TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression by Menghan Cao, Zhiying Shao, Xingyou Qian, Miaolei Chen, Chuyin Deng, Xintian Chen, Tingting Tang, Kaixu Zhang, Sufang Chu, Junnian Zheng, Jin Bai, Zhongwei Li

“…Furthermore, we demonstrate that TRIM21 suppresses the proliferation, tumorigenesis, migration, and metastasis of CRC cells by promoting the ubiquitination-mediated degradation of PRMT1. …”
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Acute Truncal Lymphedema Secondary to Axillary Metastatic Melanoma Presenting Like Cellulitis by Shelley J. E. Hwang, Benjamin Y. Kong, Shaun Chou, Deepal Wakade, Matteo S. Carlino, Pablo Fernandez-Penas

“…With the diagnosis of possible acute lymphedema, a CT scan was requested that showed significant axillary lymph node metastasis. The fever was considered secondary to dabrafenib and trametinib therapy. …”
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COSMC-Regulated O-Glycosylation: A Bioinformatics-Driven Biomarker Identification for Stratifying Glioblastoma Stem Cell Subtypes by Sara Sadat Aghamiri, Rada Amin

“…Glioblastoma stem cells (GSCs) are key drivers of relapse, metastasis, and therapy resistance in glioblastoma due to their adaptability and diversity, which make them challenging to target effectively. …”
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SLC1A4 Promotes Malignant Transformation of Hepatocellular Carcinoma by Activating the AKT Signaling by Jiaoyun Zheng, Jian Gong

“…Moreover, epithelial–mesenchymal transition (EMT) in vitro and metastasis potential in vivo of hepatic cancer cells was suppressed by the downregulated SLC1A4 level. …”
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Advances in Immunotherapy for Melanoma: A Comprehensive Review by Carmen Rodríguez-Cerdeira, Miguel Carnero Gregorio, Adriana López-Barcenas, Elena Sánchez-Blanco, Beatriz Sánchez-Blanco, Gabriella Fabbrocini, Brunilda Bardhi, Ardiana Sinani, Roberto Arenas Guzman

“…Melanomas are tumors originating from melanocytes and tend to show early metastasis secondary to the loss of cellular adhesion in the primary tumor, resulting in high mortality rates. …”
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Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma by Vishnu Priya Veeraraghavan, Bharati R. Doni, Arun Kumar Dasari, Chaitra Patil, Krishna A. Rao, Santosh R. Patil

“…Oral squamous cell carcinoma (OSCC), which is characterized by high rates of recurrence and metastasis, is a prevalent and burdensome form of head and neck cancer. …”
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Bilateral Chylothorax as a Unique Presentation of Pancreaticobiliary or Upper Gastrointestinal Cancer by Nooraldin Merza, John Lung, Mazin Saadaldin, Tarek Naguib

“…CT chest/abdomen/pelvis showed bilateral ground-glass opacities within the lungs and possible bony metastasis. A whole-body bone scan showed multiple bony metastatic lesions throughout the skeleton. …”
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Surgical Management of Pilocytic Astrocytoma of the Optic Nerve: A Case Report and Review of the Literature by Ifeoluwa Apanisile, Tamás Karosi

“…A systemic review of the literature indicates that early diagnosis and experienced multidisciplinary management are required in case of unilateral, resectable forms of ONAs with no distant metastasis, in order to provide a long-time survival of patients. …”
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Early growth response 1 transcription factor and its context-dependent functions in glioblastoma by Saleh Rasras, Esma’il Akade, Seyed Ehsan Mohammadianinejad, Maedeh Barahman, Mohammad Bahadoram

“…Despite its oncogenic functions, EGR1 can also suppress tumours by upregulating non-steroidal anti-inflammatory drug-activated gene 1 and phosphatase and tensin homolog deleted on chromosome ten, and inhibiting invasion and metastasis. Additionally, EGR1 may have hypothetical implications in the viral hit-and-run theory, particularly regarding cytomegalovirus infection. …”
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Transition Yet Energy Consuming for Tumor Growth Regulated by the Colored Microenvironment by Leiyan Chen, Yan Wang, Qingqing Li, Haohua Wang

“…Transition or metastasis is a main characteristic of tumor developmental processes. …”
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Preliminary experience and learning curve of endoscopic nipple-areolar-complex sparing total mastectomy: A single-center retrospective study. by Da Young Yu, Tae Yul Lee, Duk Woo Kim, Young Woo Chang, Gil Soo Son, Hye Yoon Lee

“…There were one locoregional recurrence patient and one distant metastasis and mortality patient observed during median follow-up of 19.12±12.01 months.…”
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Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game by Paqui G. Través, Alfonso Luque, Sonsoles Hortelano

“…Indeed, several lines of clinical evidence indicate that immune cells such as tumor-associated macrophages (TAMs) interact with tumor cells, favoring growth, angiogenesis, and metastasis of a variety of cancers. In most tumors, TAMs show properties of an alternative polarization phenotype (M2) characterized by the expression of a series of chemokines, cytokines, and proteases that promote immunosuppression, tumor proliferation, and spreading of the cancer cells. …”
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Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer by Jiangang Zhao, Jiahui Li, Hans A. Schlößer, Felix Popp, Marie Christine Popp, Hakan Alakus, Karl-Walter Jauch, Christiane J. Bruns, Yue Zhao

“…CSCs are thought to be responsible for cancer initiation, progression, metastasis, chemoresistance, and recurrence in pancreatic cancer. …”
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Identification of Potential Selective PAK4 Inhibitors Through Shape and Protein Conformation Ensemble Screening and Electrostatic-Surface-Matching Optimization by Xiaoxuan Zhang, Meile Zhang, Yihao Li, Ping Deng

“…P21-activated kinase 4 (PAK4) plays a crucial role in the proliferation and metastasis of various cancers. However, developing selective PAK4 inhibitors remains challenging due to the high homology within the PAK family. …”
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Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors by Runhan Liu, Jiaxin Zhou, Xiaochen Chen, Jie Zhang, Qunzhi Chen, Xiaoming Liu, Kunhou Yao

“…This review discusses the current challenges, such as drug resistance and tumor metastasis, and highlights how RNA molecules can be leveraged for targeted detection and treatment. …”
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Genome Stability Pathways in Head and Neck Cancers by Glenn Jenkins, Kenneth J. O'Byrne, Benedict Panizza, Derek J. Richard

“…Genomic instability underlies the transformation of host cells toward malignancy, promotes development of invasion and metastasis and shapes the response of established cancer to treatment. …”
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Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers by Shichen Huang MS, Bowen Li MS, Huanyu Chen MD, Cheng Rong, Zheng Yang MD, Xianqin Zhang PhD

“…The elevated levels of TRPM2-AS are associated with important clinicopathological parameters such as tumor size, tumor stage, and lymph node metastasis, revealing that TRPM2-AS could be a potential target for cancer diagnosis, prognosis and treatment. …”
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Co-targeting of metabolism using dietary and pharmacologic approaches reduces breast cancer metastatic burden by Qianying Zuo, Jin Young Yoo, Erik R. Nelson, Matthew J. Sikora, Rebecca B. Riggins, Zeynep Madak-Erdogan

“…Using in vitro cell lines and in vivo xenograft metastasis mouse models, we examined the molecular mechanisms of combining ER targeting with a ketogenic diet. …”
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Application of dynamic enhanced scanning with GD-EOB-DTPA MRI based on deep learning algorithm for lesion diagnosis in liver cancer patients by Bo Liu, Jinhua Yang, Yifei Wu, Xi Chen, Xueru Wu

“…Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) technology is in high demand.ObjectivesThe purpose of the study is to segment the liver using an enhanced multi-gradient deep convolution neural network (EMGDCNN) and to identify and categorize a localized liver lesion using a Gd-EOB-DTPA-enhanced MRI.MethodsWe provided the classifier images of the liver in five states (unenhanced, arterial, portal venous, equilibrium, and hepatobiliary) and labeled them with localized liver diseases (hepatocellular carcinoma, metastasis, hemangiomas, cysts, and scarring). The Shanghai Public Health Clinical Center ethics committee recruited 132 participants between August 2021 and February 2022. …”
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Pediatric Primary Alveolar Soft Part Sarcoma of the Bladder by Kazuya Tanabe, Shigeru Nakamura, Taiju Hyuga, Shina Kawai, Masahiro Yamazaki, Yohei Kawashima, Rieko Furukawa, Toshiro Niki, Shigeru Ono, Hideo Nakai

“…For 2.5 years postoperatively, the patient remained free of local recurrence and distant metastasis. The patient’s clinical course has been favorable, with good management of clean intermittent self-catheterization.…”
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