Metastatic Uterine Leiomyosarcoma Involving Bilateral Ovarian Stroma without Capsular Involvement Implies a Local Route of Hematogenous Dissemination by Monica Dandapani, Brandon-Luke L. Seagle, Amer Abdullah, Bryce Hatfield, Robert Samuelson, Shohreh Shahabi

“…Uterine sarcomas spread via lymphatic and hematogenous dissemination, direct extension, or transtubal transport. Distant metastasis often involves the lungs. Ovarian metastasis is uncommon. …”
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Advanced Alveolar Soft Part Sarcoma Treated with Pazopanib over Three Years by Yoji Shido, Yukihiro Matsuyama

“…This case suggests that pazopanib may be useful as a first-line drug against unresectable ASPS and that longitudinal assessment of brain metastasis should be performed in similar cases.…”
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tRNA-Uridine Aminocarboxypropyltransferase DTW Domain Containing 2 Suppresses Colon Adenocarcinoma Progression by Yun Qian, Yu-Jiang Li, Yi-Wei Fu, Cui-Xia Liu, Juan Wang, Bin Yang

“…DTWD2 was downregulated in colon adenocarcinoma and associated with poor prognosis. Lymph node metastasis, distant metastasis, and advanced tumor stage are all characterized by lower DTWD2 levels. …”
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Exploring the Crosstalk between Inflammation and Epithelial-Mesenchymal Transition in Cancer by Indranil Chattopadhyay, Rangarao Ambati, Rohit Gundamaraju

“…Such complex interactions provide a better understanding of tumor angiogenesis and metastasis and in defining the aggressiveness of the primary tumors. …”
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The association of codon 392 polymorphism in ESR2 gene with breast cancer in Iran by Sakineh Abbasi, Samira Kalbasi

“…ESR2 gene structure determination, in presurgical evaluation, might be a useful marker in predicting familial breast cancer and metastasis in LN. …”
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Solitary Contralateral Adrenal Metastases after Nephrectomy for Renal Cell Carcinoma by Nikolaos Antoniou, Demetrios Karanastasis

“…Two cases are reported of patients with a single metastasis in the contralateral adrenal, one and nine years respectively after nephrectomy for localized cancer in the opposite kidney. …”
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Prognostic Value of Surgical Resection for Non-small-cell Lung Cancer Patients Comorbid With Minimal Pleural Effusion by Haibo Wang MD, Tao Lu MD, Xinlong Zheng MD, Kan Jiang MD, Longfeng Zhang MD, Xiaobin Zheng MD, Qian Miao MD, Shiwen Wu MD, Zihua Zou PhD, Shanshan Yang, Yujing Li, Sihui Chen, Yiquan Xu PhD, Gen Lin PhD

“…Methods Clinical and prognostic data of operable NSCLC patients who presented no distant metastasis, no direct pleural invasion, but minimal PE on preoperative imaging were retrospectively analyzed. …”
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Microbes, macrophages, and melanin: a unifying theory of disease as exemplified by cancer by Stacie Z. Berg, Jonathan Berg

“…In this article, we provide evidence that tumors are actually complex microbial communities composed of various microorganisms living within biofilms encapsulated by a hard matrix; that these microorganisms are what cause the genetic mutations seen in cancer and control angiogenesis; that these pathogens spread by hiding in tumor cells and M2 or M2-like macrophages and other phagocytic immune cells and traveling inside them to distant sites camouflaged by platelets, which they also reprogram, and prepare the distant site for metastasis; that risk factors for cancer are sources of energy that pathogens are able to utilize; and that, in accordance with our previous unifying theory of disease, pathogens utilize melanin for energy for building and sustaining tumors and metastasis. …”
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The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton by Emma Roberts, Davina A. F. Cossigny, Gerald M. Y. Quan

“…Despite the clinical implication and high incidence of bone and spinal metastases, the molecular mechanisms behind prostate cancer metastasis to bone and spine are not well understood. …”
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Patterns of failure and prognosis in nasopharyngeal carcinoma according to Epstein-Barr virus DNA status by Lin-Feng Guo, Guan-Zhong Lu, Zhen-Zhen Lu, Yi-Feng Yu, San-Gang Wu

“…Methods We included NPC patients who were diagnosed with locoregional recurrence (LRR) and/(or) distant metastasis (DM) between January 2017 and June 2024. …”
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Radical Surgery of Only the Anterior Elements of the Spine at the Posterior Element Fusion Level due to Metastatic Thyroid Cancer by Ryuto Tsuchiya, Kazuki Fujimoto, Kazuhide Inage, Sumihisa Orita, Yasuhiro Shiga, Hiroto Kamoda, Kazuyo Yamauchi, Miyako Suzuki, Jun Sato, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Masao Koda, Takeo Furuya, Junichi Nakamura, Kazuhisa Takahashi, Seiji Ohtori

“…Spinal metastasis of differentiated thyroid cancer can have a favorable prognosis if radical surgery is performed. …”
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DYNLT3 overexpression induces apoptosis and inhibits cell growth and migration via inhibition of the Wnt pathway and EMT in cervical cancer by Jianan Zhang, Qi Shen, Lu Xia, Xueqiong Zhu, Xuejie Zhu

“…In addition, the major metastatic site of cervical cancer cells in mice was the lung, and downregulation of DYNLT3 expression increased cancer metastasis in vivo. DYNLT3 exerted inhibitory effects on cervical cancer by inhibiting cell proliferation, migration and invasion, promoting cell apoptosis in vitro, and inhibiting tumor growth and metastasis in vivo, possibly by suppressing the Wnt signaling pathway and the EMT.…”
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Primary Neuroendocrine Carcinoma of Ocular Adnexa by Daisuke Yamanouchi, Toshiyuki Oshitari, Yosuke Nakamura, Jiro Yotsukura, Kaoru Asanagi, Takayuki Baba, Tomohiro Nizawa, Takashi Kishimoto, Yoko Yonemori, Satoshi Ota, Shuichi Yamamoto

“…After surgery, he underwent 50 Gy radiotherapy on the neck to prevent metastasis. No recurrence or metastasis was found for two years. …”
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Wnt/ β-catenin and CTNNB1 gene mutation in hepatocellular carcinoma, a case study in Egyptian patients by Ramy A. Abdelsalam, Ibrahim M. El-Shawaf, Azza Abdel-Aziz, Tarek A. Bismar, Shaimaa M. Yussif

“…However, no significant association was detected with tumor site, presence of lymph node spread, distant metastasis, tumor necrosis, local recurrence and alpha-fetoprotein level. …”
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Clinicopathological Characteristics and Prognosis of Upper Gastric Cancer Patients in China: A 32-Year Single-Center Retrospective Clinical Study by Yingbo Gong, Pengliang Wang, Zhi Zhu, Junyan Zhang, Jinyu Huang, Huimian Xu

“…Sex (p=0.036), tumor diameter (p=0.001), macroscopic type (p<0.001), pTM stage (p<0.001), tissue differentiation type (p=0.003), and serosal invasion (p=0.034) were independently associated with lymph node metastasis. The macroscopic type (p=0.045), lymphovascular tumor emboli (p=0.021), and pTNM stage were independently associated with recurrence and metastasis. …”
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Kindlin-1 promotes gastric cancer cell motility through the Wnt/β-catenin signaling pathway by Jun-Ho Jang, Jiyoon Jung, Hyeon-Gu Kang, Woong Kim, Won-Jin Kim, Hana Lee, Ju Yeon Cho, Ran Hong, Jeong Won Kim, Joon-Yong Chung, Kyung-Hee Chun, Seok-Jun Kim

“…Abstract Despite advances in gastric cancer diagnosis and treatment, its prognosis remains poor owing to aggressive tumor progression and metastasis. As understanding the relevant molecular mechanisms is essential to effectively improve patient outcomes, we elucidated the role of Kindlin-1 in gastric cancer progression and metastasis. …”
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Low Serum miR-607 Level as a Potential Diagnostic and Prognostic Biomarker in Patients of Pancreatic Ductal Adenocarcinoma: A Preliminary Study by Dawei Jiang, Xiangfei Yuan, Jianqi Ni, Lan Shen, Min Cai, Liu Xu

“…The miR-607 level was found to be closely correlated with lymphatic metastasis and liver metastasis, perineural invasion, and OS and PFS, and the low miR-607 level was an independent prognostic factor for the poor OS of PDAC patients. …”
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Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy by Sadaf Alam, Leena Anjum, Muhammad Haneef

“…They exhibit promising outcomes in reducing metastasis, promoting apoptosis, and inhibiting tumor invasion and progression. …”
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PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition by Hui Xiao, Longxiao Zhang, Yuan Chen, Chengjun Zhou, Xiao Wang, Dehai Wang, Zhenzhong Liu

“…Furthermore, overexpression of PKM2 can promote EMT to encourage tumor metastasis. These findings indicate PKM2 is a potentially useful diagnostic biomarker and therapeutic target in breast cancer.…”
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Synergistic effect of blocking cancer cell invasionrevealed by computer simulations by Kazuhisa Ichikawa

“…Invasion and metastasis are the main cause of death in cancer patients. …”
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