Vernolactone Promotes Apoptosis and Autophagy in Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells by Nuwanka K. Abeysinghe, Ira Thabrew, Sameera R. Samarakoon, Meran K. Ediriweera, Kamani H. Tennekoon, Varuni P. C. Pathiranage, Anuka S. Mendis

“…Overall results confirm that vernolactone can exert antiproliferative effects, induce apoptosis and autophagy, and decrease NTERA-2 cell migration in a dose- and time-dependent manner with a very small antioxidant property.…”
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Structural Characterization of B-DNA d(CGTGAATTCACG)₂ in Complex with the Specific Minor Groove Binding Fluorescent Marker Hoechst 33342 by Hristina Sbirkova-Dimitrova, Rusi Rusew, Hristo Gerginov, Annie Heroux, Boris L. Shivachev

“…The structural comparison revealed that Hoechst 33342 inserts itself in the minor groove in a strongly specific manner, displacing the ordered spine waters.…”
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Method and Experimental Research of Transmission Line Tower Grounding Body Condition Assessment Based on Multi-Parameter Time-Domain Pulsed Eddy Current Characteristic Signal Extra... by Yun Zuo, Jie Wang, Xiaoju Huang, Yuan Liu, Zhiwu Zeng, Ruiqing Xu, Yawen Chen, Kui Liu, Hongkang You, Jingang Wang

“…To assess the operational status of a grounding body in a timely manner, this paper proposes a multi-parameter pulsed eddy current (PEC) time-domain characteristic signal corrosion classification method for the detection of the state of a pole tower grounding body. …”
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Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1 by Coco Duizer, Moniek Salomons, Merel van Gogh, Sanne Gräve, Freke A. Schaafsma, Maaike J. Stok, Merel Sijbranda, Raghuvandhanan Kumarasamy Sivasamy, Rob J. L. Willems, Marcel R. de Zoete

“…The molecular mechanisms utilized by F. nucleatum to promote colorectal tumor development have largely focused on adhesin-mediated binding to the tumor tissue and on the pro-inflammatory capacity of F. nucleatum. However, the exact manner in which F. nucleatum promotes inflammation in the tumor microenvironment and subsequent tumor promotion remains underexplored. …”
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Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome by Lucas Streckwall, Nancy Martini, Claudia Sedlinsky, León Schurman, María Virginia Gangoiti, Antonio Desmond McCarthy

“…In vitro, AGEs-modified bovine serum albumin upregulated RAGE expression of control VSMCs, and this was prevented by MET in an AMP kinase-dependent manner. Thus, experimental MetS induces RAGE upregulation and osteogenic transdifferentiation of aortic VSMCs curbed by oral treatment with MET.…”
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Chitosan oligosaccharides maintained postharvest quality and increased shelf life of mango by Nishat Nitu, Md. Sefat Ullah, Prianka Howlader, Md. Nazmul Mehedi, Habiba Meem, Santosh Bose

“…Originality/Value: COS 100mg/L have great potentiality to maintain postharvest quality and increase shelf life of mango which could be applied commercially for preservation of mango in an ecofriendly manner.…”
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Mechanistic insights into 125I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2 by Jun Luo, Zheng Yao, Weiren Liang, Danjun Song, Hui Zeng, Yi Jiang, Zhehan Bao, Jiaping Zheng, Yinan Ding

“…Results Our results demonstrate that 125I seeds effectively inhibited tumor growth in the rabbit VX2 tumor model and promoted the apoptosis of CCA cells in vitro in a dose-dependent manner. Molecular analyses indicate a marked increase in reactive oxygen species (ROS) levels following treatment with 125I seeds, suggesting the involvement of ROS-mediated apoptosis in the therapeutic mechanism. …”
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Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro by Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, Anthony Shock

“…Rozanolixizumab was also able to mediate antibody bipolar bridging (ABB), a phenomenon that led to a reduction of labeled FcγRI from the surface of human macrophages in an FcRn-dependent manner. However, the presence of exogenous human IgG, even at low concentrations, was able to prevent both binding and ABB events. …”
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Development and Evaluation of a Deep Learning–Based Pulmonary Hypertension Screening Algorithm Using a Digital Stethoscope by Ling Guo, Nivedita Khobragade, Spencer Kieu, Suleman Ilyas, Preston N. Nicely, Emmanuel K. Asiedu, Fabio V. Lima, Caroline Currie, Emileigh Lastowski, Gaurav Choudhary

“…Methods Approximately 6000 PCG recordings with the corresponding echocardiogram‐based estimated pulmonary artery systolic pressure values, as well as ≈169 000 PCG recordings without associated echocardiograms, were used for training a deep convolutional network to detect pulmonary artery systolic pressures ≥40 mm Hg in a semisupervised manner. Each 15‐second PCG, recorded using a digital stethoscope, was processed to generate 5‐second mel‐spectrograms. …”
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Construction and Release Characteristics of 3D Printed Spaced Multi-layer Structure of Lutein Emulsion Gel by Shuai DENG, Minghui ZHAO, Chunxue HAO, Ming LI, Dajing LI, Lei FENG, Zhongyuan ZHANG, Yayuan XU

“…In this study, 3D printing technology with double nozzles was applied to print lutein emulsion gels (lutein-loaded layer) and corresponding unloaded emulsion gels in an interlaced manner. The preparation parameters of lutein-loaded and unloaded emulsion gels were screened by evaluating the rheological properties and 3D printing characteristics. 3D printed gel systems with different intervals of multilayers structures were constructed to explore the effects of the number of spacer layers and the positioning of empty layers in spaced multi-layer structures on the release characteristics and bioaccessibility of lutein. …”
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Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway by Yu Long, Yan Xiang, Songyu Liu, Yulu Zhang, Jinyan Wan, Qiyue Yang, Mingquan Cui, Zhimin Ci, Nan Li, Wei Peng

“…In addition, the therapeutic effects of BA-LP showed a dose-dependent manner. Western blot analysis indicated that the anti-inflammatory action of BA could be attributed to the inhibition of the TLR4-NFκBp65 and JNK-ERK signaling pathways. …”
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Effects of Compressive and Tensile Strain on Macrophages during Simulated Orthodontic Tooth Movement by Agnes Schröder, Paul Käppler, Ute Nazet, Jonathan Jantsch, Peter Proff, Fabian Cieplik, James Deschner, Christian Kirschneck

“…While it is known that PDL fibroblasts are critically involved in the biological regulation of OTM by a mechanotransductively triggered release of cytokines, it is unclear whether macrophages also react to pressure and tension in a similar manner thus impacting on or mediating OTM. RAW264.7 macrophages were seeded onto conventional 6-well cell culture plates for pressure or on Bioflex plates for tension assays and preincubated for 24 h. …”
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An Interactive Pain Application (MServ) Improves Postoperative Pain Management by Richard Gordon-Williams, Andreia Trigo, Paul Bassett, Amanda Williams, Stephen Cone, Martin Lees, Brigitta Brandner

“…We recruited 234 patients to a prospective cohort study into sequential groups in a nonrandomised manner, one day after major thoracic or urological surgery. …”
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Soft Power and Stress: The Health Impacts of Indonesian Soap Operas on Malaysian Millennials by Rangga Cipta Perdana, Ernida Kadir, Genta Iverstika Gempita

“…Methods: To achieve the objectives and in order to avoid subjective views, this study is conducted in a controlled manner, namely by collecting data that supports presumptions, assumptions, and theories and also collecting opposing facts so that conclusions are not based on wishes, but what is found empirically. …”
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NIEKO NĖRA, ARBA BŪTIES PROBLEMA SOFISTŲ MĄSTYME by Skirmantas Jankauskas

“…Finally, it is argued here that Protagoras' famous criterion of man-measure defines the same premise in a positive manner. It also is demonstrated that the essence of the criterion consists in the sensual measuring of the cosmos (logos). …”
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Barriers and Facilitators to User Engagement and Moderation for Web-Based Peer Support Among Young People: Qualitative Study Using the Behavior Change Wheel Framework by Ananya Ananya, Janina Tuuli, Rachel Perowne, Leslie Morrison Gutman

“…ConclusionsThe study demonstrates the effectiveness of the BCW approach and the use of the TDF and COM-B model to understand the influences on behavior in a systematic manner, especially for mental health and well-being interventions. …”
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Recent Developments and Present Status of Telepathology by K. Kayser, M. Beyer, S. Blum, G. Kayser

“…Pathologists can be trained in a short time and use the systems in a routine manner. Several telepathology systems have been implemented in large Institutes of Pathology which serve for frozen section diagnosis in small hospitals located in the local area. …”
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Techno-Economic Design Analysis of Electric Vehicle Charging Stations Powered by Photovoltaic Technology on the Highways of Saudi Arabia by Yassir Alhazmi

“…Nevertheless, the rise in the number of electric vehicles is accompanied by sustainability issues, such as managing the grid’s electrical demand, building more charging stations, and providing electricity from renewable resources in an efficient and sustainable manner, especially in Saudi Arabia. This work focused on three challenges regarding the installation of fast charging stations (FCSs) for electric vehicles (EVs) on highways. …”
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Barriers and facilitators of loaded self-managed exercises and physical activity in people with patellofemoral pain: understanding the feasibility of delivering a multicentred rand... by Michael Skovdal Rathleff, Phillipa Logan, Marcus Bateman, Benjamin E Smith, Fiona Moffatt, Paul Hendrick, James Selfe, Toby O Smith

“…Both physiotherapists and patients, in the intervention group, viewed the single exercise approach in a positive manner. Participants within the intervention group described narratives demonstrating self-efficacy, with greater internal locus of control compared with those who received usual physiotherapy, particularly in relation to physical activity.Conclusions Implementation, delivery and evaluation of the intervention in clinical settings may be challenging, but feasible with the appropriate training for physiotherapists. …”
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Heat transportation of 3D chemically reactive flow of Jeffrey nanofluid over a porous frame with variable thermal conductivity by Nahid Fatima, Aaqib Majeed, Taoufik Saidani, Nouman Ijaz, Kamal Barghout, Nidal Abu-Libdeh

“…Additionally, important engineering parameters under different constraints-like skin friction, Nusselt number, and Sherwood number—are given in a thorough manner using tabular and graphical representations. …”
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