Philosophical biography : some problems of conceptualization by Irina Polyakova

“…It shows that philosophical biography has a variety of features, which limit the applications of chronology, rubrication and other principles of organizing in a linear manner the material of a biography. In this context such notions as “life-course”, “trajectory”, and “life-course trajectory” are analyzed; and the grounds of the unity of biographical content are revealed.This article claims that the unity of biographical content is determined by the author’s philosophical worldview. …”
Get full text

Equative Constructions in the Laki Language by Parisa Najafi, Seyed Najm al-din Shahrokhi, Mohammad Hosseini

“…In equative constructions the comparison is based on a gradable property, where one of the referents has the property to a higher degree, while similative constructions compare the similarity in manner. This study explored the equative constructions in the Laki language by primarily relying on classification put forth by Haspelmath (2017). …”
Get full text

Reprogramming of Mice Primary Hepatocytes into Insulin-Producing Cells by Transfection with Multicistronic Vectors by Haizhao Luo, Rongping Chen, Rui Yang, Yan Liu, Youping Chen, Yi Shu, Hong Chen

“…These triple-transfected cells activated multiple beta-cell genes, synthesized and stored considerable amounts of insulin, and released the hormone in a glucose-regulated manner in vitro. Furthermore, when transplanted into streptozotocin-induced diabetic mice, the cells markedly ameliorated glucose tolerance. …”
Get full text

Factors Affecting Antenatal Corticosteroid Administration from the Obstetricians’ Viewpoint by Emel Kurtoğlu, Migraci Tosun, Ayşe Zehra Özdemir, Erdal Malatyalıoğlu

“…The indications for delivery, gestational week at administration, dosing, residence and manner of transfer of the patients to the tertiary center, and the interval between admission to hospital and delivery were evaluated. …”
Get full text

Impact of Ligand Structures on Precipitation Kinetics of Uranyl Nitrate Coordination Polymers with Diamide Linkers by Nojima Makito, Tsushima Satoru, Takao Koichiro

“…L2, L3, and L4 formed 1D coordination polymers [UO2(NO3)2(Lx)]n (x = 2-4) in a similar manner to the previously reported case of L1. In use of the cyclic diamides, L1 and L2, the precipitation formation started right after loading these precipitants, and rapidly proceeded. …”
Get full text

Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength by Rashad Amira A., El-Helaly Sara Nageeb, Abd El Rehim Randa T., El-Gazayerly Omaima N.

“…These problems were addressed by implementing (1) a liquisol technique for promoting the dissolution rate in a controlled-release manner and (2) a core-in-cup bucco-adhesive drug delivery system as an alternative to the oral route. …”
Get full text

Immunomodulatory Effect of Flavonoids of Blueberry (Vaccinium corymbosum L.) Leaves via the NF-κB Signal Pathway in LPS-Stimulated RAW 264.7 Cells by Dazhi Shi, Mengyi Xu, Mengyue Ren, Enshan Pan, Chaohua Luo, Wei Zhang, Qingfa Tang

“…FBL significantly decreased the expression of NF-κB p65 and P-NF-κB p65 in LPS-induced RAW 264.7 cells in a dose-dependent manner. Conclusion. Our study showed the immunoregulatory effect of FBL through the suppression of TNF-α via the NF-κB signal pathway.…”
Get full text

In Vitro Antioxidant Capacity and Neuronal Cell Toxicity of Roots of Ostericum koreanum Maximowicz by Ramalingam Mahesh, Hyo Won Jung, Jun Hong Park, Yong-Ki Park

“…The results showed that there was a reduction of cell viability by the fraction in a concentration dependent manner. These results suggest that O. koreanum shows good antioxidant activities in vitro by inhibiting free radicals. …”
Get full text

A Fully Operational Framework for Handling Cellular Automata Templates by Mauricio Verardo, Pedro P. B. de Oliveira

“…In order to help along this direction, here we present the current state of cellular automata templates, a data structure that allows for the representation of sets of cellular automata in a compact manner. The template data structure is defined, along with processes by which interesting templates can be built. …”
Get full text

ARM-Cortex M3-Based Two-Wheel Robot for Assessing Grid Cell Model of Medial Entorhinal Cortex: Progress towards Building Robots with Biologically Inspired Navigation-Cognitive Maps by J. Cuneo, L. Barboni, N. Blanco, M. del Castillo, J. Quagliotti

“…The robot freely explores a limited laboratory area in the manner of a rat or mouse and reports information to a PC, thus enabling research without the use of live individuals. …”
Get full text

New Robust PCA for Outliers and Heavy Sparse Noises’ Detection via Affine Transformation, the L∗,w and L2,1 Norms, and Spatial Weight Matrix in High-Dimensional Images: From the Pe... by Peidong Liang, Habte Tadesse Likassa, Chentao Zhang, Jielong Guo

“…To mitigate the computational complexity, alternating iteratively reweighted direction method of multipliers (ADMM) method is utilized to derive a new set of recursive equations to update the optimization variables and the affine transformations iteratively in a round-robin manner. The new algorithm is superior to the state-of-the-art works in terms of accuracy on various public databases.…”
Get full text

Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment by Francesca Sardina, Federica Polverino, Sonia Valentini, Claudia Carsetti, Elisabetta Falvo, Giada Tisci, Silvia Soddu, Fabiola Moretti, Alessandro Paiardini, Cinzia Rinaldo

“…By biochemical and functional experiments, we demonstrate that MDM2 binds spastin and regulates its levels in a post-transcriptional manner independently of the E3 ubiquitin ligase activity. …”
Get full text

Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model by Myeongsu Seong, NoSoung Myoung, Songhyun Lee, Hyeryun Jeong, Sang-Youp Yim, Jae Gwan Kim

“…Then, we obtained Raman spectra during breast cancer treatment by chemotherapy from a small animal model in longitudinal manner. Our results showed that the treatment causes variations of biochemical compositions in the skin. …”
Get full text

Unstart Coupling Mechanism Analysis of Multiple-Modules Hypersonic Inlet by Jichao Hu, Juntao Chang, Lei Wang, Shibin Cao, Wen Bao

“…The combination of multiplemodules in parallel manner is an important way to achieve the much higher thrust of scramjet engine. …”
Get full text

CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective by Mohammed Akhtar, Sameera Rashid, Mohamed Ben Gashir, Noheir Mostafa Taha, Issam Al Bozom

“…They are expressed in a highly specific manner in epithelial cells where they play a crucial role in the integrity and mechanical stability of the cells. …”
Get full text

Mittag-Leffler Functions and Their Applications by H. J. Haubold, A. M. Mathai, R. K. Saxena

“…Motivated essentially by the success of the applications of the Mittag-Leffler functions in many areas of science and engineering, the authors present, in a unified manner, a detailed account or rather a brief survey of the Mittag-Leffler function, generalized Mittag-Leffler functions, Mittag-Leffler type functions, and their interesting and useful properties. …”
Get full text

Calculation of Free Energy Consumption in Gene Transcription with Complex Promoter Structure by Lifang Huang, Peijiang Liu, Kunwen Wen, Jianshe Yu

“…On the other hand, regulatory molecules present on the core promoter of a gene interact often in a dynamic, highly combinatorial, and possibly energy-dependent manner, leading to a complex promoter structure. This raises the question of how gene transcription with general promoter topology consumes free energy. …”
Get full text

New Diagnostics for Fungal Infections in Transplant Infectious Disease: A Systematic Review by Apurva Akkad, Neha Nanda

“…They can be quite difficult to diagnose in a timely manner; thus, we present a review of current studies focusing on broad categories of molecular diagnostics, i.e., metagenomic sequencing, magnetic resonance, and gas chromatography mass spectrometry. …”
Get full text

Imaging cell spheroid clusters: An MRI protocol for non-invasive standardized characterization by Rebecca Wißmann, Petros Martirosian, Marina Danalache, Gerd Grözinger, Fritz Schick, Stefanie Elser

“…Despite its limited spatial resolution, this method adeptly reveals information about the composition and vitality of stem cell and cancer spheroids and their micro-environment in a non-invasive manner. This work reports on the development of an MRI-compatible setup for culturing cell spheroids, tailored for use with standard 3 T whole-body MRI systems. …”
Get full text

Wnt5a Signaling in Normal and Cancer Stem Cells by Yan Zhou, Thomas J. Kipps, Suping Zhang

“…Wnt5a is involved in activating several noncanonical Wnt signaling pathways, which can inhibit or activate canonical Wnt/β-catenin signaling pathway in a receptor context-dependent manner. Wnt5a signaling is critical for regulating normal developmental processes, including stem cell self-renewal, proliferation, differentiation, migration, adhesion, and polarity. …”
Get full text