Model for hepatitis C virus transmissions by Elamin H. Elbasha

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Efficacy and Safety of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting Transforming Growth Factor-β and Programmed Death-Ligand 1, Plus Chemotherapy in Patients With Stage... by Christian Rolfo, MD, PhD, Laurent Greillier, MD, PhD, Remi Veillon, MD, PhD, Firas Badin, MD, MBA, Francois Ghiringhelli, MD, PhD, Nicolas Isambert, MD, PhD, Astrid Paulus, MD, PhD, Surendra Pal Chaudhary, MD, Yulia Vugmeyster, PhD, Masashi Sato, MSc, Sandrine Hiret, MD, PhD

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Optimal Use of Raltegravir (Isentress®) in the Treatment of HIV-Infected Adults – Canadian Consensus Guidelines by Anita Rachlis, Jonathan B Angel, Marianne Harris, Stephen D Shafran, Rachel Therrien, Cécile Tremblay, Mark A Wainberg

“…Their goal was to develop guidance for Canadian HIV-treating physicians on the appropriate use of raltegravir (MK-0518, Isentress®, Merck Frosst Canada Inc) in HIV-infected adults.…”
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A phase III, randomized, controlled noninferiority trial to study the efficacy and safety of imipenem/cilastatin/relebactam (IMI/REL) vs piperacillin/tazobactam (PIP/TAZ) in patien... by Junjie Li, Feng Wei, Peng Xiang, Zhengang Tang, Lianshu Ding, Luke Francis Chen, Maria Losada, Zlatka Iamboliyska, Fang Sun, Mingfen Zhu, Xiaodan Guo, Xiaoling Du, Chang Chen, Christopher Bruno, Sandra Koseoglu, Katherine Young, Min Zhou, Jieming Qu

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The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial by Matthew Stephen Block, James Hugo Armstrong Clubb, Johanna Mäenpää, Santeri Pakola, Dafne Carolina Alves Quixabeira, Tatiana Kudling, Elise Jirovec, Lyna Haybout, Mirte van der Heijden, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Sini Raatikainen, Victor Arias, Saru Basnet, Nea Ojala, Teijo Pellinen, Annabrita Hemmes, Katja Välimäki, Annukka Pasanen, Tuomo Alanko, Daniel Adamo, Susan Ramadan, Jorma Sormunen, Juha Kononen, Julia Wanda Cohen, Michael Jon Chisamore, John Goldfinch, Suvi Sorsa, Riikka Havunen, Claudia Kistler, Aino Kalervo, Víctor Cervera-Carrascon, João Manuel dos Santos, Akseli Hemminki

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Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37) by Z. Razzaque, D. Shaw, M. Bock, L. Maskell, J. Pickard, D. Sirinathsinghji, J. Longmore

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Metrology of metasurfaces: optical properties by Nicolas Kossowski, Yanel Tahmi, Amir Loucif, Martin Lepers, Benoit Wattellier, Guillaume Vienne, Samira Khadir, Patrice Genevet

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Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up by Jácome Bruges-Armas, Bruno F. Bettencourt, Ana R. Couto, Manuela Lima, Ana M. Rodrigues, Nathan Vastesaeger, Matthew A. Brown

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Real-world ePRO use and clinical outcomes using electronic patient-reported symptom monitoring for patients with advanced non-small-cell lung cancer receiving first-line pembrolizu... by L. Johnetta Blakely, Sabine Oskar, Ian Kudel, Ashley Roush, Zoya Shamsi, Toni Perry, Annette Christianson, Brittni Smith, Thomas Burke

Application of HPLC with ELSD Detection for the Assessment of Azelaic Acid Impurities in Liposomal Formulation by Stanislaw Han, Katarzyna Karlowicz-Bodalska, Dorota Szura, Lukasz Ozimek, Witold Musial

“…A chromatographic column from Merck (Purospher Star RP C18, 250–4 mm (5 μm) was used in the assay, and the mobile phase gradient consisted of three phases: A—methanol : water (5 : 95) + 1.5% (v/v) acetic acid; B—water : methanol (5 : 95) + 1.5% (v/v) acetic acid; and C—chloroform. …”
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X-Ray Computed Tomography: Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments by C. Bendtsen, M. Kietzmann, R. Korn, P. D. Mozley, G. Schmidt, G. Binnig

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Advancing the development of real-world data for healthcare research in China: challenges and opportunities by Jun Zhang, Eric Wu, Jia Zhong, Honghao Fang, Larry Liu, Jipan Xie

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Boundary Layer of Photon Absorption Applied to Heterogeneous Photocatalytic Solar Flat Plate Reactor Design by Héctor L. Otálvaro-Marín, Miguel Angel Mueses, Fiderman Machuca-Martínez

“…Six different commercial brands of titanium dioxide were studied: Evonik-Degussa P-25, Aldrich, Merck, Hombikat, Fluka, and Fisher. The local volumetric rate of photon absorption (LVRPA) inside the reactor was described using six-flux absorption-scattering model (SFM) applied to solar radiation. …”
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On the Use of Min-Max Combination of Biomarkers to Maximize the Partial Area under the ROC Curve by Hua Ma, Susan Halabi, Aiyi Liu

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Tenidap sodium inhibits secretory non-pancreatic phospholipase A2 synthesis by foetal rat calvarial osteoblasts by W. Pruzanski, B. P. Kennedy, H. van den Bosch, E. Stefanski, M. Wloch, P. Vadas

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Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation by Meritxell Boada-Pérez, Meritxell Boada-Pérez, Meritxell Boada-Pérez, Cristina Berastegui, Cristina Berastegui, Cristina Berastegui, Marta Erro, Marta Erro, Piedad Ussetti, Elena Crespo, Elena Crespo, Laura Donadeu, Laura Donadeu, Oriol Bestard, Oriol Bestard, Oriol Bestard, Gabriel Anguera, Amparo Solé, Ricardo Ponz Mir, Brian Molloy, Eva Revilla-López, Eva Revilla-López, Víctor Monforte, Víctor Monforte, Víctor Monforte, Susana Gómez-Ollés, Susana Gómez-Ollés, Susana Gómez-Ollés

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Understanding human papillomavirus vaccine response and efficacy in people living with HIV: A systematic mixed studies review and meta-analysis. by Alvine M Akumbom, Alanna J Bergman, Howard Strickler, Chakra Budhathoki, Manka Nkimbeng, Raeven Grant, Nancy R Reynolds, Kawsar R Talaat

“…The mean difference in GMT for HPV18 between PWH and PWoH was -536.23 (95% CI: -830.66, -241.81); approximately 22 times higher than HPV18 seropositivity cut-offs, assuming milli-Merck Units per milliliter. Risk factors for incident or persistent infections in PWH included: failure to seroconvert after vaccination, baseline CD4+ T-cell count <500 cells/mm3, early age of sexual debut, HIV viral load ≥ 400 copies/mL. …”
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Evaluation of the Content Validity of the COVID-19 Symptoms Daily Diary by Dine J, Guan Y, Milien M, Ervin C, Byrne DD, Brown ML, De Anda C, Norquist JM

“…Jennifer Dine,1 Yanfen Guan,2 Mirline Milien,1 Claire Ervin,1 Dana D Byrne,2 Michelle L Brown,2 Carisa De Anda,2 Josephine M Norquist2 1RTI Health Solutions, Research Triangle Park, Durham, NC, USA; 2Merck & Co., Inc., Rahway, NJ, USACorrespondence: Jennifer Dine, Patient-Centered Outcomes Assessment, RTI Health Solutions, 3040 E Cornwallis Road, Research Triangle Park, Durham, NC, 27709, USA, Email jdine@rti.orgIntroduction: The COVID-19 Symptoms Daily Diary (CSDD) is a patient-reported outcome measure designed to assess the severity of core COVID-19 symptoms in clinical trials. …”
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СТРУКТУРООБРАЗУЮЩИЕ СВОЙСТВА САПОНИНСОДЕРЖАЩИХ ПИЩЕВЫХ СИСТЕМ by Елена Николаевна Артемова, Кристина Владимировна Власова

“…Для исследования были выбраны тритерпеновые сапонины (фирмы Merck и сапонин из конских каштанов), которые имеют в качестве агликона олеаноловую кислоту, которая обуславливает антимикробный, противораковый, гепатопротекторный, антиоксидантный, гиполипидемический и другие эффекты. …”
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Validation of Mortality Data Sources Compared to the National Death Index in the Healthcare Integrated Research Database by Jamal-Allial A, Sponholtz T, Vojjala SK, Paullin M, Papazian A, Eshete B, Mahmoudpour SH, Verpillat P, Beachler DC

“…Aziza Jamal-Allial,1 Todd Sponholtz,1 Shiva K Vojjala,2 Mark Paullin,2 Anahit Papazian,1 Biruk Eshete,2 Seyed Hamidreza Mahmoudpour,3 Patrice Verpillat,3 Daniel C Beachler2 1Safety & Epidemiology, Carelon Research, Newton, MA, USA; 2Safety & Epidemiology, Carelon Research, Wilmington, DE, USA; 3Merck Healthcare KGaA, Darmstadt, GermanyCorrespondence: Daniel C Beachler, Carelon Research, 123 Justison Street, Suite 200, Wilmington, DE, 19801, USA, Email Daniel.beachler@carelon.comBackground: The National Death Index (NDI) is the gold standard for mortality data in the United States (US) but has a time lag and can be operationally intensive. …”
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