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François Gros: from antibiotics to messenger RNA
Published 2023-12-01Subjects: Get full text
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Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer
Published 2007-01-01“…The messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. …”
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Regulating Immune Responses Induced by PEGylated Messenger RNA–Lipid Nanoparticle Vaccine
Published 2024-12-01“…Messenger RNA (mRNA)-based therapeutics have shown remarkable progress in the treatment and prevention of diseases. …”
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Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA
Published 2025-01-01“…Objective To test whether messenger RNA (mRNA) splicing is altered in neutrophils from patients with systemic lupus erythematosus (SLE) and can produce neoantigens. …”
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Messenger RNA in differentiating muscle cells—my experience in François Gros’ lab in the 1970s and 80s
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Structure and Expression Analyses of SVA Elements in Relation to Functional Genes
Published 2013-09-01Subjects: Get full text
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Nitric Oxide and Prostaglandins Potentiate the Liver Regeneration Cascade
Published 2006-01-01“…The NO donor s-nitroso-n-acetylpenicillamine, the phosphodiesterase V antagonist zaprinast (ZAP) and PGI2 each potentiated c-fos messenger RNA expression, an index of initiation of the liver regeneration cascade, following PHx. …”
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Lactiplantibacillus plantarum 22 A-3 ameliorates leaky gut in mice through its anti-inflammatory effects
Published 2025-01-01“…The Lactiplantibacillus plantarum 22 A-3-treated group exhibited amelioration of increased intestinal permeability, as indicated by lower blood fluorescein isothiocyanate-dextran levels compared with that of the control group. Furthermore, the messenger RNA expression of interleukin-10, an anti-inflammatory cytokine, was upregulated in the small intestine of Lactiplantibacillus plantarum 22 A-3-treated mice. …”
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Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines
Published 2015-01-01“…The use of nanoparticles encapsulating messenger RNA (mRNA) as a vaccine has recently attracted much attention because of encouraging results achieved in many nonviral genetic antitumor vaccination studies. …”
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A Point Mutation in the Iron-Responsive Element of the L-Ferritin in a Family with Hereditary Hyperferritinemia Cataract Syndrome
Published 2005-01-01“…The genetic abnormality is identified as a mutation in the 5' regulatory region of the L-ferritin messenger RNA known as the iron-responsive element (IRE). …”
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Base Composition Characteristics of Mammalian miRNAs
Published 2013-01-01“…MicroRNAs (miRNAs) are short RNA sequences that repress protein synthesis by either inhibiting the translation of messenger RNA (mRNA) or increasing mRNA degradation. …”
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Vaccination ARN messager (ARNm), modèle de transition de la biologie fondamentale à la médecine
Published 2024-01-01“…Sixty years elapsed between the discovery of messenger RNA (mRNA) and the use of this molecule in an unprecedented global vaccination campaign that brought the Covid-19 pandemic under control. …”
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François Gros (1925–2022)
Published 2024-03-01“…In 1961, he discovered the molecular nature of the proposed intermediary between the gene and the protein, a so-called messenger RNA (mRNA), and determined its main characteristics. …”
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Small RNA Expression Profiling by High-Throughput Sequencing: Implications of Enzymatic Manipulation
Published 2012-01-01“…sRNA-based biomarkers outperform traditional messenger RNA-based biomarkers by testing fewer targets with greater accuracy and providing earlier detection for disease states. …”
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COVID-19 Booster Vaccines Administration in Different Countries
Published 2021-12-01“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that resulted in the COVID-19 global pandemic had consequently led to the development of different types of COVID-19 vaccines, including the messenger RNA (mRNA) vaccines, inactivated virus vaccines, a protein subunit vaccine, and viral vector recombinant vaccines. …”
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Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles
Published 2025-01-01“…The EVs contain much DNA, messenger RNA (mRNA), microRNA, and protein components, which can exert intracellular communication to target cells. …”
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