Microcephaly protein ANKLE2 promotes Zika virus replication by Adam T. Fishburn, Cole J. Florio, Thomas N. Klaessens, Brian Prince, Neil A. B. Adia, Nicholas J. Lopez, Nitin Sai Beesabathuni, Sydney S. Becker, Liubov Cherkashchenko, Sophia T. Haggard Arcé, Vivian Hoang, Traci N. Shiu, R. Blake Richardson, Matthew J. Evans, Claudia Rückert, Priya S. Shah

“…Taken together with our previous results, our findings indicate that ZIKV and other orthoflaviviruses hijack ANKLE2 for a conserved role in replication, and this drives unique pathogenesis for ZIKV since ANKLE2 has essential roles in developing tissues.IMPORTANCEZIKV is a major concern due to its association with birth defects, including microcephaly. …”
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Potential of long-term satellite observations and reanalysis products for characterising soil drying: trends and drought events by M. Hirschi, P. Stradiotti, B. Crezee, B. Crezee, W. Dorigo, S. I. Seneviratne

“…Furthermore, we investigate the impact of the products' trend representation on their ability to capture major seasonal soil moisture (or agroecological) drought events as a use case. …”
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Hurricane Effects on a Shallow Lake Ecosystem and Its Response to a Controlled Manipulation of Water Level by Karl E. Havens, Kang-Ren Jin, Andrew J. Rodusky, Bruce Sharfstein, Mark A. Brady, Therese L. East, Nenad Iricanin, R. Thomas James, Matthew C. Harwell, Alan D. Steinman

“…The results demonstrate that in shallow lakes, unpredictable external forces, such as hurricanes, can play a major role in ecosystem dynamics. In regions where these events are common (e.g., the tropics and subtropics), consideration should be given to how they might affect long-term lake management programs.…”
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Health risk assessment through probabilistic sensitivity analysis of carbon monoxide and fine particulate transportation exposure by E. Ernyasih, A. Mallongi, A. Daud, S. Palutturi, S. Stang, R. Thaha, E. Ibrahim, W. Al Madhoun

“…BACKGROUND AND OBJECTIVES: The rising number of vehicles used for transportation, which is attributed to the steady increase in population, is known to be a major contributor of air pollution, which, in turn, can have adverse effects on the environment and human health. …”
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Evaluation de la qualité de vie des femmes souffrant d’une fistule obstétricale à Kinshasa [Evaluation of the quality of life of women with obstetric fistula in Kinshasa] by Jonathan Enguta Mwenzi, Ruth Bukabau Babuya, Francine Manyonga Sabowa

“…English Abstract: Background-Obstetric fistula is a major maternal health problem that significantly affects women both physically and mentally. …”
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Correlation of newer inflammatory markers in patients with type 2 diabetes mellitus: A cross-sectional study by Swetha Akkina, Srikanth Akula, Rajeev Gandham, Preethi Batakala, Bhagyalakshmi Atla, Divija Reddy Bonthu, Sunkara Uha Priya

“…Background: Globally, diabetes mellitus (DM) is a major health concerns and has reached alarming levels. …”
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Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosisResearch in context by Stylianos Papadopoulos, David Hardy, Frédérique Vernel-Pauillac, Magali Tichit, Ivo G. Boneca, Catherine Werts

“…One strain, L. interrogans Manilae L495, killed the mice 4 days after infection, whereas the other strain, L. interrogans Icterohaemorrhagiae Verdun, did not induce any major symptoms in the mice. On day 3 post infection, the mice were humanely euthanised and blood and organs were collected. …”
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The potential of bacteriophage for controlling Vibrio parahaemolyticus as in-vitro by Bagus Ansani Takwin, Dinamella Wahjuningrum, Widanarni Widanarni, Hasan Nasrullah

“… Vibrio parahaemolyticus infection is a major threat to Pacific white shrimp aquaculture, causing significant shrimp mortality. …”
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核桃仁颜色与化学成分的关联分析 "Correlation analysis between color and chemical composition of walnut kernels" by 孙诗曼，郑悦雯，李庆杨，莫润宏，汤富彬，刘毅华 SUN Shiman，ZHENG Yuewen，LI Qingyang，MO Runhong，TANG Fubin，LIU Yihua

“…To provide reference for high quality breeding and deepen the development of functional products，the gray values of 13 walnut kernels from the Xinjiang region were measured, and cluster analysis was conducted using gray value as an indicator, resulting in the 13 walnut kernels being divided into two groups: light-colored walnut kernels and amber walnut kernels. The oil content and major chemical components (aroma compounds, fatty acids, tocopherols, total phenol and mineral elements) of the two groups of walnut kernel were measured. …”
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Exemples d’habitats aristocratiques sur les sites des rues Eugène-Desteuque et Ponsardin à Reims/Durocortorum by Magalie Cavé, Stéphane Sindonino, Sabine Groetembril

“…This open-air area remained a major structuring element despite changes made elsewhere to the habitat. …”
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Editorial by Daniel Halliday

“…This suggests, in turn, that inheritance is a major factor in accounting for inequality among the retired segment of the population, something which ought to be of greater concern to political philosophers. …”
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Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel by Yanhong Xing, Meng-meng Wang, Feifei Zhang, Tianli Xin, Xinyan Wang, Rong Chen, Zhongheng Sui, Yawei Dong, Dongxue Xu, Xingyu Qian, Qixia Lu, Qingqing Li, Weijie Cai, Meiqin Hu, Yuqing Wang, Jun-li Cao, Derong Cui, Jiansong Qi, Wuyang Wang

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Identification and Spatial Mapping of Locality of Streetscapes in Shanghai Hengfu Historic and Cultural Preservation Area by Yuhan SHAO, Sinan YIN, Dongbo MA, Yuting YIN

“…ObjectiveAs one of the major open spaces, urban streets not only carry the transportation function, but also promote social interaction and economic growth, while displaying the aesthetic, cultural and historical characteristics of the city. …”
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Effect of Irrigation Interval and Corn (Zea mays L.)-Sorghum (Sorghum bicolor L.) Intercropping on the Quantitative and Qualitative Characteristics of Fodder by Saeed Sadeghzadeh Hemayati, Hamed Mansouri, Mohsen Shahsavarpour

“…The agricultural sector is considered to be the major water consumer, therefore paying attention to the optimal use of water in this sector is of great importance and any saving in this sector is considered an effective contribution to saving water resources (Khajeh Khezri et al., 2018). …”
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Middle-age cerebral small vessel disease and cognitive function in later life: a population-based prospective cohort studyResearch in context by Ali Tanweer Siddiquee, Yoon Ho Hwang, Soriul Kim, Sung Jin Shin, Ji Soo Lee, June Christoph Kang, Min-Hee Lee, Hyeon Jin Kim, Seung Ku Lee, Chol Shin

“…Summary: Background: Cerebral small vessel disease (cSVD) is a major pathologic substrate of vascular contribution to cognitive impairment. …”
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Physical and molecular identification of fish and shrimp diseases in some farms of West Java, Banten and Jakarta, Indonesia by Adam Saba Anggara, Ida Ayu Mirah Meliana Dewi, Kismono Kudoasmoro, Putu Eka Sudaryatma, Putu Angga Wiradana

“… Infectious disease is a major challenge in fish and shrimp farming systems caused by microorganisms including bacteria, viruses and parasites. …”
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Association of accelerated phenotypic aging, genetic risk, and lifestyle with progression of type 2 diabetes: a prospective study using multi-state model by Lulu Pan, Yahang Liu, Chen Huang, Yifang Huang, Ruilang Lin, Kecheng Wei, Ye Yao, Guoyou Qin, Yongfu Yu

“…Abstract Background Aging is a major risk factor for type 2 diabetes (T2D), but individuals of the same chronological age may vary in their biological aging rate. …”
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Evaluation de la qualité de vie des femmes souffrant d’une fistule obstétricale à Kinshasa [Evaluation of the quality of life of women with obstetric fistula in Kinshasa] by Jonathan Enguta Mwenzi, Ruth Bukabau Babuya, Francine Manyonga Sabowa

“…English Abstract: Background-Obstetric fistula is a major maternal health problem that significantly affects women both physically and mentally. …”
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Epistemic Roots, Universal Routes and Ontological Roofs of African “Ritual Archives”: Disciplinary Formations in African Thought by Oluwatoyin Vincent Adepoju

“…This response is organized in five parts, representing my understanding of the five major thematic strategies through which the central idea is laid out and expanded. 316 Oluwatoyin Vincent Adepoju The first section, “Developing Classical African Expressions as Sources of Locally and Universally Valid Theory” explores Falola’s advocacy for an expanded cultivation of theory from Africa created and Africa inspired expressive forms. …”
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High risk of asthma among early teens is associated with quantitative differences in mite and cat allergen specific IgE and IgG4: a modified Th2 related antibody response revisited... by Thomas A. Platts-Mills, Behnam Keshavarz, Jeffrey M. Wilson, Sheryl L. Rifas-Shiman, Samuel M. Ailsworth, Joanne E. Sordillo, Lisa Workman, Martin Chapman, Jonas Lidholm, Emily Oken, Diane R. Gold

“…Although the allergen Der p 1 is a major part of the IgE response to mite allergens, this protein also induced high prevalence and levels of IgG4 antibodies and has a less strong relationship to asthma than IgE to Der p 2 or Der p 23. …”
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