Therapeutic effects of mirodenafil, a phosphodiesterase 5 inhibitor, on stroke models in rats by Fred Kim, Padmanabh Singh, Hyunji Jo, Tianyang Xi, Dong-Keun Song, Sae Kwang Ku, Jai Jun Choung

“…Effects were seen in a dose-dependent manner up to 1 ​mg/kg mirodenafil. The benefits of mirodenafil treatment increased with longer treatment duration, and the largest improvements over control were typically observed on the last assessment day. …”
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C-POS: A Context-Aware Adaptive Part-of-Speech Language Learning Framework by Shazia Maqsood, Abdul Shahid, Fakhra Nazar, Muhammad Asif, Muhammad Ahmad, Manuel Mazzara

“…Further, the need for learning an additional language has increased due to globalization in an unprecedented manner. Therefore, English is being taught as an additional language at various levels of education. …”
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Improved Antibacterial Activity of Water-Soluble Nanoformulated Kaempferol and Combretastatin Polyphenolic Compounds by Y. Santhosh Kumar, Langeswaran Kulanthaivel, G. S. Hikku, R. Saravanan, Thangavelu Lakshmi, C. Kirubhanand, Murugesan Karthikeyan, P. Vijayalakshmi, Gowtham Kumar Subbaraj

“…Owing to the size effect, the NF-k and NF-c release up to 50% of the drug in a sustained manner till 50 h showing twofold higher concentration than the control where it released 25%. …”
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Rare Presentation of Neonatal Necrotizing Fasciitis: Case Series and Review of Literature by Kruti N Shah, Shwetal Bhatt, Dipal Zanzrukriya, Salesh K Soni

“…It becomes essential to diagnose in a timely manner and culminate in a multidisciplinary approach with antimicrobial treatments and surgical aid to prevent its fulminating course. …”
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STAT3 Genotypic Variant rs744166 and Increased Tyrosine Phosphorylation of STAT3 in IL-23 Responsive Innate Lymphoid Cells during Pathogenesis of Crohn’s Disease by Ying Tang, Sanda A. Tan, Atif Iqbal, Jian Li, Sarah C. Glover

“…Signal transducer and activator of transcription 3 (STAT3) regulates gene expression in a cell-specific, cytokine-dependent manner, involving multiple immune responses. This study proposes the positive correlation between the prevalence of STAT3 rs744166 risky allele “A” with the severity of disease in a cohort of 94 CD patients. …”
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A contentious intervention to support the medical workforce: a case study of the policy of introducing physician associates in the United Kingdom by Martin McKee, Louella K. Vaughan, Giuliano Russo

“…The name soon changed, to physician associate, and the range of roles and responsibilities expanded greatly, although in a largely unregulated manner; by 2024, some were undertaking complex procedures or managing undifferentiated patients in primary care. …”
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Ellagic Acid Alleviates Rheumatoid Arthritis in Rats through Inhibiting MTA1/HDAC1-Mediated Nur77 Deacetylation by Huanjin Song, Hao Wu, Jun Dong, Sihua Huang, Jintao Ye, Ruoxi Liu

“…Western blot analysis showed that EA reduced MTA1 expression in a dose-dependent manner in MH7A cells. Then, TNF-α-treated MH7A cells were incubated with EA alone or together with MTA1 overexpression plasmid (pcDNA-MTA1), and we found that EA inhibited proliferation, inflammation cytokine levels, and oxidative stress marker protein levels and promoted apoptosis in MH7A cells, while MTA1 overexpression abolished these effects. …”
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Grouting Design of Rich Water Tunnels and the Calculation of Distance between Annular Blind Pipes by Helin Fu, Pengtao An, Kai Li, Guowen Cheng, Jie Li, Xiaohui Yu

“…The results show that (1) grouting reinforcement is an important means to reduce water seepage, and tunnel water seepage can be adjusted by changing the thickness and permeability coefficient of the grouting reinforcement circle, in which the thickness of the reinforcement circle should not be too large, and the permeability coefficient should not be less than 1/80 of the surrounding rock permeability coefficient; (2) according to the derived formula, the water pressure of the secondary lining structure decreases in a parabolic manner from the middle of the two rows of annular blind pipes to the place where the annular blind pipes are set; (3) the allowable water seepage of the tunnel and the design value of the water pressure resistance of the lining structure should be considered when determining the distance between annular blind pipes; and (4) based on the derived formula, the distance between the annular blind pipes in the test section of the Hongtu extra-long tunnel is determined to be 8 m.…”
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Charakter prawny rady społecznej w samodzielnym publicznym zakładzie opieki zdrowotnej by Michał Gornowicz

“…De lege lata, the current manner of legal shaping of social councils makes it a facade, deprived of any authority enabling effective implementation of statutory objectives accompanying their establishment within the broadly understood social control of independent public healthcare institutions. …”
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Antibacterial, Antifungal, and Antidiabetic Effects of Leaf Extracts from Persea americana Mill. (Lauraceae) by Mercy Makopa, Benjamin Mangiza, Benjamin Banda, Winnie Mozirandi, Molly Mombeshora, Stanley Mukanganyama

“…Out of all the tested extracts, the methanolic extract showed the best inhibitory activity on α-glucosidase enzyme in a time-dependent and dose-dependent manner. Ki and Kinact values were found to be 1.4 mg/mL and 2.4 U/min, respectively, after incubation for 1 hour. …”
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Comparison of Statistical, Graphical, and Wavelet Transform Analyses for Rainfall Trends and Patterns in Badulu Oya Catchment, Sri Lanka by Ashika M. Ruwangika, Anushka Perera, Upaka Rathnayake

“…The results reveal that the nonparametric Mann–Kendall test is powerful to produce the statistically significant rainfall trends in qualitative and quantitative manner. Mann–Kendall analysis shows a positive trend to Ledgerwatte Estate in monthly (3.7 mm in February and 7.4 mm in October), seasonal (6.9 mm in the 2ndintermonsoon), and annual (3 mm annually) scales. …”
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Time Course of Acute Hip Adduction Range of Motion Changes Following Foam Rolling by Anthony D’Amico, Kevin Silva, Joseph Gallo

“…# Background With the increased popularity of foam rolling (FR), it is important to establish the exact manner in which the practice is useful. # Purpose The purpose of this study was to examine the impact of FR the iliotibial (IT) band on hip adduction range of motion (ROM) and the short-term time course of any ROM changes that may occur…”
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Essential oils from Amorpha fruticosa against hepatocellular carcinoma based on network pharmacology by Yixian Liu, Xiaojun Zhang, Jiacong Hao, Ying Zhao, Min Zou, Huiping Chen, Jintao Zhang

“…Both AFLEO and AFFEO inhibited the proliferation of HCC cells in a time and dose-dependent manner. 10 compounds of AFLEO and 9 compounds of AFFEO were screened out for further analysis. 28 hub targets of AFLEO and 40 hub targets of AFFEO were detected by PPI network. …”
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High-Intensity Focused Ultrasound (HIFU) Focal Therapy for Localized Prostate Cancer with MRI-US Fusion Platform by Chi-Hang Yee, Peter Ka-Fung Chiu, Jeremy Yuen-Chun Teoh, Chi-Fai Ng, Chi-Kwok Chan, See-Ming Hou

“…HIFU focal therapy was performed in the conventional manner in the beginning 50% of the series, whereas the subsequent cases were performed with MRI-US fusion platform. …”
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Solving Nonlinear Energy Supply and Demand System Using Physics-Informed Neural Networks by Van Truong Vo, Samad Noeiaghdam, Denis Sidorov, Aliona Dreglea, Liguo Wang

“…The key factors influencing this include the manner in which the neural network architecture is designed, such as the selection of hyperparameters and appropriate optimization functions. …”
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The Role of Leadership, Religiousness and Work Environment in Supporting Employee Performance and How Motivation Affects The Relationship by Syafran Pardamean, Dodi Indrianto, Sekar Wulan

“…Originality/Value (State of The Art): This study highlights the importance of religiosity as a factor that has a positive impact on employee performance, especially if religious values are applied in a balanced and constructive manner. Leadership values driven by religiosity can improve employee performance and create a harmonious work environment. …”
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A Research on the Effect of Heterogeneities on Sandstone Matrix Acidizing Performance by Jianye Mou, Lei Wang, Shicheng Zhang, Xinfang Ma, Boyang Li

“…However, sandstone formations inevitably have small-scale heterogeneities of minerals and flow properties that may give rise to acid propagation in a manner much different from what is predicted based on homogeneous assumptions. …”
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Fuzzy Logic Recommender Model for Housing by Emanuel G. Munoz, Jaime Meza, Sebastian Ventura

“…The model predicts a percentage of membership in each cluster, which makes it possible to handle uncertainty by offering properties from different groups in a proportional manner. Euclidean distance is employed in order to measure the similarity between user preferences and housing characteristics, after which the search time is optimized by utilizing metaheuristic methods, of which the bat algorithm provides the best performance in terms of time. …”
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Injury mortality in South Africa: a 2009 and 2017 comparison to track progress to meeting sustainable development goal targets by Megan Prinsloo, Shibe Mhlongo, Rifqah A. Roomaney, Lea Marineau, Thakadu A. Mamashela, Bianca Dekel, Debbie Bradshaw, Lorna J. Martin, Carl Lombard, Rachel Jewkes, Naeemah Abrahams, Richard Matzopoulos

“…Age-standardised rates, 95% confidence intervals (CIs), and incidence rate ratios (IRRs) were calculated for manner of death rate comparisons and for age groups. …”
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Dynamic Expression of HDAC3 in db/db Mouse RGCs and Its Relationship with Apoptosis and Autophagy by Yuhong Fu, Ying Wang, Xinyuan Gao, Huiyao Li, Yue Yuan

“…In this study, we examined the morphological and immunohistochemical changes of HDAC3, Caspase3, and LC3B in a sequential manner by characterizing the process of retinal ganglion cell variation. …”
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