The mcpC mutant of Salmonella enteritidis exhibits attenuation and confers both immunogenicity and protective efficacy in mice by Lu Zhang, Li Chen, Xuqiang Zhang, Yang Li, Qingfeng Zheng, Yun Li, Ning Li, Qiumei Shi, Yanying Zhang, Tonglei Wu

“…However, ΔmcpC showed significantly reduced survival under acidic, alkaline, thermal, and oxidative stress conditions; markedly diminished motility; weakened invasion of Caco-2 cells; and reduced intracellular survival in RAW264.7 macrophages. …”
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Assessment of in vitro skin permeation and accumulation of phenolic acids from honey and honey-based pharmaceutical formulations by Anna Nowak, Anna Muzykiewicz-Szymańska, Magdalena Perużyńska, Edyta Kucharska, Łukasz Kucharski, Karolina Jakubczyk, Paulina Niedźwiedzka-Rystwej, Justyna Stefanowicz-Hajduk, Marek Droździk, Juraj Majtan

“…Heather, linden and buckwheat honey samples significantly decreased cell viability at concentrations of 5% and 2.5%, while rapeseed honey sample markedly reduced fibroblast viability only at 5%. Among the tested formulations - pure honey, hydrogel, and emulsion - higher skin permeation and accumulation rates of phenolic acids were observed with the prepared honey-based hydrogels than with the pure honeys and emulsions. …”
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Patients’ Perspectives on the Preference for the Gender of Medical Professionals in Perioperative Care and Attitudes Toward Anaesthesiologists: A Cross-sectional Study by Usha Devi, Minnu Panditrao, Shilpa Bansal

“…Patients were asked questions from the proforma in their vernacular language and appropriate answers were marked on the questionnaire sheet. All collected data was recorded in a Microsoft Excel sheet and analysed using Microsoft Excel software. …”
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Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells by Liping Mai, Guodong He, Jing Chen, Jiening Zhu, Shaoxian Chen, Xinghua Hou, Hui Yang, Mengzhen Zhang, Yueheng Wu, Qiuxiong Lin, Min Yang, Xiaohong Li

“…Hypoxia induction for 12 hours in hBMSCs reduced CCND1 expression but promoted ROS production and cell apoptosis. Such effects were markedly reduced by the PI3K agonist, 740 Y-P, and attenuated by LY294002. …”
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Investigating the neuroprotective effects of Dracocephalum moldavica extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease by Marjan Talebi, Seyed Abdulmajid Ayatollahi, Mohammad Ali As’Habi, Farzad Kobarfard, Mona Khoramjouy, Farzaneh Niki Boroujeni, Mehrdad Faizi, Alireza Ghassempour

“…Alzheimer's disease (AD) is a progressive condition marked by multiple underlying mechanisms. Therefore, the investigation of natural products that can target multiple pathways presents a potential gate for the understanding and management of AD. …”
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The prognostic value of systemic immune-inflammation index in patients with unresectable hepatocellular carcinoma treated with immune-based therapy by Tian He, Bin Xu, Lu-Na Wang, Zi-Yi Wang, Huan-Chen Shi, Cheng-Jie Zhong, Xiao-Dong Zhu, Ying-Hao Shen, Jian Zhou, Jia Fan, Hui-Chuan Sun, Bo Hu, Cheng Huang

“…Univariate and multivariate logistic regression indicated that SII was a significant predictor of the objective response rate (ORR), which was markedly different between the low and high SII subgroups (34.72% vs. 9.52%, P = 0.019). …”
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The Effects of Different Challenge-Level Balance Tasks on Stroke Cortical Responses and Balance Assessment Using EEG by Rui Xu, Yu Bai, Jun Liang, Ningning Wang, Yongzheng He, Lin Meng, Dong Ming

“…Similarly, in the parietal lobe, stroke survivors showed markedly higher pdBSI (standing: p =0.006, perturbation: p=0.012) and lower GC (standing: p=0.030, perturbation: p=0.011). …”
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Calcium hydroxide nanoparticles induce cell death, genomic instability, oxidative stress and apoptotic gene dysregulation on human HepG2 cells by Hanan R. H. Mohamed, Esraa H. Ibrahim, Shahd E. E. Shaheen, Nesma O. E. Hussein, Ayman Diab, Gehan Safwat

“…Treatment with the IC50 concentration of Ca(OH)2NPs selectively induced significant DNA damage, excessive ROS generation, and marked dysregulation of apoptotic (p53 and Bax) and anti-apoptotic (Bcl-2) gene expression in HepG2 cells, triggering apoptosis. …”
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The prevalence and distribution of malaria in Mpumalanga Province before and during COVID-19 (2017 - 2022) by I Kleinhans, S Mahanjana, F Els, M Mabona, L A Pitso, G Malatje, G Kok, J Raman

“…Although COVID-19-related restrictions on human movement greatly reduced the malaria burden in Mpumalanga Province, the high-risk group (young mobile men) remained unchanged over the study period. Of concern were the marked reduction in the reporting of Coartem doses administered and the increased prevalence of asymptomatic carriage since 2020. …”
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Unusual hypertrophic cardiomyopathy: case report of an early onset wild-type ATTR amyloidosis accompanied by a chromosomal duplication involving the MYH6 and MYH7 gene by Jassin Hamidi, Yvonne Hanel, Sven Dittmann, Wanda Maria Gerding, Huu Phuc Nguyen, Karin Klingel, Eric Schulze-Bahr

“…While early onset wtATTR is an uncommon clinical finding, another significant clinical condition was identified in this patient, marked by an unusual copy number variation (CNV) in the genes MYH6 and MYH7.…”
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MLL4 regulates postnatal palate growth and midpalatal suture development by Jung-Mi Lee, Hunmin Jung, Bruno de Paula Machado Pasqua, Yungki Park, Qinghuang Tang, Shin Jeon, Shin Jeon, Soo-Kyung Lee, Jae W. Lee, Hyuk-Jae Edward Kwon

“…Immunofluorescence staining for osteochondral differentiation markers demonstrated a marked decrease in the chondrogenic marker COL2A1, while the expression of the osteogenic marker RUNX2 remained unchanged, in the Mll4-cKO midpalatal suture. …”
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Effects of Different Light Spectra on Oxidative Stress and Nutritional Quality of the Fish <i>Plectropomus leopardus</i> by Wensheng Li, Zheng Zhang, Baoliang Liu, Yingying Fang, Shuquan Cao, Wenyang Li, Yan Sun, Chengbin He, Chuanxin Zhang, Fan Fei

“…Thr, Glu, Cys, Val, Met, Ile, Leu, Phe, Lys, His, Arg were markedly higher in the blue light versus the red light group (<i>p</i> < 0.05). …”
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CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation by Donghua Cai, Chuling Li, Yingyuan Zhang, Sisi He, Yihai Guo, Wangjun Liao, Yulin Liao, Jianping Bin, Xiang He

“…Methods and Results CircHipk3 was markedly upregulated in aortic aneurysms compared with that in normal arteries. …”
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Influence of bottled salad dressings on the development of enamel erosion in the presence or absence of salivary pellicle – An in vitro study by Aishwarya Lakshmi Billa, Jagadeeswara Rao Sukhabogi, Dolar Doshi, Prashant Sharma, T.V.S. Subrahmanyam, Sasikala Jummala

“…On the other hand, regardless of the presence/absence of the salivary pellicle, a marked decrease in enamel hardness was observed among all groups except for group 3 (sandwich spread) with a mean score of 311.5 ± 82.6 (p < 0.05). …”
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Worldwide patterns and trends in ovarian cancer incidence by histological subtype: a population-based analysis from 1988 to 2017Research in context by Yi-Fan Wei, Li Ning, Yi-Lin Xu, Jing Ma, Dong-Run Li, Zan-Fei Feng, Fang-Hua Liu, Yi-Zi Li, He-Li Xu, Peng Li, Yong-Pei Yu, Dong-Hui Huang, Xiao-Ying Li, Song Gao, Chun-Qing Lin, Ting-Ting Gong, Qi-Jun Wu, Jing-He Lang

“…Findings: The incidence of OC displayed marked disparities across regions and Human Development Index (HDI), with the highest ASRs in Eastern and Central Europe and very high HDI regions, and the lowest in Africa, Asia, and medium HDI regions. …”
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Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice by Bing Li, Yu Cheng, Songyan Yu, Li Zang, Yaqi Yin, Jiejie Liu, Lin Zhang, Yiming Mu

“…Moreover, histological lesions in the liver diminished markedly, as evidenced by reduced lipid accumulation and attenuated hepatic steatosis. …”
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PU.1 alleviates the inhibitory effects of cigarette smoke on endothelial progenitor cell function and lung-homing through Wnt/β-catenin and CXCL12/CXCR4 pathways by Xue He⁺, Yanan Cui⁺, Tiao Li, Lijuan Luo, Zihang Zeng, Yiming Ma, Yan Chen

“…In emphysematous mice, PU.1 overexpression markedly reversed the decreased proportion of EPCs in BM and promoted the lung-homing of EPCs. …”
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Mechanism of salvianolic phenolic acids and hawthorn triterpenic acids combination in intervening atherosclerosis: network pharmacology, molecular docking, and experimental validat... by Qu Zhai, Shixi Shang, Zihan Zhang, Lihua Sun, Ying Huang, Shuyi Feng, Qian Wu, Haifeng Cui, Xiaolu Shi

“…The results from animal experiments demonstrated that atorvastatin and SHC markedly reduced the area of carotid plaque and downregulated the levels of TC and LDL-C in ApoE−/− mice. …”
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A Large-Scale Agricultural Land Classification Method Based on Synergistic Integration of Time Series Red-Edge Vegetation Index and Phenological Features by Huansan Zhao, Chunyan Chang, Zhuoran Wang, Gengxing Zhao

“…The study yielded three significant findings: (1) The synergistic application of NDRE₇₀₅ and PSRI significantly outperformed single-index approaches, demonstrating the effectiveness of our dual-index strategy; (2) The integration of SFPs and PFPs with time series REVI markedly enhanced feature discrimination at crucial growth stages, with PFPs showing superior capability in distinguishing agricultural land types through amplified phenological signatures; (3) Our optimal classification scheme (FC6), leveraging both enhanced spatial and phenological features, achieved remarkable accuracy (93.21%) with a Kappa coefficient of 0.9159, representing improvements of 4.83% and 0.0538, respectively, over the baseline approach. …”
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100% oxygen mobilizes stem cells and up-regulates MIF and APRIL in humans: a new point on the hormetic dose curve by Kent J. MacLaughlin, Gregory P. Barton, Julia E. MacLaughlin, Jacob J. Lamers, Matthew D. Marcou, Matthew J. O’Brien, Rudolf K. Braun, Marlowe W. Eldridge

“…The cytokines “macrophage migration inhibitory factor” (MIF) and “a proliferation inducing ligand” (APRIL) were significantly upregulated.ConclusionThis study demonstrates that 100% normobaric oxygen mobilizes stem cells and upregulates the expression of the inflammatory cytokines marking a new point on the low dose stimulation phase of the hormetic dose curve of oxygen.…”
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