clinical opportunities by Jia-feng Wang, Meng-chuan Wang, Lei-lei Jiang, Neng-ming Lin

“…Interaction between the nervous system and breast cancer can influence tumor initiation, growth, invasion, metastasis, reverse resistance to drugs, promote inflammation in tumors, and impair the immune system's ability to combat cancer. …”
Get full text

Implication of protein post translational modifications in gastric cancer by Houji Song, Mingze Zhang, Chengwang Guo, Xi Guo, Yuqi Ma, Yuntao Ma, Yuntao Ma

“…The diverse realm of PTM and PTM crosstalk is linked to many critical signaling events involved in neoplastic transformation, carcinogenesis and metastasis. This review provides a comprehensive overview of the impact of PTM on the occurrence and progression of GC. …”
Get full text

The Regulation between CD4+CXCR5+ Follicular Helper T (Tfh) Cells and CD19+CD24hiCD38hi Regulatory B (Breg) Cells in Gastric Cancer by Ying Zhang, Jun Wu, Haibo Zhang, Chen Wu

“…Moreover, higher Tfh% was associated with lymphatic metastasis, patients’ worse outcomes and Breg%. Tfh differentiation and CXCL13 were upregulated by cocultured B cells in vitro, while Tfh cells seem to not participate in Breg cell differentiation from B cells. …”
Get full text

GLI1-altered mesenchymal tumor involving the parietal pleura: case report and literature review by Yuanli Zhong, Baizhou Li, Gangping Wang, Yuqing Liu, Zhenwei Chen

“…We conducted a review of all cases of recurrence and metastasis, concluding that this type of tumor has a distinct propensity to metastasize to the lungs. …”
Get full text

Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis by Liliana R. Balahura, Aida Selaru, Sorina Dinescu, Marieta Costache

“…During this event, proinflammatory cytokines are produced by numerous types of cells, such as fibroblasts, endothelial cells, macrophages, and tumor cells, and are able to promote the initiation, progression, and metastasis of different types of cancer. When persistent inflammation occurs, activation of inflammasome complexes is initiated, leading to its assembly and further activation of caspase, production of proinflammatory cytokines, and pyroptosis induction. …”
Get full text

Prognostic value of immune biomarkers in melanoma loco-regional metastases. by Emilia Hugdahl, Sura Aziz, Tor A Klingen, Lars A Akslen

“…Negative tumour PD-L1 expression was significantly associated with low CD8 and PD-L1 TIL count, large lymph node metastasis tumour size and presence of necrosis in lymph node metastases. …”
Get full text

Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature by Umesh Jayarajah, D. M. Hilary Fernando, Kasun Bandara Herath, M. V. Chandu de Silva, S. A. S. Goonewardena

“…Partial cystectomy may be considered in patients with localised tumour without evidence of metastasis and poor general condition. Regular cystoscopies and ultrasound imaging are necessary for follow-up and early identification of recurrences.…”
Get full text

Adenocarcinoma with Neuroendocrine Differentiation of the Colon Accompanying Osteoclast-Like Giant Cells by Mitsuhiro Tachibana, Tadahiro Isono, Yutaka Tsutsumi

“…Neuroendocrine differentiation in colorectal cancer is reportedly associated with poorer grade of tumor differentiation, nodal and distant metastasis, and other unfavorable features, contributing to a worse clinical outcome. …”
Get full text

Submandibular Gland Invasion From a Metastatic Lymph Node in Patients With Buccal Mucosal Squamous Cell Carcinoma: A Case Report by Moeka Bukawa, Kenji Yamagata, Satoshi Fukuzawa, Shohei Takaoka, Fumihiko Uchida, Naomi Ishibashi-Kanno, Hiroki Bukawa

“…Pathologically, the infiltrating SCC was observed in the SMG continuous with SMLN metastasis (pT4bN3bM0). No adjuvant therapy was performed for old age and oral intake dysfunction. …”
Get full text

Bednar Tumour Occurring after Malignant Melanoma Excision by Amedeo Ferlosio, Monia Di Prete, Piero Rossi, Elena Campione, Augusto Orlandi

“…Preoperative clinical diagnosis was “in-transit” melanoma metastasis. After surgical excision, histopathologic examination revealed a dermal nodular proliferation of spindle cells arranged in storiform pattern, with mild pleomorphism, infiltrating around appendages and into the subcutaneous tissue. …”
Get full text

Relationship between the ultrasound features of different molecular subtypes of breast cancer and positive PD-1/PD-L1 expression by Ruiqian Yan, Haixia Li, Junxi Gao

“…Among 112 PD-1-positive cases, most luminal B cases exhibited ill-defined margins, while distant metastasis was more common in triple-negative cases. …”
Get full text

Lymphatic vessel network injury reduces local tumor control despite preservation of the tumor-draining lymph node by Lauren N. Liebman, Yang Shen, Zachary S. Buchwald, Zhanna Nepiyushchikh, Zhiming Qi, Andrés J. García, J. Brandon Dixon

“…Abstract The lymphatic system plays complex, often contradictory, roles in many cancers, including melanoma; these roles include contributions to tumor cell metastasis and immunosuppression in the tumor microenvironment as well as generation of antitumor immunity. …”
Get full text