Cosmetic Outcome Assessment following Breast-Conserving Therapy: A Comparison between BCCT.core Software and Panel Evaluation by Max Hendrik Haloua, Nicole Marianna Alexandra Krekel, Gerrit Johannes Albertus Jacobs, Barbara Zonderhuis, Mark-Bram Bouman, Marlon Eugène Buncamper, Franciscus Bernardus Niessen, Henri Adolf Hubert Winters, Caroline Terwee, Sybren Meijer, Monique Petrousjka van den Tol

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Altered Left Ventricular Ion Channel Transcriptome in a High-Fat-Fed Rat Model of Obesity: Insight into Obesity-Induced Arrhythmogenesis by Reza Ashrafi, Marianne Yon, Lucy Pickavance, Joseph Yanni Gerges, Gershan Davis, John Wilding, Kun Jian, Henggui Zhang, George Hart, Mark Boyett

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Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis by Shixuan Liu, Ceryl Tan, Chloe Melo-Gavin, Miriam B Ginzberg, Ron Blutrich, Nish Patel, Michael Rape, Kevin G Mark, Ran Kafri

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Formation of the Figge Maar Seafloor Crater During the 1964 B1 Blowout in the German North Sea by Jens Karstens, Jens Schneider von Deimling, Christian Berndt, Christoph Böttner, Michel Kühn, Benedict T. I. Reinardy, Axel Ehrhardt, Jonas Gros, Bettina Schramm, Dirk Klaeschen, Judith Elger, Matthias Haeckel, Mark Schmidt, Sven Heinrich, Philipp Müller, Frithjof Bense

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Spatiotemporal evolution and driving force analysis of drought characteristics in the Yellow River Basin by Meiying Wang, Yangbo Chen, Jingyu Li, Yanjun Zhao

“…The results indicate: Precipitation changed markedly around 2000, decreasing by 17.1 mm/10 yr before 2000, and increasing by 43.8 mm/10 yr thereafter. …”
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Calm ocean, stormy sea: atmospheric and oceanographic observations of the Atlantic during the Atlantic References and Convection (ARC) ship campaign by L. Köhler, L. Köhler, J. Windmiller, D. Baranowski, M. Brennek, M. Ciuryło, L. Hayo, D. Kȩpski, S. Kinne, B. Latos, B. Lobo, T. Marke, T. Nischik, D. Paul, P. Stammes, A. Szkop, O. Tuinder

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Cytoreductive Nephrectomy and Nephrectomy/Complete Metastasectomy for Metastatic Renal Cancer by Paul Russo, Mark Synder, Andrew Vickers, Varuni Kondagunta, Robert Motzer

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Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist by Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson

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Metabolome and transcriptome analysis reveal the pigments biosynthesis pathways in different color fruit peels of Clausena lansium L. Skeels by Zhichang Zhao, Mark Owusu Adjei, Ruixiong Luo, Huaping Yu, Yali Pang, Jian Wang, Yu Zhang, Jun Ma, Aiping Gao

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A Blueprint for the Problem Formulation Phase of EPA-Type Ecological Risk Assessments for 316(b) Determinations by Webster Van Winkle, William P. Dey, Steve M. Jinks, Mark S. Bevlhimer, Charles C. Coutant

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S’unir au Prophète. L’expérience matérielle, esthétique et dévotionnelle du Dalā’il al-Khayrāt au Maroc. Approches codicologique et anthropologique by Hiba Abid, Anouk Cohen

“…The figure of al-Jazūlī emerged in a context marked by deep political, social and religious agitation in Morocco, the causes of which go back to the beginning of the 9th/15th century. …”
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Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen by Mark Hutchinson, Jeffrey A. Ruffolo, Nantaporn Haskins, Michael Iannotti, Giuliana Vozza, Tony Pham, Nurjahan Mehzabeen, Harini Shandilya, Keith Rickert, Rebecca Croasdale-Wood, Melissa Damschroder, Ying Fu, Andrew Dippel, Jeffrey J. Gray, Gilad Kaplan

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Catalysing change in health and medical research policy: an Australian case study of deliberative democracy to reform sex and gender policy recommendations by Sue Haupt, Cheryl Carcel, Lily Halliday, Saraid Billiards, Lyn Carson, Kyle Redman, Scott Lappan-Newton, Karin R. Aubrey, Xander Bickendorf, Jane E. Bourke, Michael Buchert, Jessica Da Gama Duarte, Ayan Dasvarma, Thomas F. E. Drake-Brockman, Thomas F. E. Drake-Brockman, Thomas F. E. Drake-Brockman, Thomas F. E. Drake-Brockman, Kerryn Drysdale, Stephen C. C. Dymock, Laura N. Eadie, Laura N. Eadie, Melanie Eckersley-Maslin, Melanie Eckersley-Maslin, Melanie Eckersley-Maslin, Moritz Falk Eissmann, James Fazio, Bridget G. Haire, Melinda Holder, Nicole Kleppe, Ken Knight, Jonathan Mauclair, Celine Northcott, Brian G. G. O. Oliver, Tracy A. O'Mara, Ken Pang, Steven Philpot, Tertia D. Purves-Tyson, Jacob Stewart-Olsen, Lauren Ursich, Natalia Vukelic, Marina H. Yakou, Bronwyn Graham, Bronwyn Graham, Severine Lamon, Rachel Huxley, Kelly Thompson, Kelly Thompson, Keziah Bennett-Brook, Christine Jenkins, Christine Jenkins, Zoe Wainer, Zoe Wainer, Mark Woodward, Mark Woodward, Louise Chappell, Robyn Norton, Robyn Norton

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Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms and Coronary Heart Disease by Jean Dallongeville, Carlos Iribarren, Jean Ferrières, Liisa Lyon, Alun Evans, Alan S. Go, Dominique Arveiler, Stephen P. Fortmann, Pierre Ducimetière, Mark A. Hlatky, Philippe Amouyel, Audrey Southwick, Thomas Quertermous, Aline Meirhaeghe

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Predicting Axillary Lymph Node Metastasis in Young Onset Breast Cancer: A Clinical-Radiomics Nomogram Based on DCE-MRI by Dong X, Meng J, Xing J, Jia S, Li X, Wu S

“…Precisely forecasting axillary lymph node metastasis (ALNM) is essential for customizing treatment plans and enhancing patient results.Objective: This research sought to create and verify a clinical-radiomics nomogram that combines radiomic features from Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) with standard clinical predictors to improve the accuracy of predicting ALNM in young breast cancer patients.Methods: We performed a retrospective analysis at one facility, involving the creation and validation of a nomogram in two stages.At first, a medical model was developed utilizing conventional indicators like tumor dimensions, molecular classifications, multifocal presence, and MRI-determined ALN status.A more detailed clinical-radiomics model was subsequently developed by integrating radiomic characteristics derived from DCE-MRI images.These models were created using logistic regression analyses on a training dataset, and their effectiveness was assessed by measuring the area under the receiver operating characteristic curve (AUC) in a separate validation dataset.Results: The clinical-radiomics nomogram surpassed the clinical-only model, recording an AUC of 0.892 in the training dataset and 0.877 in the validation dataset.Significant predictors included MRI-reported ALN status and select radiomic features, which markedly enhanced the model’s predictive capacity.Conclusion: Integrating radiomic features with clinical predictors in a nomogram significantly improves ALNM prediction in young onset breast cancer, providing a valuable tool for personalized treatment planning. …”
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Optimization design of an acoustic cover layer for a cylindrical cavity based on porous materials by Bohan ZHANG, Jili RONG, Xiuyan CHENG

“…Results showed a significant enhancement in the absorption performance, with a marked increase in the absorption coefficient across a broad frequency range. …”
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Applying Focal Therapy to Lesions Detected via Magnetic Resonance Imaging: Delivering Cancer Ablation Beyond the Visibility Phenomenon by Clement Orczyk, Teresa Marsden, Francesco Giganti, Joseph M. Norris, Santosh Waigankar, Louise Dickinson, Shonit Punwani, Alex Kirkham, Alex Freeman, Aiman Haider, Caroline M. Moore, Arnauld Villers, Clare Allen, Mark Emberton

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Save a trip: Clinical outcomes of cardiac allografts recovered by local surgeons compared to recipient center surgeons. by Awab Ahmad, MD, Timothy R. Harris, MD, Aaron Williams, MD, Alexandra DeBose-Scarlett, MD, Rubayet Kamal, BS, Enock Atta Adjei, MD, Hasan K. Siddiqi, MD, Chen Chia Wang, Mark Petrovic, Clifton D. Keck, Shelley R. Scholl, RN, Ashish S. Shah, MD, Swaroop Bommareddi, MD, Brian Lima, MD MBA, John M. Trahanas, MD

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Elevated Circulating Adipocyte-Fatty Acid Binding Protein Levels Predict Incident Ischemic Cardiovascular Events in a Longitudinal and Prospective AMI Aging Study by Zhao X, Zhao H, Chen R, Zhou J, Li N, Li J, Yan S, Liu C, Zhou P, Chen Y, Song L, Yan H

“…Initially, participants were stratified into three groups according to the tertile levels of FABP4, followed by further categorization based on various lipid profiles and specific inflammatory markers.Results: On follow-up (median 751 days, maximum 1506 days), a total of 158 ischemic events were recorded. 1) In multivariable models meticulously adjusted for age, gender, traditional coronary heart disease factors, Killip classification, and discharge medications, the association of elevated levels of FABP4 (Tertile 3 HR 1.618 [1.061 to 2.468], p=0.026), augmented concentrations of PTX3 (Tertile 3 HR 1.811 [1.211 to 2.710], p=0.004), or LL-37 (Tertile 3 HR 0.651 [0.433 to 0.981], p=0.040) with ischemic risk was markedly intensified. 2) Multivariate HRs associated with 1 standard deviation (SD) (mg/dL) increase in the FABP4 parameters were as follows in different subgroups. 1-SD difference in FABP4 was associated with a 23%, 23%, 21 and 29% increase in ischemic events over after fully adjusted the confounding risk factors among male, patients with hyperlipidemia, hypertension and diabetes respectively. 3) The Kaplan-Meier curve demonstrated significant differences between the tertiles of FABP4 index levels among all enrolled participants (p=0.0180).Conclusion: This study reinforces the utility of FABP4 for enhancing risk stratification specifically among older patients diagnosed with ST-elevation myocardial infarction.Keywords: FABP4, lipid profile, PTX3, LL-37, ischemic vascular events…”
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Endothelial Dysfunction and Oxidative Stress in Patients with Severe Coronary Artery Disease: Does Diabetes Play a Contributing Role? by Alexandra Maria Boieriu, Cezar Dumitrel Luca, Carmen Daniela Neculoiu, Alina Bisoc, Diana Țînț

“…The most important finding of the present study is that circulating 5-HT levels are markedly influenced by T2DM. 5-HT receptor-targeted therapy might be of interest in patients undergoing CABG, but further studies are needed to confirm this hypothesis.…”
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