Montelukast as Add-On Therapy with Inhaled Corticosteroids or Inhaled Corticosteroids and Long-Acting Beta-2-Agonists in the Management of Patients Diagnosed with Asthma and Concur... by Paul K Keith, Caroline Koch, Michel Djandji, Jacques Bouchard, Eliofotisti Psaradellis, John S Sampalis, R Robert Schellenberg, R Andrew McIvor

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PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells by Kimiyoshi Yano, Megumi Kato, Syoju Endo, Taichi Igarashi, Ryoga Wada, Takashi Kohno, Astrid Zimmermann, Heike Dahmen, Frank T. Zenke, Bunsyo Shiotani

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Establishing a new human pneumococcal standard reference serum, MPRSS-01 by Joseph M. Antonello, Rocio D. Murphy, Chitrananda Abeygunawardana, Juliana C. Malinverni, Rajam Gowrisankar, Tina Green, Rebecca Greway, Jenna Schmauch, Adrienne Howlett, Cyrille J. Bonhomme, Katrina M. Nolan

“…Antibody concentrations to 33 pneumococcal serotypes were assigned in a new Merck Pneumococcal Reference Serum Standard (MPRSS-01; Merck Pneumococcal Reference Serum Standard) using the pneumococcal electrochemiluminescence assay. …”
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Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infecti... by Laia Alemany, Marisa Felsher, Anna R. Giuliano, Tim Waterboer, Haitham Mirghani, Hisham Mehanna, Craig Roberts, Ya-Ting Chen, Núria Lara, Mark Lynam, Mayara Torres, Montse Pedrós, Emilio Sanchez, Jacque Spitzer, Bradley Sirak, Beatriz Quirós, Gema Carretero, Sonia Paytubi, Edith Morais, Miquel Angel Pavón

“…Funding: Funding for this research was provided by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA.…”
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Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India by Mathew John, Ekaterina Koledova, Kanakatte Mylariah Prasanna Kumar, Harshal Chaudhari

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Update on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes by Kerstin MG Brand, Ulrike Gottwald-Hostalek, Aimee Andag-Silva

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Dietary Fiber: Chemistry, Structure, and Properties by Qingbin Guo, Ji Kang, Yanjie Bai, Feng Xu

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Understanding the factors that shape vaccination ecosystem resilience: a qualitative assessment of international expert experiences and perspectives by Suepattra May, Meaghan Roach, Melissa Maravic, Rachel Mitrovich, Rozanne Wilson, Nadya Prood, Amanda L Eiden

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Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

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Montelukast as an Alternative to Low-Dose Inhaled Corticosteroids in the Management of Mild Asthma (The SIMPLE Trial): An Open-Label Effectiveness Trial by R Andrew McIvor, Alan Kaplan, Caroline Koch, John S Sampalis

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Distribution of Receptor Activity Modifying Protein (RAMP) mRNAS in the Rat Central Nervous System by K. R. Oliver, A. M. Kinsey, N. Keyvan-Fouladi, R. Heavens, A. Wainwright

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Administration and Monitoring Burden of High-Efficacy Disease-Modifying Therapies for Multiple Sclerosis: A Delphi Consensus of Clinical Experts from Saudi Arabia by Seraj Makkawi, Ahmad Abulaban, Yaser Al Malik, Ebtesam Alshehri, Ahmed Althobaiti, Salman Aljarallah, Ahmed Elboghdady, Lynn AlHajjar, Sahar Shami, Saeed Bohlega, Mohammed Aljumah

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Antibody Response in Seropositive Multiple Sclerosis Patients Vaccinated with Attenuated Live Varicella Zoster Virus by RT Ross, MR Dawood, Mary Cheang, Lindsay E Nicolle

“…OBJECTIVE: To determine the safety and effectiveness of live attenuated varicella zoster virus (VZV) vaccine (OKA/Merck) on 50 patients with chronic progressive multiple sclerosis (MS), based on the hypothesis that VZV might be the antigen or antigen mimic of MS plus the fact that repeated high antigen doses have produced ‘antigen paralysis’ in experimental allergic encephalomyelitis mice.…”
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Montelukast as Add-On Therapy to Inhaled Corticosteroids in the Management of Asthma (The SAS Trial) by J Mark FitzGerald, Sylvain Foucart, Stephen Coyle, John Sampalis, Denis Haine, Eliofotisti Psaradellis, R Andrew McIvor

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The Costs of Implementing the 1999 Canadian Asthma Consensus Guidelines Recommendation of Asthma Education and Spirometry for the Family Physician by Susan P Corrigan, David L Cecillon, Don D Sin, Heather M Sharpe, Elaine M Andrews, Robert L Cowie, SF Paul Man

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Towards Excellence in Asthma Management: Final Report of an Eight-Year Program Aimed at Reducing Care Gaps in Asthma Management in Quebec by Louis-Philippe Boulet, Eileen Dorval, Manon Labrecque, Michel Turgeon, Terrence Montague, Robert L Thivierge

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Sugammadex-Associated Hypotension, Bradycardia, Asystole, and Death by Kazim Mirza, Kathryn Landoski, Dilip Thakar, Jagtar Heir-Singh, Timothy Jackson, Cynthia Kassab

“…On December 16, 2015, the Food and Drug Administration (FDA) in the United States approved sugammadex (Bridion, Merck and Co), a modified gamma-cyclodextrin, to be used as a reversal agent. …”
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Pharma TARP: A Troubled Asset Relief Program for Novel, Abandoned Projects in the Pharmaceutical Industry by Tamas Bartfai, Graham Vaughan Lees

“…Within days of each other, Pfizer, Merck, and GlaxoSmithKline announced that they will focus on a few therapeutic areas only and abandon others entirely. …”
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Single-Dose Infliximab in Hepatitis C Genotype 1 Treatmentnaive Patients with High Serum Levels of Tumour Necrosis Factor-Alpha Does Not Influence the Efficacy of Pegylated Interfe... by Curtis Cooper, Stephen Shafran, Susan Greenbloom, Robert Enns, John Farley, Nir Hilzenrat, Kurt Williams, Magdy Elkashab, Nabil Abadir, Manuela Neuman

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Uma auditoria confiável adiciona valor? by Ricardo D. Brito, Eduardo P. Peres

“…Examinamos especificamente o impacto no valor de mercado dos clientes das 5 Grandes, cobrindo eventos de 2002 nos quais os procedimentos de auditoria de uma delas e sua independência encontravam-se sob escrutínio: Omnicon, Merck, WorldCom, Qwest, Xerox, Bristol Meyers, Duke Energy, El Paso e AOL. …”
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