Research Progress on Tumor Treatment Strategies Targeting TGF-β by Jian ZHANG, Binyue LYU, Xiao ZHAO

“…The TGF-β signaling pathway affects various biological processes of cancers, including proliferation, invasion, metastasis, angiogenesis, and immune escape. Currently, multiple drugs targeting this pathway are in clinical trial stage, which involve three aspects of TGF-β, namely, production, activation, and signal transduction. …”
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Duodenal Obstruction as First Presentation of Metastatic Breast Cancer by Sami Khairy, Ayman Azzam, Shamayel Mohammed, Kausar Suleman, Abdurahman Khawaji, Tarek Amin

“…The tumor presents again as brain metastasis after stop of Herceptin due to cardiac toxicity.…”
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Squamous Cell Carcinoma Developing from a Testicular Epidermal Cyst: A Case Report and Literature Review by Ryo Kasahara, Ryosuke Tajiri, Kota Kobayashi, Masahiro Yao, Kazuo Kitami

“…He is alive without recurrence or metastasis six months after surgery. Testicular SCC is an extremely rare tumor. …”
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Beta-HCG Secretion by a Pulmonary Choriocarcinoma in a Male Patient by Brecht Devos, Cedric Willemse, Mira Sterckx, Johan Debruyne, Inge Stappaerts, Tom Van den Mooter, Marjan Hertoghs, Pascale Abrams

“…MRI of the brain showed a solitary brain metastasis, while on a subsequent 18F-FDG PET/CT, no other metastatic lesions were seen. …”
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Neuroendocrine Tumor, Well Differentiated, of the Breast: A Relatively High-Grade Case in the Histological Subtype by Shogo Tajima, Hajime Horiuchi

“…In the lymph nodes, the morphology of the tumor was similar to the primary site. No distant metastasis and no relapse was seen for one year after surgery. …”
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Primary Small-Cell Carcinoma of the Palate with Cushing’s Syndrome: A Case Report by Yingqiu Song, Zhenyu Lin, Lingjuan Chen, Gang Wu

“…There was no evidence of recurrence or metastasis for more than three years. Small cell carcinoma originating in the head and neck region has been reported to be highly aggressive and has a poor prognosis. …”
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Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities by Jiarui Zhang, Jinan Zhang, Chen Yang

“…Autophagy mechanisms can influence metastasis and drug resistance in glioblastoma, and there is a complex interplay between autophagy and cellular responses to stress like hypoxia and starvation. …”
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Mesenteric Lymph Node Recurrence of a Primary Colorectal Leiomyosarcoma by Amélie Beauchamp, Roy Hajjar, Sharmila Khullar, Mathieu Latour, Frank Schwenter, Herawaty Sebajang

“…The mesenteric lymph node was resected and histopathology confirmed a leiomyosarcoma metastasis. This case opens the controversy on the management of rare lymph node recurrences in colorectal leiomyosarcoma.…”
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Progress in immune microenvironment, immunotherapy and prognostic biomarkers in pediatric osteosarcoma by Lin Zhang, Haoming Jiang, Haichao Ma

“…Despite advances in treatment, including multi-agent chemotherapy, survival rates remain suboptimal, with metastasis, particularly to the lungs, contributing significantly to mortality. …”
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Modulating lipid metabolism improves tumor immunotherapy by Yi Zhang, Yu Ping, Qiuqing Fan

“…Abnormal lipid metabolism, which is frequently observed in cancers, promotes tumor proliferation, invasion, and metastasis. Li et al from the Medical Oncology Department of Chongqing University Cancer Hospital constructed a lipid metabolism scoring system and reported that MK1775 inhibited fatty acid oxidation in tumor-associated macrophages and reduced T-cell infiltration, further enhancing the efficacy of immunotherapy. …”
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Complex Liver Resections for Colorectal Metastases: Are They Safe in the Low-Volume, Resource-Poor Caribbean Setting? by Shamir O. Cawich, Dexter A. W. Thomas, Chunilal Ramjit, Roderick Bhagan, Vijay Naraynsingh

“…A 50-year-old woman with a solitary colorectal metastasis invading the inferior vena cava underwent an extended left hepatectomy with caval resection and reconstruction. …”
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Advances in sodium-glucose transporter protein 2 inhibitors and tumors by Jiaqi Wang, Wenyong Yang

“…SGLT2 has been found to be overexpressed in many tumors and involved in tumorigenesis, progression and metastasis, suggesting that SGLT2i has a wide range of applications in tumor therapy. …”
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Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line by Zhihui Xiao, Wenjun Wu, Vladimir Poltoratsky

“…Metformin, type II diabetes medication, demonstrates anticancer properties via suppressing inflammation, tumor cell proliferation, angiogenesis, and metastasis. This study intended to address the role of metformin in regulation of CXCL8 expression and cell proliferation and migration. …”
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Case Report: Metastatic involvement of the acromioclavicular joint in a patient with papillary carcinoma of the ureter by Cihangir Türemiş, Mustafa Çeltik, Mehmet Erduran

“…Although previous studies have documented bone metastases mainly in the pelvis, spine, ribs, and femur, this case report presents the first recorded instance of metastasis occurring in the acromioclavicular joint. …”
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Epithelioid Trophoblastic Tumor: A Case Report and Review of the Literature by Eirwen M. Scott, Ashlee L. Smith, Mohamed Mokhtar Desouki, Alexander B. Olawaiye

“…ETT can be a sequela of any gestational event and can present in both intrauterine and extrauterine sites. Metastasis and death have been reported. We present a case of a 44-year-old female incidentally diagnosed with ETT following laparoscopic-assisted vaginal hysterectomy. …”
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Combining Endoscopic Submucosal Dissection and Adjuvant Chemoradiotherapy or Radiotherapy for Effective Management of Rectal Cancer with Deep Submucosal Invasion: A Case Series by Ji Hye Park, Jae Hyun Kim, Sung Hyun Ko, Seun Ja Park

“…On the other hand, a post-ESD pathological examination showed that the risk of lymph node metastasis increases with deep submucosal (SM) invasion, positive lymphovascular invasion, grade 2/3 tumor budding, and certain histological types. …”
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The interpretation of Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update by LU Yujie, ZHU Siji

“…Bone-modifying agents (BMAs), including bisphosphonate (BP) and denosumab, can reduce bone-related events caused by breast cancer bone metastasis. “Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update” was published in Journal of Clinical Oncology in January 2022. …”
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Epithelial Tight Junctional Changes in Colorectal Cancer Tissues by Xuexuan Wang, Owen Tully, Benjamin Ngo, Marc Zitin, James M. Mullin

“…It has become increasingly evident that TJs play a crucial role in maintaining cell-cell integrity, and the loss of cell junctional sealing could involve itself in the processes of carcinoma and cancer metastasis. If correlations between altered TJ proteins and CRC presence or invasiveness could be established, they may serve as important markers and guidelines for prophylactic and prognostic purposes, along with other screening methods. …”
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Metastatic Squamous Cell Carcinoma of the Anus to the Lung Confirmed with Allelotyping by Rachel Roth, Susan Moffatt-Bruce, Marino E. Leon

“…Additionally, allelotyping for loss of heterozygosity displayed similar findings and confirmed the histopathological impression of anal SCC metastasis to the lung. The patient was treated with palliative chemotherapy instead of additional surgical treatment. …”
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Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity by Brian M Ortmann

“…HIF’s dysregulation is frequently observed in various cancer types and correlates with increased aggressiveness, metastasis, resistance to therapy and poor patient prognosis. …”
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