Inhibition of platelet activation alleviates diabetes-associated cognitive dysfunction via attenuating blood-brain barrier injury by Fuxing Xu, Juan Hu, Xuying Li, Lan Yang, Shiqiu Jiang, Tao Jiang, Bo Cheng, Hailiang Du, Ruiduo Wang, Yingying Deng, Wei Gao, Yansong Li, Yaomin Zhu

“…Endothelial cells are the major component of BBB, on which the increased expression of CD40 could mediate BBB dysfunction in diabetics. …”
Get full text

Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial by Run-Cong Nie, Shu-Qiang Yuan, Ya Ding, Yong-Ming Chen, Yuan-Fang Li, Cheng-Cai Liang, Mu-Yan Cai, Guo-Ming Chen, Wei Wang, Xiao-Wei Sun, De-Sheng Weng, Dan-Dan Li, Jing-Jing Zhao, Xiao-Jiang Chen, Yuan-Xiang Guan, Zhi-Min Liu, Yao Liang, Ma Luo, Jun Chi, Hai-Bo Qiu, Zhi-Wei Zhou, Xiao-Shi Zhang, Ying-Bo Chen

“…The primary endpoint was major pathological response (MPR) rate. Thirty-two patients were enrolled. …”
Get full text

A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti by Bacot, Tiphaine, Haberkorn, Chloe, Guilliet, Joseph, Cattel, Julien, Kefi, Mary, Nadalin, Louis, Filee, Jonathan, Boyer, Frederic, Gaude, Thierry, Laporte, Frederic, Tutagata, Jordan, Vontas, John, Dusfour, Isabelle, Bonneville, Jean-Marc, David, Jean-Philippe

“…Two isofemale lines originating from French Guiana and being deprived from major target-site mutations showed distinct insecticide resistance levels. …”
Get full text

Genome-wide identification of MGT gene family in soybean (Glycine max) and their expression analyses under magnesium stress conditions by Ammar Anwar, Junaid Akhtar, Saba Aleem, Maida Aleem, Muhammad Khuram Razzaq, Saud Alamri, Qasim Raza, Iram Sharif, Arooj Iftikhar, Shehreen Naseer, Zaheer Ahmed, Iqrar Ahmed Rana, Waheed Arshad, Muhammad Imran Khan, Javaid Akhter Bhat, Muqadas Aleem, Abdel-Rhman Z. Gaafar, Mohamed S. Hodhod

“…Segmental duplication under purifying selection pressure was identified as the major driving force in the expansion of MGTs in soybean. …”
Get full text

Hierarchizing multi-scale environmental effects on agricultural pest population dynamics: a case study on the annual onset of Bactrocera dorsalis population growth in Senegalese or... by Caumette, Cécile, Diatta, Paterne, Piry, Sylvain, Chapuis, Marie-Pierre, Faye, Emile, Sigrist, Fabio, Martin, Olivier, Papaïx, Julien, Brévault, Thierry, Berthier, Karine

“…In this study, we developed an ecoinformatics approach to unravel the multi-scale environmental conditions that lead to the early re-infestation of mango orchards by a major pest in Senegal, the oriental fruit fly Bactrocera dorsalis (BD). …”
Get full text

A comparative study between condensed polytetrafluoroethylene mesh versus other composite meshes in Endo-laparoscopic ventral herniorrhaphy by Meredeth Chin, James Lee Wai Kit, Sujith Wijerathne, Avelyn Aw, Daryl Chia Kai Ann, Sean Lee Kien Fatt, Tharun Ragupathi, Harry Ng Ho Man, Davide Lomanto

“…There were no differences in terms of patient demographics and major comorbidities. At presentation, the indication was more commonly for recurrence (p = 0.043), and patients were more symptomatic (p = 0.0034) in the Omyra group than the other synthetic meshes group. …”
Get full text

FEASTS: Radial Distribution of H i Surface Densities Down to 0.01 M⊙ pc−2 of 35 Nearby Galaxies by Jing Wang, Dong Yang, Xuchen Lin, Qifeng Huang, Zhijie Qu, Hsiao-wen Chen, Hong Guo, Luis C. Ho, Peng Jiang, Zezhong Liang, Céline Péroux, Lister Staveley-Smith, Simon Weng

“…These results imply that, in the absence of major tidal interactions, physical processes must cooperate so that Σ _H _i distributes in a self-similar way in the outer region down to the 0.01 M _⊙ pc ^−2 level. …”
Get full text

Germinal Center B Cells are Uniquely Targeted by Antibody-Suppressor CXCR5+CD8+ T Cells by Jason M. Zimmerer, PhD, Sachi Chaudhari, BS, Kavya Koneru, BS, Jing L. Han, MD, PhD, Mahmoud Abdel-Rasoul, MA, Hope Uwase, MA, Tai Yi, MD, Christopher K. Breuer, MD, Ginny L. Bumgardner, MD, PhD

“…The reduction of TFH-cell quantity was dependent on CD8+ TAb-supp cell–mediated major histocompatibility complex-I-dependent cytotoxic killing of GC B cells. …”
Get full text

Host-Induced Gene Silencing of the <i>Aspergillus flavus O</i>-Methyl Transferase Gene Enhanced Maize Aflatoxin Resistance by Olanike Omolehin, Yenjit Raruang, Dongfang Hu, Zhu-Qiang Han, Surassawadee Promyou, Robert L. Brown, Qijian Wei, Kanniah Rajasekaran, Jeffrey W. Cary, Kan Wang, Dan Jeffers, Zhi-Yuan Chen

“…Maize is one of the major crops that are susceptible to <i>Aspergillus flavus</i> infection and subsequent aflatoxin contamination, which poses a serious health threat to humans and domestic animals. …”
Get full text

Protocol for a randomised ‘screen-and-treat’ Helicobacter pylori eradication trial in 14–18-years-old adolescents residing in three regions of Chile: effectiveness and microbiologi... by Ximena Aguilera, Camila Cabrera, Sergio George, Yalda Lucero, Beatriz Zabala Torres, Lilian Fernández, Nora Mamani, Anne Lagomarcino, Miguel O'Ryan

“…Introduction Gastric cancer is a major global health concern, being the final stage of a long-term process, primarily associated with Helicobacter pylori (H. pylori) infection. …”
Get full text

Protocol on establishing a prospective enhanced surveillance of vaccine preventable diseases in residential aged care facilities in Central Queensland, Australia: an observational... by Mohammad Rashidul Hashan, Robert Booy, Michael Kirk, Gulam Khandaker, Gwenda Chapman, Jacina Walker, Sonya Jayne Davidson, Jill Auriac, Nicolas Smoll, Delwar Akbar

“…Introduction Infectious diseases are a major cause of mortality and morbidity among the highly vulnerable occupants of residential aged care facilities (RACFs). …”
Get full text

Unlocking barriers and strategies of halal certification for micro and small enterprises in Indonesia: Analytic network process approach by Muhammad Anwar Fathoni, Prima Dwi Priyatno, Faizi, Fadhli Suko Wiryanto, Widarto Rachbini, Suryani

“…The findings highlight three major barriers: financial constraints, regulatory complexities, and limited awareness among MSE owners. …”
Get full text

Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis by Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S. A. Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M. Assiri, Abdelilah Aboussekhra, Ali S. Alzahrani, Ali S. Alzahrani, Yufei Shi

“…IntroductionMetastasis is the major cause of thyroid cancer morbidity and mortality. …”
Get full text

Depression Paradox in Cardiovascular Outcomes of Adult Patients with Obstructive Sleep Apnea: Insights from 2 Million Nationwide Hospitalizations by Rupak Desai, Sashwath Srikanth, Shaylika Chauhan, Zainab Gandhi, Warda Shahnawaz, Aleen Rahman, Bisharah Rizvi, Akhil Jain

“…Paradoxically, there was decreased risk of all-cause mortality [odds ratios (OR): 0.79, 95% confidence interval (CI): 0.73-0.86], major adverse cardiac and cerebrovascular events (OR: 0.83, 95% CI: 0.80-0.87), acute MI (OR: 0.80, 95% CI: 0.76-0.85), dysrhythmia/atrial fibrillation (OR: 0.81, 95% CI: 0.79-0.83), and cardiac arrest including ventricular fibrillation (OR: 0.65, 95% CI: 0.73-0.82) in the OSA+D+ cohort (P < 0.001). …”
Get full text

Anti-phenolic glycolipid antibodies in Mycobacterium bovis infected cattle by Zijie Zhou, Anouk van Hooij, J. Hessel M. van Dijk, Nina Musch, Louise Pierneef, Hamza Khalid, Kees Franken, Thomas Holder, Neil Watt, Anita L. Michel, Jeroen D.C. Codée, Martin Vordermeier, Paul L.A.M. Corstjens, Elisabeth M.D.L. van der Heijden, Jayne C. Hope, Annemieke Geluk

“…Additionally, M. bovis transmission from animals to humans can result in zoonotic TB, especially in low- and middle-income countries (LMICs), highlighting the need to enhance One Health surveillance to mitigate this threat.Antibodies directed against a major mycobacterial cell wall component of M. leprae, phenolic glycolipid-I (PGL-I), have shown excellent performance in identifying M. leprae infection in humans and animals. …”
Get full text

Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients by M. Matta, A. Pavy-Le Traon, S. Perez-Lloret, C. Laporte, I. Berdugo, N. Nasr, H. Hanaire, J. M. Senard

“…Hereby, we assessed the rate and the major risk factors for CAN initiation and progression in a cohort of type 1 diabetic patients followed over a three-year period. …”
Get full text

Risk Factors of Bacteremia following Multiple Traumas by Hak-Jae Lee, Eol Choi, Nak-Joon Choi, Hyun-Woo Sun, Jae-Suk Lee, Jeong-Woo Lee, Tae-Yoon Kim, Yoon-Joong Jung, Suk-Kyung Hong

“…Background. Bacteremia is a major nosocomial infection that frequently occurs in trauma patients, increasing morbidity and mortality. …”
Get full text

Development and predictors of bipolar disorder in children and adolescents with depressive disorders: a systematic review, meta-analysis, and meta-regression by Gonzalo Salazar de Pablo, Violeta Perez-Rodriguez, Javier de Otazu Olivares, Javier Camacho-Rubio, Aditya Sharma, Ana Catalán, Josefien Breedvelt, Claudia Aymerich, Mihai Pop, Carmen Moreno, Ian Kelleher, Jane Anderson, Paolo Fusar-Poli, Christoph U Correll, Allan H. Young

“…Studies using the DSM (21.6%, 95% CI=20.2% to 23.1%) and studies evaluating C&A with a major depressive disorder only (19.8%, 95% CI=16.8% to 23.1%) found higher rates of development of BD. …”
Get full text

The Fabrication and Evaluation of a Potential Biomaterial Produced with Stem Cell Sheet Technology for Future Regenerative Medicine by Shukui Zhou, Ying Wang, Kaile Zhang, Nailong Cao, Ranxing Yang, Jianwen Huang, Weixin Zhao, Mahbubur Rahman, Hong Liao, Qiang Fu

“…A Triton X-100 method can achieve effective cell removal, retain major ECM components, and preserve the ultrastructure of ADSC sheets. …”
Get full text

Biochar effects on durum wheat (Triticum durum) under ambient and elevated atmospheric CO2 by Lorenzo Brilli, Franz-Werner Badeck, Lorenzo Genesio, Silvia Baronti, Fulvia Rizza, Clara Fares, Luigi Cattivelli, Franco Miglietta, Anita Maienza, Alessandro Zaldei, Federica Camin, Rosella Motzo, Piero Toscano

“…While e[CO2] generally boosts wheat yield and biomass, major concerns remain about the impact on qualitative traits. …”
Get full text