The 2024 Meet & Greet Event with Alfred Werner Scholars at the Merck Switzerland Biotechnology Development Center in Corsier-sur-Vevey by Hans P. Lüthi, Petra Jordan, Michael Mühlhofer

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Beyond-Rule-of-Five Compounds Are Not Different: In Vitro–In Vivo Extrapolation of Female CD-1 Mouse Clearance Based on Merck Healthcare KGaA Compound Set by Christine K. Maurer, Zhizhou Fang, Heide M. Duevel, Stephanie Harlfinger, Carl Petersson

“…<b>Methods:</b> To further enlighten the field on these matters, we present a study comparing the predictive accuracy between mouse hepatocytes and microsomes for a set of molecules (N = 211) from the Merck Healthcare drug discovery pipeline. This set was dominated by compounds belonging to class 2 and 4 of the extended clearance classification systems (ECCS). …”
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Reseña de García Villegas, Mauricio (dir.) (2008). Jueces sin Estado: La Justicia Colombiana en Zonas de Conflicto Armado. Bogotá: DeJusticia, Siglo del Hombre Editores, Fundación Konrad Adenauer, The The John Merck Fund by Sebastián Rubiano Galvis

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Towards a Left MTL Specialization for Arbitrary-Associative Learning? A Multiple-Case Study by Pierre-Yves Jonin, Audrey Noel, Pascale Trebon, Hélène Vichard, Catherine Merck, Serge Belliard

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Extracorporeal cardiopulmonary resuscitation for refractory out‐of‐hospital cardiac arrest: Lessons learned from recent clinical trials by Stephanie DeMasi, Megan Donohue, Lisa Merck, Jarrod Mosier, for the Strategies to Innovate Emergency Care Clinical Trials Network (SIREN) investigators

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Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers by I‐Ming Wang, Bin Zhang, Xia Yang, Jun Zhu, Serguei Stepaniants, Chunsheng Zhang, Qingying Meng, Mette Peters, Yudong He, Chester Ni, Deborah Slipetz, Michael A Crackower, Hani Houshyar, Christopher M Tan, Ernest Asante‐Appiah, Gary O'Neill, Mingjuan Jane Luo, Rolf Thieringer, Jeffrey Yuan, Chi‐Sung Chiu, Pek Yee Lum, John Lamb, Yves Boie, Hilary A Wilkinson, Eric E Schadt, Hongyue Dai, Christopher Roberts

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Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening by Kevin James Metcalf, Galen Wo, Jan Paulo Zaragoza, Fahimeh Raoufi, Jeanne Baker, Daoyang Chen, Mehabaw Derebe, Jason Hogan, Amy Hsu, Esther Kofman, David Leigh, Mandy Li, Dan Malashock, Cate Mann, Soha Motlagh, Jihea Park, Karthik Sathiyamoorthy, Madhura Shidhore, Yinyan Tang, Kevin Teng, Katharine Williams, Andrew Waight, Sultan Yilmaz, Fan Zhang, Huimin Zhong, Laurence Fayadat-Dilman, Marc Bailly

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Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition by Morgan E. Walker, Wei Zhu, Janine H. Peterson, Hao Wang, Jon Patteson, Aileen Soriano, Han Zhang, Todd Mayhood, Yan Hou, Samaneh Mesbahi-Vasey, Meigang Gu, John Frost, Jun Lu, Jennifer Johnston, Christopher Hipolito, Songnian Lin, Ronald E. Painter, Daniel Klein, Abbas Walji, Adam Weinglass, Terri M. Kelly, Adrian Saldanha, Jeffrey Schubert, Harris D. Bernstein, Scott S. Walker

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Stabilization of norovirus GII.3 virus-like particles by rational disulfide engineering by Christopher Warren, Jennifer D. Galli, Karin Bystol, Gregory O’Donnell, Andrew R. Swartz, Emily A. Dewar, Corey May Fulton, Pamela Shen, Estibaliz Gonzalez-Fernandez, Lizzy Aurora DeWitt, Uijin Jeong, Oscar Chi-Chien Pan, Sean Miller, Arthur Fridman, Courtney David, Zhifeng Chen, Jiajie Wei

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Quantitative In Vivo Detection of Chlamydia muridarum Associated Inflammation in a Mouse Model Using Optical Imaging by Manishkumar Patel, Shu-An Lin, Melissa A. Boddicker, Christopher DeMaula, Brett Connolly, Bohumil Bednar, Jon H. Heinrichs, Jeffrey G. Smith

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Correction: A Phase 2a, Randomized, Placebo-Controlled Human Challenge Trial to Evaluate the Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated with Respiratory... by Mickie H. Cheng, Alex J. Mann, Brian M. Maas, Tian Zhao, Melissa Bevan, Andrea K. Schaeffer, Laura E. Liao, Andrew P. Catchpole, David W. Hilbert, S. Aubrey Stoch, Carisa S. De Anda

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Pharmacological and structural characterization of vibostolimab, a novel anti-TIGIT blocking antibody for cancer immunotherapy by Hongmei Wang, Maribel Beaumont, Wendy Blumenschein, Laurence Fayadat-Dilman, Mingmei Cai, Jing Yuan, Douglas Wilson, Thierry O Fischmann, Jeanne Baker, Tanya Keenan, Daniel Malashock, Eunseon Ahn, Komal Pradhan, Jeffery Grein, Srishti Chakravorty, Soheila Bahmanjah, David Ban, Ellen Chien, Mark Hsieh, Todd Mayhood, Janica C Wong, Mark A McCoy, Sybil M G Williams, Wolfgang Seghezzi, Jin-Hwan Han

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Utilizing non-clonal CHO cell derived materials for preclinical studies of complex molecules by Jessica Pan, Jeffrey McPhee, Alex Dow, Daniel Burke, Balrina Gupta, Patricia Rose, Xiaowen Wang, Nuno Pinto, Simon Letarte, Ying Huang, Guanghua Benson Li, Kitty Agarwal, Katelyn Smith, Ren Liu

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Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases by Manikandan Narayanan, Jimmy L Huynh, Kai Wang, Xia Yang, Seungyeul Yoo, Joshua McElwee, Bin Zhang, Chunsheng Zhang, John R Lamb, Tao Xie, Christine Suver, Cliona Molony, Stacey Melquist, Andrew D Johnson, Guoping Fan, David J Stone, Eric E Schadt, Patrizia Casaccia, Valur Emilsson, Jun Zhu

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Synthesis of 19-Norsteroids V: 13-Aminosteroids by D.B.R. Johnston, F.S. Waksmunski, T.B. Windholz

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3,5-Dimethoxyhomophthalic Acid and its Transformation to Intermediates in Mold Metabolite Syntheses by H.L. Slates, S. Weber, N.L. Wendler

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Rearrangement in the Estrone Series by R.D. Hoffsommer, D. Taub, N.L. Wendler

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Discovery of Antibodies Against Endemic Coronaviruses with NGS-Based Human Fab Phage Display Platform by Oscar Chi-Chien Pan, Sean Miller, Ruchin Patel, Shreya Mukhopadhyay, Giancarlo Sarullo, Gwenny Go, Jennifer Galli, Jamie Hessels, Barbara Schlingmann-Molina, Emmanuel Ndashimye, Zhiyun Wen, Christopher Warren, Eberhard Durr, Lan Zhang, Kalpit A. Vora, Arthur Fridman, Zhifeng Chen

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A High-Throughput and Robust Relative Potency Assay Measuring Human Cytomegalovirus Infection in Epithelial Cells for Vaccine Development by Nicole M. Smiddy, Nisarg Patel, Matthew C. Troutman, Kristine M. Kearns, Zachary P. Davis, Christopher S. Adams, Carl Hofmann, Donald J. Warakomski, Harrison Davis, Daniel Spatafore, Adam Kristopeit, Pete DePhillips, John W. Loughney

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