Geographical Differences in the Safety and Efficacy of Tofacitinib Versus TNFi: A Post Hoc Analysis of ORAL Surveillance by Bogdan Batko, Slawomir Jeka, Piotr Wiland, Agnieszka Zielińska, Maria Stopińska-Polaszewska, Marcin Stajszczyk, Magdalena Kosydar-Piechna, Mary Jane Cadatal, Jose L. Rivas

“…Abstract Introduction In ORAL Surveillance, incidence rates (IRs) of major adverse cardiovascular events (MACE) and malignancies (excluding non-melanoma skin cancer [NMSC]) in cardiovascular (CV)-risk-enriched patients with rheumatoid arthritis (RA) were numerically greater with tofacitinib in North America versus the rest of the world, due to underlying risk factors. …”
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When can cancer patient treatment nonadherence be considered intentional or unintentional? A scoping review. by Leon Wreyford, Raj Gururajan, Xujuan Zhou

“…These comprise 15 qualitative and 20 quantitative studies. One major theme, that embraces 6 sub themes has emerged: 'Physician factors can influence patient factors in treatment nonadherence'. …”
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A Pilot Study on the Age-Dependent, Biomechanical Properties of Longitudinal Ligaments in the Human Cervical Spine by Narendra Singh, Ana Trajkovski, Jovan Trajkovski, Robert Kunc, Jose Felix Rodriguez Matas

“…To explore age-related changes, we classified the samples into two groups—below and above 50 years old—aligning with the peak incidence of major musculoskeletal disorders. The investigation concentrated on the effects of age on four mechanical parameters of the uniaxial stress–stretch curve: initial tangent stiffness (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>E</mi></mrow><mrow><mn>0</mn></mrow></msub></mrow></semantics></math></inline-formula>), maximum tangent stiffness (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>E</mi></mrow><mrow><mi>m</mi></mrow></msub></mrow></semantics></math></inline-formula>), ultimate stress (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>P</mi></mrow><mrow><mi>u</mi></mrow></msub></mrow></semantics></math></inline-formula>) and ultimate stretch (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>λ</mi></mrow><mrow><mi>u</mi></mrow></msub></mrow></semantics></math></inline-formula>). …”
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Associations of combined exposure to selected metal mixtures with thyroid hormones in children: a cross-sectional study in China by Yuhan Cao, Shiting Xiang, Yuwei Du, Meiling Chen, Rumeng Xue, Qi Li, Jun Qiu, Yanying Duan

“…Fe was the predominant contributor among the metal mixture with positive contributions to TT3 (weight = 0.439), TT4 (weight = 0.502) and FT3 (weight = 0.450).ConclusionsThe combined metal exposure was associated with increased levels of TT3, TT4, and FT3 in children and Fe appeared to be the major contributor. Further studies are warranted to confirm our findings and elucidate the underlying mechanisms.…”
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Analysis of the sensitization activity of Moringa oleifera leaves protein by Juan Lu, Juan Lu, Xiaoxue Liu, Xiaoxue Liu, Wenjie Li, Wenjie Li, Chuyu Xi, Chuyu Xi, Dan Feng, Dan Feng, Shuang Song, Shuang Song

“…The molecular weight of moringa leaf protein was analyzed by SDS-PAGE, and the molecular weight was mainly concentrated around 23 kDa~70 kDa, with the highest content of 35 kDa (major allergen). The study of the hemagglutination characteristics of Moringa oleifera leaves protein revealed that the protein exhibited high stability at temperatures below 60°C, with complete loss of activity occurring at temperatures above 110°C for 20 min. …”
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Temporal trends, associated risk factors and longitudinal cardiovascular outcomes of body roundness among middle-aged and older Chinese adults: from the China Health and Retirement... by Ying-Yuan Gan, Yun-Dan Luo, Lu Zhai, Rong-Rui Huo, Xia Dai, Qian Liao

“…BackgroundObesity is a major global health issue, driving high morbidity and mortality rates. …”
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Comparative Evaluation of AI-Based Multi-Spectral Imaging and PCR-Based Assays for Early Detection of <i>Botrytis cinerea</i> Infection on Pepper Plants by Dimitrios Kapetas, Eleni Kalogeropoulou, Panagiotis Christakakis, Christos Klaridopoulos, Eleftheria Maria Pechlivani

“…This underscores the crop’s importance as a major economic driver of export revenue for producing nations. …”
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Platform for laser-driven X-ray diagnostics of heavy-ion heated extreme states of matter by P. Hesselbach, J. Lütgert, V. Bagnoud, R. Belikov, O. Humphries, B. Lindqvist, G. Schaumann, A. Sokolov, A. Tauschwitz, D. Varentsov, K. Weyrich, B. Winkler, X. Yu, B. Zielbauer, D. Kraus, D. Riley, Zs. Major, P. Neumayer

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Evaluating Ultrafine Particles and PM2.5 in Microenvironments with Health Perspectives: Variability in Concentrations and Pollutant Interrelationships by Sheng Xiang, Shaojun Zhang, Yu Ting Yu, Hui Wang, Ye Deng, Qinwen Tan, Zihang Zhou, Ye Wu

“…Moreover, the traffic emissions (PNCd,tr) contribute 30% of the PNC throughout the study while solid fuel burning (PNCd,sfb) could be a major contributor only in winter (29%). Seasonal variability in PNCd,tr and PNCd,sfb was found, with 2–3 times higher median PNCd,tr and 7 times higher median PNCd,sfb in winter compared to autumn. …”
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CCR7 and CD48 as Predicted Targets in Acute Rejection Related to M1 Macrophage after Pediatric Kidney Transplantation by Jie Zhang, Jun Pei, Chengjun Yu, Jin Luo, Yifan Hong, Yi Hua, Guanghui Wei

“…Although long and short-term survival rates for the graft have improved significantly with the development of immunosuppressants, acute rejection (AR) remains a major risk factor attacking the graft and patients. …”
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From across the globe – traumatic injuries are an international concern at the US-Mexico border wall by Allison E Berndtson, Jay Doucet, Todd W Costantini, Laura Haines, Sarah Lagan, Laura Adams, Jarrett Santorelli, Gabriella Waters

“…These border crossings have led to a dramatic increase in major trauma resulting in increased inpatient resource utilization and the need for comprehensive hospital services. …”
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Aberrant B cell receptor signaling responses in circulating double-negative 2 B cells from radiographic axial spondyloarthritis patients by Rick Wilbrink, Stefan F.H. Neys, Rudi W. Hendriks, Anneke Spoorenberg, Frans G.M. Kroese, Odilia B.J. Corneth, Gwenny M.P.J. Verstappen

“…Objective: Radiographic axial spondyloarthritis (r-axSpA) is a chronic rheumatic disease in which innate immune cells and T cells are thought to play a major role. However, recent studies also hint at B cell involvement. …”
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A novel model-based meta-analysis to indirectly estimate the comparative efficacy of two medications: an example using DPP-4 inhibitors, sitagliptin and linagliptin, in treatment o... by Yan Gong, James Rogers, Christian Friedrich, Sanjay Patel, Alexander Staab, Jorge Luiz Gross, Daniel Polhamus, William Gillespie, Brigitta Ursula Monz, Silke Retlich

“…Other covariates showed no major impact on model parameters and were not included. …”
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Predictive value of preoperative pan-immune-inflammation value index in the prognosis of oral cancer patients undergoing radical resection by Weihai Huang, Yulan Lin, Enling Xu, Yanmei Ji, Jing Wang, Fengqiong Liu, Fa Chen, Yu Qiu, Bin Shi, Lisong Lin, Baochang He

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ASPECTOS PSICOJURÍDICOS DA SÍNDROME ALCOÓLICA FETAL by Eduardo Jorge Sant'Ana Honorato, Dalila Azevedo da Silva, Eunice Braga Borges dos Santos, Alice Sobral, Daniel Cerdeira de Sousa

“…The method used was a systematic review of the literature which can be seen that the SAF is becoming a public health problem because it is a major cause of mental retardation. SAF is a disease for which no cure but is completely preventable by withdrawal of alcohol intake during the gestation period when the nervous system is the formation and development process. …”
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Association between sleep duration and hypertension in southwest China: a population-based cross-sectional study by Yu Guo, Liming Li, Zhengming Chen, Qiang Sun, Pei Pei, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Guojin Luo, John S Ji, Xiaoyu Chang, Xiaofang Chen*

“…Objective Hypertension is a major risk factor and cause of many non-communicable diseases in China. …”
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Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer by Sharon Pei Yi Chan, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Chaw Yee Beh, Eugenia Li Ling Yeo, Dennis Jun Jie Poon, Pek Lim Chu, Khee Chee Soo, Melvin Lee Kiang Chua, Edward Kai-Hua Chow

“…Enhanced histone deacetylase inhibitor (HDACi) efficacy in RR models was further examined by in vivo studies, and genetic and chemical inhibition of major Class I/II HDACs. Regulatory roles of HDAC6/SP1 axis were investigated using immunoprecipitation, gel shift and ChIP-qPCR assays. …”
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Evaluation of ecological geological environment carrying capacity and analysis of driving mechanisms based on normal cloud model and geodetector model by Rongkun Dai, Changlai Xiao, Xiujuan Liang, Lin Jia, Yi Jia, Jiarui Yao, Weifei Yang, Jiang Zhang, Linzuo Zhang, Weifeng Li

“…Any pair of the 18 variables show varying degrees of enhancement effects on the EGECC. (4) The regression coefficients of the five major driving factors exhibit significant agglomeration characteristics in spatial distribution. …”
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Transconjunctival correction of involutional entropion: A video demonstration by Neelam Pushker, B. Mounica, Sahil Agrawal

“…Disinsertion/dehiscence of inferior retractors is considered as the major reason along with the loss of orbicularis muscle tone with or without over-riding of pre-septal fibers onto pretarsal fibers, and laxity of overall eyelid and/canthal tendons. …”
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Protocol for a prospective quasi-experimental study on SARS-CoV-2 transmission during outdoor sports events in France: the COVID-ESO project by Frédéric Laurent, Philippe Vanhems, Christelle Elias, Pascal Roy, Sandrine Nail-Billaud, Patrick Basset, Emmanuelle Dantony, Mathieu Fauvernier

“…Introduction The spread of SARS-CoV-2 and its variants in the community remains a major concern despite the application of control measures including the banning of mass sporting events. …”
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