Asparagine endopeptidase regulates lysosome homeostasis via modulating endomembrane phosphoinositide composition by Linli Yao, GuangHui Zi, Miao He, Yuhong Xu, Lulu Wang, Baowei Peng

“…Here, we identified increased AEP expression in breast cancer tissues, which correlated with poorer survival rates and a propensity for lung metastasis among breast cancer patients. Loss of AEP impaired colony formation by breast cancer cells in vitro and suppressed lung metastasis in mice. …”
Get full text

Role of P2X7 receptor in the progression and clinicopathological characteristics of gastric cancer by Wen-jun Zhang, Xiong-wei Pi, Yi-guan Le, Teng-zheng Li

“…High expression of P2X7R was closely related to lymphatic metastasis, vascular invasion and Tumor-Node-Metastasis (TNM) stage in patients with gastric cancer. …”
Get full text

Clinicopathological Findings of Retinoblastoma: A 10-Year Experience from a Tertiary Hospital in Kampala, Uganda by James Joseph Yahaya, Belson Rugwizangoga, Alex Mremi, Asafu Munema

“…Also, there was a statistical significance difference between metastasis and postlaminar invasion (P=0.004). Conclusion. …”
Get full text

A Benzochalcone Derivative, (E)-1-(2-hydroxy-6-methoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one (DK-512), Inhibits Tumor Invasion through Inhibition of the TNFα-Induced NF-κB/MMP-... by Soon Young Shin, Chang Gun Kim, Seunghyun Ahn, You Jung Jung, Dongsoo Koh, Young Han Lee, Yoongho Lim

“…Tumor invasion and metastasis require disruption of the extracellular matrix. …”
Get full text

The Use of Iliac Stem Prosthesis for Acetabular Defects following Resections for Periacetabular Tumors by Massimiliano De Paolis, Alessio Biazzo, Carlo Romagnoli, Nikolin Alì, Sandro Giannini, Davide Maria Donati

“…Sixteen patients had bone or lung metastasis. We have had 6 infections, 2 aseptic loosening, and 2 cases of hip dislocation. …”
Get full text

Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma by Jin-lin Hu, Si-si Hu, Xiu-xiu Hou, Xin Zhu, Jun Cao, Lie-hao Jiang, Ming-hua Ge

“…Clinicopathological features, including differentiation stages, distant metastasis, lymph node metastasis, T classification, TNM stage, and tests of thyroid functions (TPOAb, Tg Ab, T3, FT3, T4, FT4, TSH, and Tg), were reviewed and their associations with γH2AX and ATM were analyzed. γH2AX and ATM expressed higher in thyroid cancer tissues than in benign nodular goiter and normal adjacent tissues. γH2AX was correlated with ATM in thyroid cancer. …”
Get full text

Sporoderm-Removed Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway by Jingyan Liu Master degree, Tao Zeng Doctor degree

“…Tumor metastasis is a key factor of therapeutic failure in tumor patients, but the underlying molecular mechanism remains to be explored and novel effective curative strategies are urgently required. …”
Get full text

Three Cases of Pseudo-Meigs’ Syndrome Secondary to Ovarian Metastases from Colorectal Cancer by Yuta Yamamoto, Yusuke Miyagawa, Takehito Ehara, Makoto Koyama, Satoshi Nakamura, Daisuke Takeuchi, Futoshi Muranaka, Masato Kitazawa, Shinichi Miyagawa

“…We present three cases of pseudo-Meigs’ syndrome secondary to ovarian metastasis from colorectal cancer. In case 1, the patient has severe dyspnea and hypoxia due to massive right pleural effusion; therefore preoperative thoracic drainage was needed. …”
Get full text

CTSG is a prognostic marker involved in immune infiltration and inhibits tumor progression though the MAPK signaling pathway in non-small cell lung cancer by Qian Dai, Xufeng Yao, Yanke Zhang, Qian Chai, Xueyi Feng, Hongbin Zhu, Lei Zhao

“…The downregulation of CTSG expression was associated with lymph node metastasis, tumor stage, and immune cell infiltration. …”
Get full text

Prognostic Value of TRPM7 Expression and Factor XIIIa-Expressing Tumor-Associated Macrophages in Gastric Cancer by Muhammet Calik, Ilknur Calik, Gokhan Artas, Ibrahim Hanifi Ozercan

“…TRPM7 overexpression was closely related to high depth of tumor invasion (p<0.001, ANOVA), increased lymph node metastasis (p<0.001, ANOVA), and high distant metastasis rate (p<0.001, Mann-Whitney U). …”
Get full text

Recurrent Thymic Carcinoma Treated With Median Sternotomy, Innominate Vein Replacement for Superior Vena Cava, and Iodide Implantation: A Case Report and Review of the Literature by Zhong‐zheng Chen, Wen‐dong Qu, Xing‐shu Zhang, Yong‐xiang Song

“…Despite aggressive surgery, the patient developed recurrent metastasis involving mediastinal lymph nodes and the superior vena cava. …”
Get full text

Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population by Lifeng Ning, Yaqin Yu, Xiaoli Liu, Lizhe Ai, Xin Zhang, Wenwang Rao, Jieping Shi, Hui Sun, Qiong Yu

“…However, association analysis of the rs1621 genotype with metastasis and prognosis revealed no significant correlation in both male and female patients. …”
Get full text

Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invasion Pattern: A Retrospective Study by Oguzhan OKCU, Gokce ASKAN, Bayram SEN, Cigdem OZTURK, Seda DUMAN OZTURK, Gulname FINDIK GUVENDI

“…Pan-cytokeratin staining was performed on paraffin-embedded blocks of lymph nodes for cases without lymph node metastasis. Results: The MELF pattern was observed in 29 (29.8%) patients. …”
Get full text

Lobular Mammary Carcinoma Presenting as an Obstructing Rectal Mass by Ebrahim Almahmeed, Eman Aljufairi, Noof Alshaibani

“…Breast cancer is the leading cause of cancer death in women, and while metastasis is common to areas like the bone, lungs, and brain, it is rare to metastasize to the gastrointestinal tract and especially to the rectum. …”
Get full text

PMAIP1 regulates the progression of follicular thyroid carcinoma through the Wnt3/FOSL1 pathway by Haobo Wang, Fangjian Shang, Yifang Wang, Bo Pang, Bo Pang, Longfei Kang, Longfei Kang, Chuanmin Zhou, Chuanmin Zhou, Dongyun Li, Dongyun Li, Zhongxin Li, Zhongxin Li, Xia Jiang, Xia Jiang, Bo Liu, Zengren Zhao

“…Notably, FTC exhibits a more aggressive clinical course and a higher propensity for distant metastasis. However, the underlying mechanisms governing the progression of FTC remain poorly understood. …”
Get full text

miR‐130a‐3p regulated TGF‐β1‐induced epithelial‐mesenchymal transition depends on SMAD4 in EC‐1 cells by Xiaokang Tian, Qian Fei, Mingyu Du, Hongming Zhu, Jinjun Ye, Luxi Qian, Zhiwei Lu, Wenjun Zhang, Yan Wang, Fanyu Peng, Jie Chen, Baoling Liu, Qian Li, Xia He, Li Yin

“…Abstract Metastasis and invasion are the primary causes of malignant progression in esophageal squamous cell carcinoma (ESCC). …”
Get full text

Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer by Xiao Xiao, Fangyi Long, Shaolan Yu, Wengjuan Wu, Dayan Nie, Xiaoyan Ren, Wen Li, Xujuan Wang, Ling Yu, Pinghan Wang, Gang Wang

“…This elevated expression was closely associated with tumor metastasis, poor prognosis, and advanced pathological stages in OC patients. …”
Get full text

Single-cell RNA sequencing and spatial transcriptomics of esophageal squamous cell carcinoma with lymph node metastases by Wei Guo, Bolun Zhou, Lizhou Dou, Lei Guo, Yong Li, Jianjun Qin, Zhen Wang, Qilin Huai, Xuemin Xue, Yin Li, Jianming Ying, Qi Xue, Shugeng Gao, Jie He

“…Abstract Esophageal squamous cell carcinoma (ESCC) patients often face a grim prognosis due to lymph node metastasis. However, a comprehensive understanding of the cellular and molecular characteristics of metastatic lymph nodes in ESCC remains elusive. …”
Get full text

Integrin Trafficking and Tumor Progression by Sejeong Shin, Laura Wolgamott, Sang-Oh Yoon

“…Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. …”
Get full text