Long term cost-effectiveness analysis of IDegLira in the treatment of type 2 diabetes patients compared to GLP-1RA added to basal insulin after IDegLira entered the national reimbu... by Dunming Xiao, Junling Weng, Lei Zhang, Chang Xing, Yan Wei, Yingyao Chen

“…The cost includes glucose-lowering medication, background treatment cost, and complication treatment costs. …”
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Association between polypharmacy and falls in older adults: a longitudinal study from England by Nafeesa N Dhalwani, Melanie J Davies, Kamlesh Khunti, Harini Sathanapally, Radia Fahami, Sam Seidu

“…Further exploration of the effects of these complex drug combinations in the real world with a detailed standardised assessment of polypharmacy is greatly required along with pragmatic studies in primary care, which will help inform whether the threshold for a detailed medication review should be lowered.…”
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Hydroxocobalamin for the treatment of vasoplegia after lung transplantation: A case series by Anh Nguyen, MD, PhD, Rima Bouajram, PharmD, Marek Brzezinski, MD, Sahand Hassanipour, David Gordon, Binh Trinh, MD, Tobias Deuse, MD, Aida Venado, MD, Steve Hays, MD, Jonathan Singer, MD, Jasleen Kukreja, MD, MPH

“…Patient #3 developed methemoglobinemia and a medication-related false increase in triglycerides. …”
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Design, theoretical approaches and new framework of pyrazolo[3,4-d]pyrimidine as potent anticancer agents: Efficient synthesis, ADME-T and molecular docking by Peduri Suresh Reddy, Thuraka Sekhar, Pinnu Thriveni, Gandla Mahesh Kumar, Allaka Tejeswara Rao, Mohammad Raish, Tota Giridhar, Gudipati Srinivasulu

“…With IC50 values of 2.49 ± 1.9, 1.56 ± 1.3, and 2.97 ± 2.6 μM against Caco-2, HCT116, and A549 cell lines, respectively, compound 7f demonstrated the strongest anticancer properties among all synthesised compounds when compared to the conventional medication doxorubicin (IC50 = 3.10 to 3.32 μM). Additionally, the anchoring function of the 1,3,4-thiadiazole-substituted pyrazolo[3,4-d]pyrimidine moiety in interacting with anticancer targets and hydrophobic interaction with the essential amino acid residues has been highlighted by molecular modeling studies. …”
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The integration of hospital pharmacists into primary care settings in Shenzhen, China: a qualitative study by Zhiling Deng, Pengxiang Zhou, Yiting Lu, Zhengrong Li, Mi Yao, Yang Li, Chuan Zou, Haixin Li, Songtao Cai, Yi Guo, Yuling Tong, Yang Zhao, Zhijie Xu

“…Hospital pharmacists mainly conduct medication reviews and consultations in clinics or pharmacies of CHCs and engage in home visits with GPs in a few cases. …”
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Model Prognosis Masa Pengobatan Pasien Tuberkulosis Dengan Metode C4.5 by Rusdah Rusdah, Brian Agni Bregastantyo

“…The patient's habit factor and the patient's time to take medication must be closely monitored so that the treatment period can be shortened. …”
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Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK by Tim Doran, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Siobhan Reilly, Claire Planner, Ivan Olier, Linda Gask

“…We calculated the prevalence of SMI by UK country, English region and deprivation quintile, antipsychotic and antidepressant medication prescription rates for people with SMI, and prevalence rates of common comorbidities in people with SMI compared with people without SMI.Design Retrospective cohort study from 2000 to 2012.Setting 627 general practices contributing to the Clinical Practice Research Datalink, a UK primary care database.Participants Each identified case (346 551) was matched for age, sex and general practice with 5 randomly selected control cases (1 732 755) with no diagnosis of SMI in each yearly time point.Outcome measures Prevalence rates were calculated for 16 conditions.Results SMI rates were highest in Scotland and in more deprived areas. …”
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Valproic acid targets IDH1 mutants through alteration of lipid metabolism by Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi, Yue Qin, Alvaro G. Alvarado, Brandon Gruender, Haocheng Qi, Tie Li, Albert Lai, Maria G. Castro, Pedro R. Lowenstein, Matthew C. Garrett, Harley I. Kornblum

“…In this study, we show that valproic acid (VPA), a brain penetrant anti-seizure medication and histone deacetylase inhibitor, inhibits the growth of IDH1 mutant tumors in vivo and in vitro, with at least some selectivity over IDH1 wild-type tumors. …”
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NUDT21 regulates lysyl oxidase-like 2(LOXL2) to influence ECM protein cross-linking in silica-induced pulmonary fibrosis by Lan Peng, Wenqing Sun, Demin Cheng, Xinying Jia, Wenxiu Lian, Ziwei Li, Haojie Xiong, Ting Wang, Yi Liu, Chunhui Ni

“…Currently, there is no specific medication available for the treatment of silicosis. …”
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Effect of periodontal therapy on endothelial function and serum biomarkers in patients with periodontitis and established cardiovascular disease: a pilot study by Ana Molina, Nagore Ambrosio, María Molina, Eduardo Montero, Leire Virto, David Herrera, Elena Figuero, Mariano Sanz

“…Demographic characteristics, cardiovascular risk factors, history of cardiovascular diseases, medication intake, lipids profile, blood pressure, and periodontal outcomes were also evaluated. …”
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Long-term results of irritable bowel syndrome treatment by A. I. Ulyanin, Yu. M. Poluektov, Ye. A. Poluektova, Ch. S. Pavlov, V. T. Ivashkin

“…To estimate duration of remission of irritable bowel syndrome after treatment by multistrain probiotic drug, motility regulator or antispasmodic medication. Material and methods. Original study included overall 87 patients with irritable bowel syndrome (IBS) or IBS in combination with functional dyspepsia (FD) in whom the diagnosis was confirmed according to compliance of symptoms to the Rome-III criteria and absence of organic diseases according to laboratory and instrumental investigation. …”
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Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma by Yue Dai, Hongchen Li, Shiyin Fan, Kai Wang, Ziyi Cui, Xinyu Zhao, Xue Sun, Mingen Lin, Jiaxi Li, Yi Gao, Ziyin Tian, Hui Yang, Bingbing Zha, Lei Lv, Yanping Xu

“…Here, we demonstrate that dimethyl fumarate (DMF), an approved medication for multiple sclerosis [1] and psoriasis, can inhibit the proliferation of ccRCC cells. …”
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Peer-assisted telemedicine hepatitis-C treatment for people who use drugs in rural communities: a mixed methods study by Kim Hoffman, Gillian Leichtling, Sarah Shin, Andrew Seaman, Tonhi Gailey, Hunter C. Spencer, P. Todd Korthuis

“…Peer Support Specialists (peers) conducted HCV screening in the community, facilitated pretreatment evaluation and linkage to telemedicine HCV treatment clinicians, and supported Peer TeleHCV study participants in HCV medication adherence. A qualitative investigation queried telemedicine clinicians and peers about their experiences with the implementation of the model and key drivers of implementation effectiveness. …”
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Which patients received a ReSPECT form, what was documented and what were the patient outcomes? A protocol for a retrospective observational study investigating the impact of the C... by Lucy Selman, Charlotte Chamberlain, Adam McDermott, Claire A Woodall, Lucy Victoria Pocock

“…These include emergency department attendances, emergency hospital admissions, community nurse home visits, hospice referrals, anticipatory medication prescribing, place of death and if the patient died in preferred place of death.Ethics and dissemination Approval has been obtained from a National Health Service Research Ethics Committee (20/YH/0185). …”
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E-Cigarette Use and Use of Evidence-Based Smoking Cessation Methods Among American Indian Cigarette Smokers: A Cross-Sectional Analysis by Ashley L. Comiford, DrPH, Dorothy A. Rhoades, MD, MPH, Justin D. Dvorak, PhD, Kai Ding, PhD, Noah Collins, Alexandra L. Blair, Mark P. Doescher, MD, MSPH

“…A larger study is needed to determine whether individuals who use E-cigarettes are also more likely to have tried prescription medication for smoking cessation. Whether E-cigarette use impedes or encourages the use of evidence-based cessation methods is unknown.…”
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KMS (Knowledge Management System) Obat Ibu Hamil Berbasis Android by Halimah Tus Sadiah, Muhamad Saad Nurul Ishlah, Nyayu Siti Aminah Lily Elfrieda, Mauladani Adi Gasbara

“…Sometimes this results in the decision to take medication without a prescription from a doctor or midwife. …”
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Treatment of autonomous intestinal neuropathy in critical care by prucalopride and multistrain probiotic by A. L. Kovaleva, A. I. Ulyanin, O. Yu. Kiselyova, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, V. T. Ivashkin

“…Combination of prokinetic drug (prucalopride) and multistrain probiotic medication (Bifidobacterium bifidum, B. longum, B. infantis, Lactobacillus rhamnosus) can be effective in the treatment of autonomous intestinal neuropathy in critical care.…”
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Pre-exposure Prophylaxis Awareness and Endorsement among Adolescents and Young Adults in Tanzania: Insights from the 2022 Demographic and Health Survey by Alpha Johnson Kapola, Rahma Musoke, Glenda Marie Manayon, Hassan Fredrick Fussi, Hafidha Mhando Bakari, Haji Mbwana Ally, Swalehe Mustafa Salim, Zuhura Mbwana Ally, Lynn Moshi, Mariam Salim Mbwana, Habib Omari Ramadhani

“…Participants were asked whether they had ever heard of daily medication to prevent HIV (PrEP) and whether they approved of daily PrEP use. …”
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Supporting primary care clinicians in caring for patients with alcohol use disorder: study protocol for Records for Alcohol Care Enhancement (RACE), a factorial four-arm randomized... by Kara M. Magane, Richard Saitz, Sarah Fielman, Marc R. LaRochelle, Christopher W. Shanahan, Christine A. Pace, Michael LaValley, Kaley Penington, Skylar Karzhevsky, Emily Hurstak

“…PCPs assigned to receive CCM support will receive CCM facilitation of AUD treatment processes including medication counseling, referrals, and support through direct patient interactions. …”
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Prevalence of risk factors for coronary artery disease in an urban Indian population by S Singh, M Singh, S K Singh, R Aggarwal, T Sekhri, R S Kanwar, R Wilfred, P Chugh, M Chhillar, Y K Sharma, J Sethi, J Sundriyal, K Bhadra, N Rautela, Tek Chand

“…All selected individuals were subjected to a detailed questionnaire, medical examinations and anthropometric measurements. …”
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