Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes by Laura J. Andreasen, Rikke K. Kirk, Christian Fledelius, Mark A. Yorek, Jens Lykkesfeldt, Thorbjorn Akerstrom

“…Insulin treatment lowered blood glucose in a dose-dependent manner. In addition, both doses of insulin lowered lipids and increased body fat percentage. …”
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Algorithm of Behaviour of Virtual Avatars During Public Speaking Training in a VR Environment by Karol Jędrasiak, Robert Robert Wolański, Damian Bereska

“…This algorithm integrates multiple aspects of human communication, including posture modelling, voice modulation, greet- ings mannerisms, eye contact management, gestural communication and interactive responsiveness. …”
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The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment by Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping He

“…The results in murine hippocampal cells (HT22) revealed that co-treatment with MGF significantly decreased FA-induced cytotoxicity and inhibited Tau hyperphosphorylation in a dose-dependent manner. It was further found that these protective effects were achieved by attenuating FA-induced endoplasmic reticulum stress (ERS), as indicated by the inhibition of the ERS markers, GRP78 and CHOP, and downstream Tau-associated kinases (GSK-3β and CaMKII) expression. …”
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A Large Ship Detection Method Based on Component Model in SAR Images by Tiancheng Dong, Taoyang Wang, Xuefei Li, Jianzhi Hong, Maoqiang Jing, Tong Wei

“…Following the feature extraction of GELAN, a multilevel multipooling channel attention is integrated to optimize the feature extraction structure in a hierarchical manner. The method also incorporates environmental features around the target to strengthen the association between different ship components. …”
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Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation by Merian E. Kuipers, Dennis K. Ninaber, Krista C.J. van Doorn-Wink, Annelies M. Slats, Pieter S. Hiemstra

“…Finally, IR of ALI-PBEC had a marked effect on organoid formation capacity, which was markedly impaired following IR in a dose-dependent manner. Conclusion In conclusion, epithelial progenitor cell function as assessed by organoid formation capacity is strongly reduced by IR and persists for at least 7 days. …”
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Psychological distress and associated factors among healthcare professionals in Ethiopia during the COVID-19 pandemic: a cross-sectional study by Berhanie Getnet, Dessie Abebaw Angaw, Zewudu Andualem, Habtamu Kerebih, Asmamaw Atnafu, Bizuneh Tesfaye, Demeke Demilew

“…This could contribute to implementation of mitigation measures in a standardised and sustainable manner and emphasis should be given to this aspect of health even for future similar and unanticipated events.…”
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Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells by Liza U. Ljungberg, Mulugeta M. Zegeye, Caroline Kardeby, Knut Fälker, Dirk Repsilber, Allan Sirsjö

“…Overall, our data indicate that IL6 acts in an autocrine manner to regulate basal cellular functions, such as cell cycle regulation, signaling, and cellular movement, and suggests that the autocrine functions of IL6 in human endothelial cells are mediated via IL6 classic signaling.…”
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Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial by Gilberto Arias-Hernández, Cruz Vargas-De-León, Claudia C Calzada-Mendoza, María Esther Ocharan-Hernández

“…Diltiazem controlled arterial hypertension in a more effective and uniform manner in patients under study than nifedipine. Patients treated with diltiazem had fewer collateral effects and spent less time in the hospital. …”
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Disruption of the CRF1 receptor eliminates morphine-induced sociability deficits and firing of oxytocinergic neurons in male mice by Alessandro Piccin, Anne-Emilie Allain, Jérôme M Baufreton, Sandrine S Bertrand, Angelo Contarino

“…Likewise, genetic CRF1 receptor-deficiency reduced morphine-induced firing of PVN neurons in a CRF1 gene expression-dependent manner. The electrophysiology results consistently mirrored the behavioral results, indicating a link between morphine-induced PVN activity and sociability deficits. …”
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Circadian Rhythms Fluctuate the Treatment Effects of Intravesical Treatments on Rat Urinary Frequency Models by Tomofumi Watanabe, Takuya Sadahira, Yusuke Tominaga, Yuki Maruyama, Naoya Nagasaki, Takanori Sekito, Kohei Edamura, Toyohiko Watanabe, Motoo Araki, Masami Watanabe

“…Intravesical instillation of AA increased the urinary frequency and decreased the mean voided volume (VV) in a concentration-dependent manner, with statistical significance at a concentration of 1.0% (urinary frequency; p=0.0007, mean VV; p=0.0032, respectively) compared with PBS. …”
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Reliability and Validity of the ActivForce Digital Dynamometer in Assessing Shoulder Muscle Force across Different User Experience Levels by Christos Karagiannopoulos, Sean Griech, Brian Leggin

“…Its low-cost and electronic accessibility features may promote better compliance for clinicians using dynamometry to objectively assess and store muscle force data in a cost-effective manner. # Level of Evidence 3…”
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Pore Structure and Fractal Characteristics of Inter-Layer Sandstone in Marine–Continental Transitional Shale: A Case Study of the Upper Permian Longtan Formation in Southern Sichua... by Jianguo Wang, Jizhen Zhang, Xiao Xiao, Ya’na Chen, Denglin Han

“…It also attempts to combine high-pressure mercury intrusion analysis and gas adsorption experiments to describe the structural and fractal characteristics of pores at different scales in a segmented manner. The findings reveal that the sandstone type of the Longtan Formation is mainly lithic sandstone. …”
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Supporting complex skill learning with digital tools in tertiary education: educator’s perspective by Bernarda Letnar, André Klostermann, Mirko Schmidt

“…Educators were presented with a video of a student performing a sports skill in suboptimal manner to prompt a discussion on their approach to optimize student’s movement. …”
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Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury by Jessica M. Herrera, Yun Weng, Tyler J. Lieberthal, Marcus Paoletti, Tammy T. Chang

“…ROCK1/ROCK2-deficient primary hepatocytes demonstrated increased susceptibility to both caspase-3–mediated apoptosis and caspase-3–independent forms of cell death in a cell intrinsic manner. Conclusions:. ROCK signaling plays a critical role in mediating hepatocyte cell survival pathways in response to liver injury.…”
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Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption After Arthroscopic Shoulder Surgery: A Prospective, Randomized, Double-blind Clinic... by Muhittin CALIM, Serdar YESILTAS, Mustafa GUNAY, Ismail SUMER, Sedat AKBAS

“…These patients were then randomly assigned in a double-blind manner to two groups: one receiving paracetamol (n=32), and the other receiving ibuprofen (n=32). …”
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THE DEVELOPMENT OF SCIENCE AND THE FATE OF A SCIENTIST (FOLLOWING GENETICS) by Jonas Rubikas

“…After obtaining a particular degree, a declination of the world line appears with the age and absence of renovation of methodology, if the scientist remains in the laboratory as a working person; this is the natural manner of the delta increase. If a scientist begins an administrative career, honorary titles, degrees, posts, and salaries make the declination marked. …”
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Relevance of tumor boards for the inclusion of patients in oncological clinical trials by Hendrik Dapper, Maurice Dantes, Peter Herschbach, Hana Algül, Volker Heinemann

“…In the first phase, various MDTs’ case discussions about oncological situations and their decisions regarding possible therapy trials were recorded in a structured manner. In the second phase, the actual inclusion rates of patients in therapy trials and reasons for non-inclusion were examined. …”
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Mobile base station site as a virtual power plant for grid stability by Jussi Laimio, Mika Keski-Heikkilä, Matti Pärssinen, Roope Lahti, Olli Salmela, Topi Volkov, Jari Collin, Petri Rannikko, Henri Koskela, Jukka Manner

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Comparison of Medical Students’ Peer Evaluation and Teaching Staff Evaluation of Community Health Projects: Perceptions and Experiences by Mahmoud MA, Almutairi ZS, Mahmoud AM, Alanazi HB, Abdulrahman SM, Bin Abdulrahman KA

“…Both groups evaluated the project’s level of innovation and the clarity of its target audience in a comparable manner. The analysis of the Full Project Level indicated no substantial disparity between medical students and Staff, as evidenced by the p-value of 0.920.Conclusion: This study validates that peer evaluation of student projects is equally practical as evaluation conducted by faculty members. …”
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Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells by Hanan R. H. Mohamed, Basma A. Mohamed, George M. Hakeem, Shahd H. Elnawasani, Maria Nagy, Rawan Essam, Ayman Diab, Gehan Safwat

“…These findings highlight the novel potential of Co3O4NPs as potent inducers of melanoma A-375 cell death in a concentration-dependent manner through excessive ROS production, genomic instability, mitochondrial dysfunction and dysregulation of apoptotic and mitochondrial gene expression, ultimately promoting apoptosis in A-375 cells. …”
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