Limited Diagnostic Value of miRNAs in Early Trauma-Induced Liver Injury: Only miRNA-122 Emerges as a Late-Phase Marker by Jason-Alexander Hörauf, Amit Singh, Maika Voth, Hamed Moheimani, Cora Rebecca Schindler, Borna Relja, Liudmila Leppik, Ingo Marzi, Dirk Henrich

“…This study investigates whether specific liver-related microRNAs (miRNAs) are released into the circulation in trauma patients with liver injury and whether they can indicate liver damage in the early phase after major trauma. <b>Methods</b>: A retrospective analysis of prospectively collected data and blood samples from 26 trauma patients was conducted. …”
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Eu:CROPIS AIV Program: Challenges and Solutions for a Spin-Stabilized Satellite Containing Biology by Toni Delovski, Catherin Düvel, Fabian Greif, Ansgar Heidecker, Sebastian Kottmeier, Olaf Mierheim, Falk Nohka, Fabian Orlowski-Feldhusen

“…To allow these operations as close as six months prior to launch, a highly flexible and streamlined acceptance test campaign was developed. A major impact on test planning and logistics was the fact that the secondary payload “PowerCells” contains GMOs, which European and German regulations restrict to be handled exclusively in especially certified laboratories (biosafety level 1 (BSL-1)). …”
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Pan-cancer analysis of the transcriptional expression of histone acetylation enzymes in solid tumors defines a new classification scheme for gliomas by Junhao Zhang, Lingbo Li, Aiwei Tang, Chucheng Wang, Yupeng Wang, Yongqi Hu, Guangting He, Guangting He, Wangjun Liao, Wangjun Liao, Wangjun Liao, Rui Zhou

“…Consensus clustering analysis was applied to identify distinct expression patterns of HATs and HDACs.ResultsBased on the transcriptomic data of 25 genes encoding 9 HATs and 16 HDACs, we identified five major subtypes across 31 cancer types (AC-I to AC-V). …”
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Molecular epidemiology of extended-spectrum beta-lactamases and carbapenemases-producing Shigella in Africa: a systematic review and meta-analysis by Namwin Siourimè Somda, Rabbi Nyarkoh, Abel Tankoano, Ouindgueta Juste Isidore Bonkoungou, Patience B. Tetteh-Quarcoo, Eric S. Donkor

“…Abstract Background The treatment of Shigella infections has become a major challenge due to the emergence of multidrug-resistant Shigella. …”
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ECG‐based epileptic seizure prediction: Challenges of current data‐driven models by Sotirios Kalousios, Jens Müller, Hongliu Yang, Matthias Eberlein, Ortrud Uckermann, Gabriele Schackert, Witold H. Polanski, Georg Leonhardt

“…Off‐sample optimized SVMs failed to improve performance. Major limiting factors identified include non‐stationarity, variable preictal duration and dynamics. …”
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Prevalence and Molecular Characterization of Carbapenemase-Producing Multidrug-Resistant Bacteria in Diabetic Foot Ulcer Infections by Mohd Saleem, Soha Abdallah Moursi, Tahani Nasser Almofeed Altamimi, Mohammed Salem Alharbi, Alwaleed Mohammad Alaskar, Sahar Adly Hassan Hammam, Ehab Rakha, Ozair Ilyas Syed Muhammad, Hamoud Abdulmohsin Almalaq, Metab Nasser Alshammari, Azharuddin Sajid Syed Khaja

“…Notably, the need for minor amputations was much higher in MDR cases (<i>p</i> < 0.001), as was the need for major amputations (<i>p</i> < 0.001). MDR infections were also strongly associated with polymicrobial infections (<i>p</i> < 0.001). …”
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Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences by Liwei Li, Jinxia Chen, Zhengda Cao, Ziqiang Guo, Jiachen Liu, Yanjun Zhou, Guangzhi Tong, Fei Gao

“…Reverse genetic manipulation to engineer a different transcriptional regulatory sequence (TRS) circuit introduces genetic traps into the viral genome that are lethal to recombinant RNA progeny viruses. In this study, major interlineage recombination patterns were identified between lineage 1 (L1) PRRSVs and lineage 8 (L8) PRRSVs in China, from 2019 to 2023. …”
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Harmful newborn cord care practices and associated factors among mothers who gave birth in the last six months in Chencha town, Southern Ethiopia: a mixed-methods study by Misgana Seifu, Sultan Hassen, Mekdim Kassa, Yosef Haile, Zeleke Girma, Temesgen Mohammed Toma, Agune Ashole, Mintesinot Melka Gujo, Wondimagegn Taye Dema, Aleme Mekuriya, Endashaw Shibru

“…BackgroundHarmful substance-related infections that cause neonatal deaths on the umbilical stump continue to be a major cause of worry, accounting for a large portion of the yearly mortality toll in developing nations such as Ethiopia. …”
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The Effect of Dynamic Service Innovation Capabilities on Firm Performance: The Moderating Role of Perceived Environmental Dynamism and the Mediating Role of Service Innovation and... by Rasoul Nosratpanah, Samad Barani, Aref Ashrafzadeh, Gholamhosein Atashi

“…Particularly in the service sector, the concept of dynamic service innovation capability has garnered significant attention. Four major dimensions including sensing customer needs, conceptualizing, coproducing, and scaling, have been identified as some of the most important factors to win competitive advantages. …”
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MaxEnt-Based Predictions of Suitable Potential Distribution of <i>Leymus secalinus</i> Under Current and Future Climate Change by Shimeng Zhao, Zongxian Zhang, Changyu Gao, Yiding Dong, Zeyao Jing, Lixia Du, Xiangyang Hou

“…The results showed the following: (1) Mean diurnal temperature range, annual mean temperature, precipitation of the wettest quarter, and elevation are the major factors impacting the distribution of <i>L. secalinus</i>. (2) Under the current climatic conditions, <i>L. secalinus</i> is mainly distributed in the farming–pastoral ecotone of northern China; in addition, certain suitable areas also exist in parts of Xinjiang, Tibet, Sichuan, Heilongjiang, and Jilin. (3) Under future climate change scenarios, the suitable areas for <i>L. secalinus</i> are generally the same as at present, with slight changes in area under different scenarios, with the largest expansion of 97,222 km² of suitable area in 2021–2040 under the SSP1-26 scenario and the largest shrinkage of potential suitable area in 2061–2080 under the SSP2-45 scenario, with 87,983 km². …”
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Effects of converting cropland to grassland on greenhouse gas emissions from peat and organic-rich soils in temperate and boreal climates: a systematic review by Alena Holzknecht, Magnus Land, Jacynthe Dessureault-Rompré, Lars Elsgaard, Kristiina Lång, Örjan Berglund

“…CO2 emissions represent a major part of the climate impact of cultivated peat soils, so the data analyzed allow to draw the conclusion that a conversion from arable to grassland would not lead to large benefits in terms of GHG emissions, especially if root crops are not part of the arable crop rotation, or the grassland is fertilized. …”
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Genome-Wide Characterization and Expression Analysis of the HD-ZIP Gene Family in Response to Salt Stress in Pepper by Zhongrong Zhang, Ranran Zhu, Xuehua Ji, Hui Ji Li, Hui Lv, Hai Ying Zhang

“…In addition, Pepper HD-ZIP I and II genes played a major role in salt stress. CaHDZ03, CaHDZ 10, CaHDZ17, CaHDZ25, CaHDZ34, and CaHDZ35 were significantly induced in response to salt stress. …”
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Identification of novel serum lipid metabolism potential markers and metabolic pathways for oral cancer: a population-based study by Na Wang, Yujia Chen, Jianli Lin, Yulan Lin, Haoyuan Song, Weihai Huang, Liling Shen, Fa Chen, Fengqiong Liu, Jing Wang, Yu Qiu, Bin Shi, Ling Li, Lisong Lin, Lizhen Pan, Baochang He

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Determinants of Dropout From a Virtual Agent–Based App for Insomnia Management in a Self-Selected Sample of Users With Insomnia Symptoms: Longitudinal Study by María Montserrat Sanchez Ortuño, Florian Pecune, Julien Coelho, Jean Arthur Micoulaud-Franchi, Nathalie Salles, Marc Auriacombe, Fuschia Serre, Yannick Levavasseur, Etienne De Sevin, Patricia Sagaspe, Pierre Philip

“…An important aspect is that they are accessible at a low cost, thereby increasing their potential public impact and reducing disparities. However, a major challenge to their successful implementation is the phenomenon of users dropping out early. …”
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The Effect of Weed Control with Pre-Emergence Herbicides on the Yield Level of Mung Bean Yield by Cailing Jing, Junying Wang, Yonghong Wu, Yufan Zhou, Huijun Zhu, Yaowen Zhang, Shuqi Dong, Xiaorui Li, Juan Zhao, Junli Cao, Xiangyang Yuan, Xi’e Song

“…The mung bean (<i>Vigna radiata</i> (Linn) Wilczek.) is a major grain crop in China, but its yield is significantly impacted by weeds. …”
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La répartition des chimpanzés à Sebitoli (Parc National de Kibale, Ouganda): influence des facteurs naturels et anthropiques by Sarah Bortolamiol, Marianne Cohen, Milena Palibrk, Sabrina Krief

“…Therefore, representing geographically the chimpanzee repartition in relation with human activities is a major issue for a better understanding of the stakes of their conservation as this topic is not emphasized in today’s scientific research. …”
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Pemilihan Susu Formula Anak Menggunakan Metode Analytic Hierarchy Process dan Simple Additive Weighting by Heribertus Ary Setyadi, Ahmad Fauzi, Galih S Nurohim, Doddy Satrya Perbawa

“…The criteria used in this study are divided into 3 major criteria, they are nutritional content, taste and price. …”
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Impact of Cordyceps sinensis on coronary computed tomography angiography image quality and renal function in a beagle model of renal impairment by Peiji Song, Peiji Song, Kun Li, Xiaodie Xu, Guifeng Zhang, Zengkun Wang, Linbing Sun, Zekai Zhao, Ting Li, Ximing Wang, Zhangyong Xia, Zhangyong Xia, Zhangyong Xia, Zhangyong Xia

“…Laboratory renal function markers were measured multiple times before and after the intervention, and their correlation with fMRI parameters was analyzed.ResultsCCTA imaging revealed that the CT values of the major coronary artery branches in all groups met the international diagnostic criteria for coronary arteries. …”
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Advancements and opportunities to improve bottom–up estimates of global wetland methane emissions by Qing Zhu, Daniel J Jacob, Kunxiaojia Yuan, Fa Li, Benjamin R K Runkle, Min Chen, A Anthony Bloom, Benjamin Poulter, James D East, William J Riley, Gavin McNicol, John Worden, Christian Frankenberg, Meghan Halabisky

“…These substantial uncertainties highlight gaps in our understanding of wetland CH _4 biogeochemistry and wetland inundation dynamics. Major tropical and arctic wetland complexes are regional hotspots of CH _4 emissions. …”
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Urinary System Manifestation of IgG4-Related Disease: Clinical, Laboratory, Radiological, and Pathological Spectra of a Chinese Single-Centre Study by Fei Teng, Hui Lu, Ke Zheng, Gang Chen, Yubing Wen, Zheng Liu, Linyi Peng, Li Huo, Xiaofeng Zeng, Wen Zhang, Xuemei Li

“…IgG4-related interstitial nephritis (TIN, 32.3%), glomerular nephritis (GN, 7.7%), renal pelvis and ureter involvement (21.5%), abnormal radiology with quiescent clinical presentation (13.8%), and renal parenchymal lesion plus retroperitoneal fibrosis (RPF, 18.5%) were major lesion types of IgG4-RUD. All patients had elevated serum IgG4, 76.9% had hyperglobulinemia, and 92.3% had elevated serum IgE at diagnosis. …”
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