Unveiling <i>DENND2D</i> as a Novel Prognostic Biomarker for Prostate Cancer Recurrence: From Gene to Prognosis by Chi-Fen Chang, Lih-Chyang Chen, Yei-Tsung Chen, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Te-Ling Lu, Shu-Pin Huang, Bo-Ying Bao

“…<b>Background:</b> Prostate cancer is a major global health burden, with biochemical recurrence (BCR) following radical prostatectomy affecting 20–40% of patients and posing significant challenges to prognosis and treatment. …”
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The association of HIV status and depressive symptoms in the Ndlovu Cohort study by Li Xiang Y. den Boer, Karine Scheuermaier, Hugo A. Tempelman, Roos E. Barth, Walter L. J. M. Devillé, Roel A. Coutinho, Diederick E. Grobbee, Francois Venter, Alinda G. Vos-Seda, Kerstin Klipstein-Grobusch

“…Abstract HIV majorly contributes to the disease burden in South Africa. …”
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Pneumonia among Under-Five Children in Northwest Ethiopia: Prevalence and Predictors—A Community-Based Cross-Sectional Study by Zewudu Andualem, Tsegaye Adane, Abiye Tigabu, Walelign Worku Yallew, Sintayehu Daba Wami, Henok Dagne, Jember Azanaw, Gebisa Guyasa, Zelalem Nigussie Azene, Mastewal Endalew

“…In Ethiopia, pneumonia continues to be the major childhood problem and killer, particularly in the study area. …”
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Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis by Ganesh Sharma, Neeraj Kumar, Chandra Shekhar Sharma, Taha Alqahtani, Yewulsew Kebede Tiruneh, Sharifa Sultana, Gabriel Vinícius Rolim Silva, Gabriela de Lima Menezes, Magdi E. A. Zaki, Jonas Ivan Nobre Oliveira

“…Abstract The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a major challenge to global health. Targeting the main protease of the virus (Mpro), which is essential for viral replication and transcription, offers a promising approach for therapeutic intervention. …”
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The Impact of Artificial Intelligence on Healthcare: A Comprehensive Review of Advancements in Diagnostics, Treatment, and Operational Efficiency by Md. Faiyazuddin, Syed Jalal Q. Rahman, Gaurav Anand, Reyaz Kausar Siddiqui, Rachana Mehta, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Arif Hussain, Ranjit Sah

“…Core applications like remote monitoring and predictive analytics improve operational effectiveness and patient involvement. However, there are major obstacles to the mainstream implementation of AI in healthcare, including issues with data security and budget constraints. …”
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Mobile application adjunct to the WHO basic emergency care course: a mixed methods study by Juma A Mfinanga, Hendry R Sawe, Anya L Greenberg, Andrea G Tenner, Alexandra Friedman, Paulina Nicholaus, Christian C Rose, Newton Addo, Catherine Reuben Shari, Upendo N George, Michael J Losak

“…Focus groups revealed five major themes related to BEC app adoption: educational utility, clinical utility, user experience, barriers to access and barriers to use.Conclusion The BEC app was well received, but no differences in knowledge retention and self-efficacy were observed between the two arms and only a very small number of participants reported using the app. …”
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Progress in phase field research of dead lithium in lithium batteries by Jing LIU, Huiyi CHEN, Huiyu LIU, Shu LI

“…However, the practical application of lithium metal anodes faces major challenges mainly because of the inevitable formation of lithium dendrites and dead lithium during the charge–discharge cycle. …”
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ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism by Christoffer Löf, Nasrin Sultana, Neha Goel, Samuel Heron, Gudrun Wahlström, Andrew House, Minna Holopainen, Reijo Käkelä, Johanna Schleutker

“…Genetic factors contribute substantially to PrCa risk, with up to 57% of the risk being attributed to genetic determinants. A major challenge in managing PrCa is the early identification of aggressive cases for targeted treatment, while avoiding unnecessary interventions in slow-progressing cases. …”
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Improving Patient Outcomes in mTBI: The Role of Integrated Nursing Interventions in the Emergency Department by Feng T, Zhao P, Wang J, Du X, Ai M, Yang J, Li J

“…Ting Feng, Peng Zhao, Jiao Wang, Xiaoye Du, Meimei Ai, Jing Yang, Junjie Li Department of Emergency, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, 710032, People’s Republic of ChinaCorrespondence: Ting Feng, Department of Emergency, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, 710032, People’s Republic of China, Email fengtingff24@163.comBackground: Traumatic brain injury (TBI) is a major cause of morbidity and mortality, often requiring emergency department (ED) management. …”
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The effect of dietary fish oil replacement by microalgae on the gilthead sea bream midgut bacterial microbiota by Katsoulis-Dimitriou, Stefanos, Nikouli, Eleni, Gkalogianni, Elli Zafeiria, Karapanagiotidis, Ioannis T., Kormas, Konstantinos A.

“…The overexpressed pathway was related to the metabolism of fucose, a major constituent of the polysaccharide content of several microalgal species. …”
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Short-acting beta agonist, antibiotics, oral corticosteroid and association with mortality and cardiopulmonary events in patients with COPD: a retrospective cohort study in Alberta... by Mohit Bhutani, Irvin Mayers, Arsh Randhawa, Manisha Talukdar, Suzanne McMullen, Phongsack Manivong, Aaron Gelfand

“…Associations were modelled between mortality and SABA, antibiotic and OCS history, and between major adverse cardiac events (MACE) and cardiovascular disease (CVD) death and SABA history.Results Among 188 969 patients, dose–response effects were observed. …”
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Are noise and air pollution related to the incidence of dementia? A cohort study in London, England by Derek G Cook, Frank J Kelly, Iain M Carey, H Ross Anderson, David P Strachan, Richard W Atkinson, Sean D Beevers, David Dajnak, John Gulliver

“…Traffic intensity, distance from major road and night-time noise levels (Lnight) were estimated at the postcode level. …”
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Intraspecific variation for heat stress tolerance in wild emmer-derived durum wheat populations by Mohammed Yousif Balla, Mohammed Yousif Balla, Nasrein Mohamed Kamal, Nasrein Mohamed Kamal, Izzat Sidahmed Ali Tahir, Izzat Sidahmed Ali Tahir, Yasir Serag Alnor Gorafi, Yasir Serag Alnor Gorafi, Modather Galal Abdeldaim Abdalla, Hisashi Tsujimoto

“…High temperatures pose a major threat to wheat productivity and necessitate the development of new cultivars that are resilient to future heat stress. …”
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Incidence and risk factors for clinical omphalitis among neonates in Eastern Uganda using chlorhexidine gel for cord care: a community-cohort study by John Wogabaga, Kathy Burgoine, Abel Kakuru, Brendah Nambozo, Martin Chebet, Josephine Tumuhamye, Benon Wanume, Faith Oguttu, Milton W. Musaba, Agnes Napyo, Solomon Wani, Peter Olupot-Olupot, Andrew D. Weeks, Thorkild Tylleskär, David Mukunya

“…Whereas it is known to be a major route of localized and often systemic infection, studies describing incidence and risk factors remain scanty, especially in resource limited settings where the condition is thought to be common. …”
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Prediction of growth and feed efficiency in mink using machine learning algorithms by A. Shirzadifar, G. Manafiazar, P. Davoudi, D. Do, G. Hu, Y. Miar

“…Since feed cost is the major input cost in the mink industry, evaluating of FE is a crucial step for competitiveness of the mink industry. …”
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Characteristics and Surgical Results of Patients with Hypertrophic Obstructive Cardiomyopathy without Intrinsic Mitral Valve Diseases Undergoing Mitral Subvalvular Procedures durin... by Qiang Ji, YuLin Wang, Ye Yang, LiMin Xia, WenJun Ding, Kai Song, ChunSheng Wang

“…Mitral subvalvular procedures have acquired a major role during hypertrophic obstructive cardiomyopathy (HOCM) surgery. …”
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Epidemics In The 21st Century: A Multifaceted Challenge by Shawana Sharif

“…Pakistan is experiencing major public health threats in the face of the current massive flood that facilitates the transmission of this deadly disease. …”
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The Method of Situation Analysis of International Relations as A Forecasting Tool Under Conditions of Transforming World Order by V. G. Baranovsky, I. Ya. Kobrinskaya, S. V. Utkin, B. E. Frumkin

“…The article also overviews the major principles of situation analysis: 1) participants must have high level of expertise; 2) situational analysis is multidisciplinary; 3) situational analysis allows focusing on key aspects of a problem when there is no clear, unambiguous understanding of it and when the views of experts vary widely; 4) to obtain significant analytical results, it is necessary to move above the situation under analysis in search of wider generalizations; 5) situational analysis is opposite to propaganda, it must be averted to conformism and partisanship; 6) situation analysis should be aimed at realizing national interests; 7) situation analysis is directed towards future. …”
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Concentrated Solar Power and Photovoltaic Systems: A New Approach to Boost Sustainable Energy for All (Se4all) in Rwanda by Noel Hagumimana, Jishi Zheng, Godwin Norense Osarumwense Asemota, Jean De Dieu Niyonteze, Walter Nsengiyumva, Aphrodis Nduwamungu, Samuel Bimenyimana

“…At the same time, it has highlighted its unfriendly relationship with the environment because of carbon dioxide (CO2) emission, which is a major cause of global warming. Solar power is another source of electricity that has the potential to generate electricity in Rwanda. …”
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