Upregulated SAE1 Drives Tumorigenesis and Is Associated with Poor Clinical Outcomes in Breast Cancer by Hong Liu, Jing Wang, Yunhai Li, Feng Luo, Lei Xing

“…Patients with SAE1 overexpression had a worse overall survival (OS), recurrence-free survival (RFS), and distant metastasis-free survival compared with lower expression patients. …”
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Preoperative Butyrylcholinesterase Level as an Independent Predictor of Overall Survival in Clear Cell Renal Cell Carcinoma Patients Treated with Nephrectomy by Takuya Koie, Chikara Ohyama, Jotaro Mikami, Hiromichi Iwamura, Naoki Fujita, Tendo Sato, Yuta Kojima, Ken Fukushi, Hayato Yamamoto, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Masato Kitayama, Kazuyoshi Hirota

“…Multivariate analysis revealed that preoperative BChE levels and distant metastasis status were significantly associated with OS. …”
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Health promoting activities and corresponding mechanism of (–)-epicatechin-3-gallate by Zhiliang Li, Changchun Feng, Hongjin Dong, Weibin Jin, Wenying Zhang, Jianfeng Zhan, Shuzhen Wang

“…The antineoplastic mechanism contains inhibition of phase 1 CYP enzymes, induction of phase II detoxification and antioxidant enzymes, high anti-inflammatory efficacy, arrest of cell cycle progression, regulation of apoptosis, as well as mediation of metastasis processes. In particular, the gallate moiety of ECG is critical for mediating inhibitory effects towards cancer cells. …”
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Long non-coding RNA OSTM1-AS1 promotes renal cell carcinoma progression by sponging miR-491-5p and upregulating MMP-9 by Jun-Feng Chen, Sha-Zhou Ye, Ke-Jie Wang, Xiang-yu Meng, Bin-bin Yang, Ke Rong Wu, Qi Ma

“…In summary, our findings indicate, for the first time, at least to the best of our knowledge, that OSTM1-AS1 serves as an oncogene among RCC by promoting proliferation, invasion, and metastasis through its targeting of the miR-491-5p/MMP9 axis. …”
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Metastatic Renal Cell Carcinoma Presenting as Gastric Ulcer: Case Report and Literature Review by Alhareth Al Juboori, Satinder Kaur, Atigadda Reddy

“…Herein we describe a case of delayed metastasis to gastric wall occurring more than a decade after previously curative nephrectomy for RCC. …”
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Metastase Giant Cell Tumour of Bone ke Paru by Dutia Gestin, Aswiyanti Asri, Hera Novianti

“…Belum ada penjelasan yang pasti mengenai patogenesis metastasis GCT of bone ke paru. Dilaporkan kasus giant-cell tumor of bone yang metastase ke paru pada perempuan berusia 51 tahun. …”
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Combined Effects of Pericytes in the Tumor Microenvironment by Aline Lopes Ribeiro, Oswaldo Keith Okamoto

“…In this review, we highlight the contribution of pericytes to some classical hallmarks of cancer, namely, tumor angiogenesis, growth, metastasis, and evasion of immune destruction, and discuss how collectively these hallmarks could be tackled by therapies targeting pericytes, providing a rationale for cancer drugs aiming at the TME.…”
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Breast Angiosarcoma Metastatic to the Ovary by Frederico F. Souza, Amol Katkar, Annick D. Van den Abbeele, Pamela J. Dipiro

“…We present a case of a solitary ovarian metastasis from angiosarcoma of the breast.…”
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Unusual Relapse of Primary Central Nervous System Lymphoma at Site of Lumbar Puncture by Zartaj Ahmed, Ramesh K. Ramanathan, Sunil Ram, James Newell, Maqbool Halepota

“…Local relapse of this disease is common, but extracranial or subcutaneous metastasis is rare with only a few cases being reported in literature. …”
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Concurrent Angiomyolipoma and Clear Cell Renal Cell Carcinoma in the Same Kidney: A Rare Finding in a Patient without Tuberous Sclerosis by Amal Fekkar, Kaoutar Znati, Fouad Zouaidia, Hafsa Elouazzani, Zakia Bernoussi, Ahmed Jahid

“…Six months after surgery, the patient is healthy without signs of tumor recurrence or distant metastasis.…”
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Alternative Splicing and Its Impact as a Cancer Diagnostic Marker by Yun-Ji Kim, Heui-Soo Kim

“…Genome instability and flexible proteomes by alternative splicing could affect cancer cells to grow and survive, leading to metastasis. Cancer cells that are transformed by aberrant and uncontrolled mechanisms could produce alternative splicing to maintain and spread them continuously. …”
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A Case of Gastric Metastatic Melanoma 15 Years after the Initial Diagnosis of Cutaneous Melanoma by Sohail Farshad, Scott Keeney, Alexandra Halalau, Gehad Ghaith

“…Melanoma is the most common cancer to metastasize to the gastrointestinal tract; however, metastasis to the stomach is a rare occurrence. We present the case of a patient with a history of melanoma of the chest wall 15 years prior to presentation who initially presented to the hospital with sepsis but was later found to have metastatic melanoma in the gastric cardia. …”
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Cardiac Angiosarcoma by Monique Esteves Cardoso, Leonardo Secchin Canale, Rosana Grandelle Ramos, Edson da Silva Salvador Junior, Stephan Lachtermacher

“…We report a 21-year-old man with fever, dyspnea, and hemoptysis that was diagnosed with angiosarcoma of the right atrium and pulmonary metastasis. Patient was submitted to surgical tumor resection without adjuvant therapy and died four months after diagnosis.…”
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Small Cell Carcinoma of the Larynx Treated by Concurrent Chemoradiotherapy: A Case Report by Susumu Nakahara, Norihiko Takemoto, Hidenori Inohara

“…Concurrent chemoradiotherapy using cisplatin (CDDP) and etoposide (VP-16) was given, which achieved complete response (CR). Lung metastasis became evident in 16 months whereas the locoregional control remained good. …”
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Clear Cell Adenocarcinoma of the Renal Pelvis in a Male Patient by Sarawut Kongkarnka, Pruit Kitirattakarn, Hironori Katayama, Surapan Khunamornpong

“…The tumor was associated with renal stones and hydronephrosis and invaded into the peripelvic fat tissue with regional lymph node metastasis. The patient died of metastatic disease six months postoperatively. …”
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Glioblastoma Circulating Cells: Reality, Trap or Illusion? by A. Lombard, N. Goffart, B. Rogister

“…This observation raises the question of the possible involvement of glioblastoma-circulating cells in GBM deadly recurrence by a “homing metastasis” process. Therefore, we think it is important to review the already known molecular mechanisms underlying circulating tumor cells (CTC) specific properties, emphasizing their epithelial to mesenchymal transition (EMT) abilities and their possible involvement in tumor initiation. …”
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Recent Advances in the Surgical Treatment of Differentiated Thyroid Cancer: A Comprehensive Review by Raghunandan Venkat, Marlon A. Guerrero

“…In the absence of overt nodal metastasis, the role of elective prophylactic central lymph node dissection remains a matter of debate and prospective, randomized studies are warranted to evaluate the utility of this procedure.…”
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An overview of breast cancer: Classification and related signaling pathways by Pit Foong Chan, Roslida Abd Hamid

“…Like any other cancers, several signaling pathways that enhance the proliferation, survival, invasion, and metastasis capability of tumor cells have been observed in breast cancer. …”
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Overcoming immune evasion with innovative multi-target approaches for glioblastoma by Hai Su, Yin Peng, Yilong Wu, Xiaoli Zeng, Xiaoli Zeng, Xiaoli Zeng

“…Glioblastoma (GBM) cells leverage complex endogenous and environmental regulatory mechanisms to drive proliferation, invasion, and metastasis. Tumor immune evasion, facilitated by a multifactorial network, poses a significant challenge to effective therapy, as evidenced by the limited clinical benefits of monotherapies, highlighting the adaptive nature of immune evasion. …”
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The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists by Tamotsu Tsukahara

“…Recent studies have provided evidence that the endogenously produced PPARγ antagonist, 2,3-cyclic phosphatidic acid (cPA), which is similar in structure to lysophosphatidic acid (LPA), inhibits cancer cell invasion and metastasis in vitro and in vivo. We recently observed that cPA negatively regulates PPARγ function by stabilizing the binding of the corepressor protein, silencing mediator of retinoic acid and thyroid hormone receptor. …”
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