A Fatal Case of Primary Basaloid Squamous Cell Carcinoma in the Intrahepatic Bile Ducts by Johan Kirkegaard, Mie Grunnet, Jane Preuss Hasselby

“…We describe a case of a 67-year-old man, who underwent chemotherapy and surgery for a right-sided liver tumor with an unusual presentation of metastasis to a lymph node in the left armpit. The patient was asymptomatic at the time of diagnosis but expired 20 months after surgery with epidural, lung, and spine metastasis. …”
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Embryonal Sarcoma of the Liver in an Adult Patient by Nicole Lightfoot, Mehrdad Nikfarjam

“…A case of an UES of the liver with an isolated peritoneal metastasis is described. The patient presented with a palpable mass with imaging findings suggestive of a cystic tumour. …”
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Relapsed Mantle Cell Lymphoma Presenting as “Sister Mary Joseph Nodule” by Jennifer E. Vaughn, Ajay K. Gopal

“…The finding of umbilical metastasis has historically been called a “Sister Mary Joseph Nodule”. …”
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Zosteriform cutaneous metastases: A rare occurrence in ductal carcinoma breast after mastectomy by Roshany Sakthibalan, Trishna Vaishali Muthurathinam, Roshni Menon

“…Zosteriform cutaneous metastasis (CM) is an infrequent form of skin metastasis and has a high chance of being misdiagnosed as herpes zoster. …”
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Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation by Chang Liu, Miao Wang, Changli Xu, Bo Li, Juxiang Chen, Jianchun Chen, Zhiwei Wang

“…In this review, the characteristics and interaction of bone metastases and their immune microenvironment were systematically discussed, and the relevant research progress of the immunological mechanism of tumor bone metastasis was reviewed. On this basis, we expounded the clinical application of immune checkpoint inhibitors for bone metastasis of common tumors, including non-small-cell lung cancer, renal cell carcinoma, prostate cancer, melanoma, and breast cancer. …”
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Selective expression and significance of ACKR2 in lung aerocytes by Alberto Mantovani, Gianluigi Condorelli, Raffaella Bonecchi, Massimo Locati, Marina Sironi, Roberta Carriero, Francesca Albano, Valeria Mollica Poeta, Lucia Zotti, Alessandra Castagna, Arianna Felicetta, Alessandro Mesaglio, Elisa Zaghen, Arianna Capucetti, Rachele Di Donato, Mattia Laffranchi, Matteo Massara, Silvano Sozzani

“…Leukocytes infiltrating lung metastasis were studied by fluorescence-activated cell sorting (FACS) analysis. …”
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Mechanistic insights into the role of traditional Chinese medicine in treating gastric cancer by Ziqiang Chen, Ting Yu, Yunhe Wang, Jiaxin Li, Bo Zhang, Liya Zhou

“…These actions collectively contribute to slowing tumor progression, inhibiting metastasis, and enhancing the body’s antitumor response. …”
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Modulation of gut microbiota in targeted cancer therapy: insights on the EGFR/VEGF/KRAS pathways by Li Gong, Shixue Yang, Junli Huang, Yongsheng Li

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Metastatic Status and Dissection Effect of Regional/Extraregional Lymph Nodes in Japanese Patients with Squamous Cell Carcinoma of the Anal Canal: A Multicenter Retrospective Cohor... by Takayuki Torigoe, Keiji Hirata, Kazutaka Yamada, Yoichi Ajioka, Kenichi Sugihara

“…Results: Primary tumor progression was associated with metastasis and recurrence of the inguinal node and further inferior mesenteric trunk/root node metastasis, an extraregional lymph node. …”
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Assessment of cyclin D1 activity in tumors and tumor budding and its prognostic significance in tumor budding in colorectal carcinomas by Ganime Coban, Dilek S. Arici, Busra C. Tekden, Pelin Yildiz, Tugce Kiran, Özlem Toluk, Haci M. Turk, Nurhan Şahin

“…Results: Lymph node (LN) metastasis was present in 93 (55.7%) of the cases, and distant metastasis in 35 (21%) cases. …”
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A Case of Biphasic Pulmonary Blastoma Treated with Carboplatin and Paclitaxel plus Bevacizumab by Shinya Sakata, Sho Saeki, Sayuri Hirooka, Susumu Hirosako, Hidenori Ichiyasu, Hirotsugu Kohrogi

“…Carboplatin, paclitaxel, and bevacizumab were administered and showed an effect on the metastasis. Four courses of the chemotherapy were completed, but a metastasis was found and the metastatic tumor in the spleen was enlarged. …”
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Metastatic Cerebellar Gastrointestinal Stromal Tumor with Obstructive Hydrocephalus Arising from the Small Intestine: A Case Report and Review of the Literature by Kunitomo Sato, Toshihide Tanaka, Naoki Kato, Takuya Ishii, Toru Terao, Yuichi Murayama

“…Immunohistochemical analysis showed tumor cells positive for c-kit and CD34, and cerebellar metastasis of GIST was diagnosed. Postoperative radiotherapy was administered. …”
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Metastatic Renal Cell Carcinoma to the Testis: A Clinicopathologic Analysis of Five Cases by Gang Wang, Chen Zhou, Carlos F. Villamil, Alan So, Ren Yuan, John C. English, Edward C. Jones

“…There were three ipsilateral metastases, one contralateral metastasis, and one bilateral metastasis. The metastatic deposits ranged in size from 2.0 to 5.7 cm. …”
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Clinical Impact of Sphingosine-1-Phosphate in Breast Cancer by Junko Tsuchida, Masayuki Nagahashi, Kazuaki Takabe, Toshifumi Wakai

“…It is difficult to cure the breast cancer patients with distant metastasis due to resistance to drug therapies. Elucidating the underlying mechanisms of breast cancer metastasis and drug resistance is expected to provide new therapeutic targets. …”
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Plasma Iron Levels at Early Breast Cancer Diagnosis Are Associated With Development of Secondary Metastases: A Single-Center Retrospective Cohort Study by Jasmine De Troy, Sarah-Maria Fendt, Sigrid Hatse, Patrick Neven, Ann Smeets, Annouschka Laenen, Hans Wildiers

“…Cox proportional hazard models were applied to determine the association between iron levels and risk of metastasis. Results: In total, 1113 patients were included, 10% of them developed distant metastasis over a median follow-up period of 7 years. …”
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Meta-analysis of the clinicopathologic features of endometrial cancer molecular staging by Xiaoxia Yin, Xiaoxia Yin, Bing Luo, Bing Luo, Yong Li, Yong Li

“…There was no difference in POLE in the presence or absence of LVSI. Lymph node metastasis with and without lymph node metastasis in POLE (OR = 0.25) and CNL (OR = 0.31) were lower, and CNH (OR = 3.06) was higher in lymph node metastasis than in no lymph node metastasis. …”
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The Role of TAMs in Tumor Microenvironment and New Research Progress by Yawei Feng, Zhiqiang Ye, Furong Song, Yufeng He, Jun Liu

“…Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. …”
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New insights into the mechanisms of the immune microenvironment and immunotherapy in osteosarcoma by Cong Luo, Xingxing Min, Danying Zhang

“…This review summarizes the biological characteristics of osteosarcoma, mechanisms of pulmonary metastasis, and the tumor immune microenvironment (TME). …”
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Thigmotropism of Malignant Melanoma Cells by Pascale Quatresooz, Claudine Piérard-Franchimont, Fanchon Noël, Gérald E. Piérard

“…During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. …”
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The CD4/CD8 ratio is associated with T lymphocyte functions in long-term virally suppressed patients with HIV by Qing Xiao, Fengting Yu, Liting Yan, Xiaojie Lao, Xuelei Liang, Hongxin Zhao, Liuyue Zhai, Zailin Yang, Xiaomei Zhang, Yao Liu, Fujie Zhang

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