Differentiation Potential of Early- and Late-Passage Adipose-Derived Mesenchymal Stem Cells Cultured under Hypoxia and Normoxia by Ashley G. Zhao, Kiran Shah, Julien Freitag, Brett Cromer, Huseyin Sumer

“…Physiological parameters such as oxygen concentration, media constituents, and passage numbers influence the properties of MSCs and may have major impact on their therapeutic potential. Cells grown under hypoxic conditions have been widely documented in clinical use. …”
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What are the perceptions and experiences of adults using mobile applications for self-management in diabetes? A systematic review by Benedict Hayhoe, Azeem Majeed, Geva Greenfield, Ana Luísa Neves, Henock B Taddese, Kalthum Patail, Hui Hsuan Pai

“…Data were narratively synthesised, guided by the ‘unified theory of acceptance and use of technology (UTAUT)’ framework.Results A total of 24 qualitative studies deploying interviews and surveys with open-ended questions were included in the review. We identified four major themes, which were mapped against the constructs of the ‘UTAUT’ framework: ‘performance expectancy’, ‘effort expectancy’, ‘social influence’ and ‘facilitating conditions’.More than 50% of the studies described favourable app features relating to monitoring blood glucose, diet and exercise while also emphasising the importance of customising these to patient needs. …”
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Outpatient treatment of worsening heart failure with intravenous and subcutaneous diuretics: a systematic review of the literature by Eric Wierda, Cathelijne Dickhoff, Martin Louis Handoko, Liane Oosterom, Wouter Emmanuel Kok, Y. deRover, B.A.J.M. deMol, Loek vanHeerebeek, Jutta Maria Schroeder‐Tanka

“…Abstract Aims In the coming decade, heart failure (HF) represents a major global healthcare challenge due to an ageing population and rising prevalence combined with scarcity of medical resources and increasing healthcare costs. …”
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Comprehensive approach to predictive analysis and anomaly detection for road crash fatalities by Chopparapu Gowthami, S. Kavitha

“…Since traffic accidents are a major global cause of injury and death, it is essential to comprehend and reduce their effects. …”
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Small Intestinal Bacterial Overgrowth Syndrome as a Risk Factor for Ventricular Tachycardia in Chronic Heart Failure with Left Ventricular Systolic Dysfunction by M. V. Fadeeva, M. R. Skhirtladze, V. T. Ivashkin

“…The control group consisted of 20 patients comparable to the main group by sex, age and major diseases in the absence of CHF and SIBOS.Results. …”
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Effects of Different Intertillage Practices on Soil Biochemical Properties and Soybean Yield in Soybean Fields by Mingcong Zhang, Yanhong Zhou, Chenglin Li, Cheng Yuan, Mingfen Shan, Yuxin Fan, Zhongxia Yu, Linfeng Ren, Liu Cui, Chen Wang

“…Heilongjiang Province, China, is a major soybean-producing area where low temperatures in early spring and poor soil moisture retention are the main limiting factors leading to low soybean yields. …”
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Assessment of Factories on Adherence to COVID-19 Standard Operating Procedures: A Case Study of Wakiso, Mukono, Buikwe, and Jinja Districts, Uganda by Joseph M. Kungu, Edity Namyalo, Angella Musewa, Sarah Nitumusiima, Phiona Keije, Catherine Nakakooza, Osborn Oyirwoth

“…A total of 39 factories were included in the study and were categorized into four major groups; food and beverages (15), plastics (5), construction (8), and others (11). …”
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Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and... by Ramashish Kumar, Ashok Chauhan, Sovan Sarang Dhar, Nitish Kumar

“…Radiation-induced acute skin reaction is of major concern during and after definitive course of radiotherapy. …”
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Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis by Mahsa Ranjbar, Mehran Rahimlou, Maryam Fallah, Kurosh Djafarian, Hamed Mohammadi

“…The results indicate a major influence of vitamin D supplementation on the Disease Activity Score 28 (DAS-28) (WMD: −0.83, 95 % CI: −1.38 to −0.28, p-value <0.001), C-reactive protein (CRP) level (WMD: −0.24, 95 % CI: −0.45 to −0.03, p-value = 0.03), erythrocyte sedimentation rate (ESR) level (WMD: −4.08, 95 % CI: −4.67 to −3.50, p-value <0.001), serum vitamin D level (WMD: 12.69, 95 % CI: 1.80 to 23.59, p-value = 0.02), and non-significant effect on the health assessment questionnaire (HAQ) and visual analog scale on pain (VAS-pain) scores. …”
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In Silico Identification of New Anti-SARS-CoV-2 Main Protease (Mpro) Molecules with Pharmacokinetic Properties from Natural Sources Using Molecular Dynamics (MD) Simulations and Hi... by Harrison Onyango, Patrick Odhiambo, David Angwenyi, Patrick Okoth

“…However, these drugs majorly act to reduce the symptoms of the disease. …”
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Peranan Kadar Feritin Serum terhadap Kejadian Preeklampsia by Mega Ulfah, Masrul , Arni Amir

“…<br />Kata kunci: preeklampsia, hipertensi dalam kehamilan, serum feritin</p><p> </p><p>Abstract <br />Preeclampsia is a major cause of worldwide maternal and prenatal mortality. …”
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Medico-ethnobotanical survey of medicinal plants used in the treatment of skin diseases in Tiruppur District, Tamil Nadu, India by Prakasam Radha, Chinniaya Udhayavani, Raju Nagaraj, Kumarasamy Sivaranjani

“…Out of which, herbs constitute the major portion with 31 species used for skin ailments. …”
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Intracranial CT findings in traumatic brain injury: A retrospective, cross-sectional study among Igbo population in Nigeria by Angel-Mary Anakwue, Felicitas Ugochinyere Idigo, Uloma Benedicta Nwogu, Sylvester Osita Ogbu, Anthony Nnamani, Kennedy Joseph, Camillus Chukwuemeka Ugwoke

“…Introduction: Traumatic brain injury (TBI) is a major cause of death and disability and in recent years has been increasingly reported even in developing countries. …”
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Psychological detachment from work predicts mental wellbeing of working-age adults: Findings from the 'Wellbeing of the Workforce' (WoW) prospective longitudinal cohort study. by Holly Blake, Juliet Hassard, Louise Thomson, Wei Hoong Choo, Teixiera Dulal-Arthur, Maria Karanika-Murray, Lana Delic, Richard Pickford, Lou Rudkin

“…<h4>Results</h4>Risk for major depression (T1: 20.0% to T2: 29.0%, p = .002), poor general health (T1: 4.7% to T2: 0%, p = .002) and poor life satisfaction (T1: 15.4% to T2: 25.4%, p = .002) worsened over time, moderate-to-severe anxiety remained stable (T1: 26.1% to T2: 30.2%, p = .15). …”
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An Analysis of the Gear Meshing Characteristics of the Main Planetary Gear Trains of Helicopters Undergoing Shafting Position Changes by Li Xuejun, Jiang Lingli, Hua Dengrong, Yin Daoxuan, Yang Dalian

“…This study’s research findings will provide a theoretical basis for future operational status monitoring of the main transmission systems of helicopters and are of major significance for improvements in the operational stability of helicopter transmission systems, which will potentially ensure safe and efficient operations.…”
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Selective and persistent toxicity of seven insecticides to five egg parasitoids of Spodoptera frugiperda by Hao-Ran Li, Cheng-Yang Li, Peng Dai, Lian-Sheng Zang, Nicolas Desneux, Wei Xu

“…Abstract Background Spodoptera frugiperda, a major migratory and invasive pest, inflicts significant yield loss on rice and maize in China. …”
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Secukinumab in the treatment of psoriatic arthritis: efficacy and safety results through 3 years from the year 1 extension of the randomised phase III FUTURE 1 trial by Philip J Mease, Arthur Kavanaugh, Andreas Reimold, Hasan Tahir, Jürgen Rech, Stephen Hall, Piet Geusens, Pascale Pellet, Evie Maria Delicha, Shephard Mpofu, Luminita Pricop

“…Exposure-adjusted incidence rates for selected adverse events per 100 patient-years (secukinumab 150/75 mg) were serious infections (1.7/1.6), Candida infections (1.4/0.7), Crohn’s disease (0/0.3), ulcerative colitis (0/0.3) and major adverse cardiac events (0.3/0.8).Conclusion Subcutaneous secukinumab provided sustained improvements in the signs and symptoms, quality of life and physical function of patients with active PsA with low rate of radiographic disease progression through 3 years. …”
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Correlation between the Serum Platelet-Derived Growth Factor, Angiopoietin-1, and Severity of Coronary Heart Disease by Sisi Pang, Zhengxian Tao, Xiaoyan Min, Chuanwei Zhou, Dijia Pan, Zhen Cao, Xiangming Wang

“…Patients with ACS were followed up, and the major adverse cardiovascular and cerebrovascular adverse events were recorded. …”
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Incremental Lifetime Cancer Risk of PAHs in PM2.5 via Local Emissions and Long-Range Transport during Winter by Shahzada Amani Room, Chia En Lin, Shih Yu Pan, Ta Chih Hsiao, Charles C.-K. Chou, Kai Hsien Chi

“…Our results indicated that vehicle emissions (gasoline engines: 20.8%, diesel engines: 23.3%) and coal combustion (55.9%) were the major sources of PAHs in the urban site, with higher levels in LP than in LRT. …”
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Effects of exercise dose based on the ACSM recommendations on depression in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials by Yang Fang, Yang Fang, Bai Xiaoling, Li Huan, Li Huan, Guan Yaping, Zhang Binying, Wang Man, Wu Juan, Liu Xinyu

“…ObjectiveTo explore the impact of various exercise doses on depressive symptoms among hemodialysis patients and offer valuable guidance for the selection of optimal exercise doses in clinical practice settings.MethodsA comprehensive systematic review was conducted across four major databases, namely, PubMed, Embase, Web of Science, and Cochrane Library, covering the period from their inception until August 2024. …”
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